ネオ・セルフ生成における免疫プロテアソームの機能的および病理的意義の解明

• Project Area: Creation, function and structure of neo-self
• Project/Area Number: 19H04813
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Wakayama Medical University
• Principal Investigator: 改正 恒康 和歌山県立医科大学, 先端医学研究所, 教授 (60224325)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000); Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: 自己炎症性疾患 / タンパク質輸送 / 獲得免疫 / I型インターフェロン / プロテアソーム / 炎症 / 遺伝子変異 / 樹状細胞 / 血球分化

Outline of Research at the Start

不要なタンパクを分解除去するシステム、つまりプロテアソームの異常は自己炎症性疾患と呼ばれる難治性炎症病態を引き起こす。本研究では、自己炎症性疾患患者から見出されたプロテアソームの構成サブユニットの新規遺伝子変異を導入したマウスの解析を通じて、プロテアソームの異常が炎症病態とどのように関連するのか解明し、自己炎症性疾患の新たな治療的手段の獲得を目指す。

Outline of Annual Research Achievements

COPA症候群は、間質性肺炎や関節炎を呈する常染色体優性遺伝の自己炎症性疾患であり、I型インターフェロン（IFN）により誘導される遺伝子群（ISG）の発現が増強しているが、自己抗体の産生や異常なT細胞の活性化など獲得免疫の異常も認められる。ゴルジ体から小胞体へのタンパク質輸送を担うタンパク質複合体coat protein complex I (COPI)を構成するサブユニットタンパク質Coatomer subunit α (COPA)のアミノ酸置換をきたすヘテロ変異が原因遺伝子変異であることが明らかになっているものの、その病態はほとんど不明である。今年度は、COPA症候群患者で同定された新規のアミノ酸置換変異（X変異とする）を導入したマウスを樹立し、その解析を進めた。Copa Xヘテロ変異マウスでは、外見はほぼ正常であったが、炎症細胞浸潤を伴う間質性肺炎が高率に認められ、脾臓細胞ではISGの発現が亢進していた。樹状細胞を解析したところ、細胞質内DNAセンサーSTINGシグナルによるI型IFN産生誘導が亢進しており、STINGの下流のシグナル伝達分子が過剰に活性化されていた。また、脾臓でのISGの発現亢進はSTING阻害剤により減弱した。これらの結果から、Copa Xヘテロ変異マウスにおいて、COPA症候群の病態が再現されていること、そしてその病態異常にSTINGシグナルの亢進が関与することが示唆された。今後、Copa X変異マウスにおいて、自然免疫、獲得免疫両面から解析を進め、間質性肺炎など自己炎症性疾患の病態を解明する。

Research Progress Status

令和2年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和2年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] Yale Univ./Harvard Medical School/Emory Univ.(米国)
• [Int'l Joint Research] Univ.of Melbourne/Australian National Univ./Telethon Kids Institute(オーストラリア)
• [Int'l Joint Research] Mainz Univ./Univ. Hospital Wuerzburg/Univ. Hospital Cologne(ドイツ)
• [Int'l Joint Research] London Research Institute/Imperial College/Cardiff Univ.(英国)
• [Int'l Joint Research] San Raffaele Scientific Institute/ICGEB(イタリア)
• [Int'l Joint Research]
• [Int'l Joint Research] Yale Univ./Harvard Medical School/Emory Univ.(米国)
• [Int'l Joint Research] Univ.of Melbourne/Australian National Univ./Telethon Kids Institute(オーストラリア)
• [Int'l Joint Research] Mainz Univ./Univ. Hospital Wuerzburg/Univ. Hospital Cologne(ドイツ)
• [Int'l Joint Research] London Research Institute/Imperial College/Cardiff Univ.(英国)
• [Int'l Joint Research] San Raffaele Scientific Institute/ICGEB(イタリア)
• [Journal Article] Immunogenic tumor cell death promotes dendritic cell migration and inhibits tumor growth via enhanced T cell immunity (2021)
  • Author(s): Moriya Taiki、Kitagawa Kurumi、Hayakawa Yuuki、Hemmi Hiroaki、Kaisho Tsuneyasu、Ueha Satoshi、Ikebuchi Ryoyo、Yasuda Ippei、Nakanishi Yasutaka、Honda Tetsuya、Matsushima Koji、Kabashima Kenji、Ueda Mizuki、Kusumoto Yutaka、Chtanova Tatyana、Tomura Michio
  • Journal Title: iScience Volume: 24 Issue: 5 Pages: 102424-102424
  • DOI: 10.1016/j.isci.2021.102424
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of CpG Depletion of Vector Genome on CD8 + T Cell Responses in AAV Gene Therapy. (2021)
