Human Fronto-Parietal Network for Embodied-Brain System: A Combined Electrocorticographic Decoding, Stimulation and Lesion Study
Publicly Offered Research
Project Area | Understanding brain plasticity on body representations to promote their adaptive functions |
Project/Area Number |
17H05907
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Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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Allocation Type | Single-year Grants |
Review Section |
Complex systems
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Research Institution | Kobe University (2018) Kyoto University (2017) |
Principal Investigator |
松本 理器 神戸大学, 医学研究科, 教授 (00378754)
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Project Period (FY) |
2017-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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Keywords | 前頭・頭頂葉ネット―ワーク / 皮質電気刺激 / 皮質皮質間誘発電位 / 病変研究 / 行為 / 運動主体感 / 身体意識 / 失行 / 前頭・頭頂葉ネットワーク / 脳病変研究 / 皮質脳波 / デコーディング / 前頭・頭頂ネットワーク |
Outline of Annual Research Achievements |
術前評価目的に硬膜下電極を留置した難治部分てんかん患者で本研究計画に同意を得た者を対象に、左半球では高次運動、右半球では身体意識に焦点をあてて、腹側前頭・頭頂葉ネットワークの皮質活動の探索と変容様式の同定を進めた。左半球では、通常の臨床機能マッピングより弱い刺激強度で陰性運動野に介入し、運動制御の変容の定量解析から、中心前回の陰性運動野は肢節運動失行、腹側運動前野の陰性運動野はより高次の失行への関与が示唆された(国際学会発表)。そして、電気的線維追跡法(皮質皮質間誘発電位)の検討から、中心前回と腹側運動前野間の機能分担は、異なる機能的結合様式が神経基盤であることを明らかにした(国内学会発表)。術中の皮質皮質間誘発電位の検討から、このような前頭葉-頭頂葉・側頭葉間のネットワークには左右差があることを明らかにした(論文発表)。刺激最中の誘発神経活動の検討から、高頻度皮質刺激マッピングでは、高次運動ではネットワークとして機能が発現されるものの、症状の大部分は刺激直下の皮質に由来することを明らかにした(国内学会発表)。また、運動関連皮質で、高頻度刺激を用いない、自発運動に伴う皮質脳波の脳律動解析の手法を提案した(論文発表)。一連の研究成果は、電気刺激による臨床脳機能マッピングの作動原理を明らかにし、より正確な皮質機能の同定を可能にし、今後の非侵襲的機能マッピングにつながる知見と位置づけられる。 身体意識に関しては、左右島皮質に脳腫瘍などの病変があり切除術を施行した患者7例を対象に、手術前後の運動主体感の変容を心理的手法から定量的に計測した。右島切除で運動主体感について動的変容を認め、経時的に正常化する傾向にあった (国際学会発表)。右半球が有する身体意識(運動主体感)への島皮質の関与と切除後の緩徐な代償が明らかとなり、今後のリハビリテーションへの応用が期待される。
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Research Progress Status |
平成30年度が最終年度であるため、記入しない。
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Strategy for Future Research Activity |
平成30年度が最終年度であるため、記入しない。
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Report
(2 results)
Research Products
(106 results)
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[Journal Article] The neural tides of sleep and consciousness revealed by single-pulse electrical brain stimulation.2019
Author(s)
Usami K, Korzeniewska A, Matsumoto R, Kobayashi K, Hitomi T, Matsuhashi M, Kunieda T, Mikuni N, Kikuchi T, Yoshida K, Miyamoto S, Takahashi R, Ikeda A, Crone NE.
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Journal Title
Sleep.
Volume: in press
Issue: 6
Pages: 1-9
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A rational, multispectral mapping algorithm for primary motor cortex: A primary step before cortical stimulation2019
Author(s)
Shuichiro Neshige, Katsuya Kobayashi, Masao Matsuhashi, Takefumi Hitomi, Akihiro Shimotake, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Riki Matsumoto, Susumu Miyamoto, Ryosuke Takahashi, Hirofumi Maruyama, Akio Ikeda
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Journal Title
Epilepsia
Volume: 60
Issue: 3
Pages: 547-559
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Multi-component intrinsic brain activities as a safe alternative to cortical stimulation for sensori-motor mapping in neurosurgery.2018
Author(s)
Neshige S, Matsuhashi M, Kobayashi K, Sakurai T, Shimotake A, Hitomi T, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Takahashi R, Miyamoto S, Maruyama H, Matsumoto M, Ikeda A.
