Human Fronto-Parietal Network for Embodied-Brain System: A Combined Electrocorticographic Decoding, Stimulation and Lesion Study

• Project Area: Understanding brain plasticity on body representations to promote their adaptive functions
• Project/Area Number: 17H05907
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Kobe University (2018); Kyoto University (2017)
• Principal Investigator: 松本 理器 神戸大学, 医学研究科, 教授 (00378754)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000); Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
• Keywords: 前頭・頭頂葉ネット―ワーク / 皮質電気刺激 / 皮質皮質間誘発電位 / 病変研究 / 行為 / 運動主体感 / 身体意識 / 失行 / 前頭・頭頂葉ネットワーク / 脳病変研究 / 皮質脳波 / デコーディング / 前頭・頭頂ネットワーク

Outline of Annual Research Achievements

術前評価目的に硬膜下電極を留置した難治部分てんかん患者で本研究計画に同意を得た者を対象に、左半球では高次運動、右半球では身体意識に焦点をあてて、腹側前頭・頭頂葉ネットワークの皮質活動の探索と変容様式の同定を進めた。左半球では、通常の臨床機能マッピングより弱い刺激強度で陰性運動野に介入し、運動制御の変容の定量解析から、中心前回の陰性運動野は肢節運動失行、腹側運動前野の陰性運動野はより高次の失行への関与が示唆された（国際学会発表）。そして、電気的線維追跡法（皮質皮質間誘発電位）の検討から、中心前回と腹側運動前野間の機能分担は、異なる機能的結合様式が神経基盤であることを明らかにした(国内学会発表)。術中の皮質皮質間誘発電位の検討から、このような前頭葉-頭頂葉・側頭葉間のネットワークには左右差があることを明らかにした（論文発表）。刺激最中の誘発神経活動の検討から、高頻度皮質刺激マッピングでは、高次運動ではネットワークとして機能が発現されるものの、症状の大部分は刺激直下の皮質に由来することを明らかにした(国内学会発表)。また、運動関連皮質で、高頻度刺激を用いない、自発運動に伴う皮質脳波の脳律動解析の手法を提案した（論文発表）。一連の研究成果は、電気刺激による臨床脳機能マッピングの作動原理を明らかにし、より正確な皮質機能の同定を可能にし、今後の非侵襲的機能マッピングにつながる知見と位置づけられる。
身体意識に関しては、左右島皮質に脳腫瘍などの病変があり切除術を施行した患者7例を対象に、手術前後の運動主体感の変容を心理的手法から定量的に計測した。右島切除で運動主体感について動的変容を認め、経時的に正常化する傾向にあった (国際学会発表)。右半球が有する身体意識（運動主体感）への島皮質の関与と切除後の緩徐な代償が明らかとなり、今後のリハビリテーションへの応用が期待される。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] Epilepsy Center, Cleveland Clinic(米国)
• [Int'l Joint Research] University of Mancheter/King's College of London(United Kingdom)
• [Int'l Joint Research] The Cleveland Clinic Foundation/Johns Hopkins University(米国)
• [Journal Article] The neural tides of sleep and consciousness revealed by single-pulse electrical brain stimulation. (2019)
  • Author(s): Usami K, Korzeniewska A, Matsumoto R, Kobayashi K, Hitomi T, Matsuhashi M, Kunieda T, Mikuni N, Kikuchi T, Yoshida K, Miyamoto S, Takahashi R, Ikeda A, Crone NE.
  • Journal Title: Sleep. Volume: in press Issue: 6 Pages: 1-9
  • DOI: 10.1093/sleep/zsz050
  • NAID: 120006647295
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A rational, multispectral mapping algorithm for primary motor cortex: A primary step before cortical stimulation (2019)
  • Author(s): Shuichiro Neshige, Katsuya Kobayashi, Masao Matsuhashi, Takefumi Hitomi, Akihiro Shimotake, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Riki Matsumoto, Susumu Miyamoto, Ryosuke Takahashi, Hirofumi Maruyama, Akio Ikeda
  • Journal Title: Epilepsia Volume: 60 Issue: 3 Pages: 547-559
  • DOI: 10.1111/epi.14669
  • Peer Reviewed / Open Access
• [Journal Article] てんかん外科における最新のてんかん診断学．特集「てんかん外科と機能的脳神経外科」． (2019)
  • Author(s): 松本理器，菊池隆幸，山尾幸広，中江卓郎，小林勝哉，下竹昭寛4，吉田和道，國枝武治，池田昭夫，宮本享．
  • Journal Title: 脳神経外科ジャーナル Volume: 印刷中
  • Peer Reviewed
• [Journal Article] 症例 アンカーボルトを用いた定位的深部電極挿入術(stereotactic EEG insertion)の初期経験-課題の抽出と挿入精度向上の検討 (2018)
  • Author(s): 稲田 拓、下竹 昭寛、山尾 幸広、吉田 和道、國枝 武治、松本 理器、池田 昭夫、宮本 享、菊池 隆幸、小林 勝哉、中江 卓郎、西田 誠、高橋 由紀、小林 環、永井 靖識、松本 直樹
  • Journal Title: Neurological Surgery 脳神経外科 Volume: 46 Issue: 10 Pages: 917-924
  • DOI: 10.11477/mf.1436203839
  • ISSN: 0301-2603, 1882-1251
  • Year and Date: 2018-10-10
  • Peer Reviewed
• [Journal Article] Strategy for epilepsy surgery: mapping the dual language pathways for preservation of language function (2018)
  • Author(s): 松本 理器、下竹 昭寛、山尾 幸広、菊池 隆幸、國枝 武治
  • Journal Title: Japanese Journal of Neuropsychology Volume: 34 Issue: 2 Pages: 124-134
  • DOI: 10.20584/neuropsychology.17027
  • NAID: 130007466712
  • ISSN: 0911-1085, 2189-9401
  • Year and Date: 2018-06-25
  • Peer Reviewed
• [Journal Article] Multi-component intrinsic brain activities as a safe alternative to cortical stimulation for sensori-motor mapping in neurosurgery. (2018)
  • Author(s): Neshige S, Matsuhashi M, Kobayashi K, Sakurai T, Shimotake A, Hitomi T, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Takahashi R, Miyamoto S, Maruyama H, Matsumoto M, Ikeda A.
