Visualization and manipulation of MAN-network

• Project Area: Brain information dynamics underlying multi-area interconnectivity and parallel processing
• Project/Area Number: 18H05121
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Research Institution: University of Yamanashi
• Principal Investigator: 小泉 修一 山梨大学, 大学院総合研究部, 教授 (10280752)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2019: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: アストロサイト / ミクログリア / 高精細イメージング / P2Y1受容体 / グリア細胞 / 神経細胞 / 同時Ca2+イメージング / 病態アストロサイト / 神経-グリア連関 / 同時イメージング / 海馬 / カルシウム / P2受容体

Outline of Annual Research Achievements

グリア細胞が脳機能に果たす役割の重要性が明らかにされつつある。本研究では、アストロサイト（A)、ミクログリア（M)、神経細胞（N)が構築するネットワークをMANネットワークと規定し、これらを正確に「見る」「制御する」ことで、脳情報動態におけるグリア細胞の役割を明らかにした。
1　アストロサイト。アストロサイトはシナプスを取り囲み、自身も周辺シナプスとして機能する所謂「三者間シナプス」仮説は、in situで実際に起きているのかどうかについては不明な点が多い。そこで、先ず神経細胞とアストロサイト機能を、高時空間分解能、同時、in situ、で「見る」Ca2+イメージングシステムを構築した。アストロサイトは膜移行型Ca2+蛍光指示薬Lck-GCaMP3又はGCaMP6で、神経細胞はRCaMP2（尾藤らと共同研究）により、同一標本で解析できる系を構築した。神経活動の一定潜時後に、アストロサイトのCa2+応答を認め、これはATPによる神経→アストロサイトのシグナルであった。アストロサイトにP2Y1受容体を強制発現させてこの応答を「制御」する系を構築し、その様式・機序を明らかにした。これにより、アストロサイト→神経細胞のフィードバックシグナルがグルタミン酸によって伝わっていることも明らかにした。このように、神経-アストロサイト間で双方向性のコミュニケイションが存在していること、そのシグナル分子、シグナル伝達様式をin situで明らかにすることが出来た。
2　ミクログリア。ミクログリアはシナプス再編により神経機能を制御することが良く知られている。先ず、ミクログリアを薬colony stimulating factor1 receptro (CSF1R)により可逆的に除去する実験系を構築した。これを用いてミクログリアがシナプス伝達に与える影響の機能解析を開始した。

Research Progress Status

令和元年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和元年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Aberrant Calcium Signals in Reactive Astrocytes: A Key Process in Neurological Disorders (2019)
  • Author(s): Eiji Shigetomi, Kozo Saito, Fumikazu Sano, Schuichi Koizumi
  • Journal Title: International Journal of Molecular Sciences Volume: 20 Issue: 4 Pages: 1-18
  • DOI: 10.3390/ijms20040996
  • Peer Reviewed / Open Access
• [Journal Article] Microglial ROCK is essential for chronic methylmercury-induced neurodegeneration. (2019)
  • Author(s): Shinozaki Y, Danjo Y, Koizumi S
  • Journal Title: J Neurochemistry Volume: 151 Issue: 1 Pages: 64-78
  • DOI: 10.1111/jnc.14817
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of M1-microglial activation by neurotoxic metals using optimized organotypic cerebral slice cultures (2019)
  • Author(s): Hoshi T, Toyama T, Shinozaki Y, Koizumi S, Lee JY, Naganuma A, Hwang GW.
  • Journal Title: The Journal of Toxicological Sciences Volume: 44 Issue: 7 Pages: 471-479
  • DOI: 10.2131/jts.44.471
  • NAID: 130007674444
  • ISSN: 0388-1350, 1880-3989
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hyaluronan synthesis supports glutamate transporter activity (2019)
  • Author(s): Hayashi MK, Nishioka T, Shimizu H, Takahashi K, Kakegawa W, Mikami T, Hirayama Y, Koizumi S, Yoshida S, Yuzaki M, Tammi M, Sekino Y, Kaibuchi K, Shigemoto-Mogami Y, Yasui M, Sato K.
