リアルタイムフィードバックとハイブリッド機能解析による脳機能ダイナミズムの可視化

• Project Area: Understanding brain plasticity on body representations to promote their adaptive functions
• Project/Area Number: 17H05900
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Asahikawa Medical College
• Principal Investigator: 鎌田 恭輔 旭川医科大学, 医学部, 教授 (80372374)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Project Status: Discontinued (Fiscal Year 2018)
• Budget Amount: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000); Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
• Keywords: 脳皮質電位 / 高周波律動 / 脳線維連絡画像 / 機能フィートバック / 新たなリハビリテーション / 脳血流定量化 / 機能ネットワーク / 病的ネットワーク / 異常脳活動 / High Gamma Activity / Connectivity / Epilepsy / リアルタイムフィードバック / 脳機能マッピング / 脳波 / 機能的MRI

Outline of Annual Research Achievements

1,てんかん、2,亜急性に悪化する脳腫瘍、3,突然機能を失う脳卒中の三病態に応じてリアルタイム機能フィードバックを加え、多種機能画像によるfast & slow機能回復・変容過程を可視化する。脳情報抽出には脳波(EEG), 脳皮質電位(ECoG)、functional MRI(fMRI), およびtractographyを用いる。病態1、2ではECoGによる高周波律動(HGA)を含めた多帯域リアルタイム周波数解析、運動・言語・認知機能読み取りを行い、その結果を患者にフィードバックし変容した脳機能を可視化する。覚醒下手術では、独自作成した高密度電極ECoGのα、β帯域の脱同期とHGAにRGB色を付してcolor-coded周波数ダイナミクスを解析する。Tamuraら(2016)はHGA解析と皮質-皮質誘発電位(CCEP)を併用し、術中機能ネットワークを局在した。本法は“身体性システム”で生まれた局在法であり、さらなる検証を行う。また申請者が特許を得た脳血流計測法で、開頭術中に課題による脳血流変化、ECoG周波数変化、術前fMRIとの比較を行う。病態3では脳梗塞を対象とし、一次感覚-運動野付近運動想起(Motor Imaginary: MI)-EEGのα-β帯域変化から、MI機能を読み取り、アバター操作と電気刺激(FES)の視覚・触覚フィードバックを行う。発症時とリハビリ終了後にアバター視覚フィードバックMI-fMRIで機能変容を可視化する。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Real-time spectrum quantification of tumor-related fluorescence during neurosurgery: A preliminary report. (2019)
  • Author(s): Kamada K Anei R, Kodama K, Kitajima Y, Ishizuka M, Hiroshima S, Ogawa H, Tamura Y, Takeuchi F.
  • Journal Title: Clin Neurol Neurosurg. Volume: 181 Pages: 89-97
• [Journal Article] Disconnection of the pathological connectome for multi-focal epilepsy surgery (2018)
  • Author(s): Kamada K,Ogawa H, Kapeller C, Prueckl, R, Hiroshima S, Tamura Y, Takeuchi F, Guger C,
  • Journal Title: J Neurosurgery Volume: 129(5) Issue: 5 Pages: 1182-1194
  • DOI: 10.3171/2017.6.jns17452
  • Peer Reviewed
• [Journal Article] 術中脳灌流画像の新展開 (2018)
  • Author(s): 嵯峨健広,鎌田恭輔
  • Journal Title: Annual Review 神経 2018 Volume: - Pages: 82-88
  • Peer Reviewed
• [Journal Article] Real-Time Detection and Discrimination of Visual Perception Using Electrocorticographic Signals. (2018)
  • Author(s): Kapeller C, Ogawa H, Schalk G, Kunii N, Coon WG, Scharinger J, Guger C, Kamada K.