  • Journal Title: Clin Neurophysiol. Volume: 129 Issue: 9 Pages: 2038-2048
  • DOI: 10.1016/j.clinph.2018.06.007
  • Peer Reviewed
• [Journal Article] Do scalp-recorded slow potentials during neuro-feedback training reflect the cortical activity? (2018)
  • Author(s): Tomoyuki Fumuro, Masao Matsuhashi, Riki Matsumoto, Kiyohide Usami, Akihiro Shimotake, Takeharu Kunieda, Takayuki Kikuchi, Kazumichi Yoshida, Ryosuke Takahashi, Susumu Miyamoto, Akio Ikeda
  • Journal Title: Clinical Neurophysiology Volume: 129 Issue: 9 Pages: 1884-1890
  • DOI: 10.1016/j.clinph.2018.05.015
  • Peer Reviewed
• [Journal Article] Interhemispheric Asymmetry of Network Connecting Between Frontal and Temporoparietal Cortices: A Corticocortical-Evoked Potential Study (2018)
  • Author(s): Aya Kanno, Rei Enatsu, Satoshi Ookawa, Shouhei Noshiro, Shunya Ohtaki, Kengo Suzuki, Yuto Suzuki, Rintaro Yokoyama, Satoko Ochi, Yukinori Akiyama, Takeshi Mikami, Takuro Nakae, Takayuki Kikuchi, Takeharu Kunieda, Susumu Miyamoto, Riki Matsumoto, Nobuhiro Mikuni
  • Journal Title: World Neurosurgery Volume: 120 Pages: e628-e636
  • DOI: 10.1016/j.wneu.2018.08.137
  • Peer Reviewed
• [Journal Article] Cortical Responses to Input From Distant Areas are Modulated by Local Spontaneous Alpha/Beta Oscillations (2018)
  • Author(s): Kiyohide Usami、Griffin W Milsap, Anna Korzeniewska, Maxwell J Collard, Yujing Wang, Ronald P Lesser, William S Anderson, Nathan E Crone
  • Journal Title: Cerebral Cortex Volume: 29 Issue: 2 Pages: 777-787
  • DOI: 10.1093/cercor/bhx361
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Proposal of a diagnostic algorithm for autoimmune epilepsy: preliminary investigation of its utility (2018)
  • Author(s): Mitsuhiro Sakamoto, Riki Matsumoto, Jumpei Togawa, Yuichiro Hashi, Hirofumi Takeyama, Katsuya Kobayashi, Akihiro Shimotake, Takayuki Kondo, Ryosuke Takahashi, Akio Ikeda
  • Journal Title: Rinsho Shinkeigaku Volume: 58 Issue: 10 Pages: 609-616
  • DOI: 10.5692/clinicalneurol.cn-001180
  • ISSN: 0009-918X, 1882-0654
  • Peer Reviewed
• [Journal Article] てんかんの治療戦略：てんかん外科における言語機能温存へ向けた試み (2018)
  • Author(s): 松本理器、下竹昭寛、山尾幸広、菊池隆幸、國枝武治
  • Journal Title: 神経心理学 Volume: 印刷中
  • NAID: 130007466712
• [Journal Article] Frontal Fibers Connecting the Superior Frontal Gyrus to Broca Area: A Corticocortical Evoked Potential Study (2017)
  • Author(s): Ookawa Satoshi、Enatsu Rei、Kanno Aya、Ochi Satoko、Akiyama Yukinori、Kobayashi Tamaki、Yamao Yukihiro、Kikuchi Takayuki、Matsumoto Riki、Kunieda Takeharu、Mikuni Nobuhiro
  • Journal Title: World Neurosurgery Volume: 107 Pages: 239-248
  • DOI: 10.1016/j.wneu.2017.07.166
  • Peer Reviewed
• [Journal Article] High frequency activity overriding cortico-cortical evoked potentials reflects altered excitability in the human epileptic focus (2017)
  • Author(s): Kobayashi Katsuya、Matsumoto Riki、Matsuhashi Masao、Usami Kiyohide、Shimotake Akihiro、Kunieda Takeharu、Kikuchi Takayuki、Yoshida Kazumichi、Mikuni Nobuhiro、Miyamoto Susumu、Fukuyama Hidenao、Takahashi Ryosuke、Ikeda Akio
  • Journal Title: Clinical Neurophysiology Volume: 128 Issue: 9 Pages: 1673-1681
  • DOI: 10.1016/j.clinph.2017.06.249
  • Peer Reviewed / Open Access
• [Journal Article] Magnetoencephalography with temporal spread imaging to visualize propagation of epileptic activity (2017)
  • Author(s): Shibata S, Matsuhashi M, Kunieda T, Yamao Y, Rika Inano R, Kikuchi T, Imamura H, Takaya S, Matsumoto R, Ikeda A, Takahashi R, Mima T, Fukuyama H, Mikuni N, Miyamoto S
  • Journal Title: Clin Neurophysiol Volume: 128 Issue: 5 Pages: 734-743
  • DOI: 10.1016/j.clinph.2017.01.010
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Phasic REM transiently approaches wakefulness in the human cortex - a single-pulse electrical stimulation study. (2017)
  • Author(s): Usami K, Matsumoto R, Kobayashi K, Hitomi T, Matsuhashi M, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A.
