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虚血ストレスによる炎症誘導機構の解明とその制御

Publicly Offered Research

Project AreaPreventive medicine through inflammation cellular sociology
Project/Area Number 18H05022
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Research InstitutionUniversity of Tsukuba

Principal Investigator

渋谷 彰  筑波大学, 生存ダイナミクス研究センター, 教授 (80216027)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2019: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2018: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Keywords脳梗塞 / CD300a / 死細胞 / 炎症 / DAMPs / 貪食 / 虚血ストレス / 脳虚血疾患
Outline of Annual Research Achievements

脳梗塞では、発症1~3時間でアストロサイトの細胞死と、これに伴う炎症細胞の浸潤を認め、発症6時間を越えると神経細胞の死が始まる。すなわち、脳虚血の開始時の病態は可逆的(未病)であるが、アストロサイトの細胞死と炎症反応が継続すると、神経細胞死が誘導され、神経障害の不可逆化が成立する。これらのイベントカスケードの中で、死細胞に由来するDAMPsが誘導する炎症反応が、カスケードを再増幅させ、神経障害の不可逆化を一層増強していることが推察される。しかし、この神経障害に至る一連の分子機構は充分に解明されていない。
本研究において、応募者らは、アポトーシス細胞の細胞膜上に表出するphosphatidylserein (PS) の受容体である抑制性免疫受容体CD300aが、マクロファージによる死細胞の貪食を抑制することを見出した。これは、CD300aの細胞内領域のITIMがリン酸化し、SHP-1をリクルートして、貪食促進シグナルを抑制することによるものであることを明らかにした。また、CD300a遺伝子欠損マクロファージは、死細胞をより多く貪食することをin vitroで確認した。さらにCD300a遺伝子欠損マウスの脳虚血モデルにおいて、神経障害が著明に軽度であることを見出した。これは、虚血ストレスにより誘導される死細胞を貪食することによって、DAMPsが減少し、その結果、炎症病態の軽減と遷延化の抑制によるものであることを明らかにした。さらに、CD300aに対する中和抗体が、脳虚血モデルにおいて神経障害を著明に軽減することを明らかにした。
以上の結果は、D300aが炎症の遷延化を阻止し、神経障害を可逆的に回復させ、その不可逆化を予防できる有力な標的因子であることを示したものであり、脳虚血疾患の予防と治療法の開発基盤となりうる。

Research Progress Status

令和元年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和元年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (58 results)

All 2020 2019 2018 Other

All Journal Article (22 results) (of which Int'l Joint Research: 15 results,  Peer Reviewed: 22 results,  Open Access: 13 results) Presentation (32 results) (of which Int'l Joint Research: 4 results,  Invited: 9 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] A mathematical model for dynamics of soluble form of DNAM-1 as a biomarker for graft-versus-host disease2020

    • Author(s)
      Goshima Y, Nakaoka S, Ohashi K, Sakamaki H, Shibuya K, Shibuya A
    • Journal Title

      PLOS ONE

      Volume: 15(2) Issue: 2 Pages: e0228508-e0228508

    • DOI

      10.1371/journal.pone.0228508

    • NAID

      120007161346

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tumor-derived soluble CD155 inhibits DNAM-1-mediated antitumor activity of natural killer cells.2020

    • Author(s)
      Okumura G, Iguchi-Manaka A,Murata R,Yamashita-Kanemaru Y, Shibuya A, Shibuya K
    • Journal Title

      Journal of Experimental Medicine

      Volume: 217(4) Issue: 4

    • DOI

      10.1084/jem.20191290

    • NAID

      120007165432

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Allergin-1 immunoreceptor suppresses house dust mite-induced allergic airway inflammation.2020

    • Author(s)
      Miki H, Tahara-Hanaoka S, Almeida MS, Hitomi K, Shibagaki S, Kanemaru K, Lin YH, Iwata K, Miyake S, Shibayama S, Sumida T, Shibuya K, Shibuya A
    • Journal Title

      Journal of Immunology

      Volume: 204(4) Issue: 4 Pages: 753-762

    • DOI

      10.4049/jimmunol.1900180

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High expression of soluble CD155 in estrogen receptor-negative breast cancer2020

    • Author(s)
      4.Iguchi-Manaka A, Okumura G, Ichioka E, Kiyomatsu H, Ikeda T, Bando H, Shibuya A, Shibuya K.
    • Journal Title

