Human migration to Japan by searching Helicobacter pylori genome

• Project Area: Deciphering Origin and Establishment of Japonesians mainly based on genome sequence data
• Project/Area Number: 21H00346
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Oita University
• Principal Investigator: 山岡 吉生 大分大学, 医学部, 教授 (00544248)
• Project Period (FY): 2021-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000); Fiscal Year 2022: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2021: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
• Keywords: ヘリコバクターピロリ / 人類の移動の歴史 / 遺伝子解析 / ヘリコバクター・ピロリ / ゲノム / ヤポネシア / 沖縄 / 人類移動 / 人類の移動 / 次世代シーケンス

Outline of Research at the Start

ヘリコバクター・ピロリ（ピロリ菌）は、人類と共に旅をしてきた。我々はピロリ菌ゲノムを解析することで、アイヌや沖縄に特異的なピロリ菌が存在、沖縄特異的な菌には、分岐年代が旧石器時代と縄文時代の２系統が存在することがわかった。本研究では、ピロリ菌の全ゲノム解析を通して、これらのピロリ菌の起源、さらにはヒト側のDNAの検討も加えて、ヤポネシアの人類史を明らかにしていく。

Outline of Annual Research Achievements

人類は、約5～10万年前にアフリカ大陸を出て世界各地に広がった。胃癌の原因と考えられるピロリ菌は、人類の出アフリカ前にヒトの胃への感染を確立し、人類と共に旅をしてきた。我々はピロリ菌ゲノムを解析することで、人類集団の移動、特にアジアから日本列島（ヤポネシア）への移動を追っている。本研究では、世界最大規模のピロリ菌コレクションを生かして、次世代シーケンサーを用いてピロリ菌の全ゲノム解析を行うとともに、ヒト側のDNAもヤポネシアゲノム研究者の協力を得て調査することで、ヤポネシアの人類史を明らかにしていく計画とした。コロナ禍の影響もあり、新しい検体を入手することができず、当初は、保存されてあるピロリ菌遺伝子の解析を進めた。2022年には、次世代シーケンスにより、国内において、沖縄やアイヌ人のピロリ菌にそれぞれ特有のピロリ菌が存在し、沖縄の一部のピロリ菌はその起源が中央アジアにあることをiScience誌に発表することができた。その後も検討を重ね、本土（本州や九州）のピロリ菌も、胃癌の多い北部（青森）と胃癌の比較的少ない（大分）のピロリ菌には違いがあることが分かり、前向き研究を行うこととした。本年度は、鹿児島県、宮古島、さらに大分県北部で、ピロリ菌とヒト側のDNAを得ることができ、ピロリ菌においては、明らかに北部（青森）と南部（九州）では遺伝子が異なり、胃癌に関連する可能性のあるSNPs候補を得ることができた。また、従来、沖縄のピロリ菌の7割程度は、本土のピロリ菌と同一と思われていたが（iScience 2022年でも区別不可能）、沖縄に見られる本土に近いピロリ菌も、明らかに異なる系統を示すことも分かった。現在、ヒト側の検討を別予算で進めているところである。

Research Progress Status

令和4年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和4年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] ケサル・ギャルポ医科大学/ジグメ・ドルジ・ワンチュク 国立総合病院/保健省 王立疾病 管理センター(ブータン)
• [Int'l Joint Research] 108病院/チョーライ病院/ハノイ医科大学(ベトナム)
• [Int'l Joint Research] モンゴル国立医科学大学/モンゴル国立がん研究所(モンゴル)
• [Int'l Joint Research] ベイラー医科大学(米国)
• [Int'l Joint Research] ベイラー医科大学(米国)
• [Int'l Joint Research] アイルランガ大学/インドネシア大学(インドネシア)
• [Int'l Joint Research] 108病院/チョーライ病院(ベトナム)
• [Int'l Joint Research] モンゴル国立医科学大学/ウランバートル第3病院(モンゴル)
• [Int'l Joint Research] ケサル・ギャルポ医科大学/ジグメ・ドルジ・ワンチュク 国立総合病院/保健省 王立疾病 管理センター(ブータン)
• [Int'l Joint Research]
• [Journal Article] Simultaneous detection of Helicobacter pylori infection comparing between white light and image-enhanced endoscopy (2024)
  • Author(s): Chatrangsun Boonyaorn、Aumpan Natsuda、Pornthisarn Bubpha、Chonprasertsuk Soonthorn、Siramolpiwat Sith、Bhanthumkomol Patommatat、Nunanan Pongjarat、Issariyakulkarn Navapan、Mahachai Varocha、Yamaoka Yoshio、Vilaichone Ratha-korn
  • Journal Title: BMC Gastroenterology Volume: 24 Issue: 1 Pages: 46-46
  • DOI: 10.1186/s12876-024-03132-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characterization of residual cancer by comparison of a pair of organoids established from a patient with esophageal squamous cell carcinoma before and after neoadjuvant chemotherapy (2024)
  • Author(s): Fuchino Takafumi、Kurogi Shusaku、Tsukamoto Yoshiyuki、Shibata Tomotaka、Fumoto Shoichi、Fujishima Hajime、Kinoshita Keisuke、Mizukami Kazuhiro、Kodama Masaaki、Inomata Masafumi、Murakami Kazunari、Moriyama Masatsugu、Hijiya Naoki
  • Journal Title: Human Cell Volume: 37 Issue: 2 Pages: 491-501
  • DOI: 10.1007/s13577-023-01020-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Study of Helicobacter pylori Isolated from a High-Gastric-Cancer-Risk Population: Unveiling the Comprehensive Analysis of Virulence-Associated Genes including Secretion Systems, and Genome-Wide Association Study (2023)
  • Author(s): Saruuljavkhlan B, Alfaray RI, Oyuntsetseg K, Gantuya B, Khangai A, Renchinsengee N, Matsumoto T, Akada J, Azzaya D, Davaadorj D, Yamaoka Y.