  • Journal Title: Sleep Volume: 40 Issue: 8 Pages: 1-7
  • DOI: 10.1093/sleep/zsx077
  • Peer Reviewed
• [Journal Article] Clinical impact of intraoperative CCEP monitoring in evaluating the dorsal language white matter pathway (2017)
  • Author(s): Yamao Y, Suzuki K, Kunieda T, Matsumoto R, Arakawa Y, Nakae T, Nishida S, Inano R, Shibata S, Shimotake A, Kikuchi, T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S
  • Journal Title: Human Brain Mapping Volume: 38 (4) Issue: 4 Pages: 1977-1991
  • DOI: 10.1002/hbm.23498
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Neural pattern similarity between contra- and ipsilateral movements in high-frequency band of human electrocorticograms (2017)
  • Author(s): Fujiwara Y, Matsumoto R, Nakae T, Usami K, Matsuhashi M, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Mima T, Ikeda A, Osu R
  • Journal Title: Neuroimage Volume: 15 Pages: 302-313
  • DOI: 10.1016/j.neuroimage.2016.11.058
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy (2017)
  • Author(s): Matsumoto R, Kunieda T, Nair D
  • Journal Title: Seizure Volume: 44 Pages: 27-36
  • DOI: 10.1016/j.seizure.2016.11.003
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A case of epilepsy induced by eating or by visual stimuli of food made of minced meat (2017)
  • Author(s): 三村 直哉、井上 岳司、下竹 昭寛、松本 理器、池田 昭夫、高橋 良輔
  • Journal Title: Rinsho Shinkeigaku Volume: 57 Issue: 8 Pages: 430-435
  • DOI: 10.5692/clinicalneurol.cn-001001
  • NAID: 130006034996
  • ISSN: 0009-918X, 1882-0654
  • Peer Reviewed
• [Journal Article] Wide band EEGの有用性 (slow) (2017)
  • Author(s): 井内盛遠、中谷光良、池田昭夫
  • Journal Title: Japanese Journal of Clinical Neurophysiology Volume: 45 Issue: 6 Pages: 520-524
  • DOI: 10.11422/jscn.45.520
  • NAID: 130006415823
  • ISSN: 1345-7101, 2188-031X
  • Peer Reviewed
• [Presentation] The role of the insula in Sense of Agency: supportive data from neurosurgical cases (2018)
  • Author(s): Tamaki Kobayashi, Riki Matsumoto, Akihiro Shimotake, Masaya Togo, Yoshiki Arakawa, Yukihiro Yamao, Takayuki Kikuchi, Kazumichi Yoshida, Akio Ikeda, Shiro Yano, Takaki Maeda, Hiroshi Imamizu, Susumu Miyamoto
  • Organizer: 16th Asian Oceanian Congress Of Neurology
  • Int'l Joint Research
• [Presentation] Role of the premotor and precentral negative motor area in praxis: a direct electrical stimulation study with behavioral analysis (2018)
  • Author(s): Masaya Togo, Riki Matsumoto*, Akihiro Shimotake, Tamaki Kobayashi, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda
  • Organizer: 31st International Congress of Clinical Neurophysiology
  • Int'l Joint Research
• [Presentation] Rational cortical mapping algorithm for epilepsy surgery: non-stimuli, multi-intrinsic brain activities without cortical stimulation (2018)
  • Author(s): Shuichiro Neshige, Katsuya Kobayashi, Masao Matsuhashi, Akihiro Shimotake, Takehumi Hitomi, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Riki Matsumoto*, Ryosuke Takahashi, Susumu Miyamoto, Hirofumi Maruyama, Akio Ikeda.