      Breast Cancer

      Volume: 27 Issue: 1 Pages: 92

    • DOI

      10.1007/s12282-019-00999-8

    • NAID

      120007127642

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Type 1 innate lymphoid cells protect mice from acute liver injury via interferon-g secretion for upregulating Bcl-xL expression in hepatocytes2020

    • Author(s)
      Nabekura T, Riggan L, Hildreth AD, O'Sullivan TE, Shibuya A
    • Journal Title

      Immunity

      Volume: 52(1) Issue: 1 Pages: 96-108

    • DOI

      10.1016/j.immuni.2019.11.004

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Selective suppression of oral allergen-induced anaphylaxis by Allergin-1 on basophils in mice2019

    • Author(s)
      Lin Yu-Hsien、Tahara-Hanaoka Satoko、Nagai Kei、Yoshikawa Soichiro、Kubo Masato、Shibayama Shiro、Karasuyama Hajime、Shibuya Akira
    • Journal Title

      International Immunology

      Volume: 32 Issue: 3 Pages: 213-219

    • DOI

      10.1093/intimm/dxz075

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cutting Edge:Involvement of the immunoreceptor CD300c2 on alveolar macrophages in bleomycin-induced lung fibrosis.Journal of Immunology2019

    • Author(s)
      Nakazawa Y, Ohtsuka S, Nakahashi-Oda C, Shibuya A.
    • Journal Title

      Journal of Immunology

      Volume: 203(12) Issue: 12 Pages: 3107-3111

    • DOI

      10.4049/jimmunol.1900890

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clec10a regulates mite-induced dermatitis2019

    • Author(s)
      Kanemaru K, Noguchi E, Tahara-Hanaoka S, Mizuno S, Tateno H, Denda-Nagai K, Irimura T, Matsuda H, Sugiyama F, Takahashi S, Shibuya K, Shibuya A
    • Journal Title

      Science Immunology,

      Volume: 4(42) Issue: 42 Pages: 6908-6908

    • DOI

      10.1126/sciimmunol.aax6908

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression and function of DNAM-1 on human B-lineage cells2019

    • Author(s)
      Nagayama-Hasegawa Y., Honda S, Shibuya A., Shibuya K.
    • Journal Title

      Clinical Cytometry

      Volume: - Issue: 4 Pages: 1-7

    • DOI

      10.1002/cyto.b.21859

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autonomous regulation of immunoglobulin E-mediated mast cell degranulation and immediate hypersensitivity reaction by an inhibitory receptor CD300a.2019

    • Author(s)
      Noval Rivas M, Wakita D, Franklin MK, Carvalho TT, Abolhesn A, Gomez AC, Fishbein MC, Chen S, Lehman TJ, Sato K, Shibuya A, Fasano A, Kiyono H, Abe M, Tatsumoto N, Yamashita M, Crother TR, Shimada K, Arditi M
    • Journal Title

      Immunity

      Volume: 51(3) Issue: 3 Pages: 508-521

    • DOI

      10.1016/j.immuni.2019.05.021

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Autonomous regulation of immunoglobulin E-mediated mast cell degranulation and immediate hypersensitivity reaction by an inhibitory receptor2019

    • Author(s)
      Wang Y, Nakahashi-Oda C, Okayama Y, Shibuya A.
    • Journal Title

      J Allergy Clin Immun

      Volume: 144(1) Issue: 1 Pages: 323-327

    • DOI

      10.1016/j.jaci.2019.03.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autonomous regulation of immunoglobulin E-mediated mast cell degranulation and immediate hypersensitivity reaction by an inhibitory receptor CD300a2019

    • Author(s)
      WangY, Nakahashi-Oda C, Okayama Y, Shibuya A.
    • Journal Title

      J Allergy Clin Immun

      Volume: 印刷中

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification and isolation of splenic tissue resident macrophage subpopulations by flow cytometry2019

    • Author(s)
      Fujiyama S, Nakahashi-Oda C, Abe F, Wang Y, Sato K, Shibuya A
    • Journal Title

      Int Immunol

      Volume: 31(1) Issue: 1 Pages: 51-56

    • DOI

      10.1093/intimm/dxy064

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Allergy inhibitory receptor‐1 inhibits autoantibody production via upregulation of apoptotic debris clearance by macrophages2018

