着床前胚におけるストレス応答の分子機構と疾患発症基盤としての意義

• Project Area: The germline: its developmental cycle and epigenome network
• Project/Area Number: 23013007
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: 栗原 裕基 東京大学, 大学院・医学系研究科, 教授 (20221947)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥6,200,000 (Direct Cost: ¥6,200,000); Fiscal Year 2012: ¥3,100,000 (Direct Cost: ¥3,100,000); Fiscal Year 2011: ¥3,100,000 (Direct Cost: ¥3,100,000)
• Keywords: 生殖医学 / ストレス応答 / 疾患モデル

Research Abstract

初期胚において、ミトコンドリアに局在するNAD依存性脱アセチル化酵素であるSirt3の機能低下がROS産生の亢進を介して胚発生を遅延または停止させること、その機序にp53が関与することを報告してきたが、p53+Sirt3ダブルノックアウトマウスを用いた検討から、p53とSirt3の欠損は胚発生の進行には互いに相反する効果を及ぼし、p53依存性経路の抑制が胚発生率を改善させる可能性を明らかにした。一方、成獣マウスの解析から、成長後の病態形成(腫瘍の発生)には相乗的に働くことが示唆された。また、初期発生においてはSirt3 mRNAの導入によりROS刺激による胚発生の抑制が緩和されること、ROSが関与すると考えられている排卵後の長時間培養による加齢性変化に対し、防御的に働くことなどが明らかになpた。さらに、加齢マウスからの卵子ではSirt3 mRNAレベルの低下しており、体外授精後の胚発生率が有意に低下することを確認した後、Sirt3 mRNAの顕微注入による効果を解析し、その初期発生率が改善することを見出した。Sirt3過剰発現の効果とその機序をさらに明らかにするため、Cre-loxP依存性のコンディショナルSirt3過剰発現マウスを作成し、臓器特異的Cre発現マウスを用いてその有効性を確認した。
現在卵子特異的高発現マウスの作成と解析を進めている。以上の結果から、Sirt3の導入または内因性Sirt3の発現誘導が胚発生においてストレス応答性を改善させる可能性が示され、高齢女性の生殖補助医療においてSirt3を標的とした老化卵子の人工受精率改善法の開発が期待された。

Research Products

• [Journal Article] Resistin-like molecule β is abundantly expressed in foam cells and is involved in atherosclerosis development. (2013)
  • Author(s): Akifumi Kushiyama
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology
  • Peer Reviewed
• [Journal Article] Preotic neural crest cells contribute to coronary smooth muscle involving endothelin signalling. (2012)
  • Author(s): Yuichiro Arima
  • Journal Title: Nature Communications Volume: 3 Issue: 1 Pages: 1267-1267
  • DOI: 10.1038/ncomms2258
  • Peer Reviewed
• [Journal Article] Role of Pin1 in the pathogenesis of non-alcoholic steatohepatitis in a rodent model (2012)
  • Author(s): Nakatsu Y, Otani Y, Sakoda H, Zhang J, Guo Y, Okubo H, Kushiyama A, Fujishiro M, Kikuchi T, Fukushima T, Ohno H, Tsuchiya Y, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Takahashi SI, Kurihara H, Uchida T, Asano T
  • Journal Title: J Biol Chem Volume: 287 Issue: 53 Pages: 44526-44535
  • DOI: 10.1074/jbc.m112.397133
  • Peer Reviewed
• [Journal Article] Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by expanded polyglutamine (2012)
  • Author(s): Minamiyama M, Katsuno M, Adachi H, Doi H, Kondo N, Iida M, Ishigaki S, Fujioka Y, Matsumoto S, Miyazaki Y, Tanaka F, Kurihara H, Sobue G
  • Journal Title: Nat Med Volume: 18 Issue: 10 Pages: 1531-1538
  • DOI: 10.1038/nm.2932
  • Peer Reviewed
• [Journal Article] Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and atherosclerosis development (2012)
  • Author(s): Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T.
