Energy-Harvesting-and-Sensing-Combined Integrated Blood Glucose Sensor for Continuous Blood Glucose Monitoring in Dark Space

• Project Area: Systems Science of Bio-navigation
• Project/Area Number: 19H04932
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Kyoto University (2020); Nagoya University (2019)
• Principal Investigator: 新津 葵一 京都大学, 情報学研究科, 教授 (40584785)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000); Fiscal Year 2020: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
• Keywords: 半導体集積回路 / バイオセンサ / IoT / 電力自立 / 22nm CMOS / 先端半導体 / 集積回路設計 / アナログ集積回路 / 持続血糖モニタリング / 発電センシング一体型集積センサ / CMOS集積回路 / ヘルスケア / AI / 環境発電 / 生体発電 / グルコース発電 / ＣＭＯＳ / 無線通信

Outline of Research at the Start

太陽光発電が利用できない、暗所において電力自立かつ野生動物装着可能な持続血糖モニタリングを実現することを目的として、血糖発電と血糖センシングを一体化して行う発電センシング一体型集積血糖センサ技術の研究開発を実施する。研究開発を通じて、野生動物に対する負担の小さい持続血糖モニタリングを可能とすることによる、生物移動情報学の発展への貢献について可能性を検証する。

Outline of Annual Research Achievements

本研究においては、太陽光発電が利用できない、暗所において電力自立かつ野生動物装着可能な持続血糖モニタリングを実現することを目的として、血糖発電と血糖センシングを一体化して行う発電センシング一体型集積血糖センサ技術の研究開発を実施した。研究開発を通じて、野生動物に対する負担の小さい持続血糖モニタリングを可能とすることによる、生物移動情報学の発展への貢献について可能性を検証した。
初めに、野生動物における皮下組織間質液を模擬した模擬生体液において評価を行い、その際に得られる性能指標から侵襲性を見積もり、以降における動物実験への準備を行った。
侵襲性の低い超小型の無痛針形状の固体素子型グルコース発電素子ならびに180nm/65nm/22nm CMOS プロセスにより製造したセンシング並びに無線通信等の情報伝達を行う半導体集積回路を組み合わせ、室内飼育動物搭載可能な持続血糖モニタリングデバイスのプロトタイプの試作を行った。
研究開発を通じて、極めて低電力で動作するバイオセンサ集積回路の設計・試作に成功した。具体的には、バイオ発電素子の出力から生体情報を取得・蓄積し、それを無線送信する集積回路の開発に成功した。65nm 低電力 CMOSプロセスを用いて、実集積回路デバイスにおいて実現可能性を実証することに成功した。また、極めて低電力で動作する周波数シフト型のミリ波帯バイオイメージング技術の開発に成功した。22nm 超低リーク電流 CMOSプロセスを用いて、実集積回路デバイスにおいて実現可能性を実証することに成功した。
これらの研究開発成果により、太陽光発電が利用できない環境下においても、電力自立かつ野生動物装着可能な持続血糖モニタリングの実現に成功した。

Research Progress Status

令和2年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和2年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Design and Experimental Verification of a 2.1nW 0.018mm² Slope ADC-Based Supply Voltage Monitor for Biofuel-Cell-Powered Supply-Sensing Systems in 180-nm CMOS (2022)
  • Author(s): CHEN Guowei、CHEN Xujiaming、NIITSU Kiichi
  • Journal Title: IEICE Transactions on Electronics Volume: E105.C Issue: 10 Pages: 565-570
  • DOI: 10.1587/transele.2021CTS0001
  • ISSN: 0916-8524, 1745-1353
  • Year and Date: 2022-10-01
  • Peer Reviewed / Open Access
• [Journal Article] A 4.5-mW 22-nm CMOS Label-Free Frequency-Shift 3 × 3 × 2 3-D Biosensor Array Using Vertically Stacked 60-GHz LC Oscillators (2022)
  • Author(s): Tanaka Akiyoshi、Chen Guowei、Niitsu Kiichi
  • Journal Title: IEEE Transactions on Circuits and Systems II: Express Briefs Volume: 69 Issue: 10 Pages: 4078-4082
  • DOI: 10.1109/tcsii.2022.3185542
  • Peer Reviewed / Open Access
• [Journal Article] Design and Theoretical Analysis of A BER-Modulated Inductive-Coupling Transceiver Using Dynamic Intermediate InterferenceControl Technique for Low-Power Communication (2020)
  • Author(s): G. Xu, K. Hayashi, S. Arata, S. Murakami, D. C. Bui, A. Kobayashi and K. Niitsu
  • Journal Title: Sensors and Materials Volume: -
