統計ボリュームモデルに基づく慢性肝疾患の経時進行度に関する形態定量評価

• Project Area: Computational anatomy for computer-aided diagnosis and therapy :Frontiers of medical image sciences
• Project/Area Number: 22103513
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Ritsumeikan University
• Principal Investigator: 陳 延偉 立命館大学, 情報理工学部, 教授 (60236841)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000); Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 肝硬変 / 統計形状モデル / 主成分分析 / 成分選択 / CT / 脾臓 / 機械学習 / 計算機支援診断 / CTデータ / 時系列データ / データベース / 診断支援 / 右葉,左葉

Research Abstract

研究の2年目の平成23年においては、初年度で構築した肝臓の統計形状モデルを発展させて脾臓との統合モデルをも構築した。また、肝硬変に寄与する成分の選択法を提案した。さらに、SVRという機会学習の手法を用いて選択された成分と医師の診断結果とのMapping関数を求めた。そのMapping関数で予測された肝硬変の進行度と医師の診断結果とよい一致が得られたので、計算機解剖モデルによる肝硬変支援診断の可能性を示した。具体的な成果を以下に示す。
【成果1:肝臓と脾臓の統合統計形状モデルを作成】
これまで、主に肝臓の統計モデルを作成してきたが、肝臓の統計モデルだけでは、診断に不十分であることが判明したので、肝硬変によって形状や体積なども著しく変化する脾臓にも注目し、肝臓と脾臓の統合統計形状モデルを作成した。さらに、脾臓の統計形状モデルも作成した。
【成果2:肝硬変に寄与する成分の選択と正常・異常判別】
従来の研究において、肝臓の統計形状モデルのみを用いて、固有値の大きい成分を選択し、肝硬変の診断に使用しようとしているが、本研究では、構築した三つのモデル(肝臓統計モデル、脾臓統計モデル、肝臓と脾臓の統合統計モデル)から、固有値の大きさだけではなく、医師の診断結果との相関をも考慮し、肝硬変に寄与する成分をより正確に選択することができた。本提案法によって選択した成分を用いて正常と異常の判別実験において、90%に近い正解率が得られた。一方、従来の方法では、僅か60%の正解率であった。
【成果3:機械学習による肝硬変進行度の予測】
SVRという機会学習の手法を用いて選択された成分と医師の診断結果とのMapping関数を求めた。そのMapping関数で予測された肝硬変の進行度と医師の診断結果とよい一致が得られたので、計算機解剖モデルによる肝硬変支援診断の可能性を示した。

Research Products

• [Journal Article] A Statistical Texture Model of the Liver Based on Generalized N-dimensional Principal Component Analysis (GND-PCA) and 3D Shape Normalization (2012)
  • Author(s): X.Qiao, Y.W.Chen
  • Journal Title: International Journal of Biomedical Imaging Volume: 1 Pages: 1-8
  • DOI: 10.1155/2011/601672
  • Peer Reviewed
• [Journal Article] Multilinear Supervised Neighborhood Embedding of Local Descriptor Tensor for Scene/object Recognition (2012)
  • Author(s): Xian-Hua Han, Yen-Wei Chen, Xiang Ruan
  • Journal Title: IEEE Trans.on Image Processing Volume: 21 Issue: 3 Pages: 1314-1326
  • DOI: 10.1109/tip.2011.2168417
  • Peer Reviewed
• [Journal Article] Biomedical Imaging Modality Classification Using Combined Visual Features and Textual Terms (2011)
  • Author(s): Xian-Hua Han, Yen-Wei Chen
  • Journal Title: International Journal of Biomedical Imaging Volume: Vol.2011 Pages: 1-7
  • DOI: 10.1155/2011/241396
  • Peer Reviewed
• [Journal Article] A robust method based on ICA and mixture sparsity for edgedetection in medical images for edge detection in medical images (2011)
  • Author(s): Xian-Hua Han, Yen-Wei Chen
  • Journal Title: Signal Image and Video Processing Volume: Vol.5 Issue: 1 Pages: 39-47
  • DOI: 10.1007/s11760-009-0140-5
  • Peer Reviewed
• [Journal Article] Global Selection vs Local Ordering of Color SIFT Independent Components for Object/Scene Classification (2011)
  • Author(s): Danni Ai, Xianhua Han, Xiang Ruan, Yen-Wei Chen
  • Journal Title: IEICE Transactions Volume: Vol.E94-D Pages: 1800-1808
  • Peer Reviewed
• [Journal Article] Gradient Based Edge Preserving Interpolation and Its Application to Super-Resolution (2011)
  • Author(s): 岩本祐太郎、韓先花、健山智子、大橋基範、笹谷聡、陳延偉
  • Journal Title: IEEJ Transactions on Electronics, Information and Systems Volume: 131 Issue: 11 Pages: 1901-1906
  • DOI: 10.1541/ieejeiss.131.1901
  • NAID: 10030528072
  • ISSN: 0385-4221, 1348-8155
  • Peer Reviewed
• [Journal Article] Application of ICA to X-ray coronary digital subtraction angiography (2011)
  • Author(s): Songyuan Tang, Yongtian Wang, Yen-Wei Chen
  • Journal Title: Neurocomputing Volume: 79 Pages: 168-172
