Will-dynamics of REM sleep and appetite
Publicly Offered Research
| Project Area | Creation and Promotion of the Will-Dynamics |
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| Project/Area Number |
17H06047
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Complex systems
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ラザルス ミハエル 筑波大学, 国際統合睡眠医科学研究機構, 准教授 (80469650)
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
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| Keywords | レム睡眠 / 食欲 / 意志動力学 |
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| Outline of Annual Research Achievements |
It is widely accepted that sleep disruption affects metabolism and energy balance, but the neuronal mechanisms linking sleep disruption and obesity are poorly defined. Recent work from our lab suggests a role of neurons in the medial prefrontal cortex (mPFC) in linking REM sleep to appetite for highly palatable food (HPF). REM sleep is a unique phase of sleep in mammals that is characterized by random eye movement and low muscle tone throughout the body. The prefrontal cortex plays a role in judging the palatability of foods through taste, smell and texture. Moreover, persons who are obese tend to have increased activity in the prefrontal cortex when exposed to high calorie foods.
We also discovered that REM sleep is suppressed by activation of REM-active dopaminergic or GABAergic mesopontine neurons, suggesting that these neurons may control the level of REM sleep and/or executive functions during REM sleep. In addition, we found that activation of the GABAergic, but not the dopaminergic, mesopontine neurons strongly induced slow-wave sleep. We continue to elucidate a role of dopaminergic and GABAergic mesopontine neurons in linking REM sleep to HPF consumption.
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| Research Progress Status |
平成30年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
平成30年度が最終年度であるため、記入しない。
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Report
(2 results)
Research Products
(8 results)
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[Journal Article] Adenosine and Sleep2017
Author(s)
Lazarus Michael、Chen Jiang-Fan、Huang Zhi-Li、Urade Yoshihiro、Fredholm Bertil B.
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Journal Title
Handbook of Experimental Pharmacology
Volume: -
Pages: 1-23
DOI
ISBN
9783030112707, 9783030112721
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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