    • Author(s)
      Iizuka Akira、Segawa Seiji、Kondo Yuya、Kaneko Shunta、Yokosawa Masahiro、Furuyama Kotona、Miki Haruka、Tahara‐Hanaoka Satoko、Shibuya Akira、Tsuboi Hiroto、Goto Daisuke、Matsumoto Isao、Shibayama Shiro、Sumida Takayuki
    • Journal Title

      International Journal of Rheumatic Diseases

      Volume: 21 Issue: 12 Pages: 2071-2078

    • DOI

      10.1111/1756-185x.13381

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Exploring the Gut Fungi-Lung Allergy Axis2018

    • Author(s)
      Shibuya Akira、Shibuya Kazuko
    • Journal Title

      Cell Host & Microbe

      Volume: 24 Issue: 6 Pages: 755-757

    • DOI

      10.1016/j.chom.2018.11.012

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation.2018

    • Author(s)
      Nakamura Y, Matsuzaka T, Tahara-Hanaoka S, Shibuya K, Shimano H, Nakahashi-Oda C, Shibuya A.
    • Journal Title

      Cell Death Dis.

      Volume: 9(12) Issue: 12 Pages: 1181-1181

    • DOI

      10.1038/s41419-018-1226-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain2018

    • Author(s)
      Fujiyama Tomoyuki、Miyashita Satoshi、Tsuneoka Yousuke、Kanemaru Kazumasa、Kakizaki Miyo、Kanno Satomi、Ishikawa Yukiko、Yamashita Mariko、Owa Tomoo、Nagaoka Mai、Kawaguchi Yoshiya、Yanagawa Yuchio、Magnuson Mark A.、Muratani Masafumi、Shibuya Akira、Nabeshima Yo-ichi、Yanagisawa Masashi、Funato Hiromasa、Hoshino Mikio
    • Journal Title

      Cell Reports

      Volume: 24 Issue: 1 Pages: 79-94

    • DOI

      10.1016/j.celrep.2018.06.010

    • NAID

      120006491717

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glycoprotein nmb is exposed on the surface of dormant breast cancer cells and induces stem cell-like properties2018

    • Author(s)
      Chen Chen、Okita Yukari、Watanabe Yukihide、Abe Fumie、Fikry Muhammad Ali、Ichikawa Yumu、Suzuki Hiroyuki、Shibuya Akira、Kato Mitsuyasu
    • Journal Title

      Cancer Research

      Volume: 78 Issue: 22 Pages: 6424-6435

    • DOI

      10.1158/0008-5472.can-18-0599

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4+ T cell costimulation2018

    • Author(s)
      Takenaka Eri、Van Vo Anh、Yamashita-Kanemaru Yumi、Shibuya Akira、Shibuya Kazuko
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 15180-15180

    • DOI

      10.1038/s41598-018-33437-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice2018

    • Author(s)
      Hitomi K, Tahara-Hanaoka S, Miki H, Iwata K, Shibayama S, Kubo M, Shibuya A
    • Journal Title

      Int Immunol

      Volume: 30(9) Issue: 9 Pages: 429-434

    • DOI

      10.1093/intimm/dxy025

    • NAID

      120007133761

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Crk adaptor proteins regulate NK cell expansion and differentiation during mouse cytomegalovirus infection2018

    • Author(s)
      Tsukasa Nabekura, Zhiying Chen, Casey Schroeder, Taeju Park, Eric Vivier, Lewis L. Lanier, and Dongfang Liu
    • Journal Title

      J Immunol

      Volume: in press Issue: 10 Pages: 3691-3696

    • DOI

      10.4049/jimmunol.1701639

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TX99 Is a Neutralizing Monoclonal Antibody Against Mouse TIGIT2018

    • Author(s)
      Nakamura Yuho , Naito Keisuke , Yamashita-Kanemaru Yumi , Komori Daisuke , Hirochika Rei , Shibuya Akira , and Shibuya Kazuko
    • Journal Title

      Monoclonal Antibodies in Immunodiagnosis and Immunotherapy

      Volume: 印刷中 Issue: 2 Pages: 105-109

    • DOI

      10.1089/mab.2018.0001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 粘膜免疫を基盤とした予防・治療戦略2019

    • Author(s)
      渋谷 彰
    • Organizer
      第6回総合アレルギー講習会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Protective role of type 1 innate lymphoid cells acute liver injury2019

    • Author(s)
      Tsukasa Nabekura,Shibuya A.
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Clec 10a regulated mite-induced dermatitis.2019

