光刺激を用いたシグナル伝達の時空間的に精密な制御

• Project Area: Integrative understanding of biological signaling networks based on mathematical science
• Project/Area Number: 17H06015
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Osaka City University
• Principal Investigator: 小柳 光正 大阪市立大学, 大学院理学研究科, 准教授 (30379276)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
• Keywords: 光生物学 / 光遺伝学 / ロドプシン / GPCR / Gタンパク質

Outline of Annual Research Achievements

シグナル伝達をシステムとして理解するためには、各反応の速度や持続性といった動的な情報を得ることが重要であり、そのためにはシグナル伝達の時空間的に精密な制御が必要である。最近私たちは、動物の視覚を支える光作動性のGタンパク質共役型受容体（GPCR）であるロドプシンおよびその類似光タンパク質をツールとして用いた細胞内シグナル伝達系の光制御に成功した。そこで本研究では、GPCRシグナル伝達系をモデルとして、ロドプシンベースの光制御ツールを用いたシグナル伝達系の高時間分解能制御を“細胞レベル”と“個体レベル”の両方で試みている。その結果、平成30年度は以下の成果が得られた。

・開発した光感受性GPCRツールを動物に導入することで、個体レベルでGPCRシグナル伝達を光で制御することに成功し、さらに、そのGPCRが関わる行動までも光で引き起こすことに成功した。
・従来、シグナル伝達を波長依存的に制御（色制御）するためには、異なるシグナル伝達カスケードを駆動する２種類以上の光制御ツールが必要であると考えられていたが、本研究では、１種類の光感受性GPCRツールを用いてGPCRシグナル伝達の色制御に、培養細胞および個体レベルにおいて成功した。
・光制御ツールとして有望なロドプシン類についてfloxマウスを作製し、Cre/loxPシステムを用いて、膵臓のβ細胞特異的に光制御ツールを発現させることに成功した。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] The University of Manchester(英国)
• [Int'l Joint Research] Paul Scherrer Institute(スイス)
• [Int'l Joint Research] Institut de la Vision(フランス)
• [Int'l Joint Research] The University of Toledo/Salk Institute for Biological Studies(米国)
• [Int'l Joint Research] The University of Manchester(英国)
• [Int'l Joint Research] Paul Scherrer Institute(スイス)
• [Int'l Joint Research] Institut de la Vision(フランス)
• [Int'l Joint Research] Salk Institute for Biological Studies(米国)
• [Journal Article] Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish (2018)
  • Author(s): Gerrard Elliot、Mutt Eshita、Nagata Takashi、Koyanagi Mitsumasa、Flock Tilman、Lesca Elena、Schertler Gebhard F. X.、Terakita Akihisa、Deupi Xavier、Lucas Robert J.
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 115 Issue: 24 Pages: 201721333
  • DOI: 10.1073/pnas.1721333115
  • NAID: 120006474983
  • URL: https://ocu-omu.repo.nii.ac.jp/records/2020448
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates (2018)
  • Author(s): Hara Yuichiro、Yamaguchi Kazuaki、Onimaru Koh、Kadota Mitsutaka、Koyanagi Mitsumasa、Keeley Sean D.、Tatsumi Kaori、Tanaka Kaori、Motone Fumio、Kageyama Yuka、Nozu Ryo、Adachi Noritaka、Nishimura Osamu、Nakagawa Reiko、Tanegashima Chiharu、Kiyatake Itsuki、Matsumoto Rui、Murakumo Kiyomi、Nishida Kiyonori et al.