  • Peer Reviewed
• [Journal Article] Design and Verification of a Stochastic Oscillator Using Multiple Ring Oscillators and OR Gate for Low Voltage Operation in 65 nm CMOS (2020)
  • Author(s): S. Murakami, K. Hayashi, S. Arata, G. Xu, C. D. Bui, A. Kobayashi, and K. Niitsu
  • Journal Title: Sensors and Materials Volume: -
  • Peer Reviewed
• [Journal Article] Fabrication of needle type solid-state CMOS compatible glucosefuel cell by CNT material for biomedical application (2020)
  • Author(s): M. Z. Islam, S. Arata, K. Hayashi, A. Kobayashi and K. Niitsu
  • Journal Title: Sensors and Materials Volume: -
  • Peer Reviewed
• [Journal Article] A Low-Power Inductive-Coupling Transmitter Using Supply-Insensitive Auxiliary Driving Under Supply-Voltage Fluctuation (2020)
  • Author(s): Y. Nishio, A. Kobayashi and K. Niitsu
  • Journal Title: Sensors and Materials Volume: -
  • Peer Reviewed
• [Journal Article] A 385×385µm² 0.165V 0.27nW Fully-Integrated Supply-Modulated OOK Transmitter in 65nm CMOS for Glasses-Free, Self-Powered, and Fuel-Cell-Embedded Continuous Glucose Monitoring Contact Lens (2019)
  • Author(s): HAYASHI Kenya、ARATA Shigeki、XU Ge、MURAKAMI Shunya、BUI Cong Dang、KOBAYASHI Atsuki、NIITSU Kiichi
  • Journal Title: IEICE Transactions on Electronics Volume: E102.C Issue: 7 Pages: 590-594
  • DOI: 10.1587/transele.2018CTS0005
  • NAID: 130007671363
  • ISSN: 0916-8524, 1745-1353
  • Year and Date: 2019-07-01
  • Peer Reviewed / Open Access
• [Journal Article] An FSK Inductive-Coupling Transceiver Using 60mV 0.64fJ/bit 0.0016mm² Load-Modulated Transmitter and LC-Oscillator-Based Receiver in 65nm CMOS for Energy-Budget-Unbalanced Application (2019)
  • Author(s): HAYASHI Kenya、ARATA Shigeki、XU Ge、MURAKAMI Shunya、BUI Cong Dang、KOBAYASHI Atsuki、NIITSU Kiichi
  • Journal Title: IEICE Transactions on Electronics Volume: E102.C Issue: 7 Pages: 585-589
  • DOI: 10.1587/transele.2018CTS0002
  • NAID: 130007671362
  • ISSN: 0916-8524, 1745-1353
  • Year and Date: 2019-07-01
  • Peer Reviewed / Open Access
• [Journal Article] Design and Calibration of a Small-Footprint, Low-Frequency, and Low-Power Gate Leakage Timer Using Differential Leakage Technique (2019)
  • Author(s): NISHIO Yuya、KOBAYASHI Atsuki、NIITSU Kiichi
  • Journal Title: IEICE Transactions on Electronics Volume: E102.C Issue: 4 Pages: 269-275
  • DOI: 10.1587/transele.2018CDP0005
  • NAID: 130007621829
  • ISSN: 0916-8524, 1745-1353
  • Year and Date: 2019-04-01
  • Peer Reviewed / Open Access
• [Journal Article] Design of a Self-Controlled Dual-Oscillator-Based Supply Voltage Monitor for Biofuel-Cell-Combined Biosensing Systems in 65-nm CMOS and 55-nm DDC CMOS (2019)
  • Author(s): Kobayashi Atsuki、Hayashi Kenya、Arata Shigeki、Murakami Shunya、Xu Ge、Niitsu Kiichi
  • Journal Title: IEEE Transactions on Biomedical Circuits and Systems Volume: 13 Issue: 6 Pages: 1152-1162
  • DOI: 10.1109/tbcas.2019.2950509
  • Peer Reviewed / Open Access