  • Journal Title: Journal of Neurochemistry Volume: 150 Issue: 3 Pages: 249-263
  • DOI: 10.1111/jnc.14791
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Intermittent restraint stress induces circadian misalignment in the mouse bladder, leading to nocturia. (2019)
  • Author(s): Ihara T, Nakamura Y, Mitsui T, Tsuchiya S, Kanda M, Kira S, Nakagomi H, Sawada N, Kamiyama M, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Koizumi S, Takeda M.
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 10069-10069
  • DOI: 10.1038/s41598-019-46517-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Snake venom rhodocytin induces plasma extravasation via toxin-mediated interactions between platelets and mast cells (2019)
  • Author(s): Y. Nakamura, T. Sasaki, C. Mochizuki, K. Ishimaru, S. Koizumi, H. Shinmori, K. Suzuki-Inoue, A. Nakao
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 15958-15958
  • DOI: 10.1038/s41598-019-52449-2
  • Peer Reviewed / Open Access
• [Journal Article] Aberrant astrocyte Ca2+ signals “AxCa signals” exacerbate pathological alterations in an Alexander disease model (2018)
  • Author(s): Saito Kozo、Shigetomi Eiji、Yasuda Rei、Sato Ryuichi、Nakano Masakazu、Tashiro Kei、Tanaka Kenji F.、Ikenaka Kazuhiro、Mikoshiba Katsuhiko、Mizuta Ikuko、Yoshida Tomokatsu、Nakagawa Masanori、Mizuno Toshiki、Koizumi Schuichi
  • Journal Title: Glia Volume: 66 Issue: 5 Pages: 1053-1067
  • DOI: 10.1002/glia.23300
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The oscillation of intracellular Ca2+ influx associated with the circadian expression of Piezo1 and TRPV4 in the bladder urothelium (2018)
  • Author(s): Ihara Tatsuya、Mitsui Takahiko、Nakamura Yuki、Kanda Mie、Tsuchiya Sachiko、Kira Satoru、Nakagomi Hiroshi、Sawada Norifumi、Kamiyama Manabu、Hirayama Yuri、Shigetomi Eiji、Shinozaki Youichi、Yoshiyama Mitsuharu、Nakao Atsuhito、Takeda Masayuki、Koizumi Schuichi
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 5699-5699
  • DOI: 10.1038/s41598-018-23115-w
  • Peer Reviewed / Open Access
• [Journal Article] New roles of reactive astrocytes in the brain; an organizer of cerebral ischemia. (2018)
  • Author(s): Koizumi, S., Hirayama, Y., Morizawa, YM
  • Journal Title: Neurochem Int Volume: in press Pages: 107-114
  • DOI: 10.1016/j.neuint.2018.01.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Anti-depressant fluoxetine reveals its therapeutic effects via astrocytes. (2018)
  • Author(s): M. Kinoshita, Y. Hirayama, K. Fujishita, K Shibata, Y. Shinozaki, E. Shigetomi, A. Takeda, HP Ngoc Le, H. Hayashi, M. Hiasa, Y. Moriyama, K. Ikenaka, KF Tanaka, S. Koizumi.
  • Journal Title: EBioMedicine Volume: 32 Pages: 72-83
  • DOI: 10.1016/j.ebiom.2018.05.036
  • NAID: 130007901327
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of VNUT-exocytosis in transient receptor potential vanilloid 4-dependent ATP release from gastrointestinal epithelium. (2018)
  • Author(s): Mihara, H., Uchida, K., Koizumi, S., Moriyama, Y
  • Journal Title: PloS One Volume: 13(10) Issue: 10 Pages: e0206276-e0206276
  • DOI: 10.1371/journal.pone.0206276
  • Peer Reviewed / Open Access
• [Journal Article] The time-dependent variation of ATP release in mouse primary cultured urothelial cells is regulated by the Clock gene. (2018)
  • Author(s): Ihara T, Mitsui T, Nakamura Y, Kanda M, Tsuchiya S, Kira S, Nakagomi H, Sawada N, Kamiyama M, Hirayama Y, Shigetomi E, Shinozaki Y, Yoshiyama M, Nakao A, Takeda M Koizumi S
  • Journal Title: Neurourology and urodynamics Volume: 37 Issue: 8 Pages: 2535-2543
  • DOI: 10.1002/nau.23793
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Microglia mediate non-cell-autonomous cell death of retinal ganglion cells. (2018)
  • Author(s): Takeda A, Shinozaki Y, Kashiwagi K, Ohno N, Eto K, Wake H, Nabekura J, Koizumi S.
