Cerebral bases of learning hierachy and intention sharing in early infancy

• Project Area: Studies of Language Evolution for Co-creative Human Communication
• Project/Area Number: 18H05082
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Research Institution: Keio University
• Principal Investigator: 皆川 泰代 慶應義塾大学, 文学部(日吉), 教授 (90521732)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000); Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: 人工文法 / 随伴性 / 階層構造 / 相互作用 / 自閉スペクトラム症 / 言語野 / 文法規則の獲得 / 脳機能 / 階層性 / fNIRS / 意図共有 / 乳児 / 言語獲得 / 文法規則の学習 / 脳機能結合 / NIRS

Outline of Annual Research Achievements

本研究はヒト発達初期における「階層性」と「意図共有」のそれぞれの脳内基盤を明らかにすることを目的としている。このために6－7ヶ月児を対象としNAD（非隣接依存性）文法の研究１，自然な相互作用時の随伴性反応に対する脳活動を検討する研究２を行った。
研究１：NAD規則は例えば主語(A)が来れば，その後に何(X)がはさまれようと必ず動詞(B)が後続する，といったAXB構造の非隣接性の規則であり，階層構造理解の基本的能力である。本研究ではＡＸＢの人工文法をトーンの刺激呈示による学習を行い，学習後の規則の逸脱や一致に対する脳反応をfNIRS（機能的近赤外分光法）にて計測した。対象は6－7ヶ月児41名であった。（結果）規則一致刺激と規則逸脱刺激に対する脳反応を解析した結果，規則一致条件にてより強い脳活動がみられた。特に右の下前頭回と側頭極にて前半，後半ともに規則逸脱よりも規則一致にて有意に強い活動が見られた。（考察）6－7ヶ月児はNAD規則を学習し，規則の一致・不一致の弁別が出来ていることが示された。その脳内基盤として右の下前頭回や側頭極，上側頭回が示された。右脳で大きく反応が見られたのは今回使用した刺激（5秒）が比較的長いピッチ変化を持つトーンであったことも理由として考えられる。今後より月齢の低い乳児の検討が必要である。
研究２：我々は先行研究にてライブの随伴性に関与するTPJ（側頭頭頂接合部）の脳活動を乳幼児について報告した。本研究では，自然な実験者との相互作用中に生じた視線共有や随伴性についての脳活動をfNIRSにて（１）新しいイベントデザイン手法で捉え，（２）自閉スペクトラム症(ASD)リスク児にも定型発達児と同様なTPJ活動が見られるかを検討した。その結果（１）の手法の有効性を確認し（２）ではTPJ活動が見られたがその傾向はやや異なり，異なる脳内過程を持つことが示唆された。

Research Progress Status

令和元年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和元年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] University Osnabrueck(ドイツ)
• [Int'l Joint Research] University Zurich(スイス)
• [Int'l Joint Research] University of Osnabruck(ドイツ)
• [Int'l Joint Research] University of Zurich(スイス)
• [Journal Article] Recommendations for motion correction of infant fNIRS data applicable to multiple data sets and acquisition systems. (2019)
  • Author(s): Di Lorenzo, R., Pirazzoli, L., Blasi, A., Bulgarelli, C., Hakuno, Y., Minagawa, Y., & Brigadoi, S.
  • Journal Title: NeuroImage Volume: 200 Pages: 511-527
  • Peer Reviewed
• [Journal Article] Maternal speech shapes the cerebral frontotemporal network in neonates: a hemodynamic functional connectivity study. (2019)
  • Author(s): Uchida-Ota, M., Arimitsu, T., Tsuzuki, D., Dan, I., Ikeda, D., Takahashi, T., Minagawa, Y.
  • Journal Title: Developmental Cognitive Neuroscience Volume: 39 Pages: 100701-100701
  • Peer Reviewed
• [Journal Article] Symbolic time series analysis of fNIRS signals in brain development assessment. (2018)
  • Author(s): Liang, Z., Minagawa, Y., Yang, H-C., Tian, H., Cheng, L., Arimitsu, T., Takahashi, T., Tong, Y.
  • Journal Title: Journal of Neural Engineering Volume: 15 Issue: 6 Pages: 066013-066013
  • DOI: 10.1088/1741-2552/aae0c9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Toward interactive social neuroscience: Neuroimaging the real-world interaction in various populations. (2018)
  • Author(s): Minagawa, Y., Xu, M. Morimoto, S.
  • Journal Title: Japanese Psychological Research Volume: 60 Pages: 196-224
  • Peer Reviewed
• [Journal Article] The cerebral hemodynamic response to phonetic changes of speech in preterm and term infants: The impact of postmenstrual age. (2018)
  • Author(s): Arimitsu, T., Minagawa, Y., Yagihashi, T., Uchida-Ota, M., Matsuzaki, A., Ikeda, K., Takahashi, T.