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Journal Title
Clin Neurophysiol.
Volume: 129
Issue: 9
Pages: 2038-2048
DOI
Related Report
Peer Reviewed
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[Journal Article] Do scalp-recorded slow potentials during neuro-feedback training reflect the cortical activity?2018
Author(s)
Tomoyuki Fumuro, Masao Matsuhashi, Riki Matsumoto, Kiyohide Usami, Akihiro Shimotake, Takeharu Kunieda, Takayuki Kikuchi, Kazumichi Yoshida, Ryosuke Takahashi, Susumu Miyamoto, Akio Ikeda
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Journal Title
Clinical Neurophysiology
Volume: 129
Issue: 9
Pages: 1884-1890
DOI
Related Report
Peer Reviewed
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[Journal Article] Interhemispheric Asymmetry of Network Connecting Between Frontal and Temporoparietal Cortices: A Corticocortical-Evoked Potential Study2018
Author(s)
Aya Kanno, Rei Enatsu, Satoshi Ookawa, Shouhei Noshiro, Shunya Ohtaki, Kengo Suzuki, Yuto Suzuki, Rintaro Yokoyama, Satoko Ochi, Yukinori Akiyama, Takeshi Mikami, Takuro Nakae, Takayuki Kikuchi, Takeharu Kunieda, Susumu Miyamoto, Riki Matsumoto, Nobuhiro Mikuni
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Journal Title
World Neurosurgery
Volume: 120
Pages: e628-e636
DOI
Related Report
Peer Reviewed
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[Journal Article] Proposal of a diagnostic algorithm for autoimmune epilepsy: preliminary investigation of its utility2018
Author(s)
Mitsuhiro Sakamoto, Riki Matsumoto, Jumpei Togawa, Yuichiro Hashi, Hirofumi Takeyama, Katsuya Kobayashi, Akihiro Shimotake, Takayuki Kondo, Ryosuke Takahashi, Akio Ikeda
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Journal Title
Rinsho Shinkeigaku
Volume: 58
Issue: 10
Pages: 609-616
DOI
ISSN
0009-918X, 1882-0654
Related Report
Peer Reviewed
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[Journal Article] Magnetoencephalography with temporal spread imaging to visualize propagation of epileptic activity2017
Author(s)
Shibata S, Matsuhashi M, Kunieda T, Yamao Y, Rika Inano R, Kikuchi T, Imamura H, Takaya S, Matsumoto R, Ikeda A, Takahashi R, Mima T, Fukuyama H, Mikuni N, Miyamoto S
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Journal Title
Clin Neurophysiol
Volume: 128
Issue: 5
Pages: 734-743
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Phasic REM transiently approaches wakefulness in the human cortex - a single-pulse electrical stimulation study.2017
Author(s)
Usami K, Matsumoto R, Kobayashi K, Hitomi T, Matsuhashi M, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Mikuni N, Miyamoto S, Takahashi R, Ikeda A.
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Journal Title
Sleep
Volume: 40
Issue: 8
Pages: 1-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical impact of intraoperative CCEP monitoring in evaluating the dorsal language white matter pathway2017
Author(s)
Yamao Y, Suzuki K, Kunieda T, Matsumoto R, Arakawa Y, Nakae T, Nishida S, Inano R, Shibata S, Shimotake A, Kikuchi, T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S
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Journal Title
Human Brain Mapping
Volume: 38 (4)
Issue: 4
Pages: 1977-1991
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Neural pattern similarity between contra- and ipsilateral movements in high-frequency band of human electrocorticograms2017
Author(s)
Fujiwara Y, Matsumoto R, Nakae T, Usami K, Matsuhashi M, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Mima T, Ikeda A, Osu R
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Journal Title
Neuroimage
Volume: 15
Pages: 302-313
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] The role of the insula in Sense of Agency: supportive data from neurosurgical cases2018
Author(s)
Tamaki Kobayashi, Riki Matsumoto, Akihiro Shimotake, Masaya Togo, Yoshiki Arakawa, Yukihiro Yamao, Takayuki Kikuchi, Kazumichi Yoshida, Akio Ikeda, Shiro Yano, Takaki Maeda, Hiroshi Imamizu, Susumu Miyamoto
Organizer
16th Asian Oceanian Congress Of Neurology
Related Report
Int'l Joint Research
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[Presentation] Rational cortical mapping algorithm for epilepsy surgery: non-stimuli, multi-intrinsic brain activities without cortical stimulation2018
Author(s)
Shuichiro Neshige, Katsuya Kobayashi, Masao Matsuhashi, Akihiro Shimotake, Takehumi Hitomi, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Riki Matsumoto*, Ryosuke Takahashi, Susumu Miyamoto, Hirofumi Maruyama, Akio Ikeda.