  • Journal Title: Glia Volume: 66 Issue: 11 Pages: 2366-2384
  • DOI: 10.1002/glia.23475
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neuroprotective effects of microglial P2Y1 receptors against ischemic neuronal injury. (2018)
  • Author(s): Fukumoto, Y., Tanaka, KF., Parajuli, B., Shibata, K., Yoshioka, H., Kanemaru, K., Gachet, C., Ikenaka, K., Koizumi, S. Kinouchi, H.
  • Journal Title: J Cereb Blood FloTakew Metab, Volume: - Issue: 11 Pages: 2144-2156
  • DOI: 10.1177/0271678x18805317
  • Peer Reviewed / Open Access
• [Presentation] 反応性アストロサイトによる神経ネットワークリモデリング (2020)
  • Author(s): 小泉修一
  • Organizer: 第9回と医学研シンポジウム
  • Invited
• [Presentation] Network remodeling by reactive astrocytes. (2020)
  • Author(s): Koizumi, S
  • Organizer: The 15th ISGG(The 15th International Syposium on Geriatrics and Gerontoligy
  • Int'l Joint Research / Invited
• [Presentation] グリア細胞による神経障害性疼痛の誘導 (2020)
  • Author(s): 小泉修一
  • Organizer: 帯状疱疹・神経障害性疼痛セミナー
  • Invited
• [Presentation] Network remodeling by glial cells (2020)
  • Author(s): Koizumi, S
  • Organizer: 2nd Mini-Symposium on The Blood-Brain Barrier from Basic to Clinical Research
  • Int'l Joint Research / Invited
• [Presentation] Multi-modal imaging of astrocyte-neuron communication (2020)
  • Author(s): Shigetomi, E., Koizumi, S
  • Organizer: 2nd Mini-Symposium on The Blood-Brain Barrier from Basic to Clinical Research
  • Invited
• [Presentation] Neuronal hyperexcitability mediated by GqPCR-mediated signaling in astrocytes (2020)
  • Author(s): Shigetomi, E., Hirayama, Y., Sano, F., Tanaka, KF., Bito, H., Koizumi, S
  • Organizer: 第93回日本薬理学会年会
• [Presentation] Dysregulated ABCA1 increases risk for pathogenesis of normal tension glaucoma (2020)
  • Author(s): Shinozaki, Y., Namekata, K., Segawa, T., Ohno, N., Harada, T., Kashiwagi, K., Koizumi, S
  • Organizer: 第93回日本薬理学会年会
• [Presentation] Loss of P2Y1 receptor causes ocular hypertension and glaucoma-like phenotype in mice (2020)
  • Author(s): Hamada, K., Shinozaki, Y., Segawa, T., Namekata, K., Ohno, N., Harada, T., Kashiwagi, K., Koizumi, S
  • Organizer: 第93回日本薬理学会年会
• [Presentation] Visualization of extracellular Ca2+ dynamics in hippocampus using Ca2+ Image Sensor (2020)
  • Author(s): Parajuli, B., Doi, H., Shigetomi, E., Shinozaki, Y., Sawada, K., Koizumi ,S
  • Organizer: 第93回日本薬理学会年会
• [Presentation] グリア細胞の視点から (2020)
  • Author(s): 小泉修一
  • Organizer: 第93回日本薬理学会年会
• [Presentation] 一次性アストロサイト病 「アレキサンダー病」 の分子病態の薬理学的研究 (2020)
  • Author(s): 齋藤 光象、繁富 英治、小泉 修一
  • Organizer: 第93回日本薬理学会年会
• [Presentation] 一次体性感覚野アストロサイトと慢性疼痛 (2020)
  • Author(s): 小泉修一
  • Organizer: 日本薬学会140年会
• [Presentation] アストロサイトの異常カルシウムシグナルとその病態生理学的意義 (2019)
  • Author(s): 繁冨英治、齋藤光象、小泉修一
  • Organizer: 第140回日本薬理学会関東部会
• [Presentation] Neuroprotective effects of microglia via P2Y1 receptors against ischemic neuronal injury. (2019)
  • Author(s): Fukumoto, Y., Koizumi, S., Yoshioka, H., Yagi, T., Kanemaru, K., Kinouchi, H.