  • Journal Title: Neuroimage: Clinical Volume: 19 Pages: 599-606
  • DOI: 10.1016/j.nicl.2018.05.005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Preparation-free measurement of event-related potential in oddball tasks from hairy parts using candle-like dry microneedle electrodes. (2018)
  • Author(s): Yoshida Y, Kudo Y, Hoshino E, Minagawa Y, Miki N.
  • Journal Title: Conf Proc IEEE Eng Med Biol Soc Volume: － Pages: 4685-4688
  • DOI: 10.1109/embc.2018.8513178
  • Peer Reviewed
• [Presentation] Typical and atypical development of language and communication as observed with fNIRS (2019)
  • Author(s): Minagawa, Y.
  • Organizer: Evening Symposium, Translational Research Institute, , Princess Alexandra Hospital Brisbane
  • Invited
• [Presentation] What optical imaging tells us about typical and atypical neurocognitive development (2019)
  • Author(s): Minagawa, Y.
  • Organizer: NIR 2019, NIRStralia 2019
  • Int'l Joint Research / Invited
• [Presentation] How has Broca’s area played a role in the neuroimaging data of early language acquisition? (2019)
  • Author(s): Minagawa, Y.
  • Organizer: Symposium of the Japanese Society for Language Sciences, the 21st annual meeting
  • Int'l Joint Research / Invited
• [Presentation] Several topics from fNIRS studies: Social interactive neuroscience and language acquisition. (2019)
  • Author(s): Minagawa, Y.
  • Organizer: RWTH Aachen University
  • Invited
• [Presentation] What did optical imaging reveal about Broca‘s area for early language development? (2019)
  • Author(s): Minagawa, Y.
  • Organizer: Colloquium of the Institute of Cognitive Science，Univ Osnabrueck
  • Invited
• [Presentation] 社会的相互作用における二者間・内の脳機能結合：行動の自動推定とGLMの適用 (2019)
  • Author(s): 皆川泰代
  • Organizer: 日本心理学会第83回大会，日立製作所冠シンポジウム
  • Invited
• [Presentation] 発達初期の音声言語獲得とその脳内機構：分節化，統計学習，規則学習 (2019)
  • Author(s): 皆川泰代
  • Organizer: 上智大学音声学研究室講演会
  • Invited
• [Presentation] fNIRS の特性を考慮した適切な実験計画と解析 (2019)
  • Author(s): 皆川泰代
  • Organizer: 第22回日本光脳機能イメージング学会シンポジウム
  • Invited
• [Presentation] Word meaning acquisition in the first year of life: Infant pupil dilation in response to a picture-sound match/mismatch paradigm. (2019)
  • Author(s): Hata, M., Yamamoto, E., Minagawa, Y.
  • Organizer: NEURO2019
• [Presentation] Cerebral responses to nonadjacent dependency learning in 6-7-month-old infants. (2019)
  • Author(s): Cai, L., Hakuno, Y., Hoshino, E., Minagawa, Y.
  • Organizer: NIR 2019, NIRStralia
• [Presentation] Dissociating the behavior-specific neural couplings during a naturalistic cooperation task. (2019)
  • Author(s): Xu, M., Morimoto, S., Hoshino, E., Minagawa, Y.
  • Organizer: NIR 2019
• [Presentation] Cerebral responses to social contingency during live interactions: High-risk vs. low-risk Infants. (2019)
  • Author(s): Hakuno, Y., Hata, M., Minagawa, Y
  • Organizer: The 25th Annual Meeting of the Organization for Human Brain Mapping
• [Presentation] How does a doll play affect socio-emotional development in children?: Evidence from behavioral and neuroimaging measures. (2019)
  • Author(s): Sekine, K., Yamamoto, E., Miyahara, S., Minagawa, Y.
  • Organizer: In the Annual Meeting of the Cognitive Science Society 2019
• [Presentation] Social attention during real-life interactions in Williams syndrome and autism spectrum disorder. (2019)
  • Author(s): Hakuno, Y, Naoi, N, Ikeda, A, Asada K, Minagawa, Y, Ikeda T, Yamagata, T, Hirai, M.