  • Journal Title: Nature Ecology & Evolution Volume: 2 Issue: 11 Pages: 1761-1771
  • DOI: 10.1038/s41559-018-0673-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Color opponency with a single kind of bistable opsin in the zebrafish pineal organ (2018)
  • Author(s): Wada Seiji、Shen Baoguo、Kawano-Yamashita Emi、Nagata Takashi、Hibi Masahiko、Tamotsu Satoshi、Koyanagi Mitsumasa、Terakita Akihisa
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 115 Issue: 44 Pages: 11310-11315
  • DOI: 10.1073/pnas.1802592115
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] An all-trans-retinal-binding opsin peropsin as a potential dark-active and light-inactivated G protein-coupled receptor (2018)
  • Author(s): Nagata Takashi、Koyanagi Mitsumasa、Lucas Robert、Terakita Akihisa
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 3535
  • DOI: 10.1038/s41598-018-21946-1
  • NAID: 120006408078
  • URL: https://ocu-omu.repo.nii.ac.jp/records/2020477
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expression and light-dependent translocation of β-arrestin in the visual system of the terrestrial slug Limax valentianus (2017)
  • Author(s): Matsuo Ryota、Takatori Yuka、Hamada Shun、Koyanagi Mitsumasa、Matsuo Yuko
  • Journal Title: The Journal of Experimental Biology Volume: 220 Pages: 3301-3314
  • DOI: 10.1242/jeb.162701
  • Peer Reviewed / Open Access
• [Journal Article] Vertebrate Bistable Pigment Parapinopsin: Implications for Emergence of Visual Signaling and Neofunctionalization of Non-visual Pigment. (2016)
  • Author(s): M. Koyanagi, E. Kawano-Yamashita, S. Wada and A. Terakita
  • Journal Title: Frontiers in Ecology and Evolution Volume: 5 Pages: 23-23
  • DOI: 10.3389/fevo.2017.00023
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] ゼブラフィッシュ松果体の単一オプシンによる色情報検出 (2019)
  • Author(s): 和田 清二，沈 宝國，山下（川野）絵美，永田 崇, 日比 正彦, 保 智己, 小柳 光正，寺北 明久
  • Organizer: 第13回バイオイメージングフォーラム&基礎生物学研究所重点共同利用 合同シンポジウム
• [Presentation] Optical regulation of GPCR signalings using bistable animal opsins (2019)
  • Author(s): Mitsumasa Koyanagi
  • Organizer: 1st International Symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks
  • Int'l Joint Research / Invited
• [Presentation] Animal opsins: non-visual functions and optogenetic applications (2019)
  • Author(s): Akihisa Terakita, Mitsumasa Koyanagi
  • Organizer: 10th OCARINA International Symposium
  • Int'l Joint Research
• [Presentation] A nobel type of opsin with optogenetic potential: animal opsin-based photopigment as a potential dark-active and light-Inactivated G protein-coupled receptor (2019)
  • Author(s): Takashi Nagata, Mitsumasa Koyanagi, Robert Lucas, Akihisa Terakita
  • Organizer: 10th OCARINA International Symposium
  • Int'l Joint Research
• [Presentation] Detection of “color changes” with a single kind of opsin in the zebrafish pineal organ (2019)
  • Author(s): Seiji Wada, Baoguo Shen, Emi Kawano-Yamashita, Takashi Nagata, Masahiro Hibi, Satoshi Tamotsu, Mitsumasa Koyanagi, Akihisa Terakita
  • Organizer: 10th OCARINA International Symposium
  • Int'l Joint Research
• [Presentation] Contribution of parapinopsin molecular property to cellular light responses in the zebrafish pineal organ (2019)