  • Author(s): Thais B Bertolini, Jamie L Shirley, Irene Zolotukhin, Xin Li, Tsuneyasu Kaisho, Weidong Xiao, Sandeep Kumar, Roland W. Herzog
  • Journal Title: Front Immunol Volume: in press
  • Peer Reviewed
• [Journal Article] Augmentation of STING‐induced type I interferon production in COPA syndrome (2021)
  • Author(s): Kato Takashi、Yamamoto Masaki、Honda Yoshitaka、Orimo Takashi、Sasaki Izumi、Murakami Kohei、Hemmi Hiroaki、Fukuda‐Ohta Yuri、Isono Kyoichi、Takayama Saki、Nakamura Hidenori、Otsuki Yoshiro、Miyamoto Toshiaki、Takita Junko、Yasumi Takahiro、Nishikomori Ryuta、Matsubayashi Tadashi、Izawa Kazushi、Kaisho Tsuneyasu
  • Journal Title: Arthritis & Rheumatology Volume: in press Issue: 11 Pages: 2105-2115
  • DOI: 10.1002/art.41790
  • Peer Reviewed / Open Access
• [Journal Article] The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake (2021)
  • Author(s): de Mingo Pulido Alvaro, et al. 全著者16名中10番目
  • Journal Title: Immunity Volume: S1074-7613 Issue: 6 Pages: 00181-3
  • DOI: 10.1016/j.immuni.2021.04.019
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Type I interferon mediated induction of somatostatin leads to suppression of ghrelin and appetite thereby promoting viral immunity in mice (2021)
  • Author(s): Stutte Susanne、Ruf Janina、Kugler Ina、Ishikawa-Ankerhold Hellen、Parzefall Andreas、Marconi Peggy、Maeda Takahiro、Kaisho Tsuneyasu、Krug Anne、Popper Bastian、Lauterbach Henning、Colonna Marco、von Andrian Ulrich、Brocker Thomas
  • Journal Title: Brain, Behavior, and Immunity Volume: S0889-1591 Pages: 00176-8
  • DOI: 10.1016/j.bbi.2021.04.018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Display of Native Antigen on cDC1 That Have Spatial Access to Both T and B Cells Underlies Efficient Humoral Vaccination (2020)
  • Author(s): Kato Yu、Steiner Thiago M.、Park Hae-Young、Hitchcock Rohan O.、Zaid Ali、Hor Jyh Liang、Devi Sapna、Davey Gayle M.、Vremec David、Tullett Kirsteen M.、Tan Peck S.、Ahmet Fatma、Mueller Scott N.、Alonso Sylvie、Tarlinton David M.、Ploegh Hidde L.、Kaisho Tsuneyasu、et al. 全著者24名中17番目
  • Journal Title: The Journal of Immunology Volume: 205 Issue: 7 Pages: 1842-1856
  • DOI: 10.4049/jimmunol.2000549
  • Peer Reviewed
• [Journal Article] PDLIM7 Synergizes With PDLIM2 and p62/Sqstm1 to Inhibit Inflammatory Signaling by Promoting Degradation of the p65 Subunit of NF-κB (2020)
  • Author(s): Jodo Aya、Shibazaki Azusa、Onuma Asuka、Kaisho Tsuneyasu、Tanaka Takashi
  • Journal Title: Frontiers in Immunology Volume: 11 Pages: 1559-1559
  • DOI: 10.3389/fimmu.2020.01559
  • Peer Reviewed
• [Journal Article] 自然免疫が関与する炎症―自然炎症と自己炎症性疾患 (2020)
  • Author(s): 改正恒康
  • Journal Title: 医学のあゆみ Volume: 274 Pages: 379-386
• [Journal Article] Osteoprotegerin-dependent Mcell self-regulation balances gut infection and immunity. (2020)
  • Author(s): Kimura S, Nakamura Y, Kobayashi N, Shiroguchi K, KawakamiE, Mutoh M, Takahashi-Iwanaga H, Yamada T, Hisamoto M, Nakamura M, Udagawa N, Sato S, KaishoT, Iwanaga T, Hase K.
