ヘリオロドプシンは何を伝えているのか？

• Project Area: Integrative understanding of biological signaling networks based on mathematical science
• Project/Area Number: 19H04959
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Nagoya Institute of Technology
• Principal Investigator: 神取 秀樹 名古屋工業大学, 工学(系)研究科(研究院), 教授 (70202033)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000); Fiscal Year 2020: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
• Keywords: 微生物ロドプシン / レチナール / 光反応サイクル / X線結晶構造解析 / プルダウンアッセイ / プルダウンア

Outline of Research at the Start

これまで地球上のロドプシンには、微生物に由来するタイプ１と動物に由来するタイプ２しか存在しないと考えられていた。ところが我々は2018年、全く新しいロドプシンを発見し、ヘリオロドプシンと名付けた。ヘリオロドプシンはイオンを輸送しないため光センサー機能を推測しているが実験的な証拠はない。本研究では、ヘリオロドプシンの機能解明を目指す。in vitroの生化学実験やヘリオロドプシン遺伝子を含む生菌株を用いた生理機能の解析を行うとともに、X線結晶構造解析を試みる。これらの研究により、ヘリオロドプシンが細胞に何を伝えているか明らかにする。

Outline of Annual Research Achievements

これまで地球上のロドプシンには、微生物に由来するタイプ１と動物に由来するタイプ２しか存在しないと考えられていた。ところが我々は2018年、全く新しいロドプシンを発見し、第三のロドプシンであるこのタンパク質群にヘリオロドプシンと名付けた。ヘリオロドプシンはイオンを輸送しないため、我々は光センサー機能を推測しているが実験的な証拠はない。ヘリオロドプシンが古細菌、真正細菌、藻類などの真核生物から巨大ウイルスにまで存在する事実は、普遍な光利用機構の存在を示唆している。果たしてそれがタンパク質間相互作用によるシグナル伝達なのか、あるいは全く別の機構が存在するのか、実験的に明らかにすることを目標とした。2020年度は以下の成果が得られた。
古細菌由来のヘリオロドプシンについて、前年度の野生型に続き、東大との共同研究によりE108D変異体の結晶構造解析に成功した。これにより、ヘリオロドプシンが示す特異な波長制御機構に関する構造的な示唆を得ることができた。
一方、全反射赤外分光を用いた解析により、亜鉛が特異的に結合することがわかった。亜鉛の結合は0.2 mMの解離定数であり、他の金属と異なり結合によりタンパク質骨格の変化を伴うため、その結合が特異的であることがわかる。この実験事実は、現在も未知であるヘリオロドプシンの機能に対して、亜鉛の結合が影響を与えることを示唆するものである。
また系統樹において、タイプ１ロドプシンとヘリオロドプシンの中間的な位置に存在するシゾロドプシンが内向きプロトンポンプの機能を持つことを明らかにした。

Research Progress Status

令和2年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和2年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] Israel Inst. Tech.(イスラエル)
• [Int'l Joint Research] Babe-Bolyai University(ルーマニア)
• [Int'l Joint Research] Academy of Sciences(チェコ)
• [Int'l Joint Research] Israel Inst. Tech.(イスラエル)
• [Journal Article] History and Perspectives of Ion-Transporting Rhodopsins (2021)
  • Author(s): Kandori Hideki
  • Journal Title: Adv. Exp. Med. Biol. Volume: 1293 Pages: 3-19
  • DOI: 10.1007/978-981-15-8763-4_1
  • ISBN: 9789811587627, 9789811587634
  • Peer Reviewed
• [Journal Article] Molecular Properties and Optogenetic Applications of Enzymerhodopsins (2021)
  • Author(s): Tsunoda Satoshi P.、Sugiura Masahiro、Kandori Hideki
  • Journal Title: Adv. Exp. Med. Biol. Volume: 1293 Pages: 153-165
  • DOI: 10.1007/978-981-15-8763-4_9
  • ISBN: 9789811587627, 9789811587634
  • Peer Reviewed
• [Journal Article] Light-induced difference FTIR spectroscopy of primate blue-sensitive visual pigment at 163 K (2021)
  • Author(s): Hanai Shunpei、Katayama Kota、Imai Hiroo、Kandori Hideki
  • Journal Title: Biophysics and Physicobiology Volume: 18 Issue: 0 Pages: 40-49
  • DOI: 10.2142/biophysico.bppb-v18.005
  • NAID: 130008002507
  • ISSN: 2189-4779
  • Peer Reviewed
• [Journal Article] Specific residues in the cytoplasmic domain modulate photocurrent kinetics of channelrhodopsin from Klebsormidium nitens (2021)
  • Author(s): Tashiro R, Sushmita K, Hososhima S, Sharma S, Kateriya S, Kandori H, Tsunoda SP.
