A development of an early psychological treatment for patients with schizophrenia focusing on the discrepancy between explicit and implicit, and children and their parents subjective value recognition

• Project Area: Science of personalized value development through adolescence: integration of brain, real-world, and life-course approaches
• Project/Area Number: 17H05921
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: The University of Tokyo
• Principal Investigator: 小池 進介 東京大学, 大学院総合文化研究科, 准教授 (10633167)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
• Keywords: 主体価値 / 価値の伝播 / 統合失調症 / 早期支援 / 心理社会的介入

Outline of Annual Research Achievements

A01田中、中谷、D01笠井と密に連携し、平成29年度に引き続き主体価値指標の開発と、駒場MRI計測の立ち上げに注力した。
Schwartz et al. 2012の価値観尺度（PVQ）を日本語化し、妥当性と信頼性を検討した。そのうえで、東京ティーンコホート（TTC）で用いられている価値感尺度との妥当性と信頼性を検討した（Ozawa et al., in revision）。同様に、TTCで採択されている内発的動機づけ尺度（PLOCQ）の日本語版妥当性と信頼性の検討を行い、１年後の自覚的抑うつ傾向が勉強についての内発的動機づけおよび最も時間を費やしていることについての無動機（Amotivation）から影響を受けていることを明らかにした（Shiba et al. about to submit）。これらの指標はいずれもTTCで採用されており、今後コホートデータを用いた解析を行っていく。
東大駒場キャンパスの3T-MRI, Siemens社製Prismaを用いて、現在進行中のiTTCの継続を行い、第二期計測の拡張として115名の計測を完了した。平成30年4月より、プロトコルをHuman Connectome Project（HCP）と同等のものに切り替え、第三期計測も開始した。平成31年3月までに、118名のフォロー計測と、9名の新規追加計測を実施した。この計測は2020年4月まで実施する予定である。
また、C01西田と連携し、MRI解析として尿中ペントシジン濃度とMRI構造・機能の関係について、思春期発達と精神症状を絡めて解析を開始した。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Age relative to school class peers and emotional well-being in 10-year-olds (2019)
  • Author(s): Shuntaro Ando , Satoshi Usami, Tetsuya Matsubayashi, Michiko Ueda, Shinsuke Koike, Syudo Yamasaki, Shinya Fujikawa, Tsukasa Sasaki, Mariko Hiraiwa-Hasegawa, George Patton, Kiyoto Kasai, Atsushi Nishida
  • Journal Title: PlosOne Volume: 14 (3) Issue: 3 Pages: e0214359-e0214359
  • DOI: 10.1371/journal.pone.0214359
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Maternal diabetes in early pregnancy, and psychotic experiences and depressive symptoms in 10-year-old offspring: A population-based birth cohort study (2019)
  • Author(s): Syudo Yamasaki, Shuntaro Ando, Marcus Richards, Stephani L.Hatch, Shinsuke Koike ,Shinya Fujikawa, Sho Kanata, Kaori Endo, Yuko Morimoto, Makoto Arai, Haruo Okado, Satoshi Usami, Toshiaki A.Furukawa, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai, Atsushi Nishida
  • Journal Title: Schizophrenia Research Volume: 印刷中 Pages: 30704-7
  • DOI: 10.1016/j.schres.2018.12.016
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long-term effects of filmed social contact or internet-based self-study on mental health-related stigma: a 2-year follow-up of a randomised controlled trial (2018)
  • Author(s): Yamaguchi Sosei、Ojio Yasutaka、Ando Shuntaro、Bernick Peter、Ohta Kazusa、Watanabe Kei-ichiro、Thornicroft Graham、Shiozawa Takuma、Koike Shinsuke
  • Journal Title: Social Psychiatry and Psychiatric Epidemiology Volume: 54 Issue: 1 Pages: 33-42
  • DOI: 10.1007/s00127-018-1609-8
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Fat mass and obesity-associated (FTO) rs9939609 polymorphism modifies the relationship between body mass index and affective symptoms through the life course: a prospective birth cohort study (2018)
  • Author(s): Koike Shinsuke、Richards Marcus、Wong Andrew、Hardy Rebecca
  • Journal Title: Translational Psychiatry Volume: 8 Issue: 1 Pages: 62-62
  • DOI: 10.1038/s41398-018-0110-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Social distance toward people with schizophrenia is associated with favorable understanding and negative stereotype (2018)
  • Author(s): Koike Shinsuke、Yamaguchi Sosei、Ojio Yasutaka、Ando Shuntaro
  • Journal Title: Psychiatry Res Volume: 261 Pages: 264-268
  • DOI: 10.1016/j.psychres.2017.12.081
  • Peer Reviewed
• [Journal Article] Catechol O-methyltransferase ( COMT ) functional haplotype is associated with recurrence of affective symptoms: A prospective birth cohort study (2018)
  • Author(s): Koike Shinsuke、Gaysina Darya、Jones Peter B.、Wong Andrew、Richards Marcus
  • Journal Title: J Affect Dis Volume: 229 Pages: 437-442
  • DOI: 10.1016/j.jad.2017.12.044
  • Peer Reviewed
• [Journal Article] Fat Mass and Obesity Associated (FTO) rs9939609 Polymorphism Modifies the Relationship between body mass index and Affective Symptoms through the Life Course: a prospective birth cohort study (2018)
  • Author(s): Koike S, Richards M, Wong A, Hardy R
  • Journal Title: Translational Psychiatry Volume: in press
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] スティグマの母子関係と、統合失調症名称変更の知識がスティグマに与える影響 (2018)
  • Author(s): 小池進介, 山口創生, 小塩靖崇, 安藤俊太郎
  • Journal Title: 精神神経学雑誌 Volume: in press
  • Peer Reviewed
• [Journal Article] Application of functional near infrared spectroscopy as supplementary examination for diagnosis of clinical stages of psychosis spectrum (2017)
  • Author(s): Koike Shinsuke, Satomura Yoshihiro, Kawasaki Shingo, Nishimura Yukika, Kinoshita Akihide, Sakurada Hanako, Yamagishi Mika, Ichikawa Eriko, Matsuoka Jun, Okada Naohiro, Takizawa Ryu, Kasai Kiyoto
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 71 Issue: 12 Pages: 794-806
  • DOI: 10.1111/pcn.12551
  • Peer Reviewed / Open Access
• [Presentation] 思春期コホートからみる精神疾患 (2019)
  • Author(s): 小池進介
  • Organizer: 文部科学省共同利用・共同研究拠点「社会神経科学研究拠点」シンポジウム
  • Invited