  • Organizer: BRAIN & BRAIN PET 2019
  • Int'l Joint Research
• [Presentation] Astrocytic heterogenety in modulating sensory signal processing. (2019)
  • Author(s): Kim, SK., Kim, SJ., Koizumi, S., Nabekura, J
  • Organizer: NEURO2019
  • Int'l Joint Research
• [Presentation] Heterogeneity of astrocytes in synapse remodeling. (2019)
  • Author(s): Koizmi, S.
  • Organizer: NEURO2019
  • Int'l Joint Research / Invited
• [Presentation] Elucidation of the pathogenic mechanism of CDC42EP4 deficiency-induced glaucoma. (2019)
  • Author(s): Takeda, S., Shinozaki, Y., Koizumi, S
  • Organizer: NEURO2019
  • Int'l Joint Research
• [Presentation] P2Y1 receptor deficiency induces hypertensive glaucoma-like phenotypes in mice. (2019)
  • Author(s): Hamada, K., Shinozaki, Y., Koizumi, S
  • Organizer: NEURO2019
  • Int'l Joint Research
• [Presentation] Impaired glial ABCA1 causes pathogenesis of glaucoma. (2019)
  • Author(s): Shinozaki, Y., Namekata, K., Kashiwagi, K., Ohno, N., Segawa, T., Harada, T., Koizumi, S
  • Organizer: NEURO2019
  • Int'l Joint Research
• [Presentation] Dynamic feature of bidirectional communication between neurons and astrocytes. (2019)
  • Author(s): Shigetimi, E., Hirayama, YJ., Ikenaka, K., Tanaka, KF., Bito, H., Koizumi, S.
  • Organizer: NEURO2019
  • Int'l Joint Research
• [Presentation] Involvement of microglia in Alexander Disease, the primary astrocytic disease. (2019)
  • Author(s): Kobayashi, K., Shigetomi, E., Saito, K., Ikenaka, K., Tanaka, KF., Koizumi, S
  • Organizer: NEURO2019
  • Int'l Joint Research
• [Presentation] Re-emergence of astrocytic mGluR5 assembles cortical networks in induction of neuropathic pain. (2019)
  • Author(s): Danjo, Y., Hirayama, YJ., Shigetomi, E., Shibata, K., Takanashi, K., Shinozaki, Y., Kim SK., Nabekura, J., Koizumi, S
  • Organizer: Neuro2019
  • Int'l Joint Research
• [Presentation] Deletion of glial ABCA1 causes glaucoma-like optic neuropathy (2019)
  • Author(s): Shinozaki, Y. Deletion of glial ABCA1 causes glaucoma-like optic neuropathy
  • Organizer: YougGlia Meeting
  • Int'l Joint Research
• [Presentation] Dynamic feature of bidirectional communication between neurons and glia. (2019)
  • Author(s): Shigetomi, E
  • Organizer: YougGlia Meeting
  • Int'l Joint Research
• [Presentation] Glial phagocytic clearance in health and disease (2019)
  • Author(s): Koizumi, S
  • Organizer: ISN-ASN Meeting,
  • Int'l Joint Research / Invited
• [Presentation] Network remodeling by glial cells. (2019)
  • Author(s): Koizumi, S
  • Organizer: 日米科学技術協力事業「脳研究」分野における情報交換セミナー
  • Int'l Joint Research / Invited
• [Presentation] Bi-direcional network remodeling by reactive astrocytes. (2019)
  • Author(s): Koizumi, S
  • Organizer: The 10th IBRO World Congress of Neuroscience（IBRO2019）
  • Int'l Joint Research / Invited
• [Presentation] Synapse remodeling by astrocytes (2019)
  • Author(s): Koizumi, S
  • Organizer: 2019 International Symposium of BSEI & KNUCH
  • Int'l Joint Research / Invited
• [Presentation] Glial cells as a therapeutic target for anti-depressants. (2019)
  • Author(s): Koizumi, S
  • Organizer: 第6回アジア神経精神薬理学会（AsCNP2019）
  • Invited
• [Presentation] 活性化アストロサイトはてんかん原生獲得に寄与する苔状繊維発芽を誘導する (2019)
  • Author(s): 佐野史和、繁冨英治、小泉修一、金村英秋、犬飼岳史、相原正男
  • Organizer: 第53回てんかん学会学術集会
• [Presentation] てんかん発現におけるグリアの役割 (2019)
  • Author(s): 小泉修一
  • Organizer: 第53回てんかん学会学術集会
  • Invited
• [Presentation] 活性化ミクログリアによるてんかん原性型アストロサイトの誘導 (2019)
  • Author(s): 佐野史和、繁冨英治、小泉修一
  • Organizer: 第53回てんかん学会学術集会
• [Presentation] A role of ATP as an initial DAMPs signal. (2019)
  • Author(s): Koizumi, S.