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 32 Issue: 2 Pages: 291-298
  • DOI: 10.1161/atvbaha.111.234559
  • Peer Reviewed
• [Journal Article] A soluble form of LMIR5/CD300b amplifies lipopolysaccharide-induced lethal inflammation in sepsis. (2012)
  • Author(s): Yoshinori Yamanishi
  • Journal Title: Journal of Immunology Volume: 189 Issue: 4 Pages: 1773-1779
  • DOI: 10.4049/jimmunol.1201139
  • Peer Reviewed
• [Journal Article] Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial movement. (2011)
  • Author(s): Satoshi Arima, Kaichi Nishivama
  • Journal Title: Development Volume: 138(21) Pages: 4763-4776
  • Peer Reviewed
• [Journal Article] Identification and developmental analysis of endothelin receptor type-A expressing cells in the mouse kidney (2011)
  • Author(s): Kitazawa T, Sato T, Nishiyama K, Asai R, Arima Y, Uchijima Y, Kurihara Y, Kurihara H.
  • Journal Title: Gene Expr. Patterns Volume: 11 Issue: 7 Pages: 371-377
  • DOI: 10.1016/j.gep.2011.04.001
  • Peer Reviewed
• [Presentation] Preotic Neural Crest Cells Contribute to Coronary Artery Smooth Muscle Involving Endothelin Signaling. (2013)
  • Author(s): 有馬勇一郎
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2013-03-15
• [Presentation] 血管のかたちをつくる血管細胞動態の理解 (2013)
  • Author(s): 西山功一
  • Organizer: 第42回日本心脈管作動物質学会
  • Place of Presentation: 奈良県立新公会堂(奈良市)
  • Year and Date: 2013-02-09
• [Presentation] Cell-based mechanism behind angiogenic morphogenesis. (2013)
  • Author(s): Koichi Nishiyama
  • Organizer: The 23rd CDB meeting
  • Place of Presentation: 理化学研究所 発生再生科学総合研究センター(兵庫県神戸市)
  • Year and Date: 2013-01-22
• [Presentation] Endothelin-1 regulates branchial arch morphogenesis by regulating integenic enhancer antivity of D1x5 and D1x6 in mouse embryo (2012)
  • Author(s): 内島泰信
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡(福岡県福岡市)
  • Year and Date: 2012-12-16
• [Presentation] Endothelin-1 regulates branchial arch morphogenesis by regulating integenic enhancer activity of Dlx5 and Dlx6 in mouse embryo (2012)
  • Author(s): 内島泰信
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡(福岡県福岡市)
  • Year and Date: 2012-12-16
• [Presentation] Ectopic Hox gene expression in cranial neural crest cells results in abnormal craniofacial development revealing a possible Hox/D1x crosstalk (2012)
  • Author(s): Taro Kitazawa
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡(福岡県福岡市)
  • Year and Date: 2012-12-13
• [Presentation] Ectopic Hox gene expression in cranial neural crest cells results in abnormal craniofacial development revealing a possible Hox/Dlx crosstalk (2012)
  • Author(s): Taro Kitazawa
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡(福岡県福岡市)
  • Year and Date: 2012-12-13
• [Presentation] Involvement of non-coding RNA: Evf2 in the Endothelin signaling in branchial arch development. (2012)
  • Author(s): Yukiko Kurihara
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡(福岡県福岡市)
  • Year and Date: 2012-12-12
• [Presentation] A protective role of Sirt3 against oxidative stress and aging in mouse preimplantation embryos. (2012)
  • Author(s): Yumiko Kawaiura
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡(福岡県福岡市)
  • Year and Date: 2012-12-12
• [Presentation] Endothelin type A receptor expressing cell population in the inflow tract contributes to chamber formation and cardiac conduction system development. (2012)
  • Author(s): 淺井理恵子
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡(福岡県福岡市)
  • Year and Date: 2012-12-12
• [Presentation] Involvement of non-coding RNA : Evf2 in the Endothelin signaling in branrhial arch development. (2012)
  • Author(s): Yukiko Kurihara