  • DOI: 10.1016/j.neucom.2011.10.012
  • Peer Reviewed
• [Journal Article] Individual virtual phantom reconstruction for organ dosimetry based on standard available phantoms (2010)
  • Author(s): F.Babapour Mofrad, R.Aghaeizadeh Zoroofi, A.Abbaspour Tehrani Fardl, Sh.Akhlaghpoor, Y.W.Chen, Y.Sato
  • Journal Title: Iran.J.Radiat.Res Volume: 7 Pages: 201-206
  • Peer Reviewed
• [Journal Article] Color Independent Components based SIFT Descriptors for Object/Scene Classification (2010)
  • Author(s): Danni Ai, Xianhua Han, Xiang Ruan, Yen-Wei Chen
  • Journal Title: IEICE Transactions Volume: E93-D Pages: 2577-2586
  • Peer Reviewed
• [Journal Article] Tensor-Based Subspace Learning and Its Applications in Multi-Pose Face Synthesis (2010)
  • Author(s): X.Qiao, X.H.Han, T.Igarashi, K.Nakao, Y.-W.Chen
  • Journal Title: Neurocomputing Volume: 73 Pages: 2727-2736
  • Peer Reviewed
• [Journal Article] A uniformly redundant imaging array of penumbral apertures coupled with a heuristic reconstruction for hard x-ray and neutron imaging (2010)
  • Author(s): Tatsuki Ueda, Shinsuke Fujioka, Shinya Nozaki, Rumiko Azuma, Yen-Wei Chen, Hiroaki Nishimura
  • Journal Title: Review of Scientific Instruments Volume: Vol.81, No.7
  • Peer Reviewed
• [Journal Article] Heuristic optimization in penumbral image for high resolution reconstructed image (2010)
  • Author(s): Rumiko Azuma, Shinya Nozaki, Shinsuke Fujioka, Yen-Wei Chen, Yoshinori Namihira
  • Journal Title: Review of Scientific Instruments Volume: Vol.81, No.10
  • Peer Reviewed
• [Journal Article] A novel method for gaze tracking by local pattern model and support vector repressor (2010)
  • Author(s): Hu-Chuan Lu, Guo-Liang Fang, Chao Wang, Yen-Wei Chen
  • Journal Title: Signal Processing Volume: Vol.90 Pages: 1290-1299
  • Peer Reviewed
• [Journal Article] 学習型画質改善・画像復元・超解像技術 (2010)
  • Author(s): 陳延偉
  • Journal Title: O Plus E Volume: Vol.32 Pages: 270-274
• [Journal Article] 超解像技術-ソフトウェアによる知的画像処理 (2010)
  • Author(s): 陳延偉
  • Journal Title: システム/制御/情報 Volume: Vol.54 Pages: 373-377
  • NAID: 110007817709
• [Presentation] Digital Atlases of Human Anatomy and Their Applications to Computer Assisted Diagnosis (2011)
  • Author(s): Yen-Wei Chen
  • Organizer: International Conference on Computer Sciences and Convergence Information Technology
  • Place of Presentation: Jeju, Korea(招待講演)
  • Year and Date: 2011-11-29
• [Presentation] Cross-sectional Imaging of the Bowel (2011)
  • Author(s): Akira Furukawa, Shuzo Kanasaki, Makoto Wakamiya, Kiyoshi Murata, Xin Wu, Tomoko Tateyama, Yen-Wei Chen
  • Organizer: International Conference on Computer Sciences and Convergence Information Technology
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2011-11-29
• [Presentation] Diagnosis of liver cirrhosis with the use of multi-detector row computed tomography (MDCT) : morphological approach and quantitative approach using statistical geometric hepatic model (2011)
  • Author(s): Shuzo Kanasaki, Akira Furukawa, Makoto Wakamiya, Kiyoshi Murata, Shinya Kohara, Tomoko Tateyama, Xian-hua Han, Yen-Wei Chen
  • Organizer: International Conference on Computer Sciences and Convergence Information Technology
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2011-11-29
• [Presentation] 3D Visualization of Liver and Its Vascular Structures and Surgical Plarming System--Surgical Simulation-- (2011)
  • Author(s): Tsukasa SHINDO, Tomoko TATEYAMA, Amir HOSSEIN FORUZAN, Xianhua HAN, Kosuke MIYAWAKI, Takumi TSUDA, Masaki KAIBORI, Masanori KON, Huiyan JIAMG, Yen-Wei CHEN