  • Journal Title: Commun. Biol. Volume: 4 Issue: 1 Pages: 235-235
  • DOI: 10.1038/s42003-021-01755-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] TAT Rhodopsin Is an Ultraviolet-Dependent Environmental pH Sensor (2021)
  • Author(s): Kataoka Chihiro、Sugimoto Teppei、Shigemura Shunta、Katayama Kota、Tsunoda Satoshi P.、Inoue Keiichi、Beja Oded、Kandori Hideki
  • Journal Title: Biochemistry Volume: 60 Issue: 12 Pages: 899-907
  • DOI: 10.1021/acs.biochem.0c00951
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Exploration of natural red-shifted rhodopsins using a machine learning-based Bayesian experimental design (2021)
  • Author(s): Inoue Keiichi、Karasuyama Masayuki、Nakamura Ryoko、Konno Masae、Yamada Daichi、Mannen Kentaro、Nagata Takashi、Inatsu Yu、Yawo Hiromu、Yura Kei、Beja Oded、Kandori Hideki、Takeuchi Ichiro
  • Journal Title: Communications Biology Volume: 4 Issue: 1 Pages: 362-362
  • DOI: 10.1038/s42003-021-01878-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Time-resolved serial femtosecond crystallography reveals early structural changes in channelrhodopsin (2021)
  • Author(s): Oda Kazumasa、Nomura Takashi、Nakane Takanori、Yamashita Keitaro、Inoue Keiichi、Ito Shota、Vierock Johannes、Hirata Kunio、Maturana Andres D、Katayama Kota、( 32 authers )、Kandori Hideki、Hegemann Peter、Iwata So、Kubo Minoru、Nishizawa Tomohiro、Nureki Osamu
  • Journal Title: eLife Volume: 10 Pages: 1-21
  • DOI: 10.7554/elife.62389
  • NAID: 120006996980
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Schizorhodopsins: A novel family of rhodopsins from Asgard archaea that function as light-driven inward H+ pumps (2020)
  • Author(s): Keiichi Inoue, Satoshi P. Tsunoda, Manish Singh, Sahoko Tomida, Shoko Hososhima, Masae Konno, Ryoko Nakamura, Hiroki Watanabe, Paul-Adrian Bulzu, Horia L. Banciu, Adrian Andrei, Takayuki Uchihashi, Rohit Ghai, Oded Beja, Hideki Kandori
  • Journal Title: Science Advances Volume: 6 Issue: 15
  • DOI: 10.1126/sciadv.aaz2441
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Molecular properties of new enzyme rhodopsins with PDE activity (2020)
  • Author(s): Sugiura M., Tsunoda SP., Hibi M., Kandori H
  • Journal Title: ACS Omega Volume: 5 Issue: 18 Pages: 10602-10609
  • DOI: 10.1021/acsomega.0c01113
  • Peer Reviewed / Open Access
• [Journal Article] Gate-keeper of ion transport-a highly conserved helix-3 tryptophan in a channelrhodopsin chimera, C1C2/ChRWR (2020)
  • Author(s): Nagasaka Yujiro、Hososhima Shoko、Kubo Naoko、Nagata Takashi、Kandori Hideki、Inoue Keiichi、Yawo Hiromu
  • Journal Title: Biophysics and Physicobiology Volume: 17 Issue: 0 Pages: 59-70
  • DOI: 10.2142/biophysico.bsj-2020007
  • NAID: 130007879484
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mechanism of Inward Proton Transport in an Antarctic Microbial Rhodopsin (2020)
  • Author(s): Harris Andrew、Lazaratos Michalis、Siemers Malte、Watt Ethan、Hoang Anh、Tomida Sahoko、Schubert Luiz、Saita Mattia、Heberle Joachim、Furutani Yuji、Kandori Hideki、Bondar Ana-Nicoleta、Brown Leonid S.
  • Journal Title: The Journal of Physical Chemistry B Volume: 124 Issue: 24 Pages: 4851-4872
  • DOI: 10.1021/acs.jpcb.0c02767
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Unique Retinal Binding Pocket of Primate Blue-Sensitive Visual Pigment (2020)
  • Author(s): Nonaka Yuki、Hanai Shunpei、Katayama Kota、Imai Hiroo、Kandori Hideki
  • Journal Title: Biochemistry Volume: 59 Issue: 28 Pages: 2602-2607
  • DOI: 10.1021/acs.biochem.0c00394
  • Peer Reviewed
• [Journal Article] Infrared spectroscopic analysis on structural changes around the protonated Schiff base upon retinal isomerization in light-driven sodium pump KR2. (2020)
  • Author(s): S. Tomida, S. Ito, T. Mato, Y. Furutani, K. Inoue, H. Kandori
  • Journal Title: Biochim Biophys Acta Bioenerg. Volume: - Issue: 7 Pages: 148190-148190
  • DOI: 10.1016/j.bbabio.2020.148190
  • Peer Reviewed
• [Journal Article] Active Learning of Bayesian Linear Models with High-Dimensional Binary Features by Parameter Confidence-Region Estimation (2020)
  • Author(s): Inatsu Yu、Karasuyama Masayuki、Inoue Keiichi、Kandori Hideki、Takeuchi Ichiro
  • Journal Title: Neural Computation Volume: 32 Issue: 10 Pages: 1998-2031
  • DOI: 10.1162/neco_a_01310
  • Peer Reviewed
• [Journal Article] Disruption of Hydrogen-Bond Network in Rhodopsin Mutations Cause Night Blindness (2020)
  • Author(s): Katayama Kota、Takeyama Yuri、Enomoto Akiko、Imai Hiroo、Kandori Hideki
  • Journal Title: Journal of Molecular Biology Volume: 432 Issue: 19 Pages: 5378-5389
  • DOI: 10.1016/j.jmb.2020.08.006
  • Peer Reviewed
• [Journal Article] Structural basis for unique color tuning mechanism in heliorhodopsin (2020)
  • Author(s): Tanaka Tatsuki、Singh Manish、Shihoya Wataru、Yamashita Keitaro、Kandori Hideki、Nureki Osamu
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 533 Issue: 3 Pages: 262-267
  • DOI: 10.1016/j.bbrc.2020.06.124
  • Peer Reviewed
• [Journal Article] ATP binding promotes light-induced structural changes to the protein moiety of Arabidopsis cryptochrome 1 (2020)
  • Author(s): Iwata Tatsuya、Yamada Daichi、Mikuni Katsuhiro、Agata Kazuya、Hitomi Kenichi、Getzoff Elizabeth D.、Kandori Hideki
  • Journal Title: Photochemical & Photobiological Sciences Volume: 19 Issue: 10 Pages: 1326-1331
  • DOI: 10.1039/d0pp00003e
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Zinc Binding to Heliorhodopsin (2020)
  • Author(s): Hashimoto Masanori、Katayama Kota、Furutani Yuji、Kandori Hideki
  • Journal Title: The Journal of Physical Chemistry Letters Volume: 11 Issue: 20 Pages: 8604-8609
  • DOI: 10.1021/acs.jpclett.0c02383
  • Peer Reviewed
• [Journal Article] Structural insights into the mechanism of rhodopsin phosphodiesterase (2020)
  • Author(s): Ikuta T, Shihoya W, Sugiura M, Yoshida K, Watari M, Tokano T, Yamashita K, Katayama K, Tsunoda SP, Uchihashi T, Kandori H and Nureki O.