  • Journal Title: Cancers (Basel) Volume: 15 Issue: 18 Pages: 4528-4528
  • DOI: 10.3390/cancers15184528
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Predictive factors and prognosis of upper gastrointestinal bleeding in gastric cancer: A large population-based study (UGIB-GC trial) (2023)
  • Author(s): Kiattiweerasak Anya、Bongkotvirawan Phubordee、Aumpan Natsuda、Yamaoka Yoshio、Miftahussurur Muhammad、Vilaichone Ratha-korn
  • Journal Title: PLOS ONE Volume: 18 Issue: 9 Pages: e0291926-e0291926
  • DOI: 10.1371/journal.pone.0291926
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Utilization of an Automated Latex Agglutination Turbidity Assay for Assessing Gastric Mucosal Alteration during Helicobacter pylori Infection (2023)
  • Author(s): Khangai Ayush、Akada Junko、Saruuljavkhlan Batsaikhan、Gantuya Boldbaatar、Azzaya Dashdorj、Oyuntsetseg Khasag、Davaadorj Duger、Uchida Tomohisa、Matsumoto Takashi、Yamaoka Yoshio
  • Journal Title: Gut and Liver Volume: 18 Issue: 1 Pages: 60-69
  • DOI: 10.5009/gnl220464
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Global Antimicrobial Resistance Gene Study of Helicobacter pylori: Comparison of Detection Tools, ARG and Efflux Pump Gene Analysis, Worldwide Epidemiological Distribution, and Information Related to the Antimicrobial-Resistant Phenotype (2023)
  • Author(s): Alfaray Ricky Indra、Saruuljavkhlan Batsaikhan、Fauzia Kartika Afrida、Torres Roberto C.、Thorell Kaisa、Dewi Selva Rosyta、Kryukov Kirill A.、Matsumoto Takashi、Akada Junko、Vilaichone Ratha-korn、Miftahussurur Muhammad、Yamaoka Yoshio
  • Journal Title: Antibiotics Volume: 12 Issue: 7 Pages: 1118-1118
  • DOI: 10.3390/antibiotics12071118
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A single-nucleotide polymorphism in Helicobacter pylori promotes gastric cancer development (2023)
  • Author(s): Sharafutdinov Irshad、Tegtmeyer Nicole、Linz Bodo、Rohde Manfred、Vieth Michael、Tay Alfred Chin-Yen、Lamichhane Binit、Tuan Vo Phuoc、Fauzia Kartika Afrida、Sticht Heinrich、Yamaoka Yoshio、Marshall Barry J.、Backert Steffen
  • Journal Title: Cell Host Microbe Volume: 31 Issue: 8 Pages: 1345-1358.e6
  • DOI: 10.1016/j.chom.2023.06.016
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Advantages of Whole Genome Sequencing in Mitigating the Helicobacter pylori Antimicrobial Resistance Problem (2023)
  • Author(s): Fauzia Kartika Afrida、Alfaray Ricky Indra、Yamaoka Yoshio
  • Journal Title: Microorganisms Volume: 11 Issue: 5 Pages: 1239-1239
  • DOI: 10.3390/microorganisms11051239
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genetic determinants of Biofilm formation of Helicobacter pylori using whole-genome sequencing (2023)
  • Author(s): Fauzia Kartika Afrida、Aftab Hafeza、Miftahussurur Muhammad、Waskito Langgeng Agung、Tuan Vo Phuoc、Alfaray Ricky Indra、Matsumoto Takashi、Yurugi Michiyuki、Subsomwong Phawinee、Kabamba Evariste Tshibangu、Akada Junko、Yamaoka Yoshio
  • Journal Title: BMC Microbiology Volume: 23 Issue: 1 Pages: 159-159
  • DOI: 10.1186/s12866-023-02889-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparative genomics of two Vietnamese Helicobacter pylori strains, CHC155 from a non-cardia gastric cancer patient and VN1291 from a duodenal ulcer patient. (2023)
  • Author(s): Phuc BH, Tuan VP, Binh TT, Tung PH, Tri TD, Dung HDQ, Thuan NPM, Fauzia KA, Tshibangu-Kabamba E, Alfaray RI, Saruuljavkhlan B, Matsumoto T, Akada J, Yamaoka Y.