  • Journal Title: J Neural Eng. Volume: 15(3) Issue: 3 Pages: 1-16
  • DOI: 10.1088/1741-2552/aaa9f6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quantitative blood flow assessment by multiparameter analysis of indocyanine green video angiography. (2018)
  • Author(s): Saito M,Saga T,Hayashi H,Noro S,Wada H,*Kamada K
  • Journal Title: World Neurosurg. Volume: 116
  • Peer Reviewed
• [Journal Article] 5-ALA蛍光ガイド下手術における術中リアルタイム定量化の意義 (2018)
  • Author(s): 安栄良悟、田村有希恵、小川博司、広島 覚、竹内文也、石塚昌宏、児玉 健、鎌田恭輔
  • Journal Title: CI研究 Volume: 40（1） Pages: 17-22
  • Peer Reviewed
• [Journal Article] 5-aminolevulinic acid-induced protoporphyrin IX accumulation does not correlate with ferrochelatase activity in brain tumors. (2018)
  • Author(s): Kodama K, Ishii T, Sakamoto K, Fukunaga Y, Ohta U, Kitajima Y, Anei R, Takeuchi F, Ishizuka M, Tanaka T,*Kamada K
  • Journal Title: ALA-Porphyrin Science. Volume: 7(1) Pages: 13-23
  • Peer Reviewed
• [Journal Article] A quantitative method for evaluating cortical responses to electrical stimulation (2018)
  • Author(s): Crowther LJ, Brunner P, Kapeller C, Guger C, Kamada K, Bunch ME, Frawley BK, Lynch TM, Ritaccio AL, Schalk G.
  • Journal Title: Journal of Neuroscience Methods. in press November 8, 2018 Volume: -
  • Peer Reviewed
• [Journal Article] 皮質脳波/機能的MRIによる脳内身体表現マーカーの探索 (2018)
  • Author(s): 鎌田恭輔
  • Journal Title: 身体性システムとリハビリテーションの科学2 Volume: - Pages: 85-102
  • NAID: 130007483694
  • Peer Reviewed
• [Journal Article] Evaluation of Microsurgery for Managing Giant or Complex Cerebral Aneurysms: A Retrospective Study. (2018)
  • Author(s): Ota N, Matsukawa H, Noda K, Sato H, Hatano Y, Hashimoto A, Miyazaki T, Kondo T, Kinoshita Y, Saito N, Kamiyama H, Tokuda S, Kamada K, Tanikawa R
  • Journal Title: World Neurosurg Volume: 115 Pages: e190-e199
  • DOI: 10.1016/j.wneu.2018.04.007
  • Peer Reviewed
• [Journal Article] Brain-computer interfaces for stroke rehabilitation: summary of the 2016 BCI Meeting in Asilomar. (2018)
  • Author(s): Guger C, Millan Jose del R., Mattia D, Ushiba J, Soekadar Surjo R, Prabhakaran V, Mrachacz-Kersting N, Kamada K, Allison Brendan Z.
  • Journal Title: Brain-computer interfaces Volume: 5(2-3) Pages: 41-57
  • Peer Reviewed
• [Journal Article] Clinical Impact and Implication of Real-Time Oscillation Analysis for Language Mapping (2017)
  • Author(s): Ogawa H, Kamada K, Kapeller C, Pruckle R, Takeuchi F, Hiroshima S, Anei R, Guger C
  • Journal Title: World Neurosurgery Volume: 97 Pages: 123-131
  • DOI: 10.1016/j.wneu.2016.09.071
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A biopsy-proven case of Epstein-Barr virus (EBV)-associated vasculitis of central nervous system (2017)
  • Author(s): Kano K, Kamada K (10番目),et.al.
  • Journal Title: Neuropathology Volume: 印刷中 Issue: 3 Pages: 259-264
  • DOI: 10.1111/neup.12356
  • NAID: 120006486843
  • Peer Reviewed / Open Access
• [Journal Article] 体性感覚誘発磁場(SEF) (2017)
  • Author(s): 露口尚弘、鎌田恭輔
  • Journal Title: CLINICAL NEUROSCIENCE 2月 Volume: 35(2) Pages: 210-214
• [Journal Article] リアルタイムCCEP解析ソフトウエアの開発 (2017)
  • Author(s): 鎌田恭輔、田村有希恵
  • Journal Title: 臨床神経生理学 Volume: 45(2) Pages: 102-109
  • NAID: 130006351576
• [Journal Article] てんかんとPET (2017)
  • Author(s): 露口尚弘、鎌田恭輔
  • Journal Title: CLINICAL NEUROSCIENCE 7月 Volume: 35(7) Pages: 844-848
• [Journal Article] Surgical Microanatomy of the Posterior Condylar Emissary Vein and its Anatomical Variations for the Transcondylar Fossa Approach (2017)
  • Author(s): Ota Nakao、Tanikawa Rokuya、Yoshikane Tsutomu、Miyama Masataka、Miyazaki Takanori、Kinoshita Yu、Matsukawa Hidetoshi、Yanagisawa Takeshi、Sakakibara Fumihiro、Suzuki Go、Saito Norihiro、Miyata Shiro、Noda Kosumo、Tsuboi Toshiyuki、Takeda Rihei、Kamiyama Hiroyasu、Tokuda Sadahisa、Kamada Kyousuke
  • Journal Title: Operative Neurosurgery Volume: 13 Issue: 3 Pages: 382-391
  • DOI: 10.1093/ons/opw038
  • Peer Reviewed / Open Access
• [Journal Article] 人工血管を用いて再建を行った高齢者頚動脈感染性動脈瘤の1例 (2017)
  • Author(s): 桐山健司、鎌田恭輔
  • Journal Title: 脳卒中の外科 Volume: 45(5) Pages: 398-402
  • NAID: 130006183733
• [Journal Article] Cortico-cortical potentials mapping of the face recognition network (2017)
  • Author(s): Kapeller C.、Kamada K.、Ogawa H.、Prueckl R.、Otal B.、Guger C.