  • Author(s): Baoguo Shen, Seiji Wada, Emi Kawano-Yamashita, Mitsumasa Koyanagi, Akihisa Terakita
  • Organizer: 10th OCARINA International Symposium
  • Int'l Joint Research
• [Presentation] Evaluation of the pineal wavelength discrimination based on a pineal-specific opsin parapinopsin in the zebrafish behaviours (2019)
  • Author(s): Tomoka Saito, Seiji wada, Baoguo Shen, Takashi Nagata, Mitsumasa Koyanagi and Akihisa Terakita
  • Organizer: 10th OCARINA International Symposium
  • Int'l Joint Research
• [Presentation] Behavioral investigation of non-visual photoreception with pineal-specific opsin- knockout zebrafish (2019)
  • Author(s): Genki Nakata, Seiji Wada, Mitsumasa Koyanagi and Akihisa Terakita
  • Organizer: 10th OCARINA International Symposium
  • Int'l Joint Research
• [Presentation] 板鰓類3種のゲノム解析：「サメらしさ」に分子から迫る (2019)
  • Author(s): 原 雄一郎，山口 和晃，野津 了，小柳 光正，喜屋武 樹，寺北 明久、西田 清徳，兵藤 晋，佐藤 圭一，工樂 樹洋
  • Organizer: 平成31年度日本水産学会春季大会
• [Presentation] 動物の光受容タンパク質の多様性とその活用術 (2018)
  • Author(s): 小柳 光正
  • Organizer: 大阪大学生命機能研究科研究交流会（FBSコロキウム）189
  • Invited
• [Presentation] 全トランスレチナール結合オプシン・ペロプシンの光不活性化型GPCRとしての性質 (2018)
  • Author(s): 永田 崇，小柳 光正，Robert Lucas，寺北 明久
  • Organizer: 第20回日本光生物学協会年会
• [Presentation] ゼブラフィッシュ松果体における１種類のオプシンに基づく波長検出応答 (2018)
  • Author(s): 和田 清二，沈 宝國，山下（川野）絵美，永田 崇, 日比 正彦, 保 智己, 小柳 光正，寺北 明久
  • Organizer: 第20回日本光生物学協会年会
• [Presentation] クモのロドプシンの分子進化と奥行き知覚メカニズムの関係 (2018)
  • Author(s): 小柳 光正，永田 崇，斉藤 智香，寺北 明久
  • Organizer: 日本進化学会第20回大会
• [Presentation] サメのオプシン遺伝子レパートリーと生息環境との関係を探る (2018)
  • Author(s): 山口 和晃，小柳 光正，原 雄一郎，寺北 明久，工樂 樹洋
  • Organizer: 日本進化学会第20回大会
• [Presentation] Analyses of pineal photoresponses using opsin-deficient and -replaced zebrafish mutants (2018)
  • Author(s): Seiji Wada, Baoguo Shen, Emi Kawano-Yamashita, Takashi Nagata, Masahiko Hibi, Satoshi Tamotsu, Mitsumasa Koyanagi, Akihisa Terakita
  • Organizer: 第24回小型魚類研究会
• [Presentation] クモの視物質の吸収スペクトルと奥行き知覚メカニズムの進化との関係 (2018)
  • Author(s): 小柳 光正，永田 崇，斉藤 智香，前川 優，諏訪 元，寺北 明久
  • Organizer: 日本動物学会第89回大会
• [Presentation] ゼブラフィッシュ松果体における波長識別を担う光受容体 (2018)
  • Author(s): 和田 清二，沈 宝國，山下（川野）絵美，永田 崇, 日比 正彦, 保 智己, 小柳 光正，寺北 明久
  • Organizer: 日本動物学会第89回大会
• [Presentation] 松果体におけるパラピノプシンの寄与する光応答と自然光との関わり (2018)
  • Author(s): 和田 清二，沈 宝國，山下（川野）絵美，永田 崇, 日比 正彦, 保 智己, 小柳 光正，寺北 明久
  • Organizer: 日本動物学会第89回大会
• [Presentation] 遺伝子導入ゼブラフィッシュを用いたオプシンの分子特性が寄与する松果体の光応答の解析 (2018)
  • Author(s): 沈 宝國，和田 清二，山下（川野）絵美，小柳 光正，寺北 明久
  • Organizer: 日本動物学会第89回大会
• [Presentation] 幼生期及び成体期のヤツメウナギにおける非視覚オプシンが発現する脳深部光受容器官の組織学的解析 (2018)
  • Author(s): 山下（川野）絵美，保 智己，小柳 光正，和田 清二，寺北 明久
  • Organizer: 日本動物学会第89回大会
• [Presentation] チョウの生殖行動を制御する光受容体 (2018)
  • Author(s): 塚本 寿夫，内山 博允，秋山 時穂，小柳 光正，古谷 祐詞，寺北 明久，蟻川 謙太郎
  • Organizer: 日本動物学会第89回大会
• [Presentation] ナメクジの視覚機能に関わるオプシンの解析 (2018)
  • Author(s): 松尾 亮太，小柳 光正，杉原 智博，寺北 明久，西山 春佳，松尾 優子
  • Organizer: 日本動物学会第89回大会
• [Presentation] Dark-active and light-inactivated G protein-coupled receptors based on an animal opsin, peropsin (2018)
  • Author(s): Takashi Nagata, Mitsumasa Koyanagi，Robert Lucas and Akihisa Terakita
  • Organizer: 日本生物物理学会第56回年会
• [Presentation] Functionality of bistable animal opsins for optogenetic regulation of cellular signal transductions (2018)