  • Journal Title: Sci Rep Volume: 13 Issue: 1 Pages: 8869-8869
  • DOI: 10.1038/s41598-023-35527-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Management of dyspepsia and Helicobacter pylori infection: the 2022 Indonesian Consensus Report (2023)
  • Author(s): Syam Ari Fahrial、Miftahussurur Muhammad、Makmun Dadang、etc. Lucida Maria Inge、Rezkhita Yudith Annisa Ayu、Alfaray Ricky Indra、Yamaoka Yoshio
  • Journal Title: Gut Pathogens Volume: 15 Issue: 1 Pages: 25-25
  • DOI: 10.1186/s13099-023-00551-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Current management of corrosive, alcohol, and organophosphate poisoning: Pearls and pitfalls (2023)
  • Author(s): Miftahussurur Muhammad、Nabilah Nabilah、Rezkitha YudithAnnisa Ayu、Yamaoka Yoshio
  • Journal Title: Journal of Research in Medical Sciences Volume: 28 Issue: 1 Pages: 20-20
  • DOI: 10.4103/jrms.jrms_635_21
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gastric microbiome changes in relation with Helicobacter pylori resistance (2023)
  • Author(s): Dewayani Astri、Afrida Fauzia Kartika、Alfaray Ricky Indra、Waskito Langgeng Agung、Doohan Dalla、Rejeki Purwo Sri、Alshawsh Mohammed Abdullah、Rezkitha Yudith Annisa Ayu、Yamaoka Yoshio、Miftahussurur Muhammad
  • Journal Title: PLOS ONE Volume: 18 Issue: 5 Pages: e0284958-e0284958
  • DOI: 10.1371/journal.pone.0284958
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical significance of genetic polymorphisms of interleukin-1β and cytochrome P450 2C19 on the eradication of Helicobacter pylori (2023)
  • Author(s): Karbalaei Mohsen、Yamaoka Yoshio、Keikha Masoud
  • Journal Title: New Microbes and New Infections Volume: 53 Pages: 101131-101131
  • DOI: 10.1016/j.nmni.2023.101131
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The interaction between autophagy, Helicobacter pylori, and gut microbiota in gastric carcinogenesis (2023)
  • Author(s): Nabavi-Rad Ali、Yadegar Abbas、Sadeghi Amir、Aghdaei Hamid Asadzadeh、Zali Mohammad Reza、Klionsky Daniel J.、Yamaoka Yoshio
  • Journal Title: Trends in Microbiology Volume: 31 Issue: 10 Pages: 1024-1043
  • DOI: 10.1016/j.tim.2023.04.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Hybrid, High-Dose Dual and Bismuth Quadruple Therapies for First-Line Treatment of Helicobacter pylori Infection in Taiwan: A Multicenter, Open-Label, Randomized Trial (2023)
  • Author(s): Hsu Ping-I、Chen Kuan-Yang、Tai Wei-Chen、Yang Jyh-Chin、Tsay Feng-Woei、Liu Yu-Hwa、Chen Chien-Lin、Lee Chia-Long、Yeh Hong-Zen、Kuo Chao-Hung、Chuah Seng-Kee、Lee Hsi-Chang、Shie Chang-Bih、Shiu Sz-Iuan、Kao John Y.、Yamaoka Yoshio、Graham David Y.、Wu Deng-Chyang
  • Journal Title: American Journal of Gastroenterology Volume: 118 Issue: 7 Pages: 1184-1195
  • DOI: 10.14309/ajg.0000000000002255
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Long-Term Resistance-Endurance Combined Training Reduces Pro-Inflammatory Cytokines in Young Adult Females with Obesity. (2023)
  • Author(s): Pranoto A, Cahyono MBA, Yakobus R, Izzatunnisa N, Ramadhan RN, Rejeki PS, Miftahussurur M, Effendi WI, Wungu CDK, Yamaoka Y.
  • Journal Title: Sports (Basel) Volume: 27 Issue: 3 Pages: 54-54
  • DOI: 10.3390/sports11030054
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pattern and trends of Helicobacter pylori genotypes in gastric cancer: A Kenyan 8-year study. (2023)
  • Author(s): Njenga P, Njau A, Moloo Z, Revathi G, Tshibangu E, Yamaoka Y.
  • Journal Title: Front Med (Lausanne) Volume: 10 Pages: 1119513-1119513
  • DOI: 10.3389/fmed.2023.1119513
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High levels of fecal calprotectin and C-reactive protein in patients with colitis. (2023)
  • Author(s): Anindita B, Sugihartono T, Miftahussurur M, Maimunah U, Nusi IA, Setiawan PB, Purbayu H, Kholili U, Widodo B, Thamrin H, Vidyani A, Rezkitha YAA, Yamaoka Y.
  • Journal Title: J Med Life. Volume: 16 Issue: 1 Pages: 48-51
  • DOI: 10.25122/jml-2021-0311
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mutations Related to Antibiotics Resistance in Helicobacter pylori Clinical Isolates from Bangladesh. (2023)
  • Author(s): Fauzia, Kartika Afrida, Hafeza Aftab, Evariste Tshibangu-Kabamba, Ricky Indra Alfaray, Batsaikhan Saruuljavkhlan, Alain Cimuanga-Mukanya, Takashi Matsumoto, Phawinee Subsomwong, Junko Akada, Muhammad Miftahussurur, and Yoshio Yamaoka.
  • Journal Title: Antibiotics Volume: 12 Issue: 2 Pages: 279-279
  • DOI: 10.3390/antibiotics12020279
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Single 30 min treadmill exercise session suppresses the production of pro-inflammatory cytokines and oxidative stress in obese female adolescents. (2023)
  • Author(s): Pranoto Adi、Rejeki Purwo Sri、Miftahussurur Muhammad、Setiawan Hayuris Kinandita、Yosika Ghana Firsta、Munir Misbakhul、Maesaroh Siti、Purwoto Septyaningrum Putri、Waritsu Cakra、Yamaoka Yoshio.
  • Journal Title: Journal of Basic and Clinical Physiology and Pharmacology Volume: 34 Issue: 2 Pages: 235-242
  • DOI: 10.1515/jbcpp-2022-0196
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Low-grade intestinal metaplasia in Indonesia: Insights into the expression of proinflammatory cytokines during Helicobacter pylori infection and unique East-Asian CagA characteristics (2023)
  • Author(s): Miftahussurur Muhammad、Alfaray Ricky Indra、Fauzia Kartika Afrida、Dewayani Astri、Doohan Dalla、Waskito Langgeng Agung、Rezkitha Yudith Annisa Ayu、Utomo Didik Huswo、Somayana Gde、Fahrial Syam Ari、Lubis Masrul、Akada Junko、Matsumoto Takashi、Yamaoka Yoshio
  • Journal Title: Cytokine Volume: 163 Pages: 156122-156122
  • DOI: 10.1016/j.cyto.2022.156122
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A comprehensive evaluation of an animal model for Helicobacter pylori‐associated stomach cancer: Fact and controversy. (2023)
  • Author(s): Amalia Rizki、Panenggak Nur Syahadati Retno、Doohan Dalla、Rezkitha Yudith Annisa Ayu、Waskito Langgeng Agung、Syam Ari Fahrial、Lubis Masrul、Yamaoka Yoshio、Miftahussurur Muhammad.
