Publicly Offered Research
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Recent work, including studies in my lab, have revealed that the CA2 region of the hippocampus, an area impacted in patients and mouse models of schizophrenia, could be a key node in social cognition and its dysfunction in mental disease. This project will build on our recent discovery of a hypothalamic-CA2 circuit that signals social novelty by employing in vivo recording and optogenetic approaches to elucidate the dynamics of social cognition and how they are altered in a mouse model of schizophrenia.
During FY2022 we combined in vivo physiological recordings and optogenetic manipulation of CA2 transmission during social memory behavioral paradigms. Our results found both enhancement and impairments in encoding of social identity with inhibition and stimulation of specific CA2 outputs respectively. On the level of physiology we observed changes in the power of theta band oscillations in the CA1 region of the hippocampus that corresponded to the changes in behavior that we observed. Namely, impaired encoding of social memory was correlated with a decrease in theta power during the session and enhanced encoding of social memory was correlated with an increase in the power of the theta band oscillation. Currently we are extending the analyses of these data to look at single unit activity both in CA1 and CA2 during this behavioral paradigm, as well as conducting additional experiments using in vivo imaging with sensors designed to be sensitive to the extracellular concentration of specific neuromodulators. We are excited about these results will continue these experiments in the future to test the hypothesis this is mediated through slow-time scale changes in the power of the theta oscillation.
令和4年度が最終年度であるため、記入しない。
All 2023 2022 2021 Other
All Journal Article (4 results) (of which Int'l Joint Research: 4 results, Peer Reviewed: 4 results, Open Access: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results, Invited: 1 results) Remarks (1 results)
Hippocampus
Volume: 33 Issue: 3 Pages: 252-265
10.1002/hipo.23498
Neuroscience Research
Volume: 189 Pages: 13-19
10.1016/j.neures.2022.12.010
Neuron
Volume: 109 Issue: 22 Pages: 3674-3687.e7
10.1016/j.neuron.2021.08.034
eLife
Volume: 10 Pages: 1-33
10.7554/elife.63352
https://www.riken.jp/press/2021/20211011_1/index.html