  • Journal Title: Nat Commun Volume: 11 Issue: 1 Pages: 234-234
  • DOI: 10.1038/s41467-019-13883-y
  • Peer Reviewed / Open Access
• [Journal Article] Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity (2020)
  • Author(s): Nakamura Yutaka、Mimuro Hitomi、Kunisawa Jun、Furusawa Yukihiro、Takahashi Daisuke、Fujimura Yumiko、Kaisho Tsuneyasu、Kiyono Hiroshi、Hase Koji
  • Journal Title: Mucosal Immunology Volume: in press Issue: 4 Pages: 679-690
  • DOI: 10.1038/s41385-020-0263-0
  • Peer Reviewed / Open Access
• [Journal Article] Anticancer effects of chemokine-directed antigen delivery to a cross-presenting dendritic cell subset with immune checkpoint blockade (2020)
  • Author(s): Mizumoto Y, Hemmi H, Katsuda M, Miyazawa M, Kitahata Y, Miyamoto A, Nakamori M, Ojima T, Matsuda K, Nakamura M, Hayata K, Fukuda-Ohta Y, Sugiyama M, Ohta T, Orimo T, Okura S, Sasaki I, Tamada K, Yamaue H, Kaisho T.
  • Journal Title: British Journal of Cancer Volume: 122 Issue: 8 Pages: 1185-1193
  • DOI: 10.1038/s41416-020-0757-2
  • Peer Reviewed / Open Access
• [Journal Article] The mechanism of action of Spi-B in the transcriptional activation of the interferon-α4 gene. (2020)
  • Author(s): R. Miyazaki, H. Saiga, T. Kato, T. Bakoshi, R. Senba, A. Shintani, M. Suzuki, K. Takao, I. Sasaki, A. Iizuka, M. Sugiyama, N. Iwami, Y. Fukuda-Ohta, H. Hemmi, T. Tanaka, M. Miyake, T. Kaisho, K. Hoshino.
  • Journal Title: Biochem Biophys Res Commun. Volume: 30;525 Issue: 2 Pages: 477-482
  • DOI: 10.1016/j.bbrc.2020.02.101
  • Peer Reviewed / Open Access
• [Journal Article] IL-12 From Endogenous cDC1, and Not Vaccine DC, Is Required for Th1 Induction. (2020)
  • Author(s): D. Ashour, P. Arampatzi, V. Pavlovic, K. U Forstner, T. Kaisho, A. Beilhack, F. Erhard, M. B Lutz.