  • Author(s): Mitsumasa Koyanagi
  • Organizer: 18th International Conference on Retinal Proteins
  • Int'l Joint Research / Invited
• [Presentation] Peropsin as a potential light-inactivated G protein-coupled receptor (2018)
  • Author(s): Takashi Nagata, Mitsumasa Koyanagi, Robert Lucas, Akihisa Terakita
  • Organizer: 18th International Conference on Retinal Proteins
  • Int'l Joint Research
• [Presentation] Color opponency with a bistable pigment parapinopsin in the zebrafish pineal organ (2018)
  • Author(s): Seiji Wada, Baoguo Shen, Emi Kawano-Yamashita, Takashi Nagata, Masahiko Hibi, Satoshi Tamotsu, Mitsumasa Koyanagi, Akihisa Terakita
  • Organizer: 18th International Conference on Retinal Proteins
  • Int'l Joint Research
• [Presentation] Relationship between absorption spectra of spider rhodopsins and evolution of depth perception mechanism (2018)
  • Author(s): Mitsumasa Koyanagi, Takashi Nagata, Tomoka Saito, Yu Maekawa, Gen Suwa, Akihisa Terakita
  • Organizer: 日本比較生理生化学会第40回大会
• [Presentation] Relationship between pineal wavelength discrimination involving parapinopsin and natural light conditions in the zebrafish (2018)
  • Author(s): Seiji Wada, Baoguo Shen, Emi Kawano-Yamashita, Takashi Nagata, Masahiko Hibi, Satoshi Tamotsu, Mitsumasa Koyanagi, Akihisa Terakita
  • Organizer: 日本比較生理生化学会第40回大会
• [Presentation] Comparative investigation of light responses of pineal photoreceptor cells containing different types of opsins with transgenic zebrafish (2018)
  • Author(s): Baoguo Shen, Seiji Wada, Emi Kawano-Yamashita, Mitsumasa Koyanagi, Akihisa Terakita
  • Organizer: 日本比較生理生化学会第40回大会
• [Presentation] Histochemical investigation of phototransduction-related gene expression in zebrafish pineal photoreceptor cells (2018)
  • Author(s): Haruka Nishioka, Takashi Nagata, Seiji Wada, Mitsumasa Koyanagi, Akihisa Terakita
  • Organizer: 日本比較生理生化学会第40回大会
• [Presentation] Contribution of a pineal opsin to light-suppressed melatonin secretion and light-regulated locomotor activity in zebrafish pineal organ (2018)
  • Author(s): Genki Nakata, Seiji Wada, Mitsumasa Koyanagi, Akihisa Terakita
  • Organizer: 日本比較生理生化学会第40回大会
• [Presentation] Histochemical investigation of non-visual opsin-expressing photoreceptor cells in the larval and adult lamprey brains (2018)
  • Author(s): Emi Kawano-Yamashita, Satoshi Tamotsu, Mitsumasa Koyanagi, Seiji Wada, Akihisa Terakita
  • Organizer: 日本比較生理生化学会第40回大会
• [Presentation] Opsins involved in the visual function of the terrestrial slug Limax (2018)
  • Author(s): Ryota Matsuo, Mitsumasa Koyanagi, Tomohiro Sugihara, Akihisa Terakita, Haruka Hishiyama, Yuko Matsuo
  • Organizer: 日本比較生理生化学会第40回大会
• [Presentation] 板鰓類の視覚を司る遺伝子と生息環境の関係を探る (2018)
  • Author(s): 山口 和晃，小柳 光正，原 雄一郎，寺北 明久，工樂 樹洋
  • Organizer: 板鰓類シンポジウム2018
• [Presentation] Characterization of arrestin binding to parapinopsin, a photopigment involved in pineal wavelength discrimination (2018)
  • Author(s): Takashi Nagata, Mitsumasa Koyanagi, Emi Kawano-Yamashita, Seiji Wada, Akihisa Terakita
  • Organizer: 9th OCARINA International Symposium
  • Int'l Joint Research