  • Organizer: International Conference on Computer Sciences and Convergence Information Technology
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2011-11-29
• [Presentation] Shape Representation of Human Anatomy Using Spherical Harmonic Basis Function (2011)
  • Author(s): Tomoko Tateyama, Megumi Okegawa, Shinya Kohara, Xianhua Han, Shuzo Kanasaki, Akira Furukawa, Huiyan Jiang, Kiyoshi Murata, Yen-Wei Chen
  • Organizer: International Conference on Computer Sciences and Convergence Information Technology
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2011-11-29
• [Presentation] Preliminary Study on Statistical Shape Model Applied to Diagnosis of Liver Cirrhosis (2011)
  • Author(s): Shinya Kohara, Tomoko Tateyama, Amir Hossein Foruzan, Akira Furukawa, Shuzo Kanasaki, Makoto Wakamiya, Xiong Wei, Yen-Wei Chen
  • Organizer: IEEE International Conference on Image Processing
  • Place of Presentation: Brussels, Belguim
  • Year and Date: 2011-09-14
• [Presentation] CT IMAGE CONTRAST ENHANCEMENT AND LIVER TUMOR DETECTION BY USING PROBABILITY DENSITY FUNCTION AND EM/MPM ALGORITHM (2011)
  • Author(s): Yu Masuda, Tomoko Tateyama, Wei Xiong, Jiayin Zhou, Makoto Wakamiya, Syuzo Kanasaki, Akira Furukawa, Yen WeiChen
  • Organizer: IEEE International Conference on Image Processing
  • Place of Presentation: Brussels, Belguim
  • Year and Date: 2011-09-14
• [Presentation] Canonical Correlation Analysis of Local Feature Set for View-Based Object Recognition (2011)
  • Author(s): Xian-Hua Han, Yen-Wei Chen, Xiang Ruan
  • Organizer: IEEE International Conference on Image Processing
  • Place of Presentation: Brussels, Belguim
  • Year and Date: 2011-09-14
• [Presentation] HIGH FREQUENCY COMPENSATED FACE HALLUCINATION (2011)
  • Author(s): So Sasatani, Xian-Hua Han, Takanori Igarashi, Motonori Ohashi, Yutaro Iwamoto, Yen-Wei Chen
  • Organizer: IEEE International Conference on Image Processing
  • Place of Presentation: Brussels, Belguim
  • Year and Date: 2011-09-14
• [Presentation] Batch-incremental Principal Component Analysis with Exact Mean Update (2011)
  • Author(s): Guifang Duan, Yen-Wei Chen
  • Organizer: IEEE International Conference on Image Processing
  • Place of Presentation: Brussels, Belguim
  • Year and Date: 2011-09-14
• [Presentation] 学習ベース超解像技術 (2011)
  • Author(s): 陳延偉
  • Organizer: 電子情報通信学会医用画像研究会
  • Place of Presentation: 北海道大学(北海道)(招待講演)
  • Year and Date: 2011-07-13
• [Presentation] PCA Based Regional Mutual Information for Robust Medical Image Registration (2011)
  • Author(s): Yen-Wei Chen, Chen-Lun Lin
  • Organizer: International Symposium on Neural Network
  • Place of Presentation: 桂林(中国)
  • Year and Date: 2011-05-29
• [Presentation] Hallucination法に基づいた医用画像の超解像処理 (2011)
  • Author(s): 岩本祐太郎, 韓先花, 大橋基範, 笹谷聡, 谷口和輝, 陳延偉
  • Organizer: 電子情報通信学会医用画像研究会
  • Place of Presentation: 名古屋大学(愛知県)
  • Year and Date: 2011-05-19
• [Presentation] 統計的形状モデルを用いた肝硬変データの分類精度に関する定量評価 (2011)
  • Author(s): 小原伸哉、健山智子、Amir Hossein Foruzan、古川顕、金崎周造、村田喜代史、若宮誠、Xiong Wei、陳延偉
  • Organizer: 信学技報(IEICE Technical Report)
  • Place of Presentation: 立命館大学(滋賀県)
  • Year and Date: 2011-01-20
• [Presentation] 3D Visualization and Surgical Planning Systems for Liver Based on Liver Segmentation and Vessel Extraction (2011)
  • Author(s): 健山智子、進藤典、Amir Hossein Foruzan、小原伸哉、木西基、林正倫、増田優、海掘昌樹、權雅憲、陳延偉
  • Organizer: 信学技報(IEICE Technical Report)
  • Place of Presentation: 立命館大学(滋賀県)
  • Year and Date: 2011-01-20