  • Journal Title: Helicobacter Volume: 28 Issue: 1
  • DOI: 10.1111/hel.12943
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Exploring Alternative Treatment Choices for Multidrug-Resistant Clinical Strains of Helicobacter pylori in Mongolia (2023)
  • Author(s): Khangai Ayush、Saruuljavkhlan Batsaikhan、Azzaya Dashdorj、Gantuya Boldbaatar、Oyuntsetseg Khasag、Akada Junko、Matsumoto Takashi、Yamaoka Yoshio
  • Journal Title: Microorganisms Volume: 11 Issue: 12 Pages: 2852-2852
  • DOI: 10.3390/microorganisms11122852
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Antibiotic Resistance and Therapy for Helicobacter pylori Infection (2023)
  • Author(s): Smith Stella I.、Yamaoka Yoshio
  • Journal Title: Antibiotics Volume: 12 Issue: 12 Pages: 1669-1669
  • DOI: 10.3390/antibiotics12121669
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Management of Helicobacter pylori treatment failures: A large population-based study (HP treatment failures trial) (2023)
  • Author(s): Aumpan Natsuda、Issariyakulkarn Navapan、Mahachai Varocha、Graham David、Yamaoka Yoshio、Vilaichone Ratha-korn
  • Journal Title: PLOS ONE Volume: 18 Issue: 11 Pages: e0294403-e0294403
  • DOI: 10.1371/journal.pone.0294403
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Functional genome analysis and anti-Helicobacter pylori activity of a novel bacteriocinogenic Lactococcus sp. NH2-7C from Thai fermented pork (Nham) (2023)
  • Author(s): Kingkaew Engkarat、Woraprayote Weerapong、Booncharoen Auttaporn、Niwasabutra Kanidta、Janyaphisan Thitiphorn、Vilaichone Ratha-Korn、Yamaoka Yoshio、Visessanguan Wonnop、Tanasupawat Somboon
  • Journal Title: Scientific Reports Volume: 13 Issue: 1 Pages: 20362-20362
  • DOI: 10.1038/s41598-023-47687-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pathogenomics of Helicobacter pylori (2023)
  • Author(s): Yamaoka Yoshio、Saruuljavkhlan Batsaikhan、Alfaray Ricky Indra、Linz Bodo
  • Journal Title: Curr Top Microbiol Immunol Volume: 444 Pages: 117-155
  • DOI: 10.1007/978-3-031-47331-9_5
  • ISBN: 9783031473302, 9783031473319
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 日本国内より分離されたHelicobacter pylori の集団構造解析 (2023)
  • Author(s): 友成航平, Batsaikhan S, Alfaray RI, Fauzia KA, 松成修, 赤田純子, 松本昂, 珍田大輔, 下山克, 金城渚, 金城徹, 金城福則, 山岡吉生
  • Journal Title: 大分県医学会雑誌 Volume: 24 Pages: 100-108
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] ドミニカ共和国での疫学調査その２ (2023)
  • Author(s): 山岡 吉生
  • Journal Title: Helicobacter Reserch Volume: 27 Pages: 111-125
  • Peer Reviewed
• [Journal Article] インドネシアでの疫学調査その4 (2023)
  • Author(s): 山岡 吉生
  • Journal Title: Helicobacter Reserch Volume: 27 Pages: 81-92
  • Peer Reviewed
• [Journal Article] Novel Helicobacter pylori-associated hemolysis Hp0499 and Hp1490 and its association with severity of gastritis. (2023)
  • Author(s): Sang Ketut Widiana, Titong Sugihartono, Dalla Doohan, Langgeng Agung Waskito, Kartika Afrida Fauzia, Yudith Annisa Ayu Rezkitha, Adi Wasis Prakosa, Ricky Indra Alfaray, Camilia Metadea Aji Safitri, Rizki Amalia, Yoshio Yamaoka, Muhammad Miftahussurur.
  • Journal Title: F1000Research Volume: 12 Pages: 22-22
  • DOI: 10.12688/f1000research.122306.1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 日本国内より分離された Helicobacter pylori の集団構造解析 (2023)
  • Author(s): 友成航平, Saruuljavkhlan Batsaikhan, Ricky Indra Alfaray, Kartika Afrida Fauzia1, 松成修, 赤田純子, 松本昂, 珍田大輔, 下山克, 金城渚, 金城徹, 金城福則, 山岡吉生
  • Journal Title: 大分県医学会雑誌 Volume: 29 Pages: 100-108
  • Peer Reviewed / Open Access
• [Journal Article] Cut-off value of clarithromycin resistance in the treatment of Helicobacter pylori infection: how low is low? (2022)
  • Author(s): Hsu Ping-I、Chuah Seng-Kee、Yamaoka Yoshio、Wu Deng-Chyang.
  • Journal Title: Gut Volume: online Issue: 2 Pages: 374-375
  • DOI: 10.1136/gutjnl-2022-329253
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Urease Levels and Gastritis Stage in Dyspeptic Patients. (2022)
  • Author(s): Miftahussurur M, Putri CDM, Sugihartono T, Syam AF, Purbayu H, Priyantini D, Kahar H, Rezkitha YAA, Nusi IA, Setiawan PB, Maimunah U, Waskito LA, Kholili U, Widodo B, Vidyani A, Thamrin H, Siregar GA, I'tishom R, Uchida T, Yamaoka Y.
