Publicly Offered Research
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
We established the star maze behavioral protocol in the laboratory and successfully completed analyses of navigational selection in control cohorts of animals. We characterized a novel Cre recombinase expressing transgenic mouse line that provided genetic access to principle neurons of the retrosplenial cortex. DREADD-based pharmacogenetic silencing approaches failed to produce a quantifiable change in navigation behavior in these animals. In vivo recording was used to verify the action of the circuit manipulations. We found that the administration of the DREADD ligand, CNO, was effective in reducing the firing rate of a substantial fraction of the neurons we recorded in the retrosplenial cortex. The absence of a clear behavioral impact of this silencing on the navigational strategy selection in the experimental mice remains to be clarified with future work.
平成30年度が最終年度であるため、記入しない。
All 2019 2018 2017
All Journal Article (2 results) (of which Int'l Joint Research: 2 results, Peer Reviewed: 2 results) Presentation (3 results) (of which Int'l Joint Research: 2 results, Invited: 2 results)
Science
Volume: 361 Issue: 6400 Pages: 392-397
10.1126/science.aat5397
Nature Neuroscience
Volume: 21 Issue: 7 Pages: 996-1003
10.1038/s41593-018-0163-8
