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Elucidation of neuronal mechanisms underlying same-different concept in rodents

Publicly Offered Research

Project AreaStudies of Language Evolution for Co-creative Human Communication
Project/Area Number 18H05088
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Research InstitutionDoshisha University

Principal Investigator

櫻井 芳雄  同志社大学, 脳科学研究科, 教授 (60153962)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords概念形成 / 同異概念 / メタ認知 / 階層性 / ラット / 海馬 / 前頭前野 / 意図共有
Outline of Annual Research Achievements

本研究は、齧歯類における概念形成について同異概念に焦点を当て検出し、それを担う脳内メカニズムを明らかにすることを目的とした。同時に、概念形成と同様に階層性を持つメタ認知も対象とし、知覚モニタリングに焦点を当て検証した。
同異概念課題については、視覚刺激がラットには相応しくないことがわかっため、音刺激を用いた同異概念課題を構築し、課題中のラットから神経細胞の活動を記録する準備を整えた。メタ認知については、ラットのメタ認知課題(知覚モニタリング課題)を開発し、そこでラットが主観的な見え(気づきawareness)に基づき行動を制御することを示した。次に、知覚モニタリング課題を遂行中のラットから、光刺激が最初に到達する脳部位である一次視覚皮質(V1)およびそこから入力を受ける後頭頂皮質(PPC)の神経細胞集団の活動を記録した。個々の神経細胞の活動を解析した結果、ラットの「主観的な見え」に応じて活動の強さを変える神経細胞がV1およびPPCに存在することがわかった。さらに光刺激の主観的な見えと行動選択に対応した神経細胞集団の振る舞いを定性的かつ定量的に明らかにするため、次元削減方法(dimensionality reduction analysis)により解析した。その結果、ラットの光検出行動に応じて、V1およびPPCの神経細胞集団の振る舞いが変化した。また、光刺激提示前、光刺激提示中、反応する時間に分けて解析したところ、時系列上の区間に応じて異なる神経細胞集団が異なる情報を表現しており、V1では光刺激の主観的な見えに応じた神経細胞集団の活動があり、PPCではその後の行動選択に応じた神経細胞集団の活動が現れることがわかった。

Research Progress Status

令和元年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和元年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (47 results)

All 2020 2019 2018 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 6 results) Presentation (38 results) (of which Int'l Joint Research: 13 results) Remarks (2 results)

  • [Journal Article] Left-right functional difference of the rat dorsal hippocampus for short-term memory and long-term memory2020

    • Author(s)
      Sakaguchi, Y. and Sakurai, Y.
    • Journal Title

      Behavioural Brain Research

      Volume: 382 Pages: 112478-112478

    • DOI

      10.1016/j.bbr.2020.112478

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamics of memory engrams2020

    • Author(s)
      Takamiya, S., Yuki, S., Hirokawa, J., Manabe, H. and Sakurai, Y.
    • Journal Title

      Neuroscience Research

      Volume: 153 Pages: 22-26

    • DOI

      10.1016/j.neures.2019.03.005

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The utility of internal cognitive states as discriminative cues affecting behavioral adaptation in humans and animals2019

    • Author(s)
      Yuki, S., Sakurai, Y. and Okanoya, K.
    • Journal Title

      Animal Behavior and Cognition

      Volume: 6 Issue: 4 Pages: 262-272

    • DOI

      10.26451/abc.06.04.06.2019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced theta and high-gamma coupling during late stage of rule switching task in rat hippocampus2019

    • Author(s)
      Nakazono, T., Takahashi, S. and Sakurai, Y.
    • Journal Title

      Neuroscience

      Volume: 412 Pages: 216-232

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Subjective decision threshold for accurate visual detection performance in rats2018

    • Author(s)
      Osako Yuma、Sakurai Yoshio、Hirokawa Junya
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 1-10

    • DOI

      10.1038/s41598-018-27696-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An observational learning task using Barnes maze in rats2018

    • Author(s)
      Yamada Motoki、Sakurai Yoshio
    • Journal Title

      Cognitive Neurodynamics

      Volume: 12 Issue: 5 Pages: 519-523

    • DOI

      10.1007/s11571-018-9493-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple Approaches to the Investigation of Cell Assembly in Memory Research?Present and Future2018

    • Author(s)
      Sakurai Yoshio、Osako Yuma、Tanisumi Yuta、Ishihara Eriko、Hirokawa Junya、Manabe Hiroyuki
    • Journal Title