  • Organizer: 9th International DAMPs and Alrmins Symposium
  • Int'l Joint Research
• [Presentation] ミクログリア-アストロサイト連関と脳機能 (2019)
  • Author(s): 小泉修一
  • Organizer: 第35回WAKOワークショップ
  • Invited
• [Presentation] Bidirectional synapse remodeling by reactive astrocytes. (2019)
  • Author(s): Koizumi, S
  • Organizer: ONO neurology Symposium
  • Invited
• [Presentation] てんかんとグリア細胞 (2019)
  • Author(s): 小泉修一
  • Organizer: 第49回日本臨床神経生理学会
  • Invited
• [Presentation] Impaired astrocytic ABCA1 causes normal tension glaucoma-like phenotypes in mice (2019)
  • Author(s): Shinozaki, Y., Namekata, K., Kashiwagi, K., Ohno, N., Segawa, T., Harada, T., Koizumi, S.
  • Organizer: 第24回グリア研究会
• [Presentation] グリアからみた発現メカニズム～生化学的アプローチ～ (2019)
  • Author(s): 小泉修一
  • Organizer: Glutamate Conference
  • Invited
• [Presentation] Horizontal integration of Pharmacology, Anatomy, Physiology and Biochemistry by common term of ‘Neuroscience’. (2019)
  • Author(s): Koizumi, S.
  • Organizer: 第92回日本薬理学会年会
• [Presentation] Reappearance of astrocytic mGluR5 assembles cortical networks in induction of neuropathic pain. (2019)
  • Author(s): Danjo, Y., Hirayama, YJ, Shigetomi, E., Shibata, K., Takanashi, K., Shinozaki, Y., Kim, SK, Nabekura, J., Koizumi, S.
  • Organizer: 第92回日本薬理学会年会
• [Presentation] Role of microglia in Alexander disease: the influence of microglia depletion (2019)
  • Author(s): Kobayashi, K., Shigetomi, E., Sito, K., Ikenaka, K., Tanaka, FK., Kozumi, S.
  • Organizer: 第92回日本薬理学会年会
• [Presentation] Glial purinergic signals as a target for antidepressants. (2019)
  • Author(s): Koizumi, S.
  • Organizer: 第92回日本薬理学会年会
• [Presentation] Dysregulation in glial function causes pathogenesis of glaucoma. (2019)
  • Author(s): Shinozaki, Y., Namekata, K., Kashiwagi, K., Ohno, N., Takeda, A., Harada, T., Koizumi, S.
  • Organizer: 第92回日本薬理学会年会
• [Presentation] Monitoring bidirectional information processing between neurons and astrocyte. (2019)
  • Author(s): Shigetomi, E., Koizumi, S.
  • Organizer: 第92回日本薬理学会年会
• [Presentation] Synapse remodeling by astrocytes (2019)
  • Author(s): Koizumi, S.