    • Author(s)
      Kanemaru K., Tahara-Hanaoka S., Denda-Nagai K., Irimura T., Takahashi S., Shibuya K., Shibuya A.
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] DNAM-1 limits suppresses Foxp3 stability of regulatory T cells in a TIGIT dependent manner.2019

    • Author(s)
      Sato K, Yamashita-Kanemaru Y, Abe F, Nakamura Y, Murata R, Ito M, Shibuya A, Shibuya K.
    • Organizer
      第48回日本免疫学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Involvement of CD96 in imiquimod (IMQ)-induced psoriasis through upregulastion of IL-17 production by γδT cells.2019

    • Author(s)
      Oh-oka K, Shibuya A, Shibuya K.
    • Organizer
      第48回日本免疫学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Tumor-derived soluble CD155 inhibits DNAM-1-mediated antitumor activity of natural killer cells.2019

    • Author(s)
      Okumura G, Iguchi-Manaka A, Murata R, Yamashita-Kanemaru Y, Shibuya A, Shibuya K.
    • Organizer
      第48回日本免疫学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 抑制性免疫受容体によるアレルギー炎症応答の制御2019

    • Author(s)
      渋谷 彰
    • Organizer
      日本生化学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 乾癬における免疫受容体CD96の作用機序の解析2019

    • Author(s)
      大岡 杏子、渋谷 彰、渋谷 和子
    • Organizer
      第7回筑波大学・東京理科大学合同リトリート
    • Related Report
      2018 Annual Research Report
  • [Presentation] DNAM-1とTIGITによる制御性T細胞の調節機構2019

    • Author(s)
      佐藤 和貴、金丸 由美、阿部 史枝、中村 優歩、村田 力斗、伊藤 守、渋谷 彰、渋谷 和子
    • Organizer
      第7回筑波大学・東京理科大学合同リトリート
    • Related Report
      2018 Annual Research Report
  • [Presentation] DNAM-1遺伝子上の一塩基多型による自己免疫疾患への影響2019

    • Author(s)
      村田 力斗、金丸 由美、渋谷 彰、渋谷 和子
    • Organizer
      第7回筑波大学・東京理科大学合同リトリー ト
    • Related Report
      2018 Annual Research Report
  • [Presentation] Roles of Allergin-1 immunoreceptor in oral antigen-induced active systemic anaphylaxis.2019

    • Author(s)
      Lin YH, Tahara-Hanaoka S, Shibuya A
    • Organizer
      第7回筑波大学・東京理科大学合同リトリート
    • Related Report
      2018 Annual Research Report
  • [Presentation] Self-regulation of mast cell degranulation by an inhibitory receptor CD300a2019

    • Author(s)
      Wang Y, Nakahashi-Oda C, Shibuya A
    • Organizer
      第7回筑波大学・東京理科大学合同リトリート
    • Related Report
      2018 Annual Research Report
  • [Presentation] Functions of inhibitory receptors of CD300a and CD300lf on mast cells.2019

    • Author(s)
      Lyu W, Nakahashi-Oda C, Shibuya A
    • Organizer
      第7回筑波大学・東京理科大学合同リトリート
    • Related Report
      2018 Annual Research Report
  • [Presentation] Selective expression and function of DNAM-1 (CD226) expressed on small peritoneal macrophages2019

    • Author(s)
      Vo AV, Takenaka E, Yamashita-Kanemaru Y, Shibuya A, Shibuya K
    • Organizer
      第7回筑波大学・東京理科大学合同リトリート
    • Related Report
      2018 Annual Research Report
  • [Presentation] Involvement of DNAM-1 (CD226) expressed on small peritoneal macrophages in CD4+ T cell priming2019

    • Author(s)
      Vo AV, Takenaka E, Yamashita-Kanemaru Y, Shibuya A, Shibuya K
    • Organizer
      Keystone Symposia Conference / Myeloid Cells
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抑制性免疫受容体によるアレルギー疾患の制御機構2018

    • Author(s)
      渋谷 彰
    • Organizer
      日本アレルギー学会 第5回アレルギー講習会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] DNAM-1 regulates the Foxp3 stability of regulatory T cells under inflammatory conditions2018

    • Author(s)
      Sato K, Yamashita-Kanemaru Y, Abe F, Nakamura Y, Murata R, Ito M, Shibuya A, Shibuya K
    • Organizer
      第47回日本免疫学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Phosphatidylserine exposure self-regulates mast cells’ degranulation2018