      Frontiers in Systems Neuroscience

      Volume: 12 Pages: 1-11

    • DOI

      10.3389/fnsys.2018.00021

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Distinct roles of primary, secondary visual cortex and posterior parietal cortex in visually-guided decision-making2019

    • Author(s)
      Osako, Y., Ohnuki, T., Manabe, H., Sakurai, Y. and Hirokawa, J.
    • Organizer
      49th Society for Neuroscience Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The interaction between hippocampus and temporal cortex during memory consolidation and reconsolidation2019

    • Author(s)
      Takamiya, S., Yuki, S., Hirokawa, J. and Sakurai, Y.
    • Organizer
      49th Society for Neuroscience Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamic encoding of choice-target information in the perirhinal cortex2019

    • Author(s)
      Ohnuki, T., Osako, Y., Sakurai, Y. and Hirokawa, J.
    • Organizer
      49th Society for Neuroscience Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Association of Cue Odor Signals with Predicted Behavioral Scene Signals, in Piriform Cortex Neurons2019

    • Author(s)
      Tanisumi, Y., Shiotani, K., Miura, K., Hirokawa, J., Sakurai, Y., Mori, K. and Manabe, H.
    • Organizer
      49th Society for Neuroscience Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳半球が2つあればどのようなことができるか―記憶・精神・認知柔軟性・社会性から心の理論を考える―2019

    • Author(s)
      阪口幸駿・櫻井芳雄
    • Organizer
      共創言語進化学若手の会第2回全体研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Functional left/right hippocamal asymmetry and sprit-brain in forming short/long-term memory2019

    • Author(s)
      Sakaguchi, Y. and Sakurai, Y.
    • Organizer
      The 10th International Brain Research Organization World Congress of Neuroscience
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Single-neuron and population codings in a higher-order cortical area2019

    • Author(s)
      大貫朋哉・大迫優真・塩谷和基・櫻井芳雄・廣川純也
    • Organizer
      第29回日本神経回路学会全国大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Dynamics of cell assemblies in hippocampus an auditory cortex during memory consolidation and recall2019

    • Author(s)
      Takamiya, S., Yuki, S., Hirokawa, J., and Sakurai, Y.
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ラット梨状皮質ニューロンは匂いと「匂い経験」を紐づける:Go/No-Go学習および逆転学習における多彩な応答様式と、そのポピュレーションGo/No-Go相関表現2019

    • Author(s)
      谷隅勇太・塩谷和基・三浦佳二・廣川純也・櫻井芳雄・眞部寛之
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 嗅周皮質におけるターゲット情報のダイナミックなコーディング2019

    • Author(s)
      大貫朋哉・大迫優真・櫻井芳雄・廣川純也
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ラット海馬の機能的左右半球非対称性および半球間相互作用2019

    • Author(s)
      阪口幸駿・櫻井芳雄
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Distinct contribution of rat visual cortical area in visually-guided decision-making2019

    • Author(s)
      大迫優真・大貫朋哉・櫻井芳雄・廣川純也
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Deep brain stimulation for depression in rats: correction of left/right hemispheric imbalance2019

    • Author(s)
      Sakaguchi, Y., Sakurai, Y
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional left/right hemispheric difference of dopamine D2 neurons in rat dorsolateral striatum2018

    • Author(s)
      Sakaguchi, Y., Sakurai, Y
    • Organizer
      The 18th World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 習慣形成時におけるラット背外側線条体D2細胞の機能的半球側性化2018

    • Author(s)
      阪口幸駿・櫻井芳雄
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マウス嗅結節の光刺激が場所嗜好性試験に与える影響2018

    • Author(s)
      村田航志・木下智貴・小林憲太・眞部寛之・深澤有吾・山口正洋
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マウスを用いた風味評価行動課題の確立2018

    • Author(s)
      塩谷和基・廣川純也・櫻井芳雄 ・眞部寛之
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Go/No-go 逆転学習中に現れる "All-Go" 行動戦略 - 戦略シフトに伴う腹側線条体ニューロン活動パターンのリセット・更新 -2018

    • Author(s)
      谷隅勇太・廣川純也・櫻井芳雄・眞部寛之
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ラットの嗅周皮質による異なる行動的文脈での空間的ターゲットのコーディング2018

    • Author(s)
      大貫朋哉・櫻井芳雄・廣川純也
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ラットの視覚検出課題における閾下意思決定2018

    • Author(s)
      大迫優真・櫻井芳雄・廣川純也
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Metacognitive and non-metacognitive behavior adaptation in rats after degenerated task performance2018