  • Journal Title: JCI Insight Volume: 21;5 Issue: 10 Pages: 135143-135143
  • DOI: 10.1172/jci.insight.135143
  • Peer Reviewed / Open Access
• [Journal Article] A defined commensal consortium elicits CD8 T cells and anti-cancer immunity (2019)
  • Author(s): T.Tanoue, S.Morita, D.R.Plichta, A.N.Skelly, W.Suda, Y.Sugiura, S.Narushima, H.Vlamakis, I.Motoo, K.Sugita, A.Shiota, K.Takeshita, K.Yasuma, D.Riethmacher, T.Kaisho, J.M.Norman, D.Mucida, M.Suematsu, T.Yaguchi, V.Bucci, T.Inoue, Y.Kawakami, B.Olle, B.Roberts, M.Hattori, R.J.Xavier, K.Atarashi, K.Honda
  • Journal Title: Nature Volume: 565 Issue: 7741 Pages: 600-605
  • DOI: 10.1038/s41586-019-0878-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cholera toxin B induces interleukin-1β production from resident peritoneal macrophages through the pyrin inflammasome as well as the NLRP3 inflammasome (2019)
  • Author(s): Orimo T, Sasaki I, Hemmi H, Ozasa T, Fukuda-Ohta Y, Ohta T, Morinaka M, Kitauchi M, Yamaguchi T, Sato Y, Tanaka T, Hoshino K, Katayama KI, Fukuda S, Miyake K, Yamamoto M, Satoh T, Furukawa K, Kuroda E, Ishii KJ, Takeda K, Kaisho T
  • Journal Title: International Immunology Volume: 印刷中 Issue: 10 Pages: 657-668
  • DOI: 10.1093/intimm/dxz004
  • Peer Reviewed / Open Access
• [Journal Article] Hyperglycemia is associated with psoriatic inflammation in both humans and mice (2019)
  • Author(s): Ikumi K, Odanaka M, Shime H, Imai M, Osaga S, Taguchi O, Nishida E, Hemmi H, Kaisho T, Morita A, Yamazaki S
  • Journal Title: Journal of Investigative Dermatology Volume: 印刷中 Issue: 6 Pages: 1329-1338
  • DOI: 10.1016/j.jid.2019.01.029
  • Peer Reviewed / Open Access
• [Journal Article] Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice (2019)
  • Author(s): Kimura Shunsuke、Kobayashi Nobuhide、Nakamura Yutaka、Kanaya Takashi、Takahashi Daisuke、Fujiki Ryoji、Mutoh Mami、Obata Yuuki、Iwanaga Toshihiko、Nakagawa Tomoo、Kato Naoya、Sato Shintaro、Kaisho Tsuneyasu、Ohno Hiroshi、Hase Koji
  • Journal Title: The Journal of Experimental Medicine Volume: 216 Issue: 4 Pages: 831-846
  • DOI: 10.1084/jem.20181604
  • Peer Reviewed / Open Access
• [Journal Article] Identification of a novel CCDC22 mutation in a patient with severe Epstein?Barr virus-associated hemophagocytic lymphohistiocytosis and aggressive natural killer cell leukemia (2019)
  • Author(s): Yamashita Y, Nishikawa A, Iwahashi Y, Fujimoto M, Sasaki I, Mishima H, Kinoshita A, Hemmi H, Kanazawa N, Ohshima K, Imadome KI, Murata SI、Yoshiura KI, Kaisho T, Sonoki T, Tamura S
  • Journal Title: International Journal of Hematology Volume: 印刷中 Issue: 6 Pages: 744-750
  • DOI: 10.1007/s12185-019-02595-0
  • Peer Reviewed / Open Access
• [Journal Article] Programmed cell death ligand 1 disruption by clustered regularly interspaced short palindromic repeats/Cas9‐genome editing promotes antitumor immunity and suppresses ovarian cancer progression (2019)
  • Author(s): Yahata T, Mizoguchi M, Kimura A, Orimo T, Toujima S, Kuninaka Y, Nosaka M, Ishida Y, Sasaki I, Fukuda‐Ohta Y, Hemmi H, Iwahashi N, Noguchi T, Kaisho T, Kondo T, Ino K
  • Journal Title: Cancer Science Volume: 110 Issue: 4 Pages: 1279-1292
  • DOI: 10.1111/cas.13958
  • Peer Reviewed / Open Access
• [Journal Article] Systems analysis reveals complex biological processes during virus infection fate decisions. (2019)
  • Author(s): Argilaguet. J, Pedragosa. M, Esteve-Codina. A, Riera. G, Vidal. E, Peligero-Cruz. C, Casella. V, Andreu. D, Kaisho. T, Bocharov. G, Ludewig. B, Heath. S, Meyerhans. A.
