Human migration to Japan by searching Helicobacter pylori genome

• Project Area: Deciphering Origin and Establishment of Japonesians mainly based on genome sequence data
• Project/Area Number: 21H00346
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Oita University
• Principal Investigator: 山岡 吉生 大分大学, 医学部, 教授 (00544248)
• Project Period (FY): 2021-04-01 – 2023-03-31
• Project Status: Granted (Fiscal Year 2022)
• Budget Amount: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000); Fiscal Year 2022: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2021: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
• Keywords: ヘリコバクター・ピロリ / ゲノム / ヤポネシア / 沖縄 / 人類移動 / 人類の移動 / 次世代シーケンス

Outline of Research at the Start

ヘリコバクター・ピロリ（ピロリ菌）は、人類と共に旅をしてきた。我々はピロリ菌ゲノムを解析することで、アイヌや沖縄に特異的なピロリ菌が存在、沖縄特異的な菌には、分岐年代が旧石器時代と縄文時代の２系統が存在することがわかった。本研究では、ピロリ菌の全ゲノム解析を通して、これらのピロリ菌の起源、さらにはヒト側のDNAの検討も加えて、ヤポネシアの人類史を明らかにしていく。

Outline of Annual Research Achievements

人類は、約10万年前にアフリカ大陸を出て世界各地に広がった。ヘリコバクター・ピロリ（ピロリ菌）は、人類の出アフリカ前にヒトの胃への感染を確立し、人類と共に旅をしてきた。我々はピロリ菌ゲノムを解析することで、人類集団の移動、特にアジアから日本列島（ヤポネシア）への移動を追っている。本土人のみならず、アイヌ人、沖縄人のピロリ菌解析を行い、アイヌや沖縄に特異的なピロリ菌が存在することを報告した。我々はすでに全世界からのピロリ菌株約10000株を所有しており、コロナ禍の間は、これらの菌株の解析を行ってきた。また同時の国内での菌株採取では、今までの大分、沖縄本島に加えて、青森のピロリ菌を手に入れることができた（弘前大学からの供与）。その結果、青森県及び沖縄県を除く地域では、いずれも本州型が優勢であった。一方、青森県では青森型が最も多く（約72 %）、沖縄県にはやはり多様なピロリ菌集団が分布していた。北海道アイヌ株は、既報どおりアメリカ先住民型に分類された。沖縄県に分布する各集団の割合は、従来東アジア亜型とされていた集団が約70 %(沖縄型が最も多く、沖縄全体の約半数を占める)を、hspOkinawa及びhpRyukyu合わせて約24 %を占めていた。また、中国南東型27株、韓国型16株、中国北東型2株の日本由来株が分類された。日本の地域別にみると、大陸に近い地域でその割合は高く、大分県では最も多い25 %の株が中国及び韓国型に分類された。
青森株を加えることにより新たな集団が同定されたように、解析地域数を増やすことにより、国内ピロリ菌のさらに詳細な集団構造が明らかになり、ヤポネシアへの人類移動を紐解く糸口になると考えられる。現在、新たに宮古島、石垣島、五島列島、鹿児島県の病院でのピロリ菌採取の許可（倫理委員会認可）を得ており、さらに検体を採取して解析を進める計画である。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

コロナ禍のために、期間延長となったが、国内での新たな共同研究を行えることになり、日本各地の検体を集められることとなった。また、すでに今までのデータをiScience誌や大分県医師会雑誌にも発表することができ、また本研究にNHKも興味を持ち、研究代表者の山岡がNHK BSプレミアム「ヒューマニエンス」に出演することにもつながった。これらのことから、おおむね順調に進展していると考える。

Strategy for Future Research Activity

新たに宮古島、石垣島の内視鏡医とコンタクトを取り、共同研究を行う同意ができた（宮古島：県立宮古病院、岸本信三先生、新里　雅人先生、石垣島：八重山病院、菊池　馨先生）。また、長崎県五島中央病院（竹島　史直先生)、鹿児島県いちき串木野市の花牟禮病院（花牟禮　康生先生）についても共同研究を行う同意に至り、検体の採取を進めていく計画である。
また、今までの研究での弱点は、hpRyukyu類似の菌がネパール、カザフスタンなどで見つかったが、まだ菌数が数株であることである。そこで、すでに保存されているが次世代シーケンスを行っていないネパール株を培養しなおして、シーケンスを行う計画である。可能であればカザフスタンにも現地調査に出かけたいと考えている。

Research Products

• [Int'l Joint Research] ベイラー医科大学(米国)
• [Int'l Joint Research] アイルランガ大学/インドネシア大学(インドネシア)
• [Int'l Joint Research] 108病院/チョーライ病院(ベトナム)
• [Int'l Joint Research] モンゴル国立医科学大学/ウランバートル第3病院(モンゴル)