    • Author(s)
      Wan Y, Nakahashi-Oda C, Shibuya A
    • Organizer
      第47回日本免疫学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Involvement of DNAM-1 (CD226) expressed on small peritoneal macrophages in CD4+ T cell priming2018

    • Author(s)
      Vo AV, Takenaka E, Yamashita-Kanemaru Y, Shibuya A, Shibuya K
    • Organizer
      第47回日本免疫学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腸管microbiomeと喘息 -免疫の最前線からアレルギー疾患を考える-2018

    • Author(s)
      渋谷 彰
    • Organizer
      Scientific Exchange Meeting.
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 活性化受容体DNAM-1は炎症時の制御性T細胞の機能を抑制する2018

    • Author(s)
      佐藤 和貴、金丸 由美、阿部 史枝、中村 優歩、村田 力斗、伊藤 守、渋谷 彰、渋谷 和子
    • Organizer
      第10回血液・疾患免疫療法学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腫瘍免疫応答における可溶型CD155の役割2018

    • Author(s)
      奥村 元紀、村田 力斗、井口 研子、渋谷 彰、渋谷 和子
    • Organizer
      第10回血液・疾患免疫療法学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of molecular target therapy for human acute GVHD in humanized mice2018

    • Author(s)
      Murata R, Okumura G, Abe F, Sato K, Yamashita-Kanemaru Y, Ito M, Shibuya A, Shibuya K
    • Organizer
      Tsukuba Global Science Week 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 上皮細菌叢とアレルギー、炎症2018

    • Author(s)
      渋谷 彰
    • Organizer
      第25回日本免疫毒性学会学術年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 常在細菌叢によるバリア組織の恒常性維持2018

    • Author(s)
      渋谷 彰
    • Organizer
      第33回日本乾癬学会学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 腸内微生物環境とアレルギー性疾患2018

    • Author(s)
      渋谷 彰
    • Organizer
      第23回那須ティーチイン
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] CD300a による制御性T 細胞の制御メカニズム2018

    • Author(s)
      中澤 優太、小田 ちぐさ、Kankanam G. S. Udayanga、中村 貴之、三木 春香、 渋谷 彰
    • Organizer
      第83回日本インターフェロン・サイトカイン学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Allergin-1 immunoreceptor suppresses house dust mite-induced allergic Th2 responses2018

    • Author(s)
      田原 聡子、三木 春香、人見 香織、Almeida Mariana、柴垣 翔平、金丸 和正、岩田 佳奈子、柴山 史朗、住田 孝之、渋谷 和子、渋谷 彰
    • Organizer
      第83回日本インターフェロン・サイトカイン学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Drug development by targeting immunoreceptors2018

    • Author(s)
      Shibuya A
    • Organizer
      9th Summer Research Program in Tsukuba
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 活性化受容体DNAM-1は炎症時の制御性T細胞の機能を抑制する2018

    • Author(s)
      佐藤 和貴、金丸(山下)由美、阿部 史枝、中村 優歩、村田 力斗、伊藤 守、渋谷 彰、渋谷 和子
    • Organizer
      第33回自己免疫研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アレルギー・炎症疾患における免疫受容体の役割2018

    • Author(s)
      渋谷 彰
    • Organizer
      第67回日本アレルギー学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Involvement of a new phosphatidylserine receptor, CD300a, in the regulation of Treg cells2018

    • Author(s)
      Nakahashi-Oda C, Nakazawa Y, Shibuya A.
    • Organizer
      Australia-Japan Meeting on Cell Death
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 免疫学研究室ホームページ

    • URL

      http://immuno-tsukuba.com/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] TRIOS

    • URL

      http://trios.tsukuba.ac.jp/researcher/0000001643

    • Related Report
      2018 Annual Research Report
  • [Remarks] つくばリポジトリ

    • URL

      https://tsukuba.repo.nii.ac.jp/index.php?action=pages_view_main&active_action=repository_view_main_item_snippet&index_id=543&pn=1&count=20&order=7&lang=japanese&page_id=13&block_id=83

    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] アレルギー疾患を処置することに用いるための組成物2019

    • Inventor(s)
      渋谷 彰、金丸 和正
    • Industrial Property Rights Holder
      渋谷 彰、金丸 和正
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2021-01-27  

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