• [Journal Article] Design and theoretical analysis of a clock jitter reduction circuit using gated phase blending between self-delayed clock edges (2019)
  • Author(s): Niitsu Kiichi、Kobayashi Osamu、Yamaguchi Takahiro J.、Kobayashi Haruo
  • Journal Title: IEICE Electronics Express Volume: 16 Issue: 13 Pages: 20190218-20190218
  • DOI: 10.1587/elex.16.20190218
  • NAID: 130007677138
  • ISSN: 1349-2543
  • Peer Reviewed / Open Access
• [Journal Article] An Energy-Autonomous Biosensing Platform Using Supply-Sensing CMOS Integrated Sensor and Bio Fuel Cell for Next-Generation Healthcare IoT (2019)
  • Author(s): K. Niitsu
  • Journal Title: Japanese Journal of Applied Physics Volume: 57 Issue: 10 Pages: 1002A5-1002A5
  • DOI: 10.7567/jjap.57.1002a5
  • Peer Reviewed / Open Access
• [Journal Article] Design and analysis of a three-dimensional millimeter-wave frequency-shift based CMOS biosensor using vertically stacked spiral inductors in LC oscillators (2019)
  • Author(s): M. Matsunaga, T. Nakanishi, A. Kobayashi, K. Nakazato, and K. Niitsu
  • Journal Title: Analog Integrated Circuits and Signal Processing Volume: 98 Issue: 3 Pages: 453-464
  • DOI: 10.1007/s10470-018-1267-5
  • Peer Reviewed
• [Presentation] A Battery-Less 0.37 V 126 nW 0.29 mm2 65-nm CMOS Biofuel-Cell-Modulated Biosensing System Featuring an FSK-PIM-Combined 2.4 GHz Transmitter for Continuous Glucose Monitoring Contact Lenses (2023)
  • Author(s): Guowei Chen, Akiyoshi Tanaka and Kiichi Niitsu
  • Organizer: IEEE Symposium on Circuits and Systems (ISCAS 2023)
  • Int'l Joint Research
• [Presentation] A 22nm CMOS 1.25V 29pW 0.000013 mm2 Supply Voltage Detector Using Stacked 3 Thick-Gate-Oxide PMOSs and Dynamic Leakage Suppression Buffer (2022)
  • Author(s): Yuma Hayashi and Kiichi Niitsu
  • Organizer: International Conference on Solid State Devices and Materials (SSDM 2022)
  • Int'l Joint Research
• [Presentation] A 4.5-mW 22-nm CMOS Label-Free Frequency-Shift 3×3×2 3D Biosensor Array Using Vertically-Stacked 60-GHz LC Oscillators (2022)
  • Author(s): Akiyoshi Tanaka, Guowei Chen, and Kiichi Niitsu
  • Organizer: IEEE International Symposium on Integrated Circuits and Systems (ISICAS 2022)
  • Int'l Joint Research
• [Presentation] A 0.00023 mm2 1.2V 0.48mW 18GHz Passive-Less Digital Wireless Transmitter with On-Chip Antenna in 22nm Bulk CMOS (2022)
  • Author(s): Shinichi Ito, Akiyoshi Tanaka, Guowei Chen, Xujiaming Chen and Kiichi Niitsu
  • Organizer: IEEE International Midwest Symposium on Circuits and Systems (MWSCAS 2022)
  • Int'l Joint Research
• [Presentation] A 4.8-mW Label-free Frequency-shift 3×3×2 3D Biosensor Array with Vertically-stacked60-GHz LC Oscillators in 22-nm CMOS (2022)
  • Author(s): Akiyoshi Tanaka, Guowei Chen and Kiichi Niitsu
  • Organizer: IEEE International Midwest Symposium on Circuits and Systems (MWSCAS 2022)
  • Int'l Joint Research
• [Presentation] Bio-Fuel-Cell-Operated Biosensing System: Fundamental and Forecast (2020)
  • Author(s): K. Niitsu