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡(福岡県福岡市)
  • Year and Date: 2012-12-12
• [Presentation] A protective role of Sirt3 against oxidative stress and aging in mouse preimplantation embrvos. (2012)
  • Author(s): Yumiko Kawamura
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡(福岡県福岡市)
  • Year and Date: 2012-12-12
• [Presentation] A novel mathematical model of endothelial cell dynamics during angiogenic morphogenesis : analysis of cell-based mechanisms. (2012)
  • Author(s): Kei Sugihara
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡(福岡県福岡市)
  • Year and Date: 2012-12-11
• [Presentation] Preotic neural crest cells contribute as a novel component of the coronary artery development. (2012)
  • Author(s): 有馬勇一郎
  • Organizer: 第20回日本血管生物医学会学術集会
  • Place of Presentation: あわぎんホール(徳島県徳島市)
  • Year and Date: 2012-12-07
• [Presentation] Imaging, Quantification and modeling of self-organizing behaviors of vascular cells (2012)
  • Author(s): Koichi Nishiyama
  • Organizer: 第20回日本血管生物医学会学術集会
  • Place of Presentation: あわぎんホール(徳島県徳島市)
  • Year and Date: 2012-12-06
• [Presentation] Imaging, quantification and modeling of self-organizing behaviors of vascular cells (2012)
  • Author(s): Koichi Nishiyama
  • Organizer: 第20回日本血管生物医学会学術集会
  • Place of Presentation: あわぎんホール(徳島県徳島市)
  • Year and Date: 2012-12-06
• [Presentation] MicroRNA 199/214 cluster is required for normal growth and skeletal development in mice. (2012)
  • Author(s): Yumiko Kawamura
  • Organizer: Cell Symposia; Functional RNAs
  • Place of Presentation: Hotel Melia, Sitges (スペイン)
  • Year and Date: 2012-12-04
• [Presentation] Involvement of non-coding RNA Evf2 in the endothelin signaling in branrhial arch development. (2012)
  • Author(s): Yukiko Kurihara
  • Organizer: Cell Synposia, Functional RNAs
  • Place of Presentation: Hotel Melia, Sitges (スペイン)
  • Year and Date: 2012-12-03
• [Presentation] Involvement of non-coding RNA Evf2 in the endothelin signaling in branchial arch development. (2012)
  • Author(s): Yukiko Kurihara
  • Organizer: Cell Synposia, Functional RNAs
  • Place of Presentation: Hotel Melia, Sitges (スペイン)
  • Year and Date: 2012-12-03
• [Presentation] Experimental and computational analysis underscores the importance of tip cell dynamics in angiogenic morphogenesis. (2012)
  • Author(s): Koichi Nishiyama
  • Organizer: 第16回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 東京大学本郷キャンパス
  • Year and Date: 2012-11-24
• [Presentation] Preotic neural crestはエンドセリンシグナリングを介して冠動脈平滑筋形成に寄与する (2012)
  • Author(s): 有馬勇一郎
  • Organizer: 第16回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 東京大学本郷キャンパス
  • Year and Date: 2012-11-23
• [Presentation] The novel contribution of preotic neural crest cells in the coronary artery development. (2012)
  • Author(s): 有馬勇一郎
  • Organizer: AHA scientific session 2012
  • Place of Presentation: ロサンゼルス(アメリカ)
  • Year and Date: 2012-11-15
• [Presentation] 前耳胞神経堤細胞"Preotic neural crest"の冠動脈発生における寄与 (2012)
  • Author(s): 有馬勇一郎
  • Organizer: 第11回日本心臓血管発生研究会
  • Place of Presentation: 磐梯熱海温泉ホテル華の湯(福島県 郡山市)
  • Year and Date: 2012-10-20
• [Presentation] 心流入路におけるエンドセリンA型受容体発現細胞群は心室形成および刺激伝導系形成に寄与する (2012)
  • Author(s): 淺井理恵子
  • Organizer: 第11回日本心臓血管発生研究会
  • Place of Presentation: 磐梯熱海温泉ホテル華の湯(福島県 郡山市)
  • Year and Date: 2012-10-19
• [Presentation] 心流入路におけるエンドセリンA型受容体発現細胞群は心室形成および刺激伝導系形成に寄与する (2012)
  • Author(s): 淺井理恵子
  • Organizer: 第11回日本心臓血管発生研究会
  • Place of Presentation: 磐梯熱海温泉 ホテル 華の湯(福島県 郡山市)
  • Year and Date: 2012-10-19
• [Presentation] A defensive role of Sirt3 against oxidative stress and aging in Preimplantation embryos. (2012)
  • Author(s): Yumiko Kawamura
  • Organizer: the 25th Annual Mouse Molecular Genetics Conference