Organizer
the 12th Asian&Oseanian Epilepsy Congress
Related Report
Int'l Joint Research
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[Presentation] Revised Diagonositc algorithm for autoimmune epilepsy without antibody testing: its proposal and validation with a restrospective cohort2018
Author(s)
Mitsuhiro Sakamoto, Riki Matsumoto, Junpei Togawa, Hirohumi Takeyama, Yuichiro Hashi, Katsuya Kobayashi, Akihiro Shimotake, Frank Leypoldt, Klaus- Peter Wandinger, Takayuki Kondo, Ryosuke Takahashi, Akio Ikeda
Organizer
16th Asian Oceanian Congress Of Neurology
Related Report
Int'l Joint Research
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[Presentation] Human medial parietal cortices have distinct connectivity patterns: Evidence from standardized connectivity map using cortico-cortical evoked potential2018
Author(s)
Masaya Togo, Riki Matsumoto, Takuro Nakae, Hirohumi Takeyama, Katsuya Kobayashi, Kiyohide Usami, Akihiro Shimotake, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda
Organizer
第41回神経科学大会
Related Report
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[Presentation] Electrocorticography-based non-primary motor area mapping comparable with cortical stimulation2018
Author(s)
Shuichiro Neshige, Katsuya Kobayashi, Masao Matsuhashi, Akihiro Shimotake, Takehumi Hitomi, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Riki Matsumoto*, Ryosuke Takahashi, Susumu Miyamoto, Hirofumi Maruyama, Akio Ikeda
Organizer
第59回日本神経学会学術大会
Related Report
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[Presentation] Changes in human brain network connectivity during sleep and wakefulness _ a study of neural propagation evoked by single-pulse electrical stimulation2018
Author(s)
Kiyohide Usami, Anna Korzeniewska, Riki Matsumoto*, Takefumi Hitomi, Kunieda Takeharu, Nobuhiro Mikuni, Katsuya Kobayashi, Takayuki Kikuchi, Kazumichi Yoshida, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda, and Nathan E. Crone
Organizer
31st International Congress of Clinical Neurophysiology
Related Report
Int'l Joint Research
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[Presentation] Double dissociation of the semantic and phonological processing in reading Kanji and Kana words - A quantitative low-intensity cortical stimulation study2018
Author(s)
Masako Daifu, Riki Matsumoto, Akihiro Shimotake1), Makiko Ota, Mitsuhiro Sakamoto, Katsuya Kobayashi, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Ryosuke Takahashi, Matthew A. Lambon Ralph, Akio Ikeda
Organizer
The 41th Annual Meeting of the Japan Neuroscience Society
Related Report
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[Presentation] Underlying excitability at the focus modulates network dynamics of seizure propagation: a single-pulse electrical stimulation study time-locked to spike and post-spike slow.2018
Author(s)
Katsuya Kobayashi, Riki Matsumoto, Kiyohide Usami, Akihiro Shimotake, Masao Matsuhashi, Yukihiro Yamao, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Ryosuke Takahashi, Akio Ikeda.