  • Journal Title: Acta Med Indones Volume: 54 Pages: 42-51
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Seroepidemiological survey of the prevalence of Helicobacter pylori infection in Sabah, Malaysia (2022)
  • Author(s): Mori Daisuke、John Jecelyn Leaslie、Sabri Shahnaz Irwani Binti、Shaharom Saliz Mazrina Binti、Iha Hidekatsu、Yamaoka Yoshio、Matsumoto Takashi、Ahmed Kamruddin
  • Journal Title: IJID Regions Volume: 2 Pages: 126-129
  • DOI: 10.1016/j.ijregi.2021.12.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Helicobacter pylori cagA status and gastric mucosa-associated lymphoid tissue lymphoma: a systematic review and meta-analysis (2022)
  • Author(s): Keikha Masoud、Sahebkar Amirhossein、Yamaoka Yoshio、Karbalaei Mohsen
  • Journal Title: Journal of Health, Population and Nutrition Volume: 41 Issue: 1 Pages: 2-2
  • DOI: 10.1186/s41043-021-00280-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Next-Generation Sequencing-Based Study of Helicobacter pylori Isolates from Myanmar and Their Susceptibility to Antibiotics (2022)
  • Author(s): Subsomwong Phawinee、Doohan Dalla、Fauzia Kartika Afrida、Akada Junko、Matsumoto Takashi、Yee Than Than、Htet Kyaw、Waskito Langgeng Agung、Tuan Vo Phuoc、Uchida Tomohisa、Matsuhisa Takeshi、Yamaoka Yoshio
  • Journal Title: Microorganisms Volume: 10 Issue: 1 Pages: 196-196
  • DOI: 10.3390/microorganisms10010196
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Extragastric infection of Helicobacter pylori and alopecia areata: a systematic review and meta-analysis. (2022)
  • Author(s): Ghazvini Kiarash、Yamaoka Yoshio、Karbalaei Mohsen、Keikha Masoud.
  • Journal Title: Reviews in Medical Microbiology Volume: 33 Issue: 1 Pages: 114-118
  • DOI: 10.1097/mrm.0000000000000276
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Editorial: The Role of Mobile Genetic Elements in Bacterial Evolution and Their Adaptability (2022)
  • Author(s): Vale Filipa F.、Lehours Philippe、Yamaoka Yoshio
  • Journal Title: Frontiers in Microbiology Volume: 13 Pages: 1-2
  • DOI: 10.3389/fmicb.2022.849667
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genomic differentiation within East Asian Helicobacter pylori (2022)
  • Author(s): You Yuanhai、Thorell Kaisa、He Lihua、Yahara Koji、Yamaoka Yoshio、Cha Jeong-Heon、Murakami Kazunari、Katsura Yukako、Kobayashi Ichizo、Falush Daniel、Zhang Jianzhong、TEAMHp
  • Journal Title: Microbial Genomics Volume: 8 Issue: 2 Pages: 1-14
  • DOI: 10.1099/mgen.0.000676
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Potassium intake is associated with nutritional quality and actual diet cost: a study at formulating a low sodium high potassium (LSHP) healthy diet (2022)
  • Author(s): Farapti Farapti、Buanasita Annas、Atmaka Dominikus R.、Setyaningtyas Stefania W.、Adriani Merryana、Rejeki Purwo S.、Yamaoka Yoshio、Miftahussurur Muhammad
  • Journal Title: Journal of Nutritional Science Volume: 11
  • DOI: 10.1017/jns.2021.104
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Unique TLR9 Activation by Helicobacter pylori Depends on the cag T4SS, But Not on VirD2 Relaxases or VirD4 Coupling Proteins (2022)
  • Author(s): Tegtmeyer Nicole、Linz Bodo、Yamaoka Yoshio、Backert Steffen
  • Journal Title: Current Microbiology Volume: 79 Issue: 4 Pages: 121-121
  • DOI: 10.1007/s00284-022-02813-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of Nocturnal and Diurnal Moderate-intensity Swimming Exercise on Increasing Irisin Level of Female Mice (Mus musculus). (2022)
  • Author(s): Muhamad FA, Purwo SR, Sulistiawati, Adi P, Kristanti WW, Gadis MS, Ronny L, Yamaoka Y.
  • Journal Title: CMU J Nat Sci Volume: 21
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Review: Epidemiology of Helicobacter pylori Infection. (2022)
  • Author(s): Alfaray RI , Saruuljavkhlan B. Ansari S, Fauzia KA, Yamaoka Y.
  • Journal Title: Microb Health Dis (European Helicobacter & Microbiota Study Group) Volume: 4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Helicobacter pylori genomes reveal Paleolithic human migration to the east end of Asia (2022)
  • Author(s): Suzuki Rumiko、Saitou Naruya、Matsuari Osamu、Shiota Seiji、Matsumoto Takashi、Akada Junko、Kinjo Nagisa、Kinjo Fukunori、Teruya Kuniko、Shimoji Makiko、Shiroma Akino、Kato Mototsugu、Satou Kazuhito、Hirano Takashi、Asaka Masahiro、Kryukov Kirill、Moodley Yoshan、Yamaoka Yoshio
  • Journal Title: iScience Volume: 25 Issue: 7 Pages: 104477-104477
  • DOI: 10.1016/j.isci.2022.104477
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The role of non-Helicobacter pylori bacteria in the pathogenesis of gastroduodenal diseases. (2022)
  • Author(s): Waskito LA, Rezkitha YAA, Vilaichone RK, Sugihartono T, Mustika S, Dewa Nyoman Wibawa I, Yamaoka Y, Miftahussurur M.
  • Journal Title: Gut Pathog Volume: 14 Issue: 1 Pages: 19-19
  • DOI: 10.1186/s13099-022-00494-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Animal Models and Helicobacter pylori Infection. (2022)
  • Author(s): Ansari S, Yamaoka Y.
  • Journal Title: J Clin Med Volume: 11 Issue: 11 Pages: 3141-3141
  • DOI: 10.3390/jcm11113141
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Macronutrient and micronutrient intake in dietary habits contributed to dyspeptic symptoms in Indonesia. (2022)
  • Author(s): Miftahussurur M., Alfaray R.I., Rezkitha Y.A.A., Fauzia K.A., Maulahela H., Muzellina V.N., Rotty L.S.M., Namara Y.S., Abubakar A., Mustika S., Ratnasari N., Santosa A.Y., Richardo M., Wibawa I.D.N., Adnyana I.K., Rachman P.H., Rachman B.E., Doohan D., Waskito L.A., Yamaoka Y., Khomsan A.