  • Organizer: laval大学カンファレンス
  • Int'l Joint Research
• [Presentation] Dysfunction in retinal glia causes pathogenesis of glaucoma. (2019)
  • Author(s): Shinozaki, Y
  • Organizer: laval大学カンファレンス
  • Int'l Joint Research
• [Presentation] Role of calcium signals in reactive astrocytes. (2019)
  • Author(s): Shigetomi, E
  • Organizer: laval大学カンファレンス
  • Int'l Joint Research
• [Presentation] グリアによる一次体性感覚野のシナプス再編 (2019)
  • Author(s): 小泉修一
  • Organizer: 第7回神経と免疫を語る会
  • Invited
• [Presentation] Bidirectional regulation of synapse remodeling by reactive astrocytes. (2019)
  • Author(s): Koizumi, S
  • Organizer: FAOPS2019
  • Int'l Joint Research
• [Presentation] Loss-of-function of glial ABCA1 increases the risk for pathogenesis of glaucoma (2019)
  • Author(s): Shinozaki, Y., Namekata, K., Kashiwagi, K., Ohno, N., Takeda, A., Harada, T., Koizumi, S.
  • Organizer: FAOPS2019
  • Int'l Joint Research
• [Presentation] Visualization of spatiotemporal interaction of neurons and astrocytes. (2019)
  • Author(s): Shigetomi, E., Hirayama, JY., Ikenaka, K., Tanaka, FK., Bito, H., Koizumi, S.
  • Organizer: FAOPS2019
  • Int'l Joint Research
• [Presentation] Characterizaton of epileptogenic astrocytes. (2018)
  • Author(s): Koizumi, S.
  • Organizer: 第59回日本神経学会学術大会
  • Invited
• [Presentation] グリア性てんかん原性 (2018)
  • Author(s): 小泉修一
  • Organizer: 関西医科大学学術講演会
  • Invited
• [Presentation] Microglial VNUT derived ATP mediates astrogliosis-dependent epileptogenesis after status epilepticus. (2018)
  • Author(s): 佐野史和、繁冨英治、小泉修一、金村英秋、池中一裕、田中謙二、相原正男
  • Organizer: 第60回日本小児神経学会学術集会
• [Presentation] アストロサイト性シナプス再編 (2018)
  • Author(s): 小泉修一、檀上洋右、鍋倉淳一
  • Organizer: 第2回感覚免疫学研究会
  • Invited
• [Presentation] Ischemic tolerance and glial purinergic signaling. (2018)
  • Author(s): Koizumi, S
  • Organizer: Purines2018
  • Int'l Joint Research / Invited
• [Presentation] Dysregulated P2Y6 receptor signaling increases a risk for pathogenesis of glaucoma. (2018)
  • Author(s): Shinozaki, Y., Kashiwagi, K., Namekata, K., Ohno, N., Takeda, A., Harada, T., Iwata, T., Koizumi, S
  • Organizer: Purines2018
  • Int'l Joint Research
• [Presentation] Astrocyte-synapse interaction in health and diseases (2018)
  • Author(s): Koizumi, S
  • Organizer: WCP2018
  • Int'l Joint Research
• [Presentation] Dual color Ca2+ imaging of neuron-astrocyte interaction. (2018)
  • Author(s): Shigetomi, E., Hirayama, Y., Ikenaka, K., Tanaka, FK, Bito, H., Koizumi, S.
  • Organizer: WCP2018
  • Int'l Joint Research
• [Presentation] Mechanisms underlying down-regulaton of mGluR5 in astrocytes with ages. (2018)
  • Author(s): Tanaka, M., Shigetomi, E., Parajuli, B., Shinozaki, Y., Hirayama, Y., Saitoh, K., Nabekura, J., Koizumi, S
  • Organizer: WCP2018
  • Int'l Joint Research
• [Presentation] Remodeling the brain after stroke by astrocytic phagocytosis. (2018)
  • Author(s): Morizawa, Y., Koizumi, S
  • Organizer: WCP2018
  • Int'l Joint Research
• [Presentation] Aberrant astrocyte Ca2+ signals ‘AxCa signals’ exacerbate pathological alterations in an Alexander disease model. (2018)
  • Author(s): Saito, K., Shigetomi, E., Yasuda, R., Sato, R., Tanaka, KF., Mikoshiba, K., Mizuta, I., Yoshida, T., Mizuno, T., Koizumi, S.
