Publicly Offered Research
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
It is widely accepted that sleep disruption affects metabolism and energy balance, but the neuronal mechanisms linking sleep disruption and obesity are poorly defined. Recent work from our lab suggests a role of neurons in the medial prefrontal cortex (mPFC) in linking REM sleep to appetite for highly palatable food (HPF). REM sleep is a unique phase of sleep in mammals that is characterized by random eye movement and low muscle tone throughout the body. The prefrontal cortex plays a role in judging the palatability of foods through taste, smell and texture. Moreover, persons who are obese tend to have increased activity in the prefrontal cortex when exposed to high calorie foods.We also discovered that REM sleep is suppressed by activation of REM-active dopaminergic or GABAergic mesopontine neurons, suggesting that these neurons may control the level of REM sleep and/or executive functions during REM sleep. In addition, we found that activation of the GABAergic, but not the dopaminergic, mesopontine neurons strongly induced slow-wave sleep. We continue to elucidate a role of dopaminergic and GABAergic mesopontine neurons in linking REM sleep to HPF consumption.
平成30年度が最終年度であるため、記入しない。
All 2018 2017
All Journal Article (6 results) (of which Int'l Joint Research: 5 results, Peer Reviewed: 6 results, Open Access: 3 results, Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)
Journal of Neuroscience
Volume: 0598-18 Issue: 47 Pages: 10080-10092
10.1523/jneurosci.0598-18.2018
Brain Structure & Function
Volume: - Issue: 6 Pages: 1-9
10.1007/s00429-017-1365-7
Nature Communications
Volume: 8 Issue: 1 Pages: 1-12
10.1038/s41467-017-00781-4
120007134733
Neuroscience Research
Volume: 118 Pages: 66-73
10.1016/j.neures.2017.04.008
Handbook of Experimental Pharmacology
Volume: - Pages: 1-23
10.1007/164_2017_36
医学のあゆみ
Volume: 263 Pages: 761-764
