Publicly Offered Research
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
We will test the hypothesis that the inhibition of the projections from neurons in the hippocampus to neurons in the medial septum alters the power and coherence of brain rhythms in a manner similar to that observed in schizophrenic patients and mouse models, supporting a circuit level understanding of the disorder.
During FY2020 experiments made excellent progress. We established the use of fiber phototometry and GRAB sensors to optically track real-time changes in ACh levels and collected data from four types of cre-targeted mice, CA2-Cre, ChAT-Cre, vGluT2-Cre and PV-Cre. This rich data set has confirmed our hypothesis that CA2 to MS projections can lead to modulation of hippocampal cholinergic tone. Further, we collected and are now analyzing in vivo recordings of optically identified CA2 neurons that project to MS to look at their activity in freely behaving mice. These final data will allow us to prepare a manuscript reporting these results. Further, we continue to share reagents and techniques with multiple project labs, including the Johansen lab, the Hayashi lab and Hayashi-Takagaki lab.
令和2年度が最終年度であるため、記入しない。
All 2021 2020 2019
All Journal Article (6 results) (of which Int'l Joint Research: 6 results, Peer Reviewed: 6 results, Open Access: 2 results) Presentation (6 results) (of which Int'l Joint Research: 1 results, Invited: 5 results)
Neurobiology of Stress
Volume: 14 Pages: 100327-100327
10.1016/j.ynstr.2021.100327
Nature
Volume: 586 Issue: 7828 Pages: 270-274
10.1038/s41586-020-2771-1
Neuron
Volume: 107 Issue: 5 Pages: 805-820
10.1016/j.neuron.2020.07.011
Annual Review of Neuroscience
Volume: 43 Issue: 1 Pages: 55-72
10.1146/annurev-neuro-080719-100343
Nature Communications
Volume: 11 Issue: 1 Pages: 471-471
10.1038/s41467-020-14378-x
Volume: 102 Issue: 5 Pages: 929-943
10.1016/j.neuron.2019.04.011