  • Organizer: WCP2018
  • Int'l Joint Research
• [Presentation] Disordered P2Y6 receptor signaling causes age-dependent pathogenesis of glaucoma. (2018)
  • Author(s): Shinozaki, Y., Kashiwagi, K., Namekata, K., Ohno, N., Takeda, a., Harada, T., Iwata, T., Koizumi, S.
  • Organizer: WCP2018
  • Int'l Joint Research
• [Presentation] An essential role of astrocytic mGluR5 in the somatosensory cortex in regulation of synaptogenesis and neuropathic pain. (2018)
  • Author(s): Danjo, Y., Hirayama, Y., Shigetomi, E., Shibata, K., Takanashi, K., Shinozaki, Y., Kim, SK, Nabekura, J., Koizumi, S.
  • Organizer: WCP2018
  • Int'l Joint Research
• [Presentation] The dysfunction of clock genes induces nocturia associated with disrupted gene expressin rhythm of mechano-sensory channels in the mouse bladder urothelium. (2018)
  • Author(s): 633.Ihara, T., Nakamura, Y., Shigetomi, E., Shinozaki, Y., Nakao, A., Takeda, M., Koizumi, S.
  • Organizer: WCP2018
  • Int'l Joint Research
• [Presentation] Neuroprotection by VNUT-mediated microglia ATP wexcytosis in the ischemic brain (2018)
  • Author(s): Ngoc, Le HP., Hirayama, Y., Tanaka, FK., Koiumi, S.
  • Organizer: WCP2018
  • Int'l Joint Research
• [Presentation] Anti-depressant flupoxetine reveals its therapeutic effect via astrocytes. (2018)
  • Author(s): Kinoshita, M., Hirayama, Y., Fujishita, K., Shibata, K., Shinozaki, Y., Shigetomi, E., Takeda, A., Ngoc, Le HP., Hiasa, M., Moriyama, Y., Ikenaka, K., Tanaka, FK., Koizumi, S.
  • Organizer: WCP2018
  • Int'l Joint Research
• [Presentation] Functional analysis of Down's syndrome associated molecule in the cerebellum excitatory synapse formation (2018)
  • Author(s): Dewa, K., Arimura, N., Taya, S., Sakai, K., Yamasaki, M., Miyazaki, T., Ichinohe, N., Watanabe, M., Koizumi, S., Hoshino, M
  • Organizer: WCP2018
  • Int'l Joint Research
• [Presentation] Contribution of activated glial cells in epileptogenesis after status epilepticus. (2018)
  • Author(s): Sano, F., Shigetomi, E., Koizumi, S., Kanemaru, H., Mikoshiba, K., Aihara, M.
  • Organizer: WCP2018
  • Int'l Joint Research
• [Presentation] Dynamic interaction of neurons and astrocytes revealed dual color Ca2+ imaging (2018)
  • Author(s): Shigetomi, E., Hirayama, Y., Ikenaka, K., Tanaka, FK., Bito, H., Koizumi, S.
  • Organizer: 第10回光操作研究会・第2回脳情報動態合同国際シンポジウム
  • Int'l Joint Research
• [Presentation] てんかんとグリア細胞～AMPA受容体の可能性～ (2018)
  • Author(s): 小泉修一
  • Organizer: 第2回フィコンパを考える会
  • Invited
• [Presentation] グリア細胞による脳リモデリング (2018)
  • Author(s): 小泉修一
  • Organizer: 第48回新潟神経学夏期セミナー
  • Invited
• [Presentation] Astrocyte-dependent brain remodeling (2018)
  • Author(s): Kozumi, S
  • Organizer: 第41回日本神経科学大会
• [Presentation] グリア性てんかん原性の分子メカニズム (2018)
  • Author(s): 小泉修一、佐野史和
  • Organizer: 生体機能と創薬シンポジウム2018
• [Presentation] Adenosine A2B受容体を介したアストロサイトのmGluR5の発現制御機構 (2018)
  • Author(s): 田中雅彬、繁冨英治、パラジュリ・ビージェイ、篠崎陽一、平山友里、斎藤光象、鍋倉淳一、小泉修一
  • Organizer: 生体機能と創薬シンポジウム2018
• [Presentation] Role of microglia in astrogliopahty: a study of Alexander disease model (2018)
  • Author(s): Shigetomi, E., Kobayashi, K., Saito, K., Koizumi, S.