  • Organizer: IEEE Latin American Symposium on Circuits and Systems (LASCAS)
  • Int'l Joint Research / Invited
• [Presentation] A LC-Voltage-Controlled-Oscillator-Based BiosensorFocusing on β-Dispersion for Detecting Exosome in180 nm CMOS (2019)
  • Author(s): S. Murakami, T. Nakanishi, K. Hayashi, A. Kobayashi, M. Z.Islam, and K. Niitsu
  • Organizer: IEEE Asia Pacific Conference on Circuits and Systems (APCCAS 2019)
  • Int'l Joint Research
• [Presentation] A Solar-Cell-Assisted, 99.66% Biofuel Cell Area Reduced, Biofuel-Cell-Powered Wireless Biosensing System in 65-nm CMOS for Continuous Glucose Monitoring Contact Lenses (2019)
  • Author(s): A. Kobayashi, K. Hayashi, S. Arata, G. Xu, S. Murakami, C. D. Bui, T. M. Quan, M. Z. Islam, K. Niitsu
  • Organizer: IEEE International Conference on Electronics, Circuits and Systems (ICECS 2019)
  • Int'l Joint Research
• [Presentation] Verification of Inductive-Coupling-Based CMOS Biosensor Focusing Dielectric Loss of β-Dispersion for Detecting Exosomes Through Electromagnetic Simulation (2019)
  • Author(s): S. Murakami, T. Nakanishi, A. Kobayashi, M. Z. Islam, K. Niitsu
  • Organizer: IEEE International Conference on Electronics, Circuits and Systems (ICECS 2019)
  • Int'l Joint Research
• [Presentation] A 40-GHz Fully-Integrated CMOS-Based Biosensor Circuit With an On-Chip Vector Network Analyzer for Circulaitng Tumor Cells Analysis (2019)
  • Author(s): T. Nakanishi, S. Murakami, A. Kobayashi, M. Z. Islam, and K. Niitsu
  • Organizer: IEEE NorCAS Conference
  • Int'l Joint Research
• [Presentation] A 2.1-nW Burst-Pulse-Counting Supply VoltageMonitor for Biofuel-Cell-Combined Biosensing Systems in 180-nm CMOS (2019)
  • Author(s): A. Kobayashi, K. Hayashi, S. Arata, S. Murakami, G. Xu, M. Z. Islam, and K. Niitsu
  • Organizer: IEEE Biomedical Circuits and Systems Conference (BioCAS 2019)
  • Int'l Joint Research
• [Presentation] 1D structural CNH dependency in needle type Solid-state CMOS compatible glu-cose Fuel Cell for open-circuit voltage and their biomedical application (2019)
  • Author(s): M. Z. Islam, S. Arata, K. Hayashi, A. Kobayashi, Y. Momoi and K. Niitsu
  • Organizer: 2019 international Conference on Solid State Devices and Materials
  • Int'l Joint Research
• [Presentation] Design of Inductive-Coupling-Based CMOS Biosensor Focusing Dielectric Loss of βDispersion for Detecting Exosomes (2019)
  • Author(s): S. Murakami, T. Nakanishi, A. Kobayashi, M. Z. Islam, K. Niitsu
  • Organizer: 2019 Taiwan and Japan Conference on Circuits and Systems (TJCAS 2019 at Nikko)
  • Int'l Joint Research
• [Presentation] A 40-GHz Fully Integrated On-Chip-VNA-based Circulating Tumor Cells Analyzer in 65-nm CMOS Technology (2019)
  • Author(s): T. Nakanishi, S. Murakami, A. Kobayashi, Md. Z. Islam, K. Niitsu
  • Organizer: 2019 Taiwan and Japan Conference on Circuits and Systems (TJCAS 2019 at Nikko)
  • Int'l Joint Research
• [Presentation] Design of On-Chip Integrated Solar Cells in 65nm CMOS Technology for Solar-Cell-Powered Continuous Glucose Monitoring Systems (2019)