• [Int'l Joint Research] ケサル・ギャルポ医科大学/ジグメ・ドルジ・ワンチュク 国立総合病院/保健省 王立疾病 管理センター(ブータン)
• [Int'l Joint Research]
• [Journal Article] High levels of fecal calprotectin and C-reactive protein in patients with colitis. (2023)
  • Author(s): Anindita B, Sugihartono T, Miftahussurur M, Maimunah U, Nusi IA, Setiawan PB, Purbayu H, Kholili U, Widodo B, Thamrin H, Vidyani A, Rezkitha YAA, Yamaoka Y.
  • Journal Title: J Med Life. Volume: 16 Issue: 1 Pages: 48-51
  • DOI: 10.25122/jml-2021-0311
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mutations Related to Antibiotics Resistance in Helicobacter pylori Clinical Isolates from Bangladesh (2023)
  • Author(s): Fauzia Kartika Afrida、Aftab Hafeza、Tshibangu-Kabamba Evariste、Alfaray Ricky Indra、Saruuljavkhlan Batsaikhan、Cimuanga-Mukanya Alain、Matsumoto Takashi、Subsomwong Phawinee、Akada Junko、Miftahussurur Muhammad、Yamaoka Yoshio
  • Journal Title: Antibiotics Volume: 12 Issue: 2 Pages: 279-279
  • DOI: 10.3390/antibiotics12020279
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pattern and trends of Helicobacter pylori genotypes in gastric cancer: A Kenyan 8-year study. (2023)
  • Author(s): Njenga P, Njau A, Moloo Z, Revathi G, Tshibangu E, Yamaoka Y.
  • Journal Title: Front Med (Lausanne) Volume: 10 Pages: 1119513-1119513
  • DOI: 10.3389/fmed.2023.1119513
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Novel Helicobacter pylori-associated hemolysis Hp0499 and Hp1490 and its association with severity of gastritis. (2023)
  • Author(s): Sang Ketut Widiana, Titong Sugihartono, Dalla Doohan, Langgeng Agung Waskito, Kartika Afrida Fauzia, Yudith Annisa Ayu Rezkitha, Adi Wasis Prakosa, Ricky Indra Alfaray, Camilia Metadea Aji Safitri, Rizki Amalia, Yoshio Yamaoka, Muhammad Miftahussurur.
  • Journal Title: F1000Research Volume: 12 Pages: 22-22
  • DOI: 10.12688/f1000research.122306.1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long-Term Resistance-Endurance Combined Training Reduces Pro-Inflammatory Cytokines in Young Adult Females with Obesity. (2023)
  • Author(s): Pranoto A, Cahyono MBA, Yakobus R, Izzatunnisa N, Ramadhan RN, Rejeki PS, Miftahussurur M, Effendi WI, Wungu CDK, Yamaoka Y.
  • Journal Title: Sports (Basel) Volume: 27 Issue: 3 Pages: 54-54
  • DOI: 10.3390/sports11030054
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A comprehensive evaluation of an animal model for Helicobacter pylori‐associated stomach cancer: Fact and controversy. (2023)
  • Author(s): Amalia Rizki、Panenggak Nur Syahadati Retno、Doohan Dalla、Rezkitha Yudith Annisa Ayu、Waskito Langgeng Agung、Syam Ari Fahrial、Lubis Masrul、Yamaoka Yoshio、Miftahussurur Muhammad.