  • Organizer: 第61回日本神経化学会大会
• [Presentation] Role of deficiency in glial ABCA1 on pathogenesis of glaucoma. (2018)
  • Author(s): Shinozaki, Y., Namekata, K., Kashiwagi, K., Ohno, N., Takeda, A., Harada, T
  • Organizer: 第61回日本神経化学会大会
• [Presentation] Astrocyte-mediated network remodeling. (2018)
  • Author(s): Koizumi S
  • Organizer: 第61回日本神経化学会大会
• [Presentation] Reappearance of astricytic mGluR5 in the primary somatosensory cortex is a cause of neuropathic pain - reassembles of cortical networks - (2018)
  • Author(s): Danjo, Y., Hirayama, Y., Shigetomi, E., Shibata, K., Takanashi, K., Shinozaki, Y., Kim, SK., Nabekura, J., Koizumi, S.
  • Organizer: 第61回日本神経化学会大会
• [Presentation] ブシ剤とグリア細胞：先人の知恵から学ぶ痛みの抑制 (2018)
  • Author(s): 小泉修一
  • Organizer: 第75回日本東洋医学会関東甲信越支部学術集会
  • Invited
• [Presentation] A new role of astrocytes in regulation of brain function by ABCA1. (2018)
  • Author(s): Koizumi, S., Morizawa, Y.
  • Organizer: 第91回日本生化学会大会
  • Invited
• [Presentation] てんかんとグリア細胞～AMPA受容体が関与する可能性～ (2018)
  • Author(s): 小泉修一
  • Organizer: Epilepsy Research Symposium
  • Invited
• [Presentation] Bidirectional synapse remodeling by reactive astrocytes. (2018)
  • Author(s): Koizumi, S
  • Organizer: YoungGlia glial heterogeneity meeting
• [Presentation] Astrogliosis by status epilepticus is dependent on IP3 receptor type2. (2018)
  • Author(s): 佐野史和、繁冨英治、小泉修一、金村英秋、御子柴克彦、相原正男
  • Organizer: 第52回日本てんかん学会学術集会
• [Presentation] グリア細胞による神経回路の組み替え (2018)
  • Author(s): 小泉修一
  • Organizer: 第3回トランスポーター研究会関東部会
• [Presentation] Lack of glial ABCA1 causes pathogenesis of glaucoma. (2018)
  • Author(s): Shinozaki, Y., Namekata, K., Kashiwagi, K., Ohno, N., Takeda, A., Harada, T., Koizumi, S
  • Organizer: 第23回グリア研究会
  • Invited
• [Presentation] Anti-depressant fluoxetine reveals its therapeutic effect via astrocytes. (2018)
  • Author(s): Kinoshita, M., Koizumi, S
  • Organizer: 第23回グリア研究会
• [Presentation] VNUT-mediated microglia ATP excytosis contributes to Neuroprotection in the ischemic brain (2018)
  • Author(s): Ngoc, Le HP., Hirayama, Y., Tanaka, FK., Koizumi, S.
  • Organizer: 2018 Cold Spring Harbor Asia Conference
  • Int'l Joint Research
• [Presentation] Dysfunction of ABCA1 in optic astrocytes causes pathogenesis of glaucoma. (2018)
  • Author(s): Shinozaki, Y., Namekata, K., Kashiwagi, K., Ohno, N., Takeda, A., Harada, T., Koizumi, S.
  • Organizer: 2018 Cold Spring Harbor Asia Conference.
  • Int'l Joint Research
• [Presentation] patiotemporal analysis of Neuron-Astrocyte interaction by dual-color calcium imaging (2018)
  • Author(s): Shigetomi, E., Hirayama, Y., Ikenaka, K., Tanaka, FK., Bito, H., Koizumi, S.
  • Organizer: 2018 Cold Spring Harbor Asia Conference
  • Int'l Joint Research
• [Presentation] Reactive astrocyte-mediated synapse remodeling. (2018)
  • Author(s): Koizumi, S.
  • Organizer: 2018 Cold Spring Harbor Asia Conference
  • Int'l Joint Research / Invited