  • Organizer: the 12th Asian&Oseanian Epilepsy Congress
  • Int'l Joint Research
• [Presentation] Visuospatial processing load enhance the brain activity associated with motor preparation (2018)
  • Author(s): Tomoyuki Fumuro, Masao Matsuhashi, Takehumi Hitomi, Riki Matsumoto*, Ryosuke Takahashi, Akio Ikeda
  • Organizer: 31st International Congress of Clinical Neurophysiology
  • Int'l Joint Research
• [Presentation] Revised Diagonositc algorithm for autoimmune epilepsy without antibody testing: its proposal and validation with a restrospective cohort (2018)
  • Author(s): Mitsuhiro Sakamoto, Riki Matsumoto, Junpei Togawa, Hirohumi Takeyama, Yuichiro Hashi, Katsuya Kobayashi, Akihiro Shimotake, Frank Leypoldt, Klaus- Peter Wandinger, Takayuki Kondo, Ryosuke Takahashi, Akio Ikeda
  • Organizer: 16th Asian Oceanian Congress Of Neurology
  • Int'l Joint Research
• [Presentation] Human medial parietal cortices have distinct connectivity patterns: Evidence from standardized connectivity map using cortico-cortical evoked potential (2018)
  • Author(s): Masaya Togo, Riki Matsumoto, Takuro Nakae, Hirohumi Takeyama, Katsuya Kobayashi, Kiyohide Usami, Akihiro Shimotake, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda
  • Organizer: 第41回神経科学大会
• [Presentation] Electrocorticography-based non-primary motor area mapping comparable with cortical stimulation (2018)
  • Author(s): Shuichiro Neshige, Katsuya Kobayashi, Masao Matsuhashi, Akihiro Shimotake, Takehumi Hitomi, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Riki Matsumoto*, Ryosuke Takahashi, Susumu Miyamoto, Hirofumi Maruyama, Akio Ikeda
  • Organizer: 第59回日本神経学会学術大会
• [Presentation] Role of premotor and precentral negative motor area in praxis: a direct electrical stimulation study (2018)
  • Author(s): Masaya Togo, Riki Matsumoto, Akihiro Shimotake, Tamaki Kobayashi, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda
  • Organizer: 第59回日本神経学会学術大会
• [Presentation] Changes in human brain network connectivity during sleep and wakefulness _ a study of neural propagation evoked by single-pulse electrical stimulation (2018)
  • Author(s): Kiyohide Usami, Anna Korzeniewska, Riki Matsumoto*, Takefumi Hitomi, Kunieda Takeharu, Nobuhiro Mikuni, Katsuya Kobayashi, Takayuki Kikuchi, Kazumichi Yoshida, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda, and Nathan E. Crone
  • Organizer: 31st International Congress of Clinical Neurophysiology
  • Int'l Joint Research
• [Presentation] Role of premotor and precentral negative motor area in praxis: a direct electrical stimulation study (2018)
  • Author(s): Masaya Togo, Riki Matsumoto, Akihiro Shimotake, Tamaki Kobayashi, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi and Akio Ikeda
  • Organizer: 59th annual meeting of the Japanese society of neurology
• [Presentation] Double dissociation of the semantic and phonological processing in reading Kanji and Kana words - A quantitative low-intensity cortical stimulation study (2018)
  • Author(s): Masako Daifu, Riki Matsumoto, Akihiro Shimotake1), Makiko Ota, Mitsuhiro Sakamoto, Katsuya Kobayashi, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Ryosuke Takahashi, Matthew A. Lambon Ralph, Akio Ikeda
  • Organizer: The 41th Annual Meeting of the Japan Neuroscience Society
• [Presentation] Underlying excitability at the focus modulates network dynamics of seizure propagation: a single-pulse electrical stimulation study time-locked to spike and post-spike slow. (2018)
  • Author(s): Katsuya Kobayashi, Riki Matsumoto, Kiyohide Usami, Akihiro Shimotake, Masao Matsuhashi, Yukihiro Yamao, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Ryosuke Takahashi, Akio Ikeda.
  • Organizer: American Epilepsy Society (AES) 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] Biomarkers of epilepsy: what approaches do we have? EEG biomarkers for neuron and glia. (2018)
  • Author(s): Akio Ikeda
  • Organizer: the 12th Asian&Oseanian Epilepsy Congress
  • Int'l Joint Research / Invited
• [Presentation] 高頻度皮質電気刺激による高次運動障害の発現機構の検討：皮質刺激誘発反応と行動解析の包括的検討 (2018)
  • Author(s): 十河正弥、松本理器、下竹昭寛、 松橋眞生、小林環、菊池隆幸、吉田和道、國枝武治、宮本享、高橋良輔、池田昭夫