  • Journal Title: Nat. Commun. Volume: 11 Issue: 1 Pages: 5605-5605
  • DOI: 10.1038/s41467-020-19376-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expression analysis of microbial rhodopsin-like genes in Guillardia theta (2020)
  • Author(s): Konno Masae、Yamauchi Yumeka、Inoue Keiichi、Kandori Hideki
  • Journal Title: PLOS ONE Volume: 15 Issue: 12 Pages: e0243387-e0243387
  • DOI: 10.1371/journal.pone.0243387
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Structure-affinity insights into the Na+ and Ca2+ interactions with multiple sites of a sodium-calcium exchanger. (2020)
  • Author(s): M. Iwaki, B. Refaeli, L. van Dijk, R. Hiller, M. Giladi, H. Kandori, D. Khananshvili
  • Journal Title: FEBS J. Volume: - Issue: 21 Pages: 4678-4695
  • DOI: 10.1111/febs.15250
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Allosteric Communication with the Retinal Chromophore upon Ion Binding in a Light-Driven Sodium Ion-Pumping Rhodopsin. (2020)
  • Author(s): A. Otomo, M. Mizuno, K. Inoue, H. Kandori, Y. Mizutani
  • Journal Title: Biochemistry Volume: 59 (4) Issue: 4 Pages: 520-529
  • DOI: 10.1021/acs.biochem.9b01062
  • Peer Reviewed
• [Journal Article] Acid-Base Equilibrium of the Chromophore Counterion Results in Distinct Photoisomerization Reactivity in the Primary Event of Proteorhodopsin (2019)
  • Author(s): C. Chang, H. Kuramochi, M. Singh, R. Abe-Yoshizumi, T. Tsukuda, H. Kandori, T. Tahei*
  • Journal Title: Phys Chem Chem Phys. Volume: 21(46) Issue: 46 Pages: 25728-25734
  • DOI: 10.1039/c9cp04991f
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ligand Binding-Induced Structural Changes in the M2 Muscarinic Acetylcholine Receptor Revealed by Vibrational Spectroscopy. (2019)
  • Author(s): K.Katayama, K. Suzuki, R. Suno, H. Tsujimoto, S. Iwata, T. Kobayashi, H. Kandori*
  • Journal Title: J Phys Chem Lett. Volume: 10(22) Issue: 22 Pages: 7270-7276
  • DOI: 10.1021/acs.jpclett.9b02942
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effect of a bound anion on the structure and dynamics of halorhodopsin from Natronomonas pharaonis (2019)
  • Author(s): M. Mizuno, Y. Shimoo, H. Kandori, Y. Mizutani*
  • Journal Title: Struct. Dynamics Volume: 6(5) Issue: 5 Pages: 54703-54703
  • DOI: 10.1063/1.5125621
  • Peer Reviewed / Open Access
• [Journal Article] Anion binding to mutants of the Schiff base counterion in heliorhodopsin 48C12 (2019)
  • Author(s): M. Singh, K. Katayama, O. Beja, H. Kandori*
  • Journal Title: Phys. Chem. Chem. Phys. Volume: 21(42) Issue: 42 Pages: 23663-23671
  • DOI: 10.1039/c9cp04102h
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Crystal structure of heliorhodopsin (2019)
  • Author(s): W. Shihoya, K. Inoue, M. Singh, M. Konno, S. Hososhima, K. Yamashita, K. Ikeda, A. Higuchi, T. Izume, Okazaki S, Hashimoto M, Mizutori R, Tomida S, Yamauchi Y, Abe-Yoshizumi R, K. Katayama, SP. Tsunoda, M. Shibata, Y. Furutani, A. Pushkarev, O. Béjà, T. Uchihashi, H. Kandori, O. Nureki
  • Journal Title: Nature Volume: 574 Issue: 7776 Pages: 132-136
  • DOI: 10.1038/s41586-019-1604-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ion Channel Properties of a Cation Channelrhodopsin (2019)
  • Author(s): S. Shigemura, S. Hososhima, H. Kandori, SP. Tsunoda
  • Journal Title: Appl. Sci. Volume: 9 Issue: 17 Pages: 3440-3440
  • DOI: 10.3390/app9173440
  • Peer Reviewed / Open Access
• [Journal Article] Unique photochemistry observed in a new microbial rhodopsin (2019)
  • Author(s): C. Kataoka, K. Inoue, K. Katayama, O. Beja, H. Kandori*
  • Journal Title: J. Phys. Chem. Lett. Volume: 10 Issue: 17 Pages: 5117-5121
  • DOI: 10.1021/acs.jpclett.9b01957
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] X-ray crystallographic structure and oligomerization of Gloeobacter Rhodopsin (2019)
  • Author(s): T. Morizumi, W. L. Ou, N. Van Eps, K. Inoue, H. Kandori, L. S. Brown, O. P. Ernst*
  • Journal Title: Sci. Rep. Volume: 9 Issue: 1 Pages: 11283-11283
  • DOI: 10.1038/s41598-019-47445-5
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Essential ion binding residues for Na+ flow in stator complex of the Vibrio flagellar motor (2019)
  • Author(s): Y. Onoue, M. Iwaki, A. Shinobu, Y. Nishihara, H. Iwatsuki, H. Terashima, A. Kitao, H. Kandori*, M. Homma*
  • Journal Title: Sci. Rep. Volume: 9 Issue: 1 Pages: 11216-11216
  • DOI: 10.1038/s41598-019-46038-6
  • Peer Reviewed / Open Access
• [Journal Article] FTIR Study of S180A Mutant of Primate Red-sensitive Pigment (2019)
  • Author(s): Katayama Kota、Imai Hiroo、Kandori Hideki
  • Journal Title: Chemistry Letters Volume: 48 Issue: 9 Pages: 1142-1144
  • DOI: 10.1246/cl.190458
  • NAID: 130007703039
  • Peer Reviewed