    • Author(s)
      Yuki, S., Sakurai, Y., and Okanoya, K
    • Organizer
      第78回日本動物心理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ラット海馬の長期/短期記憶に関わる機能的左右半球非対称性2018

    • Author(s)
      阪口幸駿・櫻井芳雄
    • Organizer
      日本心理学会第82回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 記憶形式に依存したラット背側海馬の機能的左右半球非対称性2018

    • Author(s)
      阪口幸駿・櫻井芳雄
    • Organizer
      第27回海馬と高次脳機能学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腹側テニアテクタの行動に相関した神経活動2018

    • Author(s)
      塩谷和基・谷隅 勇太・村田 航志・廣川純也・森 憲作・櫻井芳雄・眞部寛之
    • Organizer
      日本味と匂学会第52回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Functional left/right asymmetry of rat hippocampus depending on short/long-term memory2018

    • Author(s)
      Sakaguchi, Y. and Sakurai, Y
    • Organizer
      48th Society for Neuroscience Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A dynamic neural mechanism for encoding spatial targets and behavioral contexts in rat perirhinal cortex2018

    • Author(s)
      Ohnuki, T., Sakurai, Y. and Hirokawa, J
    • Organizer
      48th Society for Neuroscience Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] All-go behavioral state with resetting cue-outcome associations in ventral striatum during reversal learning2018

    • Author(s)
      Tanisumi, Y., Sakurai, Y., Hirokawa, J. and Manabe, H
    • Organizer
      48th Society for Neuroscience Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Behavioral state-specific responses of ventral tenia tecta neurons2018

    • Author(s)
      Shiotani, K., Murata, K., Hirokawa, J., Mori, K., Sakurai, Y. and Manabe, H
    • Organizer
      48th Society for Neuroscience Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Subthreshold decision-making in a visual cue detection task in rats2018

    • Author(s)
      Osako, Y., Sakurai, Y. and Hirokawa, J
    • Organizer
      48th Society for Neuroscience Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウスの風味評価行動課題の確立2018

    • Author(s)
      塩谷和基・廣川純也・櫻井芳雄・眞部寛之
    • Organizer
      2018 The Cutting Edge!
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cell-assembly activity in hippocampus during memory consolidation and reconsolidation2018

    • Author(s)
      Takamiya, S., Yuki, S., Hirokawa, J., and Sakurai, Y
    • Organizer
      The second international symposium on brain science: University of Yamanashi
    • Related Report
      2018 Annual Research Report
  • [Presentation] Neural correlates of subjective presence of visual perception in rat2018

    • Author(s)
      大迫優真・大貫朋哉・櫻井芳雄・廣川純也
    • Organizer
      次世代脳プロジェクト 冬のシンポジウム2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] 匂い経験に関連する神経活動パターンの再活性 ― 行動課題および睡眠時のラット嗅皮質ニューロン活動記録2018

    • Author(s)
      谷隅 勇太・櫻井 芳雄・眞部 寛之
    • Organizer
      次世代脳プロジェクト 冬のシンポジウム2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Sustaining target information but distinguishing task events: Dynamic single-neuron responses reconcile different demands in the perirhinal cortex2018

    • Author(s)
      大貫朋哉・大迫優真・櫻井芳雄・廣川純也
    • Organizer
      次世代脳プロジェクト 冬のシンポジウム2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Deep brain stimulation for depression in rats: correction of central and peripheral nervous systems left/right imbalance2018

    • Author(s)
      阪口幸駿・櫻井芳雄
    • Organizer
      次世代脳プロジェクト 冬のシンポジウム2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of flavor discrimination behavioral task in mice2018

    • Author(s)
      塩谷和基・廣川純也・櫻井芳雄・眞部寛之
    • Organizer
      次世代脳プロジェクト 冬のシンポジウム2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Search for cell assembly in hippocampus during memory consolidation and recall2018

    • Author(s)
      高宮渉吾・結城笙子・廣川純也・櫻井芳雄
    • Organizer
      次世代脳プロジェクト 冬のシンポジウム2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Dynamics of cell assemblies in hippocampus during memory consolidation and recall2018

    • Author(s)
      Takamiya, S., Yuki, S., Hirokawa, J., and Sakurai, Y
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 同志社大学脳科学研究科 神経回路情報部門

    • URL

      https://www1.doshisha.ac.jp/~ysakurai/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 同志社大学脳科学研究科 神経回路情報部門(櫻井ラボ)

    • URL

      https://www1.doshisha.ac.jp/~ysakurai/

    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2021-01-27  

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