  • Journal Title: Gaceta Medica de Caracas Volume: 130 Issue: 2 Pages: 266-275
  • DOI: 10.47307/gmc.2022.130.2.6
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Role of fecal calprotectin as a hypoxic intestinal damage biomarker in COVID-19 patients. (2022)
  • Author(s): Adriana DN, Sugihartono T, Nusi IA, Setiawan PB, Purbayu H, Maimunah U, Kholili U, Widodo B, Thamrin H, Vidyani A, Maulahela H, Yamaoka Y, Miftahussurur M.
  • Journal Title: Gut Pathog Volume: 14 Issue: 1 Pages: 34-34
  • DOI: 10.1186/s13099-022-00507-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Analysis of gastric microbiota and Helicobacter pylori infection in gastroesophageal reflux disease (2022)
  • Author(s): Sugihartono Titong、Fauzia Kartika Afrida、Miftahussurur Muhammad、Waskito Langgeng Agung、Rejeki Purwo Sri、I’tishom Reny、Alfaray Ricky Indra、Doohan Dalla、Amalia Rizki、Savitri Camilia Metadea Aji、Rezkitha Yudith Annisa Ayu、Akada Junko、Matsumoto Takashi、Yamaoka Yoshio
  • Journal Title: Gut Pathogens Volume: 14 Issue: 1 Pages: 38-38
  • DOI: 10.1186/s13099-022-00510-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Helicobacter pylori Infection, Its Laboratory Diagnosis, and Antimicrobial Resistance: a Perspective of Clinical Relevance. (2022)
  • Author(s): Ansari S, Yamaoka Y.
  • Journal Title: Clin Microbiol Rev Volume: 35 Issue: 3
  • DOI: 10.1128/cmr.00258-21
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Helicobacter pylori infection: is there circulating vacuolating cytotoxin A or cytotoxin-associated gene A protein? (2022)
  • Author(s): Imoto I, Oka S, Katsurahara M, Nakamura M, Yasuma T, Akada J, D'Alessandro-Gabazza CN, Toda M, Horiki N, Gabazza EC, Yamaoka Y.
  • Journal Title: Gut Pathog Volume: 14 Issue: 1 Pages: 43-43
  • DOI: 10.1186/s13099-022-00519-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Helicobacter pylori prevalence in Indonesia: Higher infection risk in Eastern region population. (2022)
  • Author(s): Maulahela H, Doohan D, Annisa Ayu Rezkhita Y, Syam AF, Waskito LA, Metadea Aji Savitri C, Richardo M, Rahman A, Namara YS, Shatri H, Sanityoso A, Alamsyah. Siregar G, Sudarmo E, Uchida T, Vilaichone RK, Yamaoka Y, Muhammad Miftahussurur.
  • Journal Title: F1000Research Volume: 11
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 第25回 マレーシアでの疫学調査 (2022)
  • Author(s): 山岡吉生
  • Journal Title: Helicobacter Research Volume: 26 Pages: 95-106
• [Journal Article] 35th Workshop of the European Helicobacter and Microbiota Study Group (EHMSG) 2022 (2022年9月8～10日, グラスゴー) (2022)
  • Author(s): 山岡吉生
  • Journal Title: Helicobacter Research Volume: 26 Pages: 226-229
• [Journal Article] 第26回 ドミニカ共和国での疫学調査 その1 (2022)
  • Author(s): 山岡吉生
  • Journal Title: Helicobacter Research Volume: 26 Pages: 233-242
• [Journal Article] Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations. (2022)
  • Author(s): Thorpe HA, Tourrette E, Yahara K, Vale FF, Liu S, Oleastro M, Alarcon T. Perets TT, Latifi-Navid S, Yamaoka Y, Martinez-Gonzalez B, Karayiannis I, Karamitros T, Sgouras DN, Elamin W, Pascoe B, Sheppard SK, Ronkainen J, Aro P, Engstrand L, Agreus L, Suerbaum S, Thorell K, Falush D.
  • Journal Title: Nature Communications Volume: 13 Issue: 1 Pages: 6842-6842
  • DOI: 10.1038/s41467-022-34475-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical manifestations of COVID-19 in patients with asthma, hypertension, and diabetes mellitus. (2022)
  • Author(s): Budiarti R, Ediono E, Kalaznykov M, Yamaoka Y, Miftahussurur M.
  • Journal Title: Journal of Medicine and Life Volume: 15 Issue: 12 Pages: 1502-1506
  • DOI: 10.25122/jml-2021-0364
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum pepsinogen level as a biomarker for atrophy, reflux esophagitis, and gastric cancer screening in Indonesia. (2022)
  • Author(s): Miftahussurur M, Waskito LA, Syam AF, Nusi IA, Wibawa IDN, Rezkitha YAA, Fauzia KA, Siregar GA, Akil F, Waleleng BJ, Saudale AMJ, Abubakar A, Maulahela H, Richardo M, Rahman A, Namara YS, Sudarmo E, Adi P, Maimunah U, Setiawan, Yamaoka Y.