• [Presentation] Color opponency with a single kinds of bistable opsin in the zebrafish pineal organ (2018)
  • Author(s): Seiji Wada, Baoguo Shen, Emi Kawano-Yamashita, Takashi Nagata, Masahiro Hibi, Satoshi Tamotsu, Mitsumasa Koyanagi, Akihisa Terakita
  • Organizer: 9th OCARINA International Symposium
  • Int'l Joint Research
• [Presentation] Estimating spectral sensitivities of various opsins based on biochemical responses of cultured cells expressing opsins (2018)
  • Author(s): Tomohiro Sugihara, Takashi Nagata, Benjamin Mason, Mitsumasa Koyanagi, Akihisa Terakita
  • Organizer: 9th OCARINA International Symposium
  • Int'l Joint Research
• [Presentation] Contribution of parapinopsin “bistability” to light-responses in the zebrafish pineal organs (2018)
  • Author(s): Baoguo Shen, Seiji Wada, Emi Kawano-Yamashita, Mitsumasa Koyanagi, Akihisa Terakita
  • Organizer: 9th OCARINA International Symposium
  • Int'l Joint Research
• [Presentation] Investigation of amino acid residues involved in spectral tuning of butterfly long-wavelength-sensitive opsins (2018)
  • Author(s): Tomoka Saito, Mitsumasa Koyanagi, Tomohiro Sugihara, Kentaro Arikawa, Akihisa Terakita
  • Organizer: 9th OCARINA International Symposium
  • Int'l Joint Research
• [Presentation] Functional properties of diverse animal rhodopsins and their potentials for optical regulation of cell signaling (2017)
  • Author(s): Mitsumasa Koyanagi
  • Organizer: International Symposium on Biophysics of Rhodopsins
  • Int'l Joint Research / Invited
• [Presentation] Mutational analysis of the Schiff base counterion in Jumping spider rhodopsin, an invertebrate Gq-coupled rhodopsin (2017)
  • Author(s): Takashi Nagata, Mitsumasa Koyanagi, Hisao Tsukamoto, Eshita Mutt, Xavier Deupi, Gebhard Schertler, Akihisa Terakita
  • Organizer: International Symposium on Biophysics of Rhodopsins
  • Int'l Joint Research
• [Presentation] Investigation of wavelength discrimination involving bistable parapinopsin in the zebrafish pineal organ (2017)
  • Author(s): Seiji Wada, Baoguo Shen, Emi Kawano-Yamashita, Takashi Nagata, Satoshi Tamotsu, Mitsumasa Koyanagi, Akihisa Terakita
  • Organizer: International Symposium on Biophysics of Rhodopsins
  • Int'l Joint Research
• [Presentation] Amino acid residues involved in Spectral tuning that accounts for difference in absorption maxima between two kinds of butterfly long-wavelength-sensitive opsins (2017)
  • Author(s): Tomoka Saito, Mitsumasa Koyanagi, Tomohiro Sugihara, Kentaro Arikawa, Akihisa Terakita
  • Organizer: International Symposium on Biophysics of Rhodopsins
  • Int'l Joint Research
• [Presentation] ナメクジの網膜におけるβアレスチンの発現と光依存的な細胞内局在変化 (2017)
  • Author(s): 松尾 亮太, 鷹取 由佳, 濱田 俊, 小柳 光正, 松尾 優子
  • Organizer: 日本動物学会九州支部・九州沖縄植物学会・日本生態学会九州地区 2017三学会合同大分大会
• [Presentation] Optical regulation of cell signaling using bistable animal opsins (2017)
  • Author(s): Mitsumasa Koyanagi, Baoguo Shen, Takashi Nagata, Lanfang Sun, Seiji Wada, Satomi Kamimura, Eriko Kage-Nakadai, Akihisa Terakita
  • Organizer: 2017 FASEB SUMMER RESEARCH CONFERENCES
  • Int'l Joint Research
• [Presentation] Molecular properties of animal non-visual opsins and their optogenetic potentials (2017)