  • Journal Title: Genome Res Volume: 29 Issue: 6 Pages: 907-919
  • DOI: 10.1101/gr.241372.118
  • Peer Reviewed / Open Access
• [Journal Article] Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1+ Dendritic Cells. (2019)
  • Author(s): Tsuchiya N, Zhang R, Iwama T, Ueda N, Liu T, Tatsumi M, Sasaki Y, Shimoda R, Osako Y, Sawada Y, Kubo Y, Miyashita A, Fukushima S, Cheng Z, Nakaki R, Takubo K, Okada S, Kaneko S, Ihn H, Kaisho T, Nishimura Y, Senju S, Endo I, Nakatsura T, Uemura Y.
  • Journal Title: Cell Rep. Volume: 29 Issue: 1 Pages: 162-175
  • DOI: 10.1016/j.celrep.2019.08.086
  • Peer Reviewed / Open Access
• [Presentation] The roles of unfold protein responses in cholera toxinB-induced interleukin-1β production. (2020)
  • Author(s): 佐々木泉、折茂貴是、張江伊水、滝沢優子、古川綱一、改正恒康
  • Organizer: 第27回日本免疫毒性学会学術年会（WEB開催）
• [Presentation] 遺伝性炎症性疾患COPA症候群の分子基盤の解明 (2020)
  • Author(s): 田中日尚子、林茉里、加藤喬、折茂貴是、大田（福田）有里、西山奈央子、中井千尋、佐々木泉、改正恒康
  • Organizer: 第88回和歌山医学会総会（WEB開催）
• [Presentation] 遺伝性炎症性疾患COPA症候群のモデルマウスの樹立とその解析 (2020)
  • Author(s): 張江伊水、滝沢優子、加藤喬、折茂貴是、大田（福田）有里、西山奈央子、中井千尋、佐々木泉、改正恒康
  • Organizer: 第88回和歌山医学会総会（WEB開催）
• [Presentation] 自然免疫応答における小胞体ストレスセンサ ー IREla の機能的意義 (2020)
  • Author(s): 三並桃花、石田エヴァ如月、加藤喬、折茂貴是、大田（福田）有里、西山奈央子、中井千尋、佐々木泉、改正恒康
  • Organizer: 第88回和歌山医学会総会（WEB開催）
• [Presentation] Role of cross-presenting dendritic cells in anti-PD-L1 immunotherapy of chronic viral infections. (2020)
  • Author(s): E. Domenjo-Vila, V. Casella, R. Iwabuchi, E. Fossum, M. Pedragosa, Q. Castellvi, T. Kaisho, K. Terahara, G. Bocharov, J. Argilaguet, A. Meyerhans.
  • Organizer: 2nd Research Symposium on Coronavirus / XIX Jornada de Virologia / Virology Meeting 2020. Online meeting.
  • Int'l Joint Research
• [Presentation] Impaired development of myeloid cells in mice carrying a patient-derived proteasome subunit mutation. (2020)
  • Author(s): 邊見弘明、折茂貴是、佐々木泉、加藤喬、大田(福田)有里、金城紀子、濱田聡、木下晃、吉浦孝一郎、大西秀典、金澤伸雄、改正恒康
  • Organizer: 第3回日本免疫不全・自己炎症学会総会・学術集会
  • Invited
• [Presentation] Novel proteasome-related autoinflammation and immunodeficiency disease caused by a distinct heterozygous missense mutation in the PSMB9 gene. (2019)
  • Author(s): N. Kanazawa, Y. Nakatani, Y. Inaba, K. Kunimoto, N. Kinjo, S. Hamada, T. Mizushima, A. Kinoshita, K. Yoshiura, J. Hamazaki, S. Murata, H. Ohnishi, T. Orimo, H. Hemmi, T. Kaisho.