Organizer
American Epilepsy Society (AES) 2018 Annual Meeting
Related Report
Int'l Joint Research
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[Presentation] Safety of single-pulse electrical stimulation for cortico-cortical evoked potentials in epileptic human cerebral cortex2017
Author(s)
Kobayashi K, Matsumoto R, Usami K, Matsuhashi M, Shimotake A, Nakae T, Takeyama H, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Ikeda A
Organizer
The XXⅢ World Congress of Neurology
Related Report
Int'l Joint Research / Invited
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[Presentation] Efficacy of Wide-Band Electrocorticography(ECoG) on Mapping of the Primary Sensori-Motor Area Compared with Electrical Cortical Stimulation (ECS)2017
Author(s)
Neshige S, Matsuhashi M, Sakurai T, Kobayashi K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Maruyama H, Takahashi R and Ikeda A
Organizer
The XXⅢ World Congress of Neurology
Related Report
Int'l Joint Research
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[Presentation] Role of the negative motor area in praxis: A high frequency electrical cortical stimulation study2017
Author(s)
Togo M, Matsumoto R, Shimotake A, Kobayashi T, Kikuchi T, Yoshida K, Matsuhashi M, Kunieda T, Miyamoto S, Takahashi R, Ikeda A
Organizer
The XXⅢ World Congress of Neurology
Related Report
Int'l Joint Research
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[Presentation] Functional gradient of the ventral temporal area in reading Kanji and Kana words;A quantitative low-intensity cortical stimulation study2017
Author(s)
Daifu M, Matsumoto R, Shimotake A, Ota M, Sakamoto M, Nakae T, Kobayashi K, Kikuchi T, Yoshida K, Kunieda T, Takahashi R, Lambon Ralph M, Ikeda A
Organizer
第40回日本神経科学大会
Related Report
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[Presentation] The human entorhinal cortex is connected with the broad neocortical regions through the hippocampalthalamo-cortical pathway possible as the memory network: Results from electrical tract tracing and neuropsychologicalassessment2017
Author(s)
Takeyama H, Matsumoto R, Nakae T, Kobayashi K, Usami K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R Ikeda A
Organizer
第40回日本神経科学大会
Related Report
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[Presentation] Functional connectivity from human superior parietal lobule and medial parietal lobe: A cortico-coritcal evoked potential (CCEP) study2017
Author(s)
Togo M, Matsumoto R, Nakae T, Takeyama H, Kobayashi K, Shimotake A, Usami K, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
Organizer
Society for Neuroscience 2017
Related Report
Int'l Joint Research
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[Presentation] Scoring System of Combination of Movement-related Cortical Potential and Event-related Synchronization/De-synchronization for Functional Mapping of Primary Motor Areas Concordant with Electrical Cortical Stimulation2017
Author(s)
Neshige S, Matsuhashi M, Kobayashi K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Matsumoto R, Maruyama H, Takahashi R, Ikeda A.
Organizer
第51回日本てんかん学会学術集会
Related Report
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[Presentation] Role of the Negative Motor Area in Praxis: A High Frequency Electrical Cortical Stimulation Study2017
Author(s)
Togo M, Matsumoto R, Shimotake A, Kobayashi T, Kikuchi T, Yoshida K, Matsuhashi M, Kunieda T, Miyamoto S, Takahashi R, Ikeda A.
Organizer
第51回日本てんかん学会
Related Report
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[Presentation] 難治部分てんかん患者での単発皮質電気刺激の発作誘発率に関する安全性:皮質皮質間誘発電位計測時の検討2017
Author(s)
小林勝哉, 松本理器, 宇佐美清英, 松橋眞生, 下竹昭寛, 中江卓郎, 武山博文, 菊池隆幸, 吉田和道, 國枝武治, 高橋良輔, 池田昭夫
Organizer
第47回日本臨床神経生理学会学術大会
Related Report
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[Presentation] 皮質皮質間誘発電位における非典型波形の検討2017
Author(s)
迎伸孝, 松本理器, 小林勝哉, 十河正弥, 松橋眞生, 中江卓郎, 武山博文, 下竹昭寛, 山尾幸広, 菊池隆幸, 吉田和道, 飯原弘二, 髙橋良輔, 池田昭夫
Organizer
第47回日本臨床神経生理学会学術大会
Related Report
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[Presentation] Sleep exerts a change in network effective connectivity; Causality analysis of human brain network evoked by single-pulse electrical stimulation2017
Author(s)
Kiyohide Usami, Anna Korzeniewska, Riki Matsumoto, Kunieda Takeharu, Nobuhiro Mikuni, Katsuya Kobayashi, Takayuki Kikuchi, Kazumichi Yoshida, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda, and Nathan E. Crone
Organizer
AES 2017
Related Report
Int'l Joint Research
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[Presentation] The role of the right insula in Sense of Agency: evidence from neurosurgical cases2017
Author(s)
小林 環、 松本理器, 下竹昭寛 , 十河正弥 ,荒川芳輝 ,山尾幸広 ,菊池隆幸, 吉田和道, 池田昭夫, 前田貴記, 今水寛, 宮本享
Organizer
第40回 日本神経科学大会
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[Book] ガイトン生理学2018
Author(s)
十川純平、音成秀一郎、十河正弥、池田 昭夫
Publisher
エルセビア・ジャパン
ISBN
9784860347741
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