  • Organizer: 第48回日本臨床神経生理学会学術大会
• [Presentation] 発語失行の病態：機能マッピング，電気的線維追跡からの症例の考察 (2018)
  • Author(s): 坂本光弘、松本理器、下竹昭寛、太田真紀子、中谷光良、中江卓郎、菊池隆幸、吉田和道、國枝武治、高橋良輔、池田昭夫
  • Organizer: 第59回日本神経学会学術大会
• [Presentation] 広帯域皮質脳波を用いた運動関連皮質の脳機能マッピングのアルゴリズム：てんかん外科の皮質電気刺激検査からの合理的発展の試み (2018)
  • Author(s): 音成秀一郎、松橋眞夫、松本理器、池田昭夫
  • Organizer: 第52回日本てんかん学会
• [Presentation] 低い刺激強度の皮質電気刺激と呼称課題の組み合わせによる言語機能マッピングの有用性 (2018)
  • Author(s): 下竹 昭寛、松本 理器、坂本 光弘、中谷 光良、太田 真紀子、小林 勝哉、菊池 隆幸、吉田 和道、國枝 武治、宮本 享、高橋 良輔、池田 昭夫
  • Organizer: 第59回日本神経学会学術大会
• [Presentation] 皮質電気刺激による脳機能マッピング (2018)
  • Author(s): 松本理器、下竹昭寛、十河正弥、菊池隆幸、國枝武治、池田昭夫
  • Organizer: 第48回日本臨床神経生理学会学術大会
  • Invited
• [Presentation] てんかん外科における最新のてんかん診断学. PS3 てんかん外科と機能的脳神経外科 (2018)
  • Author(s): 松本理器、山尾幸広、菊池隆幸、吉田和道、國枝武治、池田昭夫、宮本享
  • Organizer: 第38回日本脳神経外科コングレス総会
  • Invited
• [Presentation] てんかんにおける覚醒下手術の役割 (2018)
  • Author(s): 菊池隆幸、小林環、永井靖識、山尾幸広、吉田和道、小林勝哉、下竹昭寛、松本理器、池田昭夫、國枝武治、宮本享
  • Organizer: 第52回日本てんかん学会学術集会
• [Presentation] 高齢者のてんかん (2018)
  • Author(s): 松本理器
  • Organizer: 第６０回日本老年医学会学術集会
  • Invited
• [Presentation] 島皮質障害による運動主体感の動的変容：脳外科手術症例からの知見．OS21：身体性システム．脳内身体表現のモデル化からリハビリテーション (2018)
  • Author(s): 松本理器、小林環、下竹昭寛、吉田和道、矢野史朗、前田貴記、今水寛，池田昭夫
  • Organizer: 第36回日本ロボット学会
  • Invited
• [Presentation] 意識における後方皮質領野の意義：皮質脳波における異周波数間結合解析による検討 (2018)
  • Author(s): 十川純平、松本理器、井内盛遠、松橋眞生、小林勝哉、宇佐美清英、人見健文、中江卓郎、菊池隆幸、吉田和道、國枝武治、宮本享、高橋良輔、池田昭夫
  • Organizer: 第48回日本臨床神経生理学会学術大会
• [Presentation] てんかんネットワークの結合性はてんかん焦点での興奮・抑制により動的に変動する：皮質皮質間誘発電位を用いた検討 (2018)
  • Author(s): 小林勝哉、松本理器、宇佐美清英、下竹昭寛、山尾幸宏、菊池隆幸、吉田和道、國枝武治、高橋良輔、池田昭夫
  • Organizer: 第48回日本臨床神経生理学会学術大会
• [Presentation] 皮質刺激皮質誘発電位（CCEP）における律動反応～機能ネットワークから見た反応特性の多様性～ (2018)
  • Author(s): 中江卓郎、松本理器、十河正弥、武山博文、小林勝哉、下竹昭寛、松橋眞生、山尾幸広、菊池隆幸、吉田和道、國枝武治、池田昭夫、宮本享
  • Organizer: 第48回日本臨床神経生理学会学術大会
• [Presentation] 皮質皮質間誘発電位（CCEP）の分類と分布の検討 (2018)
  • Author(s): 迎伸孝、松本理器、小林勝哉、十河正弥、松橋眞生、中江卓郎、武山博文、下竹昭寛、山尾幸広、菊池隆幸、吉田和道、飯原弘二、高橋良輔、池田昭夫
  • Organizer: 第48回日本臨床神経生理学会学術大会
• [Presentation] 術中言語白質路モニタリングにおける皮質-皮質間誘発電位の麻酔の影響－言語機能保護を目指して－ (2018)
  • Author(s): 山尾幸広、松本理器、國枝武治、荒川芳輝、中江卓郎、菊池隆幸、吉田和道、池田昭夫、宮本享
  • Organizer: 日本脳神経外科学会 第77回学術総会
  • Invited
• [Presentation] 術中脳機能モニタリング (2018)
  • Author(s): 山尾幸広、松本理器、國枝武治、荒川芳輝、中江卓郎、菊池隆幸、吉田和道、池田昭夫、宮本享
  • Organizer: 第48回日本臨床神経生理学会学術大会
  • Invited
• [Presentation] てんかんネットワークの結合性はてんかん焦点での興奮・抑制により動的に変容する：皮質皮質間誘発電位を用いた検討． (2018)
  • Author(s): 小林勝哉、松本理器、宇佐美清英、下竹昭寛、松橋眞生、十河正弥、梶川駿介、尾谷真弓、山尾幸広、菊池隆幸、吉田和道、國枝武治、_橋良輔、池田昭夫．
  • Organizer: 第48回日本臨床神経生理学会学術集会
• [Presentation] Clinical EEG in 21st century:a research topic or tool? (2018)
  • Author(s): Akio Ikeda
  • Organizer: 第48回日本臨床神経生理学会
  • Invited
• [Presentation] Cortico-cortical evoked potentials & soectral responses to probe connectivity and cortical excitability. (2017)
  • Author(s): Matsumoto R
  • Organizer: 51st Annual Congress of the Japan Epilepsy Society
  • Invited
• [Presentation] Subdural recording in epilepsy. (2017)
  • Author(s): Matsumoto R, Kikuchi T, Yoshida K, Kunieda T, Ikeda A
  • Organizer: The XXⅢ World Congress of Neurology
  • Int'l Joint Research / Invited
• [Presentation] Neural basis of altered consciousness during sleep: insights from effective connectivity and induced high gamma activities (2017)
  • Author(s): Matsumoto R, Usami K, Kikuchi T, Yoshida K, Ikeda A
  • Organizer: Neural Oscillation Conference 2017
  • Int'l Joint Research / Invited
• [Presentation] Novel surrogate biomarkers of epileptogenicity using wideband ECoG analyses. (2017)
  • Author(s): Matsumoto R, Kobayashi K, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Ikeda A
  • Organizer: The 76th Annual Meeting of the Japan Neurosurgery Society
  • Invited
• [Presentation] Introduction. Dual stream model of language - its function, connectivity and plasticity: insights from clinical neuroscience (2017)
  • Author(s): Matsumoto R
  • Organizer: The 40th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2017)
  • Invited
• [Presentation] てんかんの治療戦略：てんかん外科における言語機能温存へ向けた試み. シンポジウムII．高次脳機能障害の治療戦略． (2017)
  • Author(s): 松本理器，下竹昭寛，山尾幸広，菊池隆幸，國枝武治
  • Organizer: 第41回日本神経心理学会
  • Invited