  • Journal Title: Helicobacter Volume: 28 Issue: 1
  • DOI: 10.1111/hel.12943
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Low-grade intestinal metaplasia in Indonesia: Insights into the expression of proinflammatory cytokines during Helicobacter pylori infection and unique East-Asian CagA characteristics (2023)
  • Author(s): Miftahussurur Muhammad、Alfaray Ricky Indra、Fauzia Kartika Afrida、Dewayani Astri、Doohan Dalla、Waskito Langgeng Agung、Rezkitha Yudith Annisa Ayu、Utomo Didik Huswo、Somayana Gde、Fahrial Syam Ari、Lubis Masrul、Akada Junko、Matsumoto Takashi、Yamaoka Yoshio
  • Journal Title: Cytokine Volume: 163 Pages: 156122-156122
  • DOI: 10.1016/j.cyto.2022.156122
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Single 30 min treadmill exercise session suppresses the production of pro-inflammatory cytokines and oxidative stress in obese female adolescents. (2023)
  • Author(s): Pranoto Adi、Rejeki Purwo Sri、Miftahussurur Muhammad、Setiawan Hayuris Kinandita、Yosika Ghana Firsta、Munir Misbakhul、Maesaroh Siti、Purwoto Septyaningrum Putri、Waritsu Cakra、Yamaoka Yoshio.
  • Journal Title: Journal of Basic and Clinical Physiology and Pharmacology Volume: 34 Issue: 2 Pages: 235-242
  • DOI: 10.1515/jbcpp-2022-0196
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 日本国内より分離された Helicobacter pylori の集団構造解析 (2023)
  • Author(s): 友成航平, Saruuljavkhlan Batsaikhan, Ricky Indra Alfaray, Kartika Afrida Fauzia1, 松成修, 赤田純子, 松本昂, 珍田大輔, 下山克, 金城渚, 金城徹, 金城福則, 山岡吉生
  • Journal Title: 大分県医学会雑誌 Volume: 29 Pages: 100-108
  • Peer Reviewed / Open Access
• [Journal Article] Urease Levels and Gastritis Stage in Dyspeptic Patients. (2022)
  • Author(s): Miftahussurur M, Putri CDM, Sugihartono T, Syam AF, Purbayu H, Priyantini D, Kahar H, Rezkitha YAA, Nusi IA, Setiawan PB, Maimunah U, Waskito LA, Kholili U, Widodo B, Vidyani A, Thamrin H, Siregar GA, I'tishom R, Uchida T, Yamaoka Y.
  • Journal Title: Acta Med Indones Volume: 54 Pages: 42-51
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Seroepidemiological survey of the prevalence of Helicobacter pylori infection in Sabah, Malaysia (2022)
  • Author(s): Mori Daisuke、John Jecelyn Leaslie、Sabri Shahnaz Irwani Binti、Shaharom Saliz Mazrina Binti、Iha Hidekatsu、Yamaoka Yoshio、Matsumoto Takashi、Ahmed Kamruddin
  • Journal Title: IJID Regions Volume: 2 Pages: 126-129
  • DOI: 10.1016/j.ijregi.2021.12.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Helicobacter pylori cagA status and gastric mucosa-associated lymphoid tissue lymphoma: a systematic review and meta-analysis (2022)
  • Author(s): Keikha Masoud、Sahebkar Amirhossein、Yamaoka Yoshio、Karbalaei Mohsen
  • Journal Title: Journal of Health, Population and Nutrition Volume: 41 Issue: 1
  • DOI: 10.1186/s41043-021-00280-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Next-Generation Sequencing-Based Study of Helicobacter pylori Isolates from Myanmar and Their Susceptibility to Antibiotics (2022)
  • Author(s): Subsomwong Phawinee、Doohan Dalla、Fauzia Kartika Afrida、Akada Junko、Matsumoto Takashi、Yee Than Than、Htet Kyaw、Waskito Langgeng Agung、Tuan Vo Phuoc、Uchida Tomohisa、Matsuhisa Takeshi、Yamaoka Yoshio
  • Journal Title: Microorganisms Volume: 10 Issue: 1 Pages: 196-196
  • DOI: 10.3390/microorganisms10010196
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Extragastric infection of Helicobacter pylori and alopecia areata: a systematic review and meta-analysis. (2022)
  • Author(s): Ghazvini Kiarash、Yamaoka Yoshio、Karbalaei Mohsen、Keikha Masoud.
