初期神経発生過程に生じる体細胞変異の頻度とパターンの解析

• Project Area: Integrative research toward elucidation of generative brain systems for individuality
• Project/Area Number: 17H05954
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Kumamoto University
• Principal Investigator: 岩本 和也 熊本大学, 大学院生命科学研究部(医), 教授 (40342753)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Project Status: Discontinued (Fiscal Year 2018)
• Budget Amount: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000); Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
• Keywords: 体細胞変異 / 精神疾患 / poly(I:C) / トランスポゾン / 脳神経疾患 / ゲノム

Outline of Annual Research Achievements

初期発生過程における体細胞変異パターン解析のための超深度エクソームデータを昨年度取得した。本年度はエクソームデータの解析および解析結果に基づく多検体解析の準備を進めていたが、新学術領域研究課題の新規採択に伴う規定により6月29日より中断した。今後、新たに採択された研究費との関係を見直し再開する予定である。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Somatic mutations in the human brain: implications for psychiatric research (2018)
  • Author(s): Nishioka M, Bundo M, Iwamoto K, Kato T
  • Journal Title: Molecular Psychiatry Volume: - Issue: 6 Pages: 839-856
  • DOI: 10.1038/s41380-018-0129-y
  • Peer Reviewed / Open Access
• [Journal Article] Identification of somatic mutations in monozygotic twins discordant for psychiatric disorders. (2018)
  • Author(s): Nishioka M, Bundo M, Ueda J, Yoshikawa A, Nishimura F, Sasaki T, Kakiuchi C, Kasai K, Kato T, Iwamoto K.
  • Journal Title: NPJ Schizophr. Volume: 4 Issue: 1 Pages: 7-7
  • DOI: 10.1038/s41537-018-0049-5
  • Peer Reviewed / Open Access
• [Journal Article] DNA methylation analyses of the candidate genes identified by a methylome-wide association study revealed common epigenetic alterations in schizophrenia and bipolar disorder. (2018)
  • Author(s): Sugawara H, Murata Y, Ikegame T, Sawamura R, Shimanaga S, Takeoka Y, Saito T, Ikeda M, Yoshikawa A, Nishimura F, Kawamura Y, Kakiuchi C, Sasaki T, Iwata N, Hashimoto M, Kasai K, Kato T, Bundo M, Iwamoto K.
  • Journal Title: Psychiatry Clin Neurosci Volume: in press Issue: 4 Pages: 245-254
  • DOI: 10.1111/pcn.12645
  • Peer Reviewed / Open Access
• [Journal Article] Identification of somatic mutations in postmortem human brains by whole genome sequencing and their implications for psychiatric disorders. (2018)
  • Author(s): Nishioka M, Bundo M, Ueda J, Katsuoka F, Sato Y, Kuroki Y, Ishii T, Ukai W, Murayama S, Hashimoto E, Nagasaki M, Yasuda J, Kasai K, Kato T, Iwamoto K.
  • Journal Title: Psychiatry Clin Neurosci. Volume: 72 Issue: 4 Pages: 280-294
  • DOI: 10.1111/pcn.12632
  • Peer Reviewed / Open Access