  • Journal Title: Brain Stimulation Volume: 10 Issue: 2 Pages: 512-512
  • DOI: 10.1016/j.brs.2017.01.495
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Passive functional mapping guides electrical cortical stimulation for efficient determination of eloquent cortex in epilepsy patients (2017)
  • Author(s): Prueckl R, Kapeller C, Gruenwald J, Ogawa H, Kamada K, Korostenskaja M, Swift J, Scharinger J, Edlinger G, Guger C
  • Journal Title: 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Volume: -
• [Journal Article] A Contralateral Transcondylar Fossa Approach with Bilateral V3 Segment Exposure for Repairing Complex Vertebral Artery Aneurysms (2017)
  • Author(s): Ota Nakao、Tanikawa Rokuya、Miyama Masataka、Miyazaki Takanori、Kinoshita Yu、Matsukawa Hidetoshi、Sakakibara Fumihiro、Saito Norihiro、Miyata Shiro、Noda Kosumo、Tsuboi Toshiyuki、Kamiyama Hiroyasu、Tokuda Sadahisa、Kamada Kyousuke
  • Journal Title: World Neurosurgery Volume: 99 Pages: 340-347
  • DOI: 10.1016/j.wneu.2016.12.033
  • Peer Reviewed / Open Access
• [Journal Article] Facephenes and rainbows: Causal evidence for functional and anatomical specificity of face and color processing in the human brain (2017)
  • Author(s): Schalk Gerwin、Kapeller Christoph、Guger Christoph、Ogawa Hiroshi、Hiroshima Satoru、Lafer-Sousa Rosa、Saygin Zeynep M.、Kamada Kyousuke、Kanwisher Nancy
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 114 Issue: 46 Pages: 12285-12290
  • DOI: 10.1073/pnas.1713447114
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] てんかん原性ネットワークの可視化と治療法への応用 (2019)
  • Author(s): 鎌田恭輔
  • Organizer: 第42回日本てんかん外科学会
• [Presentation] Dynamics of High Frequency Oscillations between Visual Recognition and Receptive/Expressive Language Functions (2018)
  • Author(s): Kamada K
  • Organizer: 50 years of MEG
  • Int'l Joint Research
• [Presentation] Neurosurgery with Academia Lecture for Neurosurgical Residents (2018)
  • Author(s): Kamada K
  • Organizer: Neurosurgery. Ground Round, Stanford University
  • Int'l Joint Research
• [Presentation] Passive Mapping and Monitoring ICG-VG / ECoG for Neurosurgery Lecture for Neurosurgery (2018)
  • Author(s): Kamada K
  • Organizer: Neurosurgery, Ground Round, Stanford University Morning conference
  • Int'l Joint Research
• [Presentation] Rehabilitation with recoveriX and its positive effects oh fMRI in stroke patients (2018)
  • Author(s): Kamada K
  • Organizer: 2018 BCI meeting
  • Int'l Joint Research
• [Presentation] Passive Mapping and Monitoring using ECoG for Neurosurgery (2018)
  • Author(s): Kamada K
  • Organizer: 2018 BCI meeting
  • Int'l Joint Research
• [Presentation] Clinical needs for quantitative evaluation of “Consciousness” (2018)
  • Author(s): Kamada K
  • Organizer: 2018 BCI meeting
  • Int'l Joint Research
• [Presentation] Rehabilitation with recoveriX and fMRI evaluation for acute stroke patients (2018)
  • Author(s): Kamada K
  • Organizer: 2nd recoveriX & mindBEAGLE conderence 2018
  • Int'l Joint Research