• [Presentation] EEG and electrophysiological monitoring (2017)
  • Author(s): Ikeda A
  • Organizer: 15th Advanced International Epilepsy Course: Bridging Basic with Clinical Epileptology-6
  • Int'l Joint Research / Invited
• [Presentation] Safety of single-pulse electrical stimulation for cortico-cortical evoked potentials in epileptic human cerebral cortex (2017)
  • Author(s): Kobayashi K, Matsumoto R, Usami K, Matsuhashi M, Shimotake A, Nakae T, Takeyama H, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Ikeda A
  • Organizer: The XXⅢ World Congress of Neurology
  • Int'l Joint Research / Invited
• [Presentation] Efficacy of Wide-Band Electrocorticography(ECoG) on Mapping of the Primary Sensori-Motor Area Compared with Electrical Cortical Stimulation (ECS) (2017)
  • Author(s): Neshige S, Matsuhashi M, Sakurai T, Kobayashi K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Maruyama H, Takahashi R and Ikeda A
  • Organizer: The XXⅢ World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Higher-order motor cortices actively engage in motor inhibition: cortical stimulation and event-related potentials as an evidence from subdural electrodes (2017)
  • Author(s): Takeyama H, Matsumoto R, Usami K, Shimotake A, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: The XXⅢ World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Role of the negative motor area in praxis: A high frequency electrical cortical stimulation study (2017)
  • Author(s): Togo M, Matsumoto R, Shimotake A, Kobayashi T, Kikuchi T, Yoshida K, Matsuhashi M, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
  • Organizer: The XXⅢ World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Functional gradient of the ventral temporal area in reading Kanji and Kana words;A quantitative low-intensity cortical stimulation study (2017)
  • Author(s): Daifu M, Matsumoto R, Shimotake A, Ota M, Sakamoto M, Nakae T, Kobayashi K, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Lambon Ralph M, Ikeda A
  • Organizer: 第40回日本神経科学大会
• [Presentation] The human entorhinal cortex is connected with the broad neocortical regions through the hippocampalthalamo-cortical pathway possible as the memory network: Results from electrical tract tracing and neuropsychologicalassessment (2017)
  • Author(s): Takeyama H, Matsumoto R, Nakae T, Kobayashi K, Usami K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R Ikeda A
  • Organizer: 第40回日本神経科学大会
• [Presentation] Role of the anterior temporal lobe in the ventral pathway: evidence from presurgical evaluations in epilepsy patient (2017)
  • Author(s): Shimotake A, Matsumoto R, Kikuchi R, Yoshida K, Kunieda R, Ikeda A.
  • Organizer: The 40th Annual Meeting of the Japan Neuroscience Society
  • Invited
• [Presentation] 皮質脳波と高次脳機能ネットワーク (2017)
  • Author(s): 松本理器、下竹昭寛，菊池隆幸，國枝武治、池田昭夫
  • Organizer: 第47回日本臨床神経生理学会
  • Invited
• [Presentation] てんかんの治療戦略：てんかん外科における言語機能温存へ向けた試み．シンポジウムII．高次脳機能障害の治療戦略． (2017)
  • Author(s): 松本理器，下竹昭寛，山尾幸広，菊池隆幸，國枝武治
  • Organizer: 第41回日本神経心理学会
  • Invited
• [Presentation] Active engagement of higher-order motor cortices in motor inhibition: Evidence fromdirect neural recording and stimulation during Go/No-Go paradigm (2017)
  • Author(s): Takeyama H, Matsumoto R, Usami K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
  • Organizer: Society for Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Functional connectivity from human superior parietal lobule and medial parietal lobe: A cortico-coritcal evoked potential (CCEP) study (2017)
  • Author(s): Togo M, Matsumoto R, Nakae T, Takeyama H, Kobayashi K, Shimotake A, Usami K, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
  • Organizer: Society for Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Scoring System of Combination of Movement-related Cortical Potential and Event-related Synchronization/De-synchronization for Functional Mapping of Primary Motor Areas Concordant with Electrical Cortical Stimulation (2017)
  • Author(s): Neshige S, Matsuhashi M, Kobayashi K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Maruyama H, Takahashi R, Ikeda A.