  • Journal Title: Reviews in Medical Microbiology Volume: 33 Issue: 1 Pages: 114-118
  • DOI: 10.1097/mrm.0000000000000276
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Editorial: The Role of Mobile Genetic Elements in Bacterial Evolution and Their Adaptability (2022)
  • Author(s): Vale Filipa F.、Lehours Philippe、Yamaoka Yoshio
  • Journal Title: Frontiers in Microbiology Volume: 13 Pages: 1-2
  • DOI: 10.3389/fmicb.2022.849667
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genomic differentiation within East Asian Helicobacter pylori (2022)
  • Author(s): You Yuanhai、Thorell Kaisa、He Lihua、Yahara Koji、Yamaoka Yoshio、Cha Jeong-Heon、Murakami Kazunari、Katsura Yukako、Kobayashi Ichizo、Falush Daniel、Zhang Jianzhong、TEAMHp
  • Journal Title: Microbial Genomics Volume: 8 Issue: 2 Pages: 1-14
  • DOI: 10.1099/mgen.0.000676
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Potassium intake is associated with nutritional quality and actual diet cost: a study at formulating a low sodium high potassium (LSHP) healthy diet (2022)
  • Author(s): Farapti Farapti、Buanasita Annas、Atmaka Dominikus R.、Setyaningtyas Stefania W.、Adriani Merryana、Rejeki Purwo S.、Yamaoka Yoshio、Miftahussurur Muhammad
  • Journal Title: Journal of Nutritional Science Volume: 11
  • DOI: 10.1017/jns.2021.104
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Unique TLR9 Activation by Helicobacter pylori Depends on the cag T4SS, But Not on VirD2 Relaxases or VirD4 Coupling Proteins (2022)
  • Author(s): Tegtmeyer Nicole、Linz Bodo、Yamaoka Yoshio、Backert Steffen
  • Journal Title: Current Microbiology Volume: 79 Issue: 4
  • DOI: 10.1007/s00284-022-02813-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of Nocturnal and Diurnal Moderate-intensity Swimming Exercise on Increasing Irisin Level of Female Mice (Mus musculus). (2022)
  • Author(s): Muhamad FA, Purwo SR, Sulistiawati, Adi P, Kristanti WW, Gadis MS, Ronny L, Yamaoka Y.
  • Journal Title: CMU J Nat Sci Volume: 21
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Review: Epidemiology of Helicobacter pylori Infection. (2022)
  • Author(s): Alfaray RI , Saruuljavkhlan B. Ansari S, Fauzia KA, Yamaoka Y.
  • Journal Title: Microb Health Dis (European Helicobacter & Microbiota Study Group) Volume: 4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Helicobacter pylori genomes reveal Paleolithic human migration to the east end of Asia (2022)
  • Author(s): Suzuki Rumiko、Saitou Naruya、Matsuari Osamu、Shiota Seiji、Matsumoto Takashi、Akada Junko、Kinjo Nagisa、Kinjo Fukunori、Teruya Kuniko、Shimoji Makiko、Shiroma Akino、Kato Mototsugu、Satou Kazuhito、Hirano Takashi、Asaka Masahiro、Kryukov Kirill、Moodley Yoshan、Yamaoka Yoshio
  • Journal Title: iScience Volume: 25 Issue: 7 Pages: 104477-104477
  • DOI: 10.1016/j.isci.2022.104477
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The role of non-Helicobacter pylori bacteria in the pathogenesis of gastroduodenal diseases. (2022)
  • Author(s): Waskito LA, Rezkitha YAA, Vilaichone RK, Sugihartono T, Mustika S, Dewa Nyoman Wibawa I, Yamaoka Y, Miftahussurur M.