• [Journal Article] Role of Gln114 in spectral tuning of a long-wavelength sensitive visual pigment (2019)
  • Author(s): K. Katayama, S. Nakamura, T. Sasaki, H. Imai, H. Kandori*
  • Journal Title: Biochemistry Volume: 58 Issue: 26 Pages: 2944-2952
  • DOI: 10.1021/acs.biochem.9b00340
  • Peer Reviewed
• [Journal Article] Engineered Functional Recovery of Microbial Rhodopsin without Retinal-Binding Lysine. (2019)
  • Author(s): Yumeka Yamauchi, Masae Konno, Daichi Yamada, Kei Yura, Keiichi Inoue, Oded Beja, Hideki Kandori
  • Journal Title: Photochem. Photobiol. Volume: 印刷中 Issue: 5 Pages: 1116-1121
  • DOI: 10.1111/php.13114
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Red-shiftingmutation of light-driven sodium-pump rhodopsin (2019)
  • Author(s): K. Inoue, M. Del Carmen Marin, S. Tomida, R. Nakamura, Y. Nakajima, M. Olivucci, H. Kandori*
  • Journal Title: Nat. Commun. Volume: 10 Issue: 1 Pages: 1993-1993
  • DOI: 10.1038/s41467-019-10000-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Distortion and a Strong Hydrogen Bond in the Retinal Chromophore Enable Sodium Ion Transport by the Sodium Ion Pump KR2 (2019)
  • Author(s): Nao Nishimura, Misao Mizuno, Hideki Kandori, and Yasuhisa Mizutani
  • Journal Title: J. Phys. Chem. B Volume: 印刷中 Issue: 16 Pages: 3430-3440
  • DOI: 10.1021/acs.jpcb.9b00928
  • Peer Reviewed
• [Journal Article] Casting light on Asgardarchaeota metabolism in a sunlit microoxic niche (2019)
  • Author(s): Paul-Adrian Bulzu†, Adrian-Stefan Andrei†, Michaela M. Salcher, Maliheh Mehrshad, Keiichi Inoue, Hideki Kandori, Oded Beja;, Rohit Ghai*, Horia L. Banciu
  • Journal Title: Nature Microbiology Volume: in press Issue: 7 Pages: 1129-1137
  • DOI: 10.1038/s41564-019-0404-y
  • Peer Reviewed / Int'l Joint Research
• [Presentation] ビブリオ属PRにおける極端な酸性pHで起こる波長制御機構の探究 (2021)
  • Author(s): 澄川瑞季、吉住玲、神取秀樹
  • Organizer: 第8回将来を見据えた生体分子の構造・機能解析から分子設計に関する研究会
• [Presentation] TATロドプシンのT82D変異体に対する分光学的研究 (2021)
  • Author(s): 杉本哲平、片山耕大、神取秀樹
  • Organizer: 令和2年度中部支部講演会
• [Presentation] 低温赤外分光法によるウイルスロドプシンの構造解析 (2021)
  • Author(s): 青山真子、杉本哲平、片山耕大、神取秀樹
  • Organizer: 令和2年度中部支部講演会
• [Presentation] CNGチャネルを用いた高時間分解での酵素ロドプシンの機能計測系の確立 (2021)
  • Author(s): 石川和季、細島頌子、角田聡、神取秀樹
  • Organizer: 令和2年度中部支部講演会
• [Presentation] 赤外分光法によるオピオイド受容体の選択的リガンド認識機構研究 (2021)
  • Author(s): 岩田聖矢、鱸洸平、片山耕大、神取秀樹
  • Organizer: 令和2年度中部支部講演会
• [Presentation] プロトンポンプロドプシンの駆動力の系統的比較 (2021)
  • Author(s): 奥山あかり、細島頌子、角田聡、神取秀樹
  • Organizer: 令和2年度中部支部講演会
• [Presentation] 動物ロドプシンの光活性化におけるMet86の役割 (2021)
  • Author(s): 渡辺航平、片山耕大、佐々木拓磨、今井啓雄、神取秀樹
  • Organizer: 令和2年度中部支部講演会
• [Presentation] Conformational dynamics upon ligand binding in muscarinic acetylcholine receptor revealed by FTIR spectroscopy (2020)
  • Author(s): K. Katayama, K. Suzuki, R. Suno and H. Kandori
  • Organizer: 第20回日本蛋白質科学会年会
• [Presentation] Analysis of ligand recognition and activation mechanisms in muscarinic acetylcholine receptor 2 (mACR2) by ATR-FTIR spectroscopy (2020)
  • Author(s): K. Suzuki , K. Katayama , R. Suno and H. Kandori
  • Organizer: 第20回日本蛋白質科学会年会
• [Presentation] Mapping analysis to probe the local/global conformational changes in proteins by FTIR spectroscopy with aspartic acid scanning (2020)
  • Author(s): M. Hashimoto, K. Katayama, M. Singh, Y. Furutani and H. Kandori
  • Organizer: 第20回日本蛋白質科学会年会
• [Presentation] 共鳴ラマン分光法を用いたナトリウムイオンポンプロドプシンKR2の脱水和に伴う長波長シフト機構解析 (2020)
  • Author(s): 富田紗穂子、和田昭盛、神取秀樹、古谷祐詞
  • Organizer: 分子科学会オンライン討論会
• [Presentation] 振動分光による霊長類青視物質の中間体構造解析 (2020)
  • Author(s): 華井竣平、片山耕大、佐々木拓磨、 今井啓雄、 神取秀樹
  • Organizer: 分子科学会オンライン討論会
• [Presentation] Spectroscopic study of cation binding to a TAT rhodopsin mutant (2020)
  • Author(s): 杉本哲平、片山耕大、神取秀樹
  • Organizer: 分子科学会オンライン討論会
• [Presentation] Disruption of hydrogen-bond network in rhodopsin mutations cause night blindness (2020)
  • Author(s): K.Katayama, Y. Takeyama, A. Enomoto, H. Imai and H. Kandori
  • Organizer: The 58th Annual Meeting of the Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Expression of Heliorhodopsin in Actinotalea fermentans (2020)
  • Author(s): R. Abe-Yoshizumi, A. Muto and H. Kandori
  • Organizer: The 58th Annual Meeting of the Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Anion binding to mutants of the Schiff base counterion in heliorhodopsin (2020)
  • Author(s): M. Singh, K. Katayama, O. Beja and Hideki Kandori
  • Organizer: The 58th Annual Meeting of the Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Gene expression analysis of microbial rhodopsins from marine algae Guillardia theta (2020)
  • Author(s): Y. Yamauchi, M. Konno, K. Inoue and H. Kandori
  • Organizer: The 58th Annual Meeting of the Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Molecular properties of eight novel rhodopsin phosphodiesterases (Rh-PDEs) (2020)
