Publicly Offered Research
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
In this fiscal year we will develop a cell type specific molecular perturbation technique. In addition, we will examine the role of specific molecules in brainstem noradrenaline neurons and in amygdala neurons important in aversive emotional learning and memory.
The locus coeruleus noradrenaline (LC-NA) system controls emotion and is implicated in psychiatric disorders. We've developed cell type specific molecular and circuit based perturbation and viral tracing approaches and and used them to study the role of the LC-NA system in aversive emotional learning and memory. In the last year we have finished tracing brain-wide afferent inputs to two projection defined LC-NA cell populations we've found to play opposing roles in aversive learning and extinction of aversive responding (Sulkes et al. 2023). In addition, we've identified opposing functional roles of distinct afferent inputs from prefrontal cortex in regulating fear extinction learning (Watanabe et al. in preparation). This work shows how LC-NA cell types are regulated by afferent inputs
令和4年度が最終年度であるため、記入しない。
All 2023 2022 2021
All Journal Article (4 results) (of which Int'l Joint Research: 4 results, Peer Reviewed: 4 results, Open Access: 4 results) Presentation (15 results) (of which Int'l Joint Research: 10 results, Invited: 15 results)
Neuroscience Research
Volume: 23 Pages: 1-14
10.1016/j.neures.2023.04.004
Journal of Neuroscience
Volume: 12 Issue: 12 Pages: 2153-2167
10.1523/jneurosci.1450-22.2022
Molecular Brain
Volume: 14 Issue: 1 Pages: 136-136
10.1186/s13041-021-00844-0
Volume: 14 Issue: 1
10.1186/s13041-021-00884-6