• [Presentation] CCEPを用いた覚醒下手術における超受動的言語機能マッピング (2018)
  • Author(s): 鎌田恭輔、小川博司、田村有希恵、広島 覚、竹内文也
  • Organizer: 第57回日本生体医工学会大会
• [Presentation] 皮質脳波／機能的MRIによる脳内身体表現マーカーの探索 (2018)
  • Author(s): 鎌田恭輔、小川博司、広島 覚、竹内文也
  • Organizer: 第57回日本生体医工学会大会
• [Presentation] Treatment and Rehabilitation with recoveriX for acute stroke patients (2018)
  • Author(s): Kamada K
  • Organizer: BCI Workshop
  • Int'l Joint Research
• [Presentation] Rehabilitation with recoveriX and its positive effects oh fMRI in acute stroke patients (2018)
  • Author(s): Kamada K
  • Organizer: EMBC2018
  • Int'l Joint Research
• [Presentation] Characterization and Decoding with Intracranial Recording (2018)
  • Author(s): Kamada K
  • Organizer: EMBC2018
  • Int'l Joint Research
• [Presentation] ECoG-based Passive Functional Brain Mapping (2018)
  • Author(s): Kamada K
  • Organizer: EMBC2018
  • Int'l Joint Research
• [Presentation] Basic and advanced functional Brain Mapping/Monitoring for tumor surgery (2018)
  • Author(s): Kamada K
  • Organizer: SNSA CONGRESS 2018
  • Int'l Joint Research
• [Presentation] Clinical Impact of Real-time Monitoring for Deep-seated Brain Pathology (2018)
  • Author(s): Kamada K
  • Organizer: SNSA CONGRESS 2018
  • Int'l Joint Research
• [Presentation] Real-time Passive Language Mapping for Awake Craniotomy (2018)
  • Author(s): Kamada K
  • Organizer: WFNS FOUNDATION & ACNS MYANMAR SEMINAR YANGON
  • Int'l Joint Research
• [Presentation] Multi-spectrum Indocyanin Green Videography for CNS Vascular Pathology (2018)
  • Author(s): Kamada K
  • Organizer: WFNS FOUNDATION & ACNS MYANMAR SEMINAR YANGON
  • Int'l Joint Research
• [Presentation] Basics and Characteristics of Microscope for Vascular Disease (2018)
  • Author(s): Kamada K
  • Organizer: WFNS FOUNDATION & ACNS MYANMAR SEMINAR YANGON
  • Int'l Joint Research
• [Presentation] Non-invasive and invasive Brain-Computer Interfaces for medical application and research projects (2018)
  • Author(s): Kamada K
  • Organizer: IEEE SMC2018
  • Int'l Joint Research
• [Presentation] マルチスペクトラム蛍光システムによる解剖―蛍光―血流の可視化 (2018)
  • Author(s): 鎌田恭輔、嵯峨健広、田村有希恵、野呂昇平、真田隆広、齊藤仁十
  • Organizer: 日本脳神経外科学会第77回学術集会
• [Presentation] 覚醒下手術におけるSuper-passive mapping の有用性とピットフォール (2018)
  • Author(s): 鎌田恭輔
  • Organizer: 第48回日本臨床神経生理学会学術大会
• [Presentation] 脳皮質-皮質下機能ネットワーク解析とピットフォール (2018)
  • Author(s): 鎌田恭輔
  • Organizer: 第5回脳神経外科BMI研究会
• [Presentation] 多焦点難治てんかんに対する病的ネットワーク離断術のインパクト (2018)
  • Author(s): 鎌田恭輔
  • Organizer: 第41回日本てんかん外科学会
• [Presentation] Super-passive mapping for language-related functions during awake craniotomy (2018)
  • Author(s): Kamada K
  • Organizer: Brain and Cognitive Science Meeting
  • Int'l Joint Research
• [Presentation] Cerebravascular surgery in posterior fossa using multi-spectrum florescence angiography (2018)
  • Author(s): Kamada K
  • Organizer: 2018 China-Japan Cerebrovascular Disease Forum
  • Int'l Joint Research
• [Presentation] 手術顕微鏡オプティクス性能、操作性、付加機能の違いによる視覚情報特性 (2017)
  • Author(s): 鎌田恭輔、広島覚、竹内文也、安栄良悟