  • Organizer: Budapest CEU Conference on Cognitive Development
• [Presentation] 情動価の異なる表情に対する自閉症リスク児と定型発達児の視線特性 (2019)
  • Author(s): 秦政寛、山本絵里子、白野陽子、皆川泰代
  • Organizer: 日本赤ちゃん学会第19回学術集会
• [Presentation] 母親と他人による身体揺動が乳児の心拍に与える影響 (2019)
  • Author(s): 白野陽子、小島香菜里、山本絵里子、星野英一、皆川泰代
  • Organizer: 日本赤ちゃん学会第19回学術集会
• [Presentation] 幼児における向社会行動の理解と産出に関わる神経基盤 (2019)
  • Author(s): 山本絵里子、増田れい、関根和生、宮原冴佳、白野陽子、皆川泰代
  • Organizer: 日本赤ちゃん学会第19回学術集会
• [Presentation] 幼児の心の理論獲得における人形を用いた見立て遊びの役割 (2019)
  • Author(s): 宮原冴佳、山本絵里子、関根和生、白野陽子、増田れい、皆川泰代
  • Organizer: 第19回日本赤ちゃん学会
• [Presentation] 乳児期における「おどり」行動の発達的変遷 (2019)
  • Author(s): 山本絵里子、秦政寛、皆川泰代
  • Organizer: 第71回舞踊学会大会
• [Presentation] 文章黙読における目の動きと読解処理に関わる認知機能 (2019)
  • Author(s): 星野英一、計良陽子、皆川泰代
  • Organizer: 日本行動計量学会第47回大会
• [Presentation] 協調ゲーム中における脳活動の二者間相互作用についての解析手法 (2019)
  • Author(s): 森本智志、徐鳴鏑、星野英一、皆川泰代
  • Organizer: 光脳機能イメージング学会第22回学術集会
• [Presentation] 乳幼児における知覚情報環境とコミュニケーションの育ち (2019)
  • Author(s): 皆川泰代
  • Organizer: 日本音響学会春季大会
  • Invited
• [Presentation] 「引きあい引き込む関係性」からコミュニケーション発達をひも解く（指定討論） (2019)
  • Author(s): 皆川泰代
  • Organizer: 第30回日本発達心理学会
  • Invited
• [Presentation] 自閉症スペクトラム障害の脳神経基盤と効果的介入（指定討論） (2019)
  • Author(s): 皆川泰代
  • Organizer: 第30回日本発達心理学会 委員会企画シンポジウム
  • Invited
• [Presentation] 脳計測から探る意図共有：社会脳ネットワークの発達 (2019)
  • Author(s): 皆川泰代
  • Organizer: 第30回日本発達心理学会 日本発達心理学会言語発達分科会シンポジウム
  • Invited
• [Presentation] 自閉症スペクトラム障害児とリスク児の音声コミュニケーション (2018)
  • Author(s): 皆川泰代
  • Organizer: 日本音響学会秋季大会
  • Invited
• [Presentation] Development of social interactive brain: Behavioral and neurocognitive evidence (2018)
  • Author(s): Minagawa, Y.
  • Organizer: ICDL-EPIROB 2018
  • Int'l Joint Research / Invited
• [Presentation] A longitudinal assessment of infants' motor and language development using an automatic quantification method of motor skills. (2018)
  • Author(s): Abe, K., Inoue. Y., Aoki, Y., Hakuno, Y., Minagawa. Y.
  • Organizer: Intl. Cong. Infant Study
  • Int'l Joint Research
• [Presentation] Differential selective attention to the mouth of a talking face in infants at-risk for ASD and typically developing infants. (2018)
  • Author(s): Hata, M. Hakuno, Y., Asano, M., Abe, K., Minagawa. Y.
  • Organizer: Intl. Cong. Infant Study
  • Int'l Joint Research
• [Presentation] Hyperscanning of mother-infant brains: synchronized cerebral activities during interaction. (2018)
  • Author(s): Minagawa, Y., Morimoto. S., Hoshino, E-I., Asano, M., Hata, M.
  • Organizer: Intl. Cong. Infant Study
  • Int'l Joint Research
• [Presentation] Cerebral activations to socially positive, negative, and non-social contingency during live interactions in infancy. (2018)
  • Author(s): Hakuno, Y., Hata, M., Hachisu, T., Suzuki, K., Minagawa, Y.
  • Organizer: Intl. Cong. Infant Study
  • Int'l Joint Research
• [Presentation] Long range connectivity develops slowly in very preterm infants: fNIRS study on resting state networks in preterm and term infants. (2018)
  • Author(s): Arimitsu, T., Hoshino, E., Shinohara, N., Hoshino, E., Hata, M., Takahashi, T. and Minagawa, Y.
  • Organizer: fNIRS 2018
  • Int'l Joint Research
• [Presentation] A cross-sectional fNIRS study on resting state connectivity in term, preterm and very preterm infants (2018)
  • Author(s): Minagawa, Y. Arimitsu, T., Shinohara, N., Hoshino, E., Hata, M., Takahashi, T.
  • Organizer: Neuroscience 2018
  • Int'l Joint Research
• [Presentation] Sensitivity to social and non-social contingency during live interactions in infancy: an fNIRS study (2018)
  • Author(s): Hakuno, Y., Hata, M., Hachisu, T., Suzuki, K., Minagawa, Y
  • Organizer: Neuroscience 2018
  • Int'l Joint Research
• [Presentation] Cerebral responses during joint attention in infants. (2018)
  • Author(s): Naoi, N., Hakuno, Y., and Minagawa, Y.