  • Organizer: 第51回日本てんかん学会学術集会
• [Presentation] Functional brain mapping of higher-order motor cortices engaging in motor inhibition: A combined event-related potential and stimulation study (2017)
  • Author(s): Takeyama H, Matsumoto R, Usami K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
  • Organizer: 第51回日本てんかん学会学術大会
• [Presentation] Role of the Negative Motor Area in Praxis: A High Frequency Electrical Cortical Stimulation Study (2017)
  • Author(s): Togo M, Matsumoto R, Shimotake A, Kobayashi T, Kikuchi T, Yoshida K, Matsuhashi M, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
  • Organizer: 第51回日本てんかん学会
• [Presentation] 難治部分てんかん患者での単発皮質電気刺激の発作誘発率に関する安全性：皮質皮質間誘発電位計測時の検討 (2017)
  • Author(s): 小林勝哉, 松本理器, 宇佐美清英, 松橋眞生, 下竹昭寛, 中江卓郎, 武山博文, 菊池隆幸, 吉田和道, 國枝武治, 高橋良輔, 池田昭夫
  • Organizer: 第47回日本臨床神経生理学会学術大会
• [Presentation] アンカーボルトを用いた定位的頭蓋内深部電極挿入術の国内への本格導入に向けて－単一施設での導入経験－ (2017)
  • Author(s): 稲田拓, 菊池隆幸, 小林勝哉, 山尾幸広, 吉田和道, 國枝武治, 松本理器, 池田昭夫, 宮本享
  • Organizer: 日本脳神経外科学会第 76 回学術総会
• [Presentation] 皮質皮質間誘発電位における非典型波形の検討 (2017)
  • Author(s): 迎伸孝, 松本理器, 小林勝哉, 十河正弥, 松橋眞生, 中江卓郎, 武山博文, 下竹昭寛, 山尾幸広, 菊池隆幸, 吉田和道, 飯原弘二, 髙橋良輔, 池田昭夫
  • Organizer: 第47回日本臨床神経生理学会学術大会
• [Presentation] 皮質電気刺激による行為関連ネットワークマッピング (2017)
  • Author(s): 下竹昭寛,松本理器,小林勝哉,國枝武治,三國信啓,宮本亨,高橋良輔,池田昭夫
  • Organizer: 第47回日本臨床神経生理学会
• [Presentation] 皮質電気刺激を用いたてんかん原性評価と関連ネットワーク解析 (2017)
  • Author(s): 小林勝哉、松本理器、宇佐美清英、菊池隆幸、吉田和道、國枝武治、池田昭夫
  • Organizer: 第51回日本てんかん学会学術集会
• [Presentation] Sleep exerts a change in network effective connectivity; Causality analysis of human brain network evoked by single-pulse electrical stimulation (2017)
  • Author(s): Kiyohide Usami, Anna Korzeniewska, Riki Matsumoto, Kunieda Takeharu, Nobuhiro Mikuni, Katsuya Kobayashi, Takayuki Kikuchi, Kazumichi Yoshida, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda, and Nathan E. Crone
  • Organizer: AES 2017
  • Int'l Joint Research
• [Presentation] Anesthetic effect on cortico-cortical evoked potentials during intraoperative dorsal language pathway monitoring (2017)
  • Author(s): 山尾 幸広、松本 理器、國枝 武治、荒川 芳輝、中江 卓郎、菊池 隆幸、吉田 和道、池田 昭夫、宮本 享
  • Organizer: Neuroscience 2017
• [Presentation] 術中言語白質モニタリングにおける皮質-皮質間誘発電位への麻酔の影響の検討 (2017)
  • Author(s): 山尾 幸広、松本 理器、國枝 武治、荒川 芳輝、中江 卓郎、菊池 隆幸、吉田 和道、池田 昭夫、宮本 享
  • Organizer: 第51回日本てんかん学会学術集会
• [Presentation] 皮質-皮質間誘発電位の機能的結合を基としたトラクトグラフィーでの一次運動野・一次感覚野間の機能的結合の同定 (2017)
  • Author(s): 山尾 幸広、松本 理器、國枝 武治、荒川 芳輝、菊池 隆幸、吉田 和道、池田 昭夫、Marco Catani, 宮本 享
  • Organizer: 日本脳神経外科学会 第76回 学術総会
• [Presentation] 運動主体感における島皮質の役割:島皮質切除症例での縦断的神経心理学的検討 (2017)
  • Author(s): 小林 環、松本理器、下竹昭寛、十河正弥、高橋由紀、稲田拓、山尾幸広、菊池隆幸、荒川芳輝、吉田和道、池田昭夫、前田貴記、今水寛、宮本享
  • Organizer: 日本脳神経外科学会 第76回学術総会
• [Presentation] 発作時DC電位とその病理組織学的検討 (2017)
  • Author(s): 小林環、北浦弘樹、村井智彦、中谷光良、菊池隆幸、人見 健文、井内盛遠、松本理器、國枝武治、宮本享、白水洋史、井上有史、前原健寿、池田昭夫、柿田明美
  • Organizer: 第51回日本てんかん学会学術集会
• [Presentation] The role of the right insula in Sense of Agency: evidence from neurosurgical cases (2017)
  • Author(s): 小林 環、 松本理器, 下竹昭寛 , 十河正弥 ,荒川芳輝 ,山尾幸広 ,菊池隆幸, 吉田和道, 池田昭夫, 前田貴記, 今水寛, 宮本享