• [Presentation] Image recognition by learned linear subspace of combined bag-of-features and low-level features (2010)
  • Author(s): Xian-Hua Han, Yen-Wei Chen, Xiang Ruan
  • Organizer: 2010 IEEE International Conference on Image Processing (ICIP2010)
  • Place of Presentation: Hong Kong
  • Year and Date: 2010-09-26
• [Presentation] Statistical Texture Modeling for Medical Volume Using Generalized N-Dimensional Principal Component Analysis Method and 3D Volume Morphing (2010)
  • Author(s): Qiao Xu, Yen-Wei Chen
  • Organizer: 20^<th> International Conference on Pattern Recognition (ICPR2010)
  • Place of Presentation: トルコ・イスタンブール
  • Year and Date: 2010-08-23
• [Presentation] Bag of Features Tracking (2010)
  • Author(s): Fan Yang, Huchuan Lu, Yen-Wei Chen
  • Organizer: 20^<th> International Conference on Pattern Recognition (ICPR2010)
  • Place of Presentation: トルコ・イスタンブール
  • Year and Date: 2010-08-23
• [Presentation] Image Categorization by Learned Nonlinear Subspace of Combined Visual-Words and Low-Level Features (2010)
  • Author(s): Xian-Hua Han, Yen-Wei Chen, Xiang Ruan
  • Organizer: 20^<th> International Conference on Pattern Recognition (ICPR2010)
  • Place of Presentation: トルコ・イスタンブール
  • Year and Date: 2010-08-23
• [Presentation] Statistical Atlases of Human Anatomy and Computer Assisted Diagnostic System (2010)
  • Author(s): Yen-Wei Chen, Tomoko Tateyama, Amir H.Foruzan, F.Babapour Mofrad, Xu Qiao, Akira Furukawa
  • Organizer: The 1st International Workshop on Computational Intelligence for Bio-Medical Scienceand Engineering
  • Place of Presentation: 中国・成都(Special Talk)
  • Year and Date: 2010-06-24
• [Presentation] A Statistical Shape Model Using 2D-Principal Component Analysis from Few Medical Samples and Its Evaluation (2010)
  • Author(s): Tomoko Tateyama, Taishi Tanaka, Shinya Kohara, Amir Hossein Foruzan, Akira Furukawa, Yen-Wei Chen
  • Organizer: 2^<nd> International Conference on Software Engine Bring and Data Mining
  • Place of Presentation: 中国・成都
  • Year and Date: 2010-06-23
• [Presentation] Spherical Harmonics Based 3-D Shape Modeling for spleen (2010)
  • Author(s): T.Tanaka, T.Tateyama, F.Babapour Mofrad, Y.-W.Chen, K.Chihara
  • Organizer: 2^<nd> International Conference on Software Engine Bring and Data Mining
  • Place of Presentation: 中国・成都
  • Year and Date: 2010-06-23
• [Presentation] Liver Segmentation from Low Contrast Open MR Scans Using K-Means Clustering and Graph-Cuts (2010)
  • Author(s): Yen-Wei Chen, Katsumi Tsubokawa, Amir H.Foruzan
  • Organizer: 7th International Symposium on Neural Networks (Lecture Notes in Computer Science, Springer, LNCS6064)
  • Place of Presentation: 中国・上海
  • Year and Date: 2010-06-06
• [Presentation] Multilinear Tensor Supervised Neighborhood Embedding Analysis for View-Based Object Recognition (2010)
  • Author(s): Xian-Hua Han, Yen-Wei Chen, Xiang Ruan
  • Organizer: The IEEE Pacific-Rim Conference on Multimedia (PCM2010)
  • Place of Presentation: 中国・上海
• [Book] Proc.of the 6th International Conference on Computer Sciences and Convergence Information Technology (2011)
  • Author(s): Franz I.S.Ko, Kae Dal Kwack, Soonwook Hwang, Shigeo Kawata, Yen-Wei Chen (Eds)
  • Total Pages: 1165
  • Publisher: IEEE Press
• [Book] 入門 画質改善・画像復元・超解像技術 (2011)
  • Author(s): 陳延偉
  • Total Pages: 131
  • Publisher: トリケップス社
• [Book] Software Engineering and Data Mining (2010)
  • Author(s): Gang Kou, Yi Peng, Franz I.S.Ko, Yen-Wei Chen, Tomoko Tateyama (Eds)
  • Total Pages: 1500
  • Publisher: IEEE Computer Society