  • Author(s): M. Sugiura, S. P. Tsunoda, M. Hibi and H. Kandori
  • Organizer: The 58th Annual Meeting of the Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Infrared spectroscopic study for elucidating ligand recognition mechanism of human M2 muscarinic acetylcholine receptor (2020)
  • Author(s): K. Suzuki , K. Katayama , R. Suno , Y.Sumii , N. Shibata and H. Kandori
  • Organizer: The 58th Annual Meeting of the Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Importance of the C-terminal region in cation channelrhodopsin Ts_Rh3 (2020)
  • Author(s): R. Tashiro, K. Sushmita, S. Kateriya, H. Kandori and S. P. Tsunoda
  • Organizer: The 58th Annual Meeting of the Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Mapping of the local environmental changes in proteins by FTIR spectroscopy with aspartic acid scanning (2020)
  • Author(s): M. Hashimoto, K. Katayama, M. Singh, Y. Furutani and H. Kandori
  • Organizer: The 58th Annual Meeting of the Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Photochemical dynamics of a primate blue-sensitive pigment by spectroscopic study (2020)
  • Author(s): S. Hanai, K. Katayama, T. Sasaki, H. Imai and H. Kandori
  • Organizer: The 58th Annual Meeting of the Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Elucidation of the repair mechanism of (6-4) photolyase by low-temperature FTIR spectroscopy (2020)
  • Author(s): K. Maeda, M. Kumagai, D. Yamada, Y. Terai, J. Yamamoto and H. kandori
  • Organizer: The 58th Annual Meeting of the Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Study on physiological functions and physical properties of heliorhodopsin possessed by Rhodococcus bacteria (2020)
  • Author(s): A. Muto, R. Abe-Yoshizumi and H. Kandori
  • Organizer: The 58th Annual Meeting of the Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Spectroscopic study of cation binding to a TAT rhodopsin mutant (2020)
  • Author(s): T. Sugimoto, K. Katayama and H. Kandori
  • Organizer: The 58th Annual Meeting of the Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] 動物型 (ヒト) ロドプシンの構造ダイナミクス解析に向けた分光研究 (2020)
  • Author(s): 片山耕大、N. Nuemket、南後恵理子、神取秀樹
  • Organizer: 令和二年度 新学術領域研究「高速分子動画」シンポジウム
• [Presentation] ロドプシンフォスホジエステラーゼ（Ｒｈ― ＰＤＥ）の非対称的ｐＨ効果 (2020)
  • Author(s): 杉浦雅大、角田聡、日比正彦、神取秀樹
  • Organizer: 第10回CSJ化学フェスタ2020
• [Presentation] FTIR study of visual and non-visual G protein-coupled receptors (2020)
  • Author(s): K. Katayama, K. Suzuki, R. Suno, H. Kandori
  • Organizer: 日本化学会 第100春季年会 (2020)
• [Presentation] 海洋性藻類Guillardia thetaにおける微生物型ロドプシン様遺伝子の発現解析 (2020)
  • Author(s): 山内夢叶、今野雅恵、井上圭一、神取秀樹
  • Organizer: 第61回日本植物生理学会年会
• [Presentation] チャネルとポンプ：いのちを支える２つのイオン輸送 (2020)
  • Author(s): 神取秀樹
  • Organizer: 理化学研究所研究会
  • Invited
• [Presentation] Rhodococcus属細菌由来へリオロドプシンの物性と生理機能の探索 (2020)
  • Author(s): 武藤亜衣、吉住玲、神取秀樹
  • Organizer: 第7回将来を見据えた生体分子の構造・機能解明から分子設計に関する研究会
• [Presentation] 新奇ロドプシンフォスホジエステラーゼのオプトジェネティクスツールとしての可能性 (2020)
  • Author(s): 杉浦雅大, 吉田一帆, 日比正彦, 角田聡, 神取秀樹
  • Organizer: 第7回将来を見据えた生体分子の構造・機能解析から分子設計に関する研究会
• [Presentation] 全反射赤外分光法によるムスカリン性アセチルコリン受容体のリガンド誘起構造変化解析 (2020)
  • Author(s): 魲洸平 , 片山耕大 , 寿野良二 ,神取秀樹
  • Organizer: 第７回将来を見据えた生体分子の構造・機能解析から分子設計に関する研究会
• [Presentation] カチオンチャネルロドプシンTs_Rh3のユニークなカイネティクス解析 (2020)
  • Author(s): 田代凜太郎、Kumari Sushmita、Suneel Kateriya、神取秀樹、角田聡
  • Organizer: 第7回将来を見据えた生体分子の構造・機能解析から分子設計に関する研究会
• [Presentation] アスパラギン酸マッピングによるタンパク質内部環境変化の赤外分光解析 (2020)
  • Author(s): 橋本真典、片山耕大、Manish Singh、古谷祐詞、神取秀樹
  • Organizer: 第7回将来を見据えた生体分子の構造・機能解析から分子設計に関する研究会
• [Presentation] Stractural change of a primate blue-sensitive pigment by photochemical reaction (2020)
  • Author(s): 華井竣平、佐々木拓磨、片山耕大、今井啓雄、神取秀樹
  • Organizer: 第7回将来を見据えた生体分子の構造・機能解析から分子設計に関する研究会
• [Presentation] T(6-4)Cを用いた(6-4)光回復酵素の低温赤外測定 (2020)
  • Author(s): 前田克弥、熊谷真衣、山田大智、神取秀樹
  • Organizer: 第7回将来を見据えた生体分子の構造・機能解析から分子設計に関する研究会
• [Presentation] Characterization of a novel sub-family of rhodopsin (Heliorhodopsin), spectral tuning and anion binding to counterion mutants in 48C12 (2019)
  • Author(s): M. Singh, A. Pushkarev, K. Inoue, W. Shihoya, O. Nureki, O. Beja, H. Kandori
  • Organizer: ISAJ 2019 (Indian Scientist Association in Japan)
  • Int'l Joint Research
• [Presentation] 新奇光依存性フォスホジエステラーゼRh-PDEの分子特性評価 (2019)
  • Author(s): 杉浦雅大、吉田一帆、日比正彦、角田聡、神取秀樹
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] 電気生理学的解析による新規チャネルロドプシンTs_Rh3のイオン輸送メカニズム解明 (2019)
  • Author(s): 田代凜太郎, K. Sushmita, S. Kateriya, 神取秀樹, 角田聡
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] 微生物ロドプシンが教えてくれること (2019)
  • Author(s): 神取秀樹
  • Organizer: 基礎生物学研究所研究会「異分野融合による次世代光生物学」
  • Invited
• [Presentation] 能動輸送のパナマ運河モデルと光駆動ナトリウムポンプの特殊性 (2019)
  • Author(s): 神取秀樹、井上圭一、角田 聡
  • Organizer: 基礎生物学研究所研究会「異分野融合による次世代光生物学」
• [Presentation] 低温赤外分光解析による(6-4)光回復酵素の光修復メカニズムの解明 (2019)
  • Author(s): 前田克弥、熊谷真衣、山田大智、神取秀樹
  • Organizer: 基礎生物学研究所研究会「異分野融合による次世代光生物学」
• [Presentation] Rhodococcus 属細菌が有するヘリオロドプシンの物性および生理機能の探索 (2019)
  • Author(s): 武藤亜衣、吉住玲、神取秀樹
  • Organizer: 基礎生物学研究所研究会「異分野融合による次世代光生物学」
• [Presentation] 全反射赤外分光法によるムスカリン性アセチルコリン受容体のリガンド認識・活性化機構解析 (2019)
  • Author(s): 魲洸平、片山耕大、寿野良二、神取秀樹
  • Organizer: 第9回CSJ化学フェスタ2019
• [Presentation] 電気生理学的解析による新規チャネルロドプシンTs_Rh3の分子特性解明 (2019)
  • Author(s): 田代凜太郎, K. Sushmita, S. Kateriya, 神取秀樹, 角田聡
  • Organizer: 第9回CSJ化学フェスタ2019
• [Presentation] アスパラギン酸をプローブとして用いた赤外分光測定によるタンパク質内部の構造解析 (2019)
  • Author(s): 橋本真典、片山耕大、M. Singh、古谷祐詞、神取秀樹
  • Organizer: 第9回CSJ化学フェスタ2019
• [Presentation] T(6-4)Cを用いた光修復中間体の低温赤外分光解析 (2019)
  • Author(s): 前田克弥、熊谷真衣、山田大智、寺井悠馬、山元淳平、神取秀樹
  • Organizer: 第9回CSJ化学フェスタ2019
• [Presentation] 天然のバクテリアを用いたヘリオロドプシンの機能研究 (2019)
  • Author(s): 武藤亜衣、吉住玲、神取秀樹
  • Organizer: 第9回CSJ化学フェスタ2019
• [Presentation] Role of Gln114 in spectral tuning of a long-wavelength sensitive visual pigment (2019)
  • Author(s): K. Katayama, S. Nakamura, T. Sasaki, H. Imai, H. Kandori
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] The cation-induced structural changes in the Na+-driven flagellar stator studied by ATR-FTIR (2019)
  • Author(s): M. Iwaki, T. Nishikino, H. Terashima, M. Homma, H. Kandori
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Electrophysiological study and Optogenetics application of inward-directed proton-pumping rhodopsin, NsXeR (2019)
  • Author(s): S. Tsunoda, S. Hososhima, H. Kandori
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Molecular properties of Heliorhodopsin from Actinotalea fementans (2019)
  • Author(s): R. Abe-Yoshizumi, A. Muto, H. Kandori
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Novel optogenetics tool: A light-gated cation channel with high-reactivity to weak light (2019)
  • Author(s): S. Hososhima, S. Shigemura, H. Kandori, S. Tsunoda
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Engineering microbial rhodopsin without retinal-binding lysine to gain photosensitive function (2019)
  • Author(s): Y. Yamauchi, M. Konno, D. Yamada, K. Yura, K. Inoue, O. Beja, H. Kandori
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Time-resolved FTIR spectroscopy for studying molecular mechanisms of sodium and lithium ion transportation of Krokinobacter rhodopsin 2 (2019)
  • Author(s): S. Tomida, H. Kandori, Y. Furutani
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Molecular properties of light-dependent homo-oligomerizing At CRY2 (2019)
  • Author(s): K. Agata, D. Yamada, H. Kandori
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Different structural dynamics between cone pigments and rhodopsin revealed by FTIR spectroscopy (2019)
  • Author(s): T. Sasaki, K. Katayama, H. Imai, H. Kandori
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Study of cation channelrhodopsin Gt_CCR4 from cryptophyte for optogenetics (2019)
  • Author(s): S. Shigemura, S. Hososhima, H. Kandori, S. Tsunoda
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Effects of the L/Q switch on color tuning of heliorhodopsin (2019)
  • Author(s): Y. Nakajima, H. Kandori
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Molecular characterization of heliorhodopsin from marine giant virus light-dependently infecting to Emiliania huxleyi (2019)
  • Author(s): R. Mizutori, M. Konno, K. Inoue, O. Beja, H. Kandori
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Structural features of enzyme rhodopsins revealed by infrared spectroscopy (2019)
  • Author(s): M. Watari, T. Tatsuya, H. Hutamata, D. Yamada, W. Shihoya, K. Yoshida, Y. Furutani, S. Tsunoda, O. Nureki, H. Kandori
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Asymmetric pH effect on the enzyme rhodopsin, Rh-PDE (2019)
  • Author(s): M. Sugiura, K. Yoshida, M. Hibi, S, Tsunoda, H. Kandori
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Ligand recognition and activation mechanism in muscarinic acetylcholine receptor M2 (M2R) study by ATR-FTIR spectroscopy (2019)
  • Author(s): K. Suzuki, K. Katayama, R. Suno, H. Kandori
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Electrophysiological analysis of a novel channelrhodopsin Ts_Rh3 (2019)
  • Author(s): R. Tashiro, K. Sushmita, S. Kateriya, H. Kandori, S. Tsunoda
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Mapping of aspartic acids to probe protein structural changes by FTIR spectroscopy (2019)
  • Author(s): M. Hashimoto, K. Katayama, M. Singh, Y. Furutani, H. Kandori
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Ptotochemical reactions of a primate blue-sensitive pigment by spectroscopy (2019)