  • Organizer: The Functional Near Infrared Spectroscopy Conference 2018
  • Int'l Joint Research
• [Presentation] Extraction of Synchronizing Cortical Activities between Mother and Infant. (2018)
  • Author(s): Morimoto, S., Hoshino, E., Hata, M., Asano, M. and Minagawa, Y.
  • Organizer: fNIRS2018
  • Int'l Joint Research
• [Presentation] Guidelines for motion correction for infant fNIRS signals based on multiple data sets and acquisition systems. (2018)
  • Author(s): Di Lorenzo, R., Pirazzoli, L., Blasi, A., Bulgarelli, C., Hakuno, Y., Minagawa, Y., and Brigadoi S.
  • Organizer: The Functional Near Infrared Spectroscopy Conference 2018
  • Int'l Joint Research
• [Presentation] Cortical responses to affective touch in 7 and 9 month-old infants. (2018)
  • Author(s): Pirazzoli, L., Hakuno, Y., Lloyd-Fox, S., and Minagawa, Y.
  • Organizer: The Functional Near Infrared Spectroscopy Conference 2018
  • Int'l Joint Research
• [Presentation] Inter-brain synchronization during a freestyle PC game: an fNIRS hyperscanning study. (2018)
  • Author(s): Xu, M., Morimoto, S., Hoshino, E., and Minagawa, Y.
  • Organizer: The Functional Near Infrared Spectroscopy Conference 2018
  • Int'l Joint Research
• [Presentation] The time-delay of oxygenated-hemoglobin changes in early infancy. (2018)
  • Author(s): Liang, Z., Tian, H., Minagawa, Y., Arimitsu, T., Takahashi, T., Tong, Y.
  • Organizer: The Functional Near Infrared Spectroscopy Conference 2018
  • Int'l Joint Research
• [Presentation] Statistical learning of phonemic contrast in neonates: cerebral networks and activities. (2018)
  • Author(s): Hoshino, E., Arimitsu, T., Shinohara, N., Takahashi, T. and Minagawa, Y.
  • Organizer: fNIRS 2018
  • Int'l Joint Research
• [Presentation] Preparation-free measurement of event-related potential in oddball tasks from hairy parts using candle-like dry microneedle electrodes. (2018)
  • Author(s): Yoshida, Y., Kudo, Y., Hoshino, E., Minagawa, Y., Miki, N.
  • Organizer: the 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Int'l Joint Research
• [Presentation] 幼児の心の理論獲得と文法理解発達における見立て遊びの役割 (2018)
  • Author(s): 宮原冴佳，浅野路子，白野陽子，磯部美和，小林ゆきの，岡部玲子，桃生朋子，川原繁人，皆川泰代
  • Organizer: 日本赤ちゃん学会第18回学術集会
• [Presentation] 利他的行動と共同注意行動における人形遊びの役割 (2018)
  • Author(s): 増田れい，浅野路子，宮原冴佳，白野陽子，磯部美和，小林ゆきの，岡部玲子，桃生朋子，川原繁人，皆川泰代
  • Organizer: 日本赤ちゃん学会第18回学術集会
• [Presentation] 微細運動の発達メカニズムと認知発達への影響 (2018)
  • Author(s): 阿部和大，大塚恭平，井上悠，青木義満，皆川泰代
  • Organizer: 日本赤ちゃん学会第18回学術集会
• [Presentation] 自閉症スペクトラム障害幼児の共同注意への発達支援の効果 ライブ視線反応計測を用いた検討 (2018)
  • Author(s): 直井望，松崎敦子，石塚祐香，白野陽子，山本淳一，皆川泰代
  • Organizer: 日本赤ちゃん学会第18回学術集会
• [Presentation] 幼児における向社会的行動と気質の関連 (2018)
  • Author(s): 白野陽子，浅野路子，増田れい，宮原冴佳，孫怡，菅原ますみ，皆川泰代
  • Organizer: 日本赤ちゃん学会第18回学術集会
• [Presentation] 顔に対する視線行動にみる自閉症リスク児と定型発達児の違い (2018)
  • Author(s): 秦政寛, 白野陽子, 浅野路子, 阿部和大, 皆川泰代
  • Organizer: 第18回日本赤ちゃん学会学術集会
• [Book] 発達と学習 (未来の教育を創る教職教養指針) (2018)
  • Author(s): 皆川泰代
  • Total Pages: 192
  • Publisher: 学文社
  • ISBN: 9784762028366
• [Remarks] お母さんの語りかけは新生児のコミュニケーション脳回路形成を促す
  • URL: https://www.keio.ac.jp/ja/press-releases/2019/8/22/28-59870/