Risk of hypothermia for memory function
Publicly Offered Research
| Project Area | "LIVING IN SPACE" - Integral Understanding of life-regulation mechanism from "SPACE" |
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| Project/Area Number |
18H04966
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ラザルス ミハエル 筑波大学, 国際統合睡眠医科学研究機構, 准教授 (80469650)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2019: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 低体温状態 / 記憶固定 / 薬理遺伝学 |
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| Outline of Annual Research Achievements |
Whereas hibernation is common in rodents and other animals, there are only a very few cases of suspected hibernation or states similar to hibernation in humans. Induced hibernation, also known as suspended animation, is the slowing or stopping of life processes without termination by cooling the body down. This technology has great potential for long distance space travel and medicine. Induced hypothermia has been used for open-heart surgeries and other clinical procedures, but the risk for brain functions is largely unknown. In this research, we plan to elucidate the effects of genetically or pharmacologically induced hypothermia on the consolidation of fear or spatial memories.
We have established chemogenetic and pharmacologic methods to induce hypothermia in mice. For the chemogenetic method, we have used an innovative genetically engineered system to induce hypothermia by activating GABAergic neurons in the median preoptic area of the hypothalamus. For the pharmacologic method, we used an adenosine A2A receptor agonist which strongly decreases body temperature. By using these methods, we observed that hypothermia may be beneficial for the suppression of traumatic memories.
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| Research Progress Status |
令和元年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和元年度が最終年度であるため、記入しない。
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Report
(2 results)
Research Products
(5 results)
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[Journal Article] Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function2018
Author(s)
Korkutata M, Saitoh T, Cherasse Y, Ioka S, Duo F, Qin R, Murakoshi N, Fujii S, Zhou X, Sugiyama F, Chen JF, Kumagai H, Nagase H, Lazarus M
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Journal Title
Neuropharmacology
Volume: 144
Pages: 122-132
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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