  • Journal Title: Journal of Research in Medical Sciences Volume: 27 Issue: 1 Pages: 90-90
  • DOI: 10.4103/jrms.jrms_983_21
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characterization of Helicobacter pylori tlyA and Its Association with Bacterial Density (2021)
  • Author(s): Prakosa Adi Wasis、Miftahussurur Muhammad、Juniastuti Juniastuti、Waskito Langgeng Agung、Doohan Dalla、Fauzia Kartika Afrida、Rezkitha Yudith Annisa Ayu、Sugihartono Titong、Syam Ari Fahrial、Uchida Tomohisa、Yamaoka Yoshio
  • Journal Title: Digestive Diseases Volume: Online ahead of print Issue: 4 Pages: 417-426
  • DOI: 10.1159/000518538
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The effect of long-term ketogenic diet on serum adiponectin and insulin-like growth factor-1 levels in mice (2021)
  • Author(s): Widiatmaja Deandra M.、Lutvyani Alif、Sari Desi R.、Kurniasari Hamidah、Meiliana Ismi D.、Fasitasari Minidian、Yamaoka Yoshio、Rejeki Purwo S.
  • Journal Title: Journal of Basic and Clinical Physiology and Pharmacology Volume: 1 Issue: 5 Pages: 1-10
  • DOI: 10.1515/jbcpp-2021-0287
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Microbiome analysis for the diagnosis of H. pylori infection (2023)
  • Author(s): Yoshio Yamaoka
  • Organizer: International Symposium on Helicobacter and Upper Gastrointestinal Disease
  • Int'l Joint Research / Invited
• [Presentation] Gastric microbiota and H. pylori in an Asian population (2023)
  • Author(s): Yoshio Yamaoka
  • Organizer: International Symposium on Helicobacter and Upper Gastrointestinal Disease
  • Int'l Joint Research / Invited
• [Presentation] Human gut microbiota related to GI tract diseases (2023)
  • Author(s): Yoshio Yamaoka
  • Organizer: ASEAN GASTRO2023
  • Int'l Joint Research / Invited
• [Presentation] H.pylori evolujtion and pathogenesis in Asia (2023)
  • Author(s): Yoshio Yamaoka
  • Organizer: HGSC2023
  • Int'l Joint Research / Invited
• [Presentation] Helicobacter pylori eradication experiences in Bhutan (2023)
  • Author(s): Yoshio Yamaoka
  • Organizer: APDW2023
  • Int'l Joint Research / Invited
• [Presentation] Outer membrane protein HopF is involved in biofilm formation and virulence in Helicobacter pylori (2023)
  • Author(s): Fauzia KA, Sugawara Y, Obata, M, Amalia R, Alfaray RI, Metadea C, Akada, J, Matsumoto, T, Miftahussurur M, Yamaoka Y.
  • Organizer: The 19th Korea-Japan H. pylori Joint Symposium
  • Int'l Joint Research
• [Presentation] Mutations Related to Antibiotics Resistance in Helicobacter pylori Clinical Isolates from Bangladesh (2023)
  • Author(s): Fauzia, KA, Hafeza A, Tshibangu-Kabamba E, Alfaray RI, Batsaikhan S, Cimuanga-Mukanya A, Matsumoto T, Subsomwong P, Akada J, Miftahussurur M, Yamaoka Y.
  • Organizer: International Symposium on Helicobacter and Upper Gastrointestinal Disease
  • Int'l Joint Research
• [Presentation] Amoxicillin resistance in Helicobacter pylori: Identification of new resistance-conferring mutations in the penicillin-binding protein 1A (2023)
  • Author(s): Cimuanga-Mukanya A, Tshibangu-Kabamba E, Ngoma-Kisoko PdeJ , Disashi-Tumba G, Matsumoto T,Akada J and Yamaoka Y
  • Organizer: The 19th Korea-Japan H. pylori Joint Symposium
  • Int'l Joint Research
• [Presentation] Utilization of an Automated Latex Agglutination Turbidity Assay for Assessing Gastric Mucosal Alteration during Helicobacter pylori Infection (2023)
  • Author(s): Khangai A Akada J, Azzaya D, Batsaikhan S, Gantuya B, Oyuntsetseg K, Davaadaorj D, Matsumoto T, Uchida T, Akada J, and Yamaoka Y.
  • Organizer: The 19th Korea-Japan H. pylori Joint Symposium
  • Int'l Joint Research
• [Presentation] Entroccus Hirae Attenuates chemokine and Induces Dna Damage In Gastric Epithelial Cell (2023)
  • Author(s): Saruuljavkhlan B, Yamaoka Y
  • Organizer: DDW2023
  • Int'l Joint Research
• [Presentation] Investigation of Low－Grade Intestinal Metaplasia From Clinical Dyspepsia Patients INA Country With Low-Incidence of Gastric Cancer:From Human to Helicobactor pylori Perspective (2023)
  • Author(s): Ricky indra alfary, Yamaoka Y
  • Organizer: DDW2023
  • Int'l Joint Research
• [Presentation] Comprehensive genomic analysis of helicobacter pylori in highand low gastric cancer risk populations (2023)
  • Author(s): Saruuljavkhlan B, Yamaoka Y
  • Organizer: APDW2023
  • Int'l Joint Research / Invited
• [Presentation] Global level study of Helicobacter pylori mobile genetic elements on antibicrobial resistance and clinical disease (2023)
  • Author(s): Ricky indra alfary, Yamaoka Y
  • Organizer: APDW2023
  • Int'l Joint Research / Invited
• [Presentation] Outer membrane protein HopF is involved in biofilm formation and virulence in Helicobacter pylori (2023)
  • Author(s): Kartika Afrida Fauzia, Yuri Sugawara, Mayu Obata, Rizki Amalia, Ricky Indra Alfaray, Camilia Metadea, Junko Akada, Takashi Matsumoto, Muhammad Miftahussurur, Yoshio Yamaoka
  • Organizer: The 19th Korea-Japan H. pylori Joint Symposium, Gut and liver
  • Int'l Joint Research
• [Presentation] Microbiome analysis for the diagnosis of H. pylori infection (2023)
  • Author(s): Yamaoka Y.
  • Organizer: International Symposium on Helicobacter and Upper Gastrointestinal Disease
  • Int'l Joint Research / Invited
• [Presentation] Gastric microbiota and H. pylori in an Asian population (2023)
  • Author(s): Yamaoka Y.