  • Journal Title: Gut Pathog Volume: 14 Issue: 1
  • DOI: 10.1186/s13099-022-00494-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Animal Models and Helicobacter pylori Infection. (2022)
  • Author(s): Ansari S, Yamaoka Y.
  • Journal Title: J Clin Med Volume: 11 Issue: 11 Pages: 3141-3141
  • DOI: 10.3390/jcm11113141
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Macronutrient and micronutrient intake in dietary habits contributed to dyspeptic symptoms in Indonesia. (2022)
  • Author(s): Miftahussurur M., Alfaray R.I., Rezkitha Y.A.A., Fauzia K.A., Maulahela H., Muzellina V.N., Rotty L.S.M., Namara Y.S., Abubakar A., Mustika S., Ratnasari N., Santosa A.Y., Richardo M., Wibawa I.D.N., Adnyana I.K., Rachman P.H., Rachman B.E., Doohan D., Waskito L.A., Yamaoka Y., Khomsan A.
  • Journal Title: Gaceta Medica de Caracas Volume: 130 Issue: 2 Pages: 266-275
  • DOI: 10.47307/gmc.2022.130.2.6
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Role of fecal calprotectin as a hypoxic intestinal damage biomarker in COVID-19 patients. (2022)
  • Author(s): Adriana DN, Sugihartono T, Nusi IA, Setiawan PB, Purbayu H, Maimunah U, Kholili U, Widodo B, Thamrin H, Vidyani A, Maulahela H, Yamaoka Y, Miftahussurur M.
  • Journal Title: Gut Pathog Volume: 14 Issue: 1
  • DOI: 10.1186/s13099-022-00507-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Analysis of gastric microbiota and Helicobacter pylori infection in gastroesophageal reflux disease (2022)
  • Author(s): Sugihartono Titong、Fauzia Kartika Afrida、Miftahussurur Muhammad、Waskito Langgeng Agung、Rejeki Purwo Sri、I’tishom Reny、Alfaray Ricky Indra、Doohan Dalla、Amalia Rizki、Savitri Camilia Metadea Aji、Rezkitha Yudith Annisa Ayu、Akada Junko、Matsumoto Takashi、Yamaoka Yoshio
  • Journal Title: Gut Pathogens Volume: 14 Issue: 1 Pages: 38-38
  • DOI: 10.1186/s13099-022-00510-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Helicobacter pylori Infection, Its Laboratory Diagnosis, and Antimicrobial Resistance: a Perspective of Clinical Relevance. (2022)
  • Author(s): Ansari S, Yamaoka Y.
  • Journal Title: Clin Microbiol Rev Volume: 35 Issue: 3
  • DOI: 10.1128/cmr.00258-21
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Helicobacter pylori infection: is there circulating vacuolating cytotoxin A or cytotoxin-associated gene A protein? (2022)
  • Author(s): Imoto I, Oka S, Katsurahara M, Nakamura M, Yasuma T, Akada J, D'Alessandro-Gabazza CN, Toda M, Horiki N, Gabazza EC, Yamaoka Y.
  • Journal Title: Gut Pathog Volume: 14 Issue: 1
  • DOI: 10.1186/s13099-022-00519-8
  • Peer Reviewed / Open Access
• [Journal Article] Helicobacter pylori prevalence in Indonesia: Higher infection risk in Eastern region population. (2022)
  • Author(s): Maulahela H, Doohan D, Annisa Ayu Rezkhita Y, Syam AF, Waskito LA, Metadea Aji Savitri C, Richardo M, Rahman A, Namara YS, Shatri H, Sanityoso A, Alamsyah. Siregar G, Sudarmo E, Uchida T, Vilaichone RK, Yamaoka Y, Muhammad Miftahussurur.