  • Organizer: The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Invited
• [Presentation] 乳児期から発熱と凍瘡様皮疹を反復し、新規のインターフェロン調節遺伝子異常が疑われた親子例 (2019)
  • Author(s): 本田尭、土橋隆俊、番場正博、大方詩子、渡辺絵美子、宮川俊一、杉浦仁、稲葉豊、神人正寿、井澤和司、邊見弘明、改正恒康、三嶋博之、木下晃、吉浦孝一郎、金澤伸雄
  • Organizer: 第2回日本免疫不全・自己炎症学会総会・学術集会
  • Invited
• [Presentation] 複合免疫不全症を来す新規LIG4症候群モデルマウスは炎症性腸疾患を自然発症する (2019)
  • Author(s): 田村志宣、山下友佑、大田（福田）有里、小笹俊哉、金澤伸雄、安岡弘直, 邊見弘明, 大島孝一、改正恒康、園木孝志
  • Organizer: 第59回リンパ網内系学会
  • Invited
• [Presentation] コレラ毒素Bサブユニットは細胞内病原体センサーNLRP3とPyrinを介して炎症性サイトカインIL-1βの産生を誘導する (2019)
  • Author(s): 佐々木泉、折茂貴是、邊見弘明、古川鋼一、改正恒康
  • Organizer: 第29回日本樹状細胞研究会
  • Invited
• [Presentation] ヒト疾患由来プロテアソームサブユニット突然変異導入マウスにおける樹状細胞分化障害 (2019)
  • Author(s): 邊見弘明、小笹俊哉、加藤喬、折茂貴是、大田（福田）有里、金澤伸雄、改正恒康
  • Organizer: 第29回日本樹状細胞研究会
  • Invited
• [Presentation] Lig4遺伝子改変マウスを用いた腸管免疫寛容破綻の病態解明 (2019)
  • Author(s): 田村志宣、山下友佑、折茂貴是、大田（福田）有里、小笹俊哉、中嶋一貴、金澤伸雄、邊見弘明、大島孝一、改正恒康、園木孝志
  • Organizer: 第47回日本臨床免疫学会総会
  • Invited
• [Presentation] 実験的自己免疫性脳脊髄炎の病態形成における腸管免疫系の重要性の検証 (2019)
  • Author(s): 込山星河、江川愛子、高橋大輔、改正恒康、長谷耕二
  • Organizer: 日本薬学会関東支部会
  • Invited
• [Presentation] コレラ毒素Bサブユニットによる炎症性サイトカインIL-1β産生誘導機構 (2019)
  • Author(s): 佐々木泉、折茂貴是、邊見弘明、土屋慧馬、井上正一、熊谷直光、古川鋼一、改正恒康
  • Organizer: 第26回日本免疫毒性学会学術年会
  • Invited
• [Presentation] Akimichi Morita, Sayuri Yamazaki.Successful treatment of psoriatic inflammation improves hyperglycemia in humans and mice. (2019)
  • Author(s): M. Odanaka, K. Ikumi, H. Shime, M. Imai, E. Nishida, H. Hemmi, T. Kaisho.
  • Organizer: 第48回日本免疫学会総会・学術集会記録
  • Invited
• [Presentation] Defective dendritic cell and monocyte development in proteasome subunit mutant miceDefective dendritic cell and monocyte development in proteasome subunit mutant mice. (2019)
  • Author(s): H. Hemmi, T. Orimo, I. Sasaki, T. Kato, Y. Fukuda-Ohta, N. Kinjo, S. Hamada, A. Kinoshita, K. Yoshiura, H. Ohnishi, N. Kanazawa, T. Kaisho.
