• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Simulating the process to produce genetic diversity within a tumor

Publicly Offered Research

Project AreaIntegrated analysis and regulation of cellular diversity
Project/Area Number 18H05097
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Research InstitutionThe Graduate University for Advanced Studies

Principal Investigator

印南 秀樹  総合研究大学院大学, 先導科学研究科, 教授 (90444140)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords腫瘍内多型 / がん / シミュレーション / 進化 / 腫瘍内変異 / がん細胞進化
Outline of Annual Research Achievements

本研究は、細胞集団の増殖プロセスに進化生物学と集団遺伝学の理論を応用し、腫瘍内多様性の形成メカニズムを構成的アプローチで理解することを目的とする。これは、当該領域が細胞社会ダイバーシティーの統合的解明を目指す上で重要な部分を補完するものである。当該領域の計画班は、(A01)シングルセルのオー ミクス解析や3Dイメージングなど、急速に発展する定量化技術を用いた解析的実験研究が中核となっている。理論系の研究では(A02)、定量的実験データの統計解 析や数理モデリングを行うものが多い。そのマクロな理解を受けて、最終的にはオルガノイドや異種移植といった構成的実験研究による実証も視野に入れている (A03)。しかし、細胞社会ダイバーシティーのような組織レベルの特性は、個々の細胞の性質の単なる総和ではなく、局所的な相互作用の連鎖から創発する高次の 表現型であり、解析的理論によって諸要素に還元する方向性には限界がある。また実証実験には膨大な時間やコストがかかる。この問題を解決するために我々は、要素の記述から全体の振る舞いを組み立てていく構成的理論モデルを用いて、実証実験につながる橋渡しとなることを目指す(A02')。その結果は、(A03)構成的実験研究に対して、より効率的に研究対象を絞り込むことを助ける。

Research Progress Status

令和元年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和元年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (19 results)

All 2020 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (9 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 3 results) Presentation (8 results) (of which Int'l Joint Research: 4 results,  Invited: 4 results)

  • [Int'l Joint Research] Harvard University(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Universite Paris Diderot(フランス)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] The Muller’s ratchet and aging2020

    • Author(s)
      Govindaraju, D. R., H. Innan, and R. A. Veitia
    • Journal Title

      Trends in Genet.

      Volume: 36 Issue: 6 Pages: 395-402

    • DOI

      10.1016/j.tig.2020.02.004

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A unified simulation model for understanding the diversity of cancer evolution.2020

    • Author(s)
      Niida A, Hasegawa T, Innan H, Shibata T, Mimori K, Miyano S
    • Journal Title

      PeerJ

      Volume: 8 Pages: e8842-e8842

    • DOI

      10.7717/peerj.8842

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Duplication with structural modification through extrachromosomal circular and lariat DNA in the human genome2020

    • Author(s)
      Takahashi, K., and H. Innan
    • Journal Title

      Sci. Rep

      Volume: 10 Issue: 1 Pages: 7150-7150

    • DOI

      10.1038/s41598-020-63665-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic and epigenetic Muller’s ratchet as a mechanism of frailty and morbidity during aging: a demographic genetic model2020

    • Author(s)
      Innan, H., V. Reiner and D. Govindaraju
    • Journal Title

      Hum. Genet.

      Volume: 139 Issue: 3 Pages: 409-420

    • DOI

      10.1007/s00439-019-02067-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mutation load and aging2019

    • Author(s)
      Govindaraju R., and H. Innan
    • Journal Title

      Encyclopedia of Gerontology and Population Aging

      Volume: ー

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Neutral theory in cancer cell evolution2018

    • Author(s)
      Niida, A., Iwasaki, W. M, and H. Innan
    • Journal Title

      Mol. Biol. Evol.

      Volume: 35 Issue: 6 Pages: 1316-1321

    • DOI

      10.1093/molbev/msy091

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replication stress induces accumulation of FANCD2 at central region of large fragile genes.2018

    • Author(s)
      Okamoto Y, Iwasaki WM, Kugou K, Takahashi KK, Oda A, Sato K, Kobayashi W, Kawai H, Sakasai R, Takaori-Kondo A, Yamamoto T, Kanemaki MT, Taoka M, Isobe T, Kurumizaka H, Innan H, Ohta K, Ishiai M, Takata M.
    • Journal Title

      Nucleic Acids Res.

      Volume: 46(6) Issue: 6 Pages: 2932-2944

    • DOI

      10.1093/nar/gky058

    • NAID

      120006488604

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Coalescent framework of prokaryotes undergoing interspecific homologous recombination.2018

    • Author(s)
      Akita, T., S. Takuno, and H. Innan
    • Journal Title

      Heredity

      Volume: 120 Issue: 5 Pages: 474-484

    • DOI

      10.1038/s41437-017-0034-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] がんゲノミクスと集団遺伝学の融合2018

    • Author(s)
      印南秀樹、岩嵜航、新井田厚司
    • Journal Title

      BIOClinica

      Volume: -

    • Related Report
      2018 Annual Research Report
  • [Presentation] Evolution of duplicated genes2018

    • Author(s)
      Hideki Innan
    • Organizer
      分子生物学会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional and genomic evolution after duplication2018

    • Author(s)
      Hideki Innan
    • Organizer
      The 43rd Naito Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Evolutionary fates of extra gene copies and their evolution2018

    • Author(s)
      Hideki Innan
    • Organizer
      siaEvo Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Evolution of alpha satellites in the human genome2018

    • Author(s)
      Manatsu Hamazaki and Hideki Innan
    • Organizer
      SMBE2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Simulation of Intratumor Heterogeneity and its Medical Implication2018

    • Author(s)
      Watal M. Iwasaki and Hideki Innan
    • Organizer
      SMBE2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Comprehensive Framework for Evolutionary Simulation of Intratumor Heterogeneity2018

    • Author(s)
      Watal M. Iwasaki and Hideki Innan
    • Organizer
      International Workshop for Systems Genetics 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The impact of germline mutations on cancer risk2018

    • Author(s)
      Kazuki Takahashi and Hideki Innan
    • Organizer
      SMBE2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] 集団内での超低頻度変異のガン化への寄与2018

    • Author(s)
      高橋 数冴、印南秀樹
    • Organizer
      分子生物学学会
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2021-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi