Multiscale analyses of dynamic states in the schizophrenic brain
Publicly Offered Research
| Project Area | Constructive understanding of multi-scale dynamism of neuropsychiatric disorders |
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| Project/Area Number |
19H05233
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
McHugh Thomas 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (50553731)
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| Project Period (FY) |
2019-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | hippocampus / schizophrenia / medial septum / CA2 / theta / Oscillations / Hippocampus / Schizophrenia / Septum / oscillations / memory / ripple / actylcholine |
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| Outline of Research at the Start |
We will test the hypothesis that the inhibition of the projections from neurons in the hippocampus to neurons in the medial septum alters the power and coherence of brain rhythms in a manner similar to that observed in schizophrenic patients and mouse models, supporting a circuit level understanding of the disorder.
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| Outline of Annual Research Achievements |
During FY2020 experiments made excellent progress. We established the use of fiber phototometry and GRAB sensors to optically track real-time changes in ACh levels and collected data from four types of cre-targeted mice, CA2-Cre, ChAT-Cre, vGluT2-Cre and PV-Cre. This rich data set has confirmed our hypothesis that CA2 to MS projections can lead to modulation of hippocampal cholinergic tone. Further, we collected and are now analyzing in vivo recordings of optically identified CA2 neurons that project to MS to look at their activity in freely behaving mice. These final data will allow us to prepare a manuscript reporting these results. Further, we continue to share reagents and techniques with multiple project labs, including the Johansen lab, the Hayashi lab and Hayashi-Takagaki lab.
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| Research Progress Status |
令和2年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和2年度が最終年度であるため、記入しない。
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Report
(2 results)
Research Products
(12 results)
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[Journal Article] A hypothalamic novelty signal modulates hippocampal memory2020
Author(s)
Chen Shuo、He Linmeng、Huang Arthur J. Y.、Boehringer Roman、Robert Vincent、Wintzer Marie E.、Polygalov Denis、Weitemier Adam Z.、Tao Yanqiu、Gu Mingxiao、Middleton Steven J.、Namiki Kana、Hama Hiroshi、Therreau Ludivine、Chevaleyre Vivien、Hioki Hiroyuki、Miyawaki Atsushi、Piskorowski Rebecca A.、McHugh Thomas J.
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Journal Title
Nature
Volume: 586
Issue: 7828
Pages: 270-274
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection2019
Author(s)
Adaikkan Chinnakkaruppan, Middleton Steven J, Marco Asaf, Pao Ping-Chieh, Mathys Hansruedi, Kim David Nam-Woo, Gao Fan, Young Jennie Z, Suk Ho-Jun, Boyden Edward S, McHugh Thomas J, Tsai Li-Huei
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Journal Title
Neuron
Volume: 102
Issue: 5
Pages: 929-943
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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