  • Organizer: 第48回日本免疫学会総会・学術集会記録
  • Invited
• [Presentation] Roles of endoplasmic reticulum stress in cholera toxinB-induced interleukine-1β production from resident peritoneal macrophages. (2019)
  • Author(s): I. Sasaki, S. Morita, D. Okuzaki, T. Orimo, H. Hemmi, K. Furukawa, T. Kaisho.
  • Organizer: 第48回日本免疫学会総会・学術集会記録
  • Invited
• [Presentation] Novel proteasome-related autoinflammation and immunodeficiency disease caused by a distinct heterozygous missense mutation in the PSMB9 gene. (2019)
  • Author(s): N. Kanazawa, N. Kinjo, S. Hamada, T. Mizushima, A. Kinoshita, K. Yoshiura, J. Hamazaki, S. Murata, H. Ohnishi, T. Orimo, H. Hemmi, T. Kaisho.
  • Organizer: 第48回日本免疫学会総会・学術集会記録
  • Invited
• [Presentation] Generation and analysis of mice carrying a novel heterozygous missense mutation of a protease subunit, PSMB9, in patients with autoinflammation and immunodeficiency. (2019)
  • Author(s): H. Hemmi, N. Kanazawa, N. Kinjo, S. Hamada, H. Ohnishi, T. Mizushima, A. Kinoshita, K.-I. Yoshiura, T. Kaisho.
  • Organizer: The 10th Biannual Meeting of the International Society of Systemic Auto-Inflammatory Diseases (ISSAID)
  • Int'l Joint Research
• [Presentation] A case of neonatal-onset proteasome-associated autoinflammation and immunodeficiency disease resembling but distinct from Nakajo-Nishimura syndrome. (2019)
  • Author(s): Kinjo, S. Hamads, K. Nakanishi, H. Mishima, A. Kinoshita, K.-I. Yoshiura, T. Mizushima, J. Hamazaki, S. Murata, H. Hemmi, T. Kaisho, N. Kanazawa.
  • Organizer: The 10th Biannual Meeting of the International Society of Systemic Auto-Inflammatory Diseases
  • Int'l Joint Research
• [Presentation] Regulatory T cells with a distinctive feature expand through dermal dendritic cells in the ultraviolet B exposed skin. (2019)
  • Author(s): S. Yamazaki, M. Odanaka, H. Shime, M. Imai, H. Hemmi, T. Kaisho, N. Ohkura, S. Sakaguchi, A. Morita.
  • Organizer: 16th International Workshop on Langerhans Cells
  • Int'l Joint Research
• [Presentation] Sox8 is essential for the maturation of M cells and accelerates IgA response at the early stage after weaning. The 18th Awaji International Forum on Infection and Immunity. (2019)
  • Author(s): N. Kobayashi, S. Kimura, Y. Nakamura, T. Kanaya, T. Kaisho, H. Ohno, T. Iwanaga, K. Hase.
  • Organizer: Awaji Yumebutai International Conference Center
  • Int'l Joint Research
• [Presentation] Cholera toxin B can induce interleukine-1β production from resident peritoneal macrophages in synergy with lipopolysaccharides. (2019)
  • Author(s): I. Sasaki, T. Orimo, H. Hemmi, K. Furukawa, T. Kaisho.
  • Organizer: The 18th Awaji International Forum on Infection and Immunity.
  • Int'l Joint Research
• [Presentation] ケモカイン受容体XCR1を発現する樹状細胞サブセットによる免疫制御 (2019)
  • Author(s): 改正恒康.
  • Organizer: 近畿大学薬学部
  • Invited
• [Remarks] 新規抗がんワクチン開発 県立医大が成果を発表
  • URL: https://www.wakayamashimpo.co.jp/2020/03/20200317_92750.html
• [Remarks] 県立医科大研究チームが新がんワクチン開発
  • URL: https://www.hidakashimpo.co.jp/news1/2020/03
• [Remarks] 抗がん活性の強い樹状細胞へがん抗原ペプチドを選択的に送達させる新規抗がんワクチンの開発
  • URL: https://research-er.jp/articles/view/87282