  • Organizer: 第26回脳神経外科手術と機器学会
• [Presentation] 神経・自然科学を取り込む脳神経外科ー発想から実現、そして実用にむけてー (2017)
  • Author(s): 鎌田恭輔
  • Organizer: 日本核医学会分科会 第54回腫瘍・免疫核医学研究会
  • Invited
• [Presentation] マルチスペクトラル蛍光画像による脳神経外科手術革命 (2017)
  • Author(s): 鎌田恭輔
  • Organizer: 第37回日本脳神経外科コングレス総会
• [Presentation] Super-passive mapping for language-related functions during awake craniotomy (2017)
  • Author(s): Kamada K, Yukie Tamura
  • Organizer: Biomagnetic Sendai
  • Int'l Joint Research
• [Presentation] Recent trends of AVM treatment (2017)
  • Author(s): Kamada K
  • Organizer: 2017 PCCVD
  • Int'l Joint Research / Invited
• [Presentation] Clipping of posterior fossa Aneurysms using multi-spectrum florescence video (2017)
  • Author(s): Kamada K
  • Organizer: 2017 PCCVD
  • Int'l Joint Research / Invited
• [Presentation] Integration and quantification of digital signals for tumor surgery (2017)
  • Author(s): Kamada K
  • Organizer: Leica company workshop
• [Presentation] リアルタイム生体デジタル処理がもたらす脳機能モニタリングの可能性 (2017)
  • Author(s): 鎌田恭輔
  • Organizer: 第23回日本脳神経モニタリング学会
  • Invited
• [Presentation] Clinical Impact of real-time mapping and decoding for brain signals. -CortiQ>RecoveriX, Concept of mindBEAGLE- (2017)
  • Author(s): Kamada K
  • Organizer: 38th EMBC Workshops & Tutorials
  • Int'l Joint Research
• [Presentation] 侵襲脳計測の最先端 (2017)
  • Author(s): 鎌田恭輔
  • Organizer: 第二回脳情報の解読と制御研究会（科学技術振興機構さきがけ終了領域研究会）
• [Presentation] Rehabilitation with recoveriX and fMRI evaluation for acute stroke patients: clinical impact and pitfalls (2017)
  • Author(s): Kamada K
  • Organizer: ecoveriX & mindBEAGLE conference 2017
  • Int'l Joint Research / Invited
• [Presentation] Evaluation and decoding of consciousness levels in drowsy or comatose patients by recoding various kinds of EEG and ECoG (2017)
  • Author(s): 鎌田恭輔
  • Organizer: 平成29年度生理学研究所研究会「認知神経科学の先端 意識の脳内メカニズム」
• [Presentation] 異分野・海外研究者との絆 特別企画 i知の創出 1 Communication とPresentationの極意を探る (2017)
  • Author(s): 鎌田恭輔
  • Organizer: 日本脳神経外科学会第76回学術総会
• [Presentation] 後頭蓋窩瘤・病変に対するアプローチと治療戦略 (2017)
  • Author(s): 鎌田恭輔
  • Organizer: 日本脳神経外科学会第76回学術総会
• [Presentation] Online superpassive mapping of higher brain functions (tentative) postcongress symposium (2017)
  • Author(s): Kamada K
  • Organizer: JNS2017
• [Presentation] Cerebravascular surgery in posterior fossa using anatomical and quantitative florescence angiography (2017)
  • Author(s): kamada K
  • Organizer: 2017Huashan International Neurosurgical Conference
  • Int'l Joint Research
• [Presentation] 生体信号とデジタルデータ処理の基本 (2017)
  • Author(s): 鎌田恭輔、竹内文也
  • Organizer: 第4回 脳神経外科 BMI懇話会
• [Presentation] Passive mapping and network analysis with ECoG (2017)
  • Author(s): Kamada K
  • Organizer: 13th International Workshop on Advances in Electrocorticography
  • Int'l Joint Research
• [Presentation] Disconnection of the pathological connectome for multifocal epilepsy surgery (2017)
  • Author(s): Kamada K
  • Organizer: American Epilepsy Society, 2017
  • Int'l Joint Research