  • Organizer: International Symposium on Helicobacter and Upper Gastrointestinal Disease
  • Int'l Joint Research / Invited
• [Presentation] Mutations Related to Antibiotics Resistance in Helicobacter pylori Clinical Isolates from Bangladesh (2023)
  • Author(s): Fauzia, Kartika Afrida, Hafeza Aftab, Evariste Tshibangu-Kabamba, Ricky Indra Alfaray, Batsaikhan Saruuljavkhlan, Alain Cimuanga-Mukanya, Takashi Matsumoto, Phawinee Subsomwong, Junko Akada, Muhammad Miftahussurur, and Yoshio Yamaoka
  • Organizer: International Symposium on Helicobacter and Upper Gastrointestinal Disease
  • Int'l Joint Research
• [Presentation] Ancient human footprints left in Helicobacter pylori (2022)
  • Author(s): Yamaoka Y.
  • Organizer: The 11th Asian Pacific Topic Conference in the 108th General Meeting of the Japanese Society of Gastroenterology
  • Int'l Joint Research / Invited
• [Presentation] Biofilm Formation and antibiotic resistance phenotype of Helicobacter pylori clinical isolates. (2022)
  • Author(s): Fauzia KA, Matsumoto T, Akada J, Yonezawa H, Kamiya S, Yamaoka Y.
  • Organizer: The 18th Japan-Korea H. pylori Joint Symposium,
  • Int'l Joint Research
• [Presentation] The impact of mobile genetic elemants and toxin-antitoxin system on Helicobacter pylori adaptability and antimicrobial resistance: A wisdom from Japan-South Korea whole-genome sequence collection. (2022)
  • Author(s): Alfaray RI, Batsaikhan S, Fauzia KA, Akada J, Matsumoto T, Yamaoka Y.
  • Organizer: The 18th Japan-Korea H. pylori Joint Symposium,
  • Int'l Joint Research
• [Presentation] Identification of the Helicobacter pylori genomic islands in a high gastric cancer region. (2022)
  • Author(s): Batsaikhan S, Alfaray RI, Matsumoto T, Akada J, Yamaoka Y.
  • Organizer: The 18th Japan-Korea H. pylori Joint Symposium,
  • Int'l Joint Research
• [Presentation] Helicobacter pylori and host human genetics in the Caribbean countries (2022)
  • Author(s): Yamaoka Y.
  • Organizer: IX INTERNATIONAL SYMPOSIUM OF Helicobacter pylori INFECTION AND GASTRIC CANCER
  • Int'l Joint Research / Invited
• [Presentation] Helicobacter pylori isolates from Mongolia describing gastric carcinogenesis and human migration (2022)
  • Author(s): Gantuya B, Yoshio Y, Oyuntsetseg K
  • Organizer: 2022 The Japanese Society of Medical Oncology Annual Meeting
  • Int'l Joint Research
• [Presentation] Global genome study of helicobacter pylori phage opens new paradigm on their worldwide distribution, genetic feature, and impacts on antimicrobial resistance, disease advancement, and achievement for phage-based therapy (2022)
  • Author(s): Alfaray IR, Saruuljavkhlan B, Fauzia KA, Matsumoto T, Yamaoka Y.
  • Organizer: Gut
  • Int'l Joint Research
• [Presentation] A novel pathogen enterococcus hirae induced dysbiosis in the stomach and the genomic instability to promote gastric cancer (2022)
  • Author(s): Saruuljavkhlan B, Gantuya B, Akada J, Matsumoto T, Alfaray RI, Oyuntsetseg K, Yamaoka Y.
  • Organizer: Gut
  • Int'l Joint Research
• [Presentation] Pro-Inflammatory Cytokine Expression Observed During Helicobacter pylori Infection Revealed the Possibility Reason of Low-Grade Intestinal Metaplasia in Indonesia. (2022)
  • Author(s): Rezkitha, Y.A, Yamaoka Y.
  • Organizer: ASEAN Stomach and Microbiota Study Group
  • Int'l Joint Research
• [Presentation] Worldwide Helicobacter pylori Phage Study: Genome Analysis, Epidemiology, Clinical Data, until New Phage-based Medicine Candidate. (2022)
  • Author(s): Alfaray RI, Yamaoka Y.
  • Organizer: The 21st International Workshop on Campylobacter, Helicobacter and Related Organisms
  • Int'l Joint Research
• [Presentation] Comprehensive Study of Helicobacter pylori Genomic Islands and Their Correlation to Gastric Diseases, Phylogenetic Pattern. (2022)
  • Author(s): Saruuljavkhlan B, Yamaoka Y.
  • Organizer: The 21st International Workshop on Campylobacter, Helicobacter and Related Organisms
  • Int'l Joint Research
• [Presentation] Identification of Flagella and Outer Membrane Protein Genes associated with Biofilm Formation (2022)
  • Author(s): Kartika Afrida Fauzia, Yamaoka Y.
  • Organizer: The 21st International Workshop on Campylobacter, Helicobacter and Related Organisms
  • Int'l Joint Research
• [Presentation] Effect of gastric microbiota to gastric cancer development (2022)
  • Author(s): Yamaoka Y.
  • Organizer: 28th Conference on Gastroenterology & Hepatology by VIETNAM ASSOCIATION OF GASTROENTEROLOGY
  • Int'l Joint Research / Invited
• [Presentation] H. pylori and the pathogenesis of gastric cancer (2022)
  • Author(s): Yamaoka Y.
  • Organizer: ASEAN Gastro2022
  • Int'l Joint Research / Invited
• [Remarks] 大分大学医学部環境・予防医学講座
  • URL: https://oitadepm.com/
• [Remarks] SATREPS 大分大学
  • URL: https://satreps-oitauniv.com/