  • Journal Title: F1000Research Volume: 11
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 第25回 マレーシアでの疫学調査 (2022)
  • Author(s): 山岡吉生
  • Journal Title: Helicobacter Research Volume: 26 Pages: 95-106
• [Journal Article] 35th Workshop of the European Helicobacter and Microbiota Study Group (EHMSG) 2022 (2022年9月8～10日, グラスゴー) (2022)
  • Author(s): 山岡吉生
  • Journal Title: Helicobacter Research Volume: 26 Pages: 226-229
• [Journal Article] 第26回 ドミニカ共和国での疫学調査 その1 (2022)
  • Author(s): 山岡吉生
  • Journal Title: Helicobacter Research Volume: 26 Pages: 233-242
• [Journal Article] Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations. (2022)
  • Author(s): Thorpe HA, Tourrette E, Yahara K, Vale FF, Liu S, Oleastro M, Alarcon T. Perets TT, Latifi-Navid S, Yamaoka Y, Martinez-Gonzalez B, Karayiannis I, Karamitros T, Sgouras DN, Elamin W, Pascoe B, Sheppard SK, Ronkainen J, Aro P, Engstrand L, Agreus L, Suerbaum S, Thorell K, Falush D.
  • Journal Title: Nature Communications Volume: 13 Issue: 1 Pages: 6842-6842
  • DOI: 10.1038/s41467-022-34475-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical manifestations of COVID-19 in patients with asthma, hypertension, and diabetes mellitus. (2022)
  • Author(s): Budiarti R, Ediono E, Kalaznykov M, Yamaoka Y, Miftahussurur M.
  • Journal Title: Journal of Medicine and Life Volume: 15 Issue: 12 Pages: 1502-1506
  • DOI: 10.25122/jml-2021-0364
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum pepsinogen level as a biomarker for atrophy, reflux esophagitis, and gastric cancer screening in Indonesia. (2022)
  • Author(s): Miftahussurur M, Waskito LA, Syam AF, Nusi IA, Wibawa IDN, Rezkitha YAA, Fauzia KA, Siregar GA, Akil F, Waleleng BJ, Saudale AMJ, Abubakar A, Maulahela H, Richardo M, Rahman A, Namara YS, Sudarmo E, Adi P, Maimunah U, Setiawan, Yamaoka Y.
  • Journal Title: Journal of Research in Medical Sciences Volume: 27 Issue: 1 Pages: 90-90
  • DOI: 10.4103/jrms.jrms_983_21
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cut-off value of clarithromycin resistance in the treatment of Helicobacter pylori infection: how low is low? (2022)
  • Author(s): Hsu Ping-I、Chuah Seng-Kee、Yamaoka Yoshio、Wu Deng-Chyang.
  • Journal Title: Gut Volume: omline Issue: 2 Pages: 374-375
  • DOI: 10.1136/gutjnl-2022-329253
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Characterization of Helicobacter pylori tlyA and Its Association with Bacterial Density (2021)
  • Author(s): Prakosa Adi Wasis、Miftahussurur Muhammad、Juniastuti Juniastuti、Waskito Langgeng Agung、Doohan Dalla、Fauzia Kartika Afrida、Rezkitha Yudith Annisa Ayu、Sugihartono Titong、Syam Ari Fahrial、Uchida Tomohisa、Yamaoka Yoshio
  • Journal Title: Digestive Diseases Volume: Online ahead of print Issue: 4 Pages: 417-426
  • DOI: 10.1159/000518538
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The effect of long-term ketogenic diet on serum adiponectin and insulin-like growth factor-1 levels in mice (2021)
  • Author(s): Widiatmaja Deandra M.、Lutvyani Alif、Sari Desi R.、Kurniasari Hamidah、Meiliana Ismi D.、Fasitasari Minidian、Yamaoka Yoshio、Rejeki Purwo S.