  • Author(s): S. Hanai, K. Katayama, T. Sasaki, H. Imai, H. Kandori
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Elucidation of the repair mechanism of <6-4> photolyase by infrared spectroscopy with T(6-4)C (2019)
  • Author(s): K. Maeda, M. Kumagai, D. Yamada, Y. Terai, J. Yamamoto, H. Kandori
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Function study of heliorhodopsin using native bacteria (2019)
  • Author(s): A. Muto, R.Yoshizumi, H. Kandori
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] Characterization of the inward proton transport pathway in Schizorhodopsin (2019)
  • Author(s): M. Konno, K. Inoue, R. Ghai、O. Beja、H. Kandori
  • Organizer: The 57th Annual Meeting of The Biophysical Society of Japan
  • Int'l Joint Research
• [Presentation] オプトジェネティクスに求められるチャネルロドプシンの基礎特性 (2019)
  • Author(s): 重村竣太、細島頌子、神取秀樹、角田聡
  • Organizer: 第13回分子科学討論会
• [Presentation] pH dependent activity change of the enzyme rhodopsin (2019)
  • Author(s): M. Sugiura, K. Yoshida, M. Hibi, S. Tsunoda, H. Kandori
  • Organizer: 第13回分子科学討論会2019
• [Presentation] Novel Microbial Rhodopsins: Molecular Mechanisms and Optogenetic Application (2019)
  • Author(s): H. Kandori
  • Organizer: 第11回光操作研究会
  • Invited
• [Presentation] A High light-sensitive channelrhodopsin from cryptophyte (2019)
  • Author(s): S. Hososhima, S. Shigemura, H. Kandori, S. Tsunoda
  • Organizer: 第11回光操作研究会
• [Presentation] Monovalent metal cation selectivity channelrhodopsin Gt_CCR4 (2019)
  • Author(s): S. Shigemura, S. Hososhima, H. Kandori, S. Tsunoda
  • Organizer: 第11回光操作研究会
• [Presentation] Asymmetric pH effect of rhodopsin phosphodiesterase (2019)
  • Author(s): M. Sugiura, K. Yoshida, M. Hibi, S. Tsunoda, H. Kandori
  • Organizer: 第11回光操作研究会
• [Presentation] Molecular mechanisms of a novel channelrhodopsin Ts_Rh3 (2019)
  • Author(s): R. Tashiro, K. Sushmita, S. Kateriya, H. Kandori, S. Tsunoda
  • Organizer: 第11回光操作研究会
• [Presentation] ロドプシンを定義する (2019)
  • Author(s): 神取秀樹
  • Organizer: ISSPワークショップ「レチナールタンパク質の光機能発現の物理と化学」
  • Invited
• [Presentation] 能動輸送のパナマ運河モデルと光駆動ナトリウムポンプの特殊性 (2019)
  • Author(s): 神取秀樹、井上圭一、角田 聡
  • Organizer: ISSPワークショップ「レチナールタンパク質の光機能発現の物理と化学」
• [Presentation] Anion binding to mutants of the Schiff base counterion in heliorhodopsin 48C12 (2019)
  • Author(s): Manish Singh, 片山耕大, Oded Beja, 神取秀樹
  • Organizer: ISSPワークショップ「レチナールタンパク質の光機能発現の物理と化学」
• [Presentation] レチナールを結合するリジンを保存しない微生物型ロドプシンの光機能獲得 (2019)
  • Author(s): 山内夢叶、今野雅恵、山田大智、由良敬、井上圭一、Oded Beja、神取秀樹
  • Organizer: ISSPワークショップ「レチナールタンパク質の光機能発現の物理と化学」
• [Presentation] 霊長類色覚センサー蛋白質の光反応ダイナミクスの赤外分光解析 (2019)
  • Author(s): 佐々木拓磨、片山耕大、今井啓雄、神取秀樹
  • Organizer: ISSPワークショップ「レチナールタンパク質の光機能発現の物理と化学」
• [Presentation] 4つのドメインからなるヘリオロドプシンがもつ光反応ダイナミクス比較 (2019)
  • Author(s): 水鳥律、今野雅恵、Manish Singh、井上圭一、Oded Beja、神取秀樹
  • Organizer: ISSPワークショップ「レチナールタンパク質の光機能発現の物理と化学」
• [Presentation] Panama Canal Model for Active Transport and One Exception (2019)
  • Author(s): H. Kandori
  • Organizer: 10th Toyota RIKEN International Workshop on "Science of Life Phenomena Woven by Water and Biomolecules"
  • Int'l Joint Research / Invited
• [Presentation] レチナールを結合するリジンを保存しない微生物型ロドプシンの機能解明 (2019)
  • Author(s): 山内夢叶、今野雅恵、山田大智、由良敬、井上圭一、O. Beja、神取秀樹
  • Organizer: 新学術領域「数理シグナル」第3回若手ワークショップ
• [Presentation] Retinal Proteins in Microbes: Diversity and Mechanisms (2019)
  • Author(s): H. Kandori
  • Organizer: 17th International Congress on Photobiology, Symposium SENS-1: "Retinal Proteins in Microbes: Diversity and Mechanisms"
  • Int'l Joint Research / Invited
• [Presentation] Ultrafast Photoisomerization and Role of Protein Environment in Rhodopsins (2019)
  • Author(s): H. Kandori
  • Organizer: 17th International Congress on Photobiology, Symposium PCHEM-10: "Femtobiology"
  • Int'l Joint Research / Invited
• [Presentation] Structural study of thermo-stabilized mutation in cone visual opsin (2019)
  • Author(s): K. Katayama, H. Kandori
  • Organizer: 17th International Congress on Photobiology 18th Congress of the European Society for Photobiology
  • Int'l Joint Research
• [Presentation] Effect of pH and metal ion on the activity of enzyme rhodopsins (2019)
  • Author(s): M. Sugiura, K. Yoshida, S. P. Tsunoda, H. Kandori
  • Organizer: 17th International Congress on Photobiology 18th Congress of the European Society for Photobiology
  • Int'l Joint Research
• [Presentation] Spectroscopic study of photochemical reactions of a primate blue-sensitive pigment (2019)
  • Author(s): S. Hanai, K. Katayama, T. Sasaki, H. Imai, H. Kandori
  • Organizer: 17th International Congress on Photobiology 18th Congress of the European Society for Photobiology
  • Int'l Joint Research
• [Presentation] Functional improvement of enzyme rhodopsin for optogenetics applications (2019)