  • Organizer: 第40回 日本神経科学大会
• [Presentation] 覚醒下手術における電気生理学的線維追跡法の応用―高次脳機能温存の試み― (2017)
  • Author(s): 菊池隆幸 山尾幸広 吉田和道 荒川芳輝 松本理器 國枝武治 宮本享
  • Organizer: Awake Surgery学会
• [Presentation] Introduction of SEEG to a single institute in Japan -A case of Kyoto University Hospital- (2017)
  • Author(s): Kikuchi T, Inada T, Kobayashi K, Kunieda T, Matsumoto R, Ikeda A, Miyamoto S
  • Organizer: 日本てんかん学会
• [Presentation] 頭蓋内電極埋め込み中のMRI撮像についての国内の現状と今後の方策 (2017)
  • Author(s): 菊池隆幸 松本理器 小林勝哉 國枝武治 三國信啓 前原健寿
  • Organizer: 日本脳神経外科学会
• [Book] 単純部分発作 １．側頭葉てんかん、前頭葉てんかん．第１０章／１４ けいれん性疾患、機能性疾患／３局在関連性てんかん．新内科学第10版（矢﨑義雄編） (2019)
  • Author(s): 松本理器
  • Publisher: 医学書院
• [Book] 複雑部分発作 １．側頭葉てんかん、前頭葉てんかん．第１０章／１４ けいれん性疾患、機能性疾患／３局在関連性てんかん．新内科学第10版（矢﨑義雄編） (2019)
  • Author(s): 松本理器
  • Publisher: 医学書院
• [Book] 薬剤抵抗性でありながら外科治療適応が考慮されない/月刊薬事 61(1): (2019)
  • Author(s): 宇佐美清英，菊池隆幸，松本理器
  • Publisher: 株式会社 じほう
• [Book] Subdural EEG in frontal lobe epilepsy. Invasive Studies of the Human Epileptic Brain: Principles and Practice of Invasive Brain Recordings and Stimulation in Epilepsy. (2018)
  • Author(s): Akio Ikeda
  • Publisher: Oxford University Press
  • ISBN: 9780198714668
• [Book] Cortico-cortical evoked potential mapping (Section 4: Human Brain Mapping). In: Lhatoo S, Kahane P, Luders H, eds. Invasive Studies of the Human Epileptic Brain: Principles and Practice of Invasive Brain Recordings and Stimulation in Epilepsy. (2018)
  • Author(s): Riki Matsumoto, Takeharu Kunieda
  • Publisher: Oxford University Press
• [Book] てんかんの内科治療 今日の治療指針 2018年版［デスク判］ (2018)
  • Author(s): 松本理器
  • Publisher: 医学書院
  • ISBN: 9784260032339
• [Book] III 各種疾患 11．機能性疾患 １ てんかんの新規治療薬．Annual Review 神経 2018 (2018)
  • Author(s): 吉村元,松本理器
  • Publisher: 中外医学社
  • ISBN: 9784498328068
• [Book] 自己免疫介助性脳炎・脳症,/希少てんかんの診療指標 (2018)
  • Author(s): 坂本光弘、松本理器、池田昭夫
  • Publisher: 診断と治療社
• [Book] 第3章 身体意識の脳内身体表現マーカー．身体性システムとリハビリテーションの科学2 身体認知（近藤 敏之 編今水 寛 編森岡 周 編） (2018)
  • Author(s): 松本理器．
  • Publisher: 東京大学出版会
• [Book] ガイトン生理学 (2018)
  • Author(s): 十川純平、音成秀一郎、十河正弥、池田 昭夫
  • Publisher: エルセビア・ジャパン
  • ISBN: 9784860347741
• [Book] Invasive Studies of the Human Epileptic Brain: Principles and Practice of Invasive Brain Recordings and Stimulation in Epilepsy (2017)
  • Author(s): Matsumoto R, Kunieda T
  • Publisher: Oxford University Press (London)
• [Book] Invasive Studies of the Human Epileptic Brain: Principles and Practice of Invasive Brain Recordings and Stimulation in Epilepsy (2017)
  • Author(s): Ikeda A
  • Publisher: Oxford University Press (London)
• [Book] Clinical Neuroscience 37(7) (2017)
  • Author(s): 中谷光良，小林勝哉，松本理器
  • Publisher: 中外医学社
• [Book] 臨床神経生理検査入門 (2017)
  • Author(s): 下竹昭寛、松本理器
  • Total Pages: 288
  • Publisher: 中山書店
  • ISBN: 9784521745459
• [Remarks] http://epilepsy.med.kyoto-u.ac.jp/research
• [Remarks] 京都大学大学院医学研究科てんかん・運動異常生理学講座 研究紹介
  • URL: http://epilepsy.med.kyoto-u.ac.jp/research
• [Remarks] 京都大学大学院医学研究科臨床神経学 研究紹介
  • URL: https://www.kuhp.kyoto-u.ac.jp/~neurology/laboratory/lab_3_5.htm