  • Journal Title: Journal of Basic and Clinical Physiology and Pharmacology Volume: 1 Issue: 5 Pages: 1-10
  • DOI: 10.1515/jbcpp-2021-0287
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Outer membrane protein HopF is involved in biofilm formation and virulence in Helicobacter pylori (2023)
  • Author(s): Kartika Afrida Fauzia, Yuri Sugawara, Mayu Obata, Rizki Amalia, Ricky Indra Alfaray, Camilia Metadea, Junko Akada, Takashi Matsumoto, Muhammad Miftahussurur, Yoshio Yamaoka
  • Organizer: The 19th Korea-Japan H. pylori Joint Symposium, Gut and liver
  • Int'l Joint Research
• [Presentation] Microbiome analysis for the diagnosis of H. pylori infection (2023)
  • Author(s): Yamaoka Y.
  • Organizer: International Symposium on Helicobacter and Upper Gastrointestinal Disease
  • Int'l Joint Research / Invited
• [Presentation] Gastric microbiota and H. pylori in an Asian population (2023)
  • Author(s): Yamaoka Y.
  • Organizer: International Symposium on Helicobacter and Upper Gastrointestinal Disease
  • Int'l Joint Research / Invited
• [Presentation] Mutations Related to Antibiotics Resistance in Helicobacter pylori Clinical Isolates from Bangladesh (2023)
  • Author(s): Fauzia, Kartika Afrida, Hafeza Aftab, Evariste Tshibangu-Kabamba, Ricky Indra Alfaray, Batsaikhan Saruuljavkhlan, Alain Cimuanga-Mukanya, Takashi Matsumoto, Phawinee Subsomwong, Junko Akada, Muhammad Miftahussurur, and Yoshio Yamaoka
  • Organizer: International Symposium on Helicobacter and Upper Gastrointestinal Disease
  • Int'l Joint Research
• [Presentation] Amoxicillin resistance in Helicobacter pylori: Identification of new resistance-conferring mutations in the penicillin-binding protein 1A (2023)
  • Author(s): Cimuanga-Mukanya A, Tshibangu-Kabamba E, Ngoma-Kisoko PdeJ , Disashi-Tumba G, Matsumoto T,Akada J and Yamaoka Y
  • Organizer: The 19th Korea-Japan H. pylori Joint Symposium
  • Int'l Joint Research
• [Presentation] Utilization of an Automated Latex Agglutination Turbidity Assay for Assessing Gastric Mucosal Alteration during Helicobacter pylori Infection (2023)
  • Author(s): Khangai A Akada J, Azzaya D, Batsaikhan S, Gantuya B, Oyuntsetseg K, Davaadaorj D, Matsumoto T, Uchida T, Akada J, and Yamaoka Y.
  • Organizer: The 19th Korea-Japan H. pylori Joint Symposium
  • Int'l Joint Research
• [Presentation] Ancient human footprints left in Helicobacter pylori (2022)
  • Author(s): Yamaoka Y.
  • Organizer: The 11th Asian Pacific Topic Conference in the 108th General Meeting of the Japanese Society of Gastroenterology
  • Int'l Joint Research / Invited
• [Presentation] Biofilm Formation and antibiotic resistance phenotype of Helicobacter pylori clinical isolates. (2022)
  • Author(s): Fauzia KA, Matsumoto T, Akada J, Yonezawa H, Kamiya S, Yamaoka Y.
  • Organizer: The 18th Japan-Korea H. pylori Joint Symposium,
  • Int'l Joint Research
• [Presentation] The impact of mobile genetic elemants and toxin-antitoxin system on Helicobacter pylori adaptability and antimicrobial resistance: A wisdom from Japan-South Korea whole-genome sequence collection. (2022)
  • Author(s): Alfaray RI, Batsaikhan S, Fauzia KA, Akada J, Matsumoto T, Yamaoka Y.