  • Author(s): M. Sugiura, K. Yoshida, M. Hibi, S. Tsunoda, H. Kandori
  • Organizer: Scientific Seminar in Freie Universitat Berlin
  • Int'l Joint Research / Invited
• [Presentation] Spectroscopic study of photochemical reactions of a primate blue-sensitive pigment (2019)
  • Author(s): S. Hanai, K. Katayama, T. Sasaki, H, Imai, H. Kandori
  • Organizer: Scientific Seminar in Freie Universitat Berlin
  • Int'l Joint Research / Invited
• [Presentation] 光感受性イオンチャネルのゲーティング機構と光遺伝学への応用 (2019)
  • Author(s): 細島頌子、神取秀樹、角田聡
  • Organizer: 第4回イオンチャネル研究会
• [Presentation] Study of monovalent cation selectivite channelrhodopsin Gt_CCR4 for optogenetics (2019)
  • Author(s): S. Shigemura, S. Hososhima, H. Kandori, S. Tsunoda
  • Organizer: The 42nd Annual Meeting of the Japan Neuroscience Society and The 62nd Annual Meeting of the Japanese Society for Neurochemistry
  • Int'l Joint Research
• [Presentation] ロドプシンの作動メカニズム イオンの輸送を中心として (2019)
  • Author(s): 神取秀樹
  • Organizer: 第62回数理医学研究会
  • Invited
• [Presentation] Light-induced Diffrence FTIR Spectroscopy of Rhodopsins (2019)
  • Author(s): H. Kandori
  • Organizer: 10th International Conference on Advanced Vibrational Spectroscopy
  • Int'l Joint Research / Invited
• [Presentation] Vibrational spectroscopic approaches for understanding interactions of ligand with G protein-coupled receptors (2019)
  • Author(s): K. Katayama, R. Suno, K. Suzuki, S. Iwata, H. Kandori
  • Organizer: 第19回日本蛋白質科学会年会 第71回日本細胞生物学会大会 合同年次大会
• [Presentation] 色覚センサーの光反応ダイナミクスの赤外分光解析 (2019)
  • Author(s): 佐々木拓磨、片山耕大、今井啓雄、神取秀樹
  • Organizer: 第19回日本蛋白質科学会年会 第71回日本細胞生物学会大会 合同年次大会
• [Presentation] パワフルで一価金属カチオン選択性を持つチャネルロドプシンのオプトジェネティクスに向けたイオン透過解析 (2019)
  • Author(s): 重村竣太、細島頌子、神取秀樹、角田聡
  • Organizer: 第19回日本蛋白質科学会年会 第71回日本細胞生物学会大会 合同年次大会
• [Presentation] 植物クリプトクロム2のホモオリゴマー時の構造状態の解析 (2019)
  • Author(s): 縣和哉、山田大智、神取秀樹
  • Organizer: 第46回生体分子科学討論会
• [Presentation] 全反射赤外分光法によるムスカリン性アセチルコリン受容体M2の活性化機構解析 (2019)
  • Author(s): 魲洸平、片山耕大、寿野良二、神取秀樹
  • Organizer: 第46回生体分子科学討論会
• [Presentation] 低温赤外分法によるHeliorhodopsinの初期中間体構造解析 (2019)
  • Author(s): 橋本真典、富田紗穂子、片山耕大、古谷祐詞、神取秀樹
  • Organizer: 第46回生体分子科学討論会
• [Presentation] 分光計測による霊長類青感受性視物質の光反応中間体構造解析 (2019)
  • Author(s): 華井竣平、佐々木拓磨、片山耕大、今井啓雄、神取秀樹
  • Organizer: 第46回生体分子科学討論会
• [Presentation] ヘリオロドプシンは何を伝えているのか？ (2019)
  • Author(s): 神取秀樹
  • Organizer: 新学術領域「数理シグナル」領域推進会議
  • Invited
• [Presentation] 発色団を結合するリジンを保存しない微生物型ロドプシンの光応答性機能獲得 (2019)
  • Author(s): 山内夢叶、今野雅恵、山田大智、由良敬、井上圭一、Oded Beja、神取秀樹
  • Organizer: 新学術領域「数理シグナル」領域推進会議
• [Book] History and perspectives of light-sensing proteins (2021)
  • Author(s): H. Kandori
  • Publisher: Optogenetics, Adv Exp Med Biol, Vol. 1293, Springer Nature
• [Book] Molecular properties and optogenetic applications of enzymerhodopsins (2021)
  • Author(s): S. P. Tsunoda, M. Sugiura and H. Kandori
  • Publisher: Optogenetics, Adv Exp Med Biol, Vol. 1293, Springer Nature
• [Book] 巻頭言 若い研究者のために 私を驚かせてください (2021)
  • Author(s): 神取秀樹
  • Publisher: 内藤財団時報
• [Book] Microbial Rhodopsins (2021)
  • Author(s): A. Rozenberg, K. Inoue, H. Kandori and O. Beja
  • Publisher: Annu. Rev. Microbiol
• [Book] Biophysics of rhodopsins and optogenetics (2020)
  • Author(s): H. Kandori
  • Publisher: Biophys. Rev. 12, 355-361, Springer Nature
• [Book] オプトジェネティクスツールとしてのロドプシン (2020)
  • Author(s): 神取秀樹
  • Total Pages: 624
  • Publisher: 膜タンパク質工学ハンドブック, 第1編第２章14, （株）NTS
  • ISBN: 9784860435370
• [Book] Structure/Function Study of Photoreceptive Proteins by FTIR Spectroscopy (2020)
  • Author(s): H. Kandori
  • Publisher: Bull. Chem. Soc. Jpn 93, 904-926, 日本化学会
• [Book] Biophysics of rhodopsins and optogenetics. (2020)
  • Author(s): H. Kandori
  • Publisher: SPRINGER NATURE
• [Book] Novel optogenetics tool: Gt_CCR4 A light-gated cation channel with high-reactivity to weak light (2020)
  • Author(s): S. Hososhima, S. Shigemura, H. Kandori, S. P. Tsunoda
  • Publisher: SPRINGER NATURE
• [Book] Retinal Proteins: Photochemistry and Optogenetics (2020)
  • Author(s): H. Kandori
  • Publisher: The Chemical Society of Japan
• [Book] オプトジェネティクスツールとしてのロドプシン (2020)
  • Author(s): 神取秀樹
  • Total Pages: 624
  • Publisher: （株）NTS
• [Book] 視覚の初期過程を捉えるための超高速分光 (2020)
  • Author(s): 神取秀樹
  • Publisher: 一般社団法人 日本生物物理学会
• [Book] 光を信号へと変換する第3のロドプシン: ヘリオロドプシンの発見 (2019)
  • Author(s): 井上圭一、神取秀樹
  • Publisher: バイオインダストリー協会
• [Book] "Light-induced difference FTIR spectroscopy of photoreceptive proteins" Vibrational Spectroscopy in Protein Research: From Purified Proteins to Aggregates and Assemblies (Y. Ozaki, M. Baranska, I. Lednev, B. R. Wood, eds) (2019)
  • Author(s): H. Kandori, K. Katayama
  • Publisher: -
• [Book] ロドプシンの作動メカニズム (2019)
  • Author(s): 神取秀樹
  • Publisher: 公益社団法人日本生化学会