  • Author(s): K. Uchiyama, S. Jodo, S. Murakami, M. Z. Islam, A. Kobayashi, K. Niitsu
  • Organizer: 2019 Taiwan and Japan Conference on Circuits and Systems (TJCAS 2019 at Nikko)
  • Int'l Joint Research
• [Presentation] Design of CMOS GaN Gate Driver for 13.56MHz GaN-Based Power Electronics Application in 180nm High-Voltage CMOS Technology (2019)
  • Author(s): S. Jodo, C. D. Bui, K. Uchiyama, M. Z. Islam, A. Kobayashi, K. Niitsu
  • Organizer: 2019 Taiwan and Japan Conference on Circuits and Systems (TJCAS 2019 at Nikko)
  • Int'l Joint Research
• [Presentation] Desing of A CML-Based NMOS-Only SelfOscillating Voltage Doubler for Enabling UltraLow Start-Up Voltage in 65-nm CMOS Technology (2019)
  • Author(s): R. Sakai, S. Murakami, T. Nakanishi, M. Z. Islam, A. Kobayashi, K. Niitsu
  • Organizer: 2019 Taiwan and Japan Conference on Circuits and Systems (TJCAS 2019 at Nikko)
  • Int'l Joint Research
• [Presentation] Enhance OCV of CNH dependency in Solid-state CMOS compatible glucose Fuel Cell for next-generation internet of things (IoT) (2019)
  • Author(s): M. Z. Islam, S. Arata, K. Hayashi, A. Kobayashi, Y. Momoi and K. Niitsu
  • Organizer: Molecular Electronics and Bioelectronics (M&BE)
  • Int'l Joint Research
• [Presentation] 0.27nW Fully-Integrated Supply-Modulated OOK Transmitter in 65nm CMOS for Self-Powered and Low-Cost Continuous Glucose Monitoring Contact Lens (2019)
  • Author(s): K. Hayashi, S. Arata, G. Xu, S. Murakami, C. D. Bui, A. Kobayashi, and K. Niitsu
  • Organizer: ISPlasma2019 / IC-PLANTS2019
  • Int'l Joint Research
• [Presentation] Various Type of CNT Dispersion Applied to Bio-Fuel Cell for High Yield of Production (2019)
  • Author(s): M. Z. Islam, S. Arata, K. Hayashi, A. Kobayashi and K. Niitsu
  • Organizer: ISPlasma2019 / IC-PLANTS2019
  • Int'l Joint Research
• [Presentation] A 65-nm CMOS 1.4-nW Self-Controlled Dual-Oscillator-Based Supply Voltage Monitor for Biofuel-Cell-Combined Biosensing Systems (2019)
  • Author(s): A. Kobayashi, K. Hayashi, S. Arata, S. Murakami, G. Xu, and K. Niitsu
  • Organizer: IEEE International Conference on International Symposium Circuits and Systems (ISCAS 2019)
  • Int'l Joint Research
• [Presentation] CMOS biomedical IoT design for tissue engineering and regenerative medicine (2019)
  • Author(s): K. Niitsu
  • Organizer: The 3rd Conference on Tissue Engineering and Regenerative Medicine (CTERM 2019)
  • Int'l Joint Research / Invited
• [Presentation] AI-Based Edge-Intelligent Hypoglycemia Prediction System Using Alternate Learning and Inference Method for Blood Glucose Level Data with Low-periodicity (2019)
  • Author(s): T. M. Quan, T. Doike, D. C. Bui, K. hayashi, S. Arata, A. Kobayashi, Md. Z. Islam, K. Niitsu
  • Organizer: IEEE International Conference on Artificial Intelligence Circuits and Systems (AICAS 2019)
  • Int'l Joint Research
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