  • Organizer: The 18th Japan-Korea H. pylori Joint Symposium,
  • Int'l Joint Research
• [Presentation] Identification of the Helicobacter pylori genomic islands in a high gastric cancer region. (2022)
  • Author(s): Batsaikhan S, Alfaray RI, Matsumoto T, Akada J, Yamaoka Y.
  • Organizer: The 18th Japan-Korea H. pylori Joint Symposium,
  • Int'l Joint Research
• [Presentation] Helicobacter pylori and host human genetics in the Caribbean countries (2022)
  • Author(s): Yamaoka Y.
  • Organizer: IX INTERNATIONAL SYMPOSIUM OF Helicobacter pylori INFECTION AND GASTRIC CANCER
  • Int'l Joint Research / Invited
• [Presentation] Helicobacter pylori isolates from Mongolia describing gastric carcinogenesis and human migration (2022)
  • Author(s): Gantuya B, Yoshio Y, Oyuntsetseg K
  • Organizer: 2022 The Japanese Society of Medical Oncology Annual Meeting
  • Int'l Joint Research
• [Presentation] Global genome study of helicobacter pylori phage opens new paradigm on their worldwide distribution, genetic feature, and impacts on antimicrobial resistance, disease advancement, and achievement for phage-based therapy (2022)
  • Author(s): Alfaray IR, Saruuljavkhlan B, Fauzia KA, Matsumoto T, Yamaoka Y.
  • Organizer: Gut
  • Int'l Joint Research
• [Presentation] A novel pathogen enterococcus hirae induced dysbiosis in the stomach and the genomic instability to promote gastric cancer (2022)
  • Author(s): Saruuljavkhlan B, Gantuya B, Akada J, Matsumoto T, Alfaray RI, Oyuntsetseg K, Yamaoka Y.
  • Organizer: Gut
  • Int'l Joint Research
• [Presentation] Pro-Inflammatory Cytokine Expression Observed During Helicobacter pylori Infection Revealed the Possibility Reason of Low-Grade Intestinal Metaplasia in Indonesia. (2022)
  • Author(s): Rezkitha, Y.A, Yamaoka Y.
  • Organizer: ASEAN Stomach and Microbiota Study Group
  • Int'l Joint Research
• [Presentation] Worldwide Helicobacter pylori Phage Study: Genome Analysis, Epidemiology, Clinical Data, until New Phage-based Medicine Candidate. (2022)
  • Author(s): Alfaray RI, Yamaoka Y.
  • Organizer: The 21st International Workshop on Campylobacter, Helicobacter and Related Organisms
  • Int'l Joint Research
• [Presentation] Comprehensive Study of Helicobacter pylori Genomic Islands and Their Correlation to Gastric Diseases, Phylogenetic Pattern. (2022)
  • Author(s): Saruuljavkhlan B, Yamaoka Y.
  • Organizer: The 21st International Workshop on Campylobacter, Helicobacter and Related Organisms
  • Int'l Joint Research
• [Presentation] Identification of Flagella and Outer Membrane Protein Genes associated with Biofilm Formation (2022)
  • Author(s): Kartika Afrida Fauzia, Yamaoka Y.
  • Organizer: The 21st International Workshop on Campylobacter, Helicobacter and Related Organisms
  • Int'l Joint Research
• [Presentation] Effect of gastric microbiota to gastric cancer development (2022)
  • Author(s): Yamaoka Y.
  • Organizer: 28th Conference on Gastroenterology & Hepatology by VIETNAM ASSOCIATION OF GASTROENTEROLOGY
  • Int'l Joint Research / Invited
• [Presentation] H. pylori and the pathogenesis of gastric cancer (2022)
  • Author(s): Yamaoka Y.
  • Organizer: ASEAN Gastro2022
  • Int'l Joint Research / Invited
• [Remarks] 大分大学医学部環境・予防医学講座
  • URL: https://oitadepm.com/
• [Remarks] SATREPS 大分大学
  • URL: https://satreps-oitauniv.com/