  • Author(s): Baoguo Shen, Takashi Nagata, Seiji Wada, Satomi Kamimura, Eriko Kage-Nakadai, Robert J. Lucas, Gebhard F. X. Schertler, Mitsumasa Koyanagi, Akihisa Terakita
  • Organizer: 17th HFSP Awardees Meeting
  • Int'l Joint Research
• [Presentation] 有袋類に着目した哺乳類の進化過程で失われた非視覚系光受容タンパク質の機能解析 (2017)
  • Author(s): 小柳 光正, 冨田 和志, 清成 寛, 寺北 明久
  • Organizer: 日本進化学会第19回大会
• [Presentation] パラピノプシンの双安定性に着目した細胞応答の波長依存的な光制御 (2017)
  • Author(s): 小柳 光正, 沈 宝國, 永田 崇, 孫 蘭芳, 和田 清二, 上村 了美, 中台(鹿毛)枝里子, 寺北 明久
  • Organizer: 日本動物学会第88回大会
• [Presentation] ゼブラフィッシュ松果体におけるメラトニン分泌の光制御に関わるオプシンの解析 (2017)
  • Author(s): 寺北 明久, 和田 清二, 藤井 耀, 小柳 光正
  • Organizer: 日本動物学会第88回大会
• [Presentation] 松果体波長識別応答に関わる光受容タンパク質パラピノプシンのアレスチン結合に関する解析 (2017)
  • Author(s): 永田 崇, 小柳 光正, 山下(川野)絵美, 和田 清二, 小澤 岳昌, 寺北 明久
  • Organizer: 日本動物学会第88回大会
• [Presentation] ゼブラフィッシュ松果体の波長識別応答における光受容タンパク質パラピノプシンの分子特性の重要性 (2017)
  • Author(s): 和田 清二, 沈 宝國, 山下(川野)絵美, 永田 崇, 保 智己, 小柳 光正, 寺北 明久
  • Organizer: 日本動物学会第88回大会
• [Presentation] ゼブラフィッシュ松果体の光応答におけるパラピノプシンの分子特性“双安定性”の寄与についての解析 (2017)
  • Author(s): 沈 宝國, 和田 清二, 山下(川野)絵美, 小柳 光正, 寺北 明久
  • Organizer: 日本動物学会第88回大会
• [Presentation] Contribution of a molecular property of a pineal opsin parapinopsin to cellular responses (2017)
  • Author(s): Seiji Wada, Baoguo Shen, Emi Kawano-Yamashita, Takashi Nagata, Satoshi Tamotsu, Mitsumasa Koyanagi, Akihisa Terakita
  • Organizer: 第55回生物物理学会年会
• [Presentation] Diversity of animal rhodopsins and their potentials for optical regulation of cell signaling (2017)
  • Author(s): Mitsumasa Koyanagi, Baoguo Shen, Takashi Nagata, Lanfang Sun, Seiji Wada, Satomi Kamimura, Eriko Kage-Nakadai, Akihisa Terakita
  • Organizer: 第9回光操作研究会
• [Presentation] Detergent-free approach to spectral tuning mechanisms of long-wavelength-sensitive opsins in butterfly (2017)
  • Author(s): Tomoka Saito, Mitsumasa Koyanagi, Tomohiro Sugihara, Kentaro Arikawa, Akihisa Terakita
  • Organizer: The 8th Asia & Oceania Conference on Photobiology
  • Int'l Joint Research
• [Presentation] 動物の非視覚光受容タンパク質の多様性と光操作への応用 (2017)
  • Author(s): 小柳 光正
  • Organizer: 日本比較生理生化学会第39回大会
  • Invited
• [Presentation] Characterization of an opsin, peropsin, distributing to the spider brain and eyes (2017)
  • Author(s): Takashi Nagata, Mitsumasa Koyanagi, Akihisa Terakita
  • Organizer: 日本比較生理生化学会第39回大会
• [Presentation] Investigation of the pineal photoresponse involving parapinopsin in the zebrafish under blight light conditions (2017)
  • Author(s): Seiji Wada, Baoguo Shen, Emi Kawano-Yamashita, Takashi Nagata, Satoshi Tamotsu, Mitsumasa Koyanagi, Akihisa Terakita
  • Organizer: 日本比較生理生化学会第39回大会
• [Presentation] Investigation of amino acid residues involved in spectral tuning of butterfly long-wavelength-sensitive opsins (2017)
  • Author(s): Tomoka Saito, Mitsumasa Koyanagi, Tomohiro Sugihara, Kentaro Arikawa, Akihisa Terakita
  • Organizer: 日本比較生理生化学会第39回大会
• [Remarks] 大阪市立大学大学院理学研究科生物地球系専攻 生体高分子機能学II研究室
  • URL: http://www.sci.osaka-cu.ac.jp/biol/mphys/index.html
• [Patent(Industrial Property Rights)] 特許権 (2017)
  • Inventor(s): 永田崇，小柳光正， 寺北明久
  • Industrial Property Rights Holder: 永田崇，小柳光正， 寺北明久
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017