  • Place of Presentation: Pacific Grove, CA (アメリカ)
  • Year and Date: 2012-10-03
• [Presentation] A defensive role of Sirt3 against oxidative stress and aging in preimplantation embryos. (2012)
  • Author(s): Yumiko Kawamura
  • Organizer: the 25th Annual Mouse Molecular Genetics Conference
  • Place of Presentation: Pacific Grove, CA (アメリカ)
  • Year and Date: 2012-10-03
• [Presentation] Cell-based mechanism behind angiogenic morphogenesis : analysis using both experomental and computational approaches. (2012)
  • Author(s): Koichi Nishiyama
  • Organizer: 7th International Kloster Seeon Meeting 'Angiogenesis' : Molecular Mechanisms and
  • Place of Presentation: KLOSTER SEEON (ドイツ)
  • Year and Date: 2012-09-15
• [Presentation] Cell-based mechanism behind angiogenic morphogenesis: analysis using both experimental and computational approaches. (2012)
  • Author(s): Koichi Nishiyama
  • Organizer: 7th International Kloster Seeon Meeting 'Angiogenesis': Molecular Mechanisms and
  • Place of Presentation: KLOSTER SEEON (ドイツ)
  • Year and Date: 2012-09-15
• [Presentation] 血管の形づくりを担う内皮細胞動態 (2012)
  • Author(s): 西山功一
  • Organizer: 第22回日本数理生物学会大会
  • Place of Presentation: 岡山大学津島キャンパス(岡山県岡山市)
  • Year and Date: 2012-09-12
• [Presentation] 神経堤細胞によるエンドセリンシグナルを介した新規の冠動脈発生機構 (2012)
  • Author(s): 有馬勇一郎
  • Organizer: 第48回日本小児循環器学会総会・学術集会
  • Place of Presentation: 京都国際会議場(京都府京都市)
  • Year and Date: 2012-07-05
• [Presentation] 血管構造をつくる血管内皮細胞動態の可視化と理解 (2012)
  • Author(s): 西山功一
  • Organizer: 第34回日本血栓止血学会学術集会
  • Place of Presentation: ハイアットリージェンシー東京
  • Year and Date: 2012-06-09
• [Presentation] Analysis of cell-based mechanisms involved in angiogenic morphogenesis by biological and computational approaches. (2012)
  • Author(s): Koichi Nishiyama
  • Organizer: 17th International Vascular Biology Meeting 2012
  • Place of Presentation: Rhein-Main-Hallen Wiesbaden(ドイツ)
  • Year and Date: 2012-06-02
• [Presentation] Analysis of cell-based mechanisms involved in angiogenic morphogenesis by biological and computational aporoaches. (2012)
  • Author(s): Koichi Nishiyama
  • Organizer: 17th International Vascular Biology Meeting 2012
  • Place of Presentation: Rhein-Main-Hallen Wiesbaden (ドイツ)
  • Year and Date: 2012-06-02
• [Presentation] Hox gene function and possible crosstalk with D1x genes in craniofacial morphogenesis. (2012)
  • Author(s): Taro Kitazawa
  • Organizer: 第45回日本発生生物学会 第64回細胞生物学会 合同大会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2012-05-30
• [Presentation] A novel mathematical model of angiogenic morphogenesis : implication of tip cell dynamics. (2012)
  • Author(s): Kei Sugihara
  • Organizer: 第45回日本発生生物学会 第64回細胞生物学会 合同大会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2012-05-30
• [Presentation] Hox gene function and possible crosstalk with Dlx genes in craniofacial morphogenesis. (2012)
  • Author(s): Taro Kitazawa
  • Organizer: 第45回日本発生生物学会第64回細胞生物学会合同大会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2012-05-30
• [Presentation] The neural crest contributes to coronary artery smooth muscle formation through endothelin signaling. (2012)
  • Author(s): Yuichiro Arima
  • Organizer: Weinstein Cardiovascular Development Conference 2012
  • Place of Presentation: シカゴ(アメリカ)
  • Year and Date: 2012-05-03
• [Presentation] Mouse-chick chimeric transplantation reveals the regional contribution of the cell population arising from the inflow tract to cardiac chamber formation. (2012)
  • Author(s): Rieko Asai
  • Organizer: Weinstein Cardiovascular Development Conference 2012
  • Place of Presentation: シカゴ(アメリカ)
  • Year and Date: 2012-05-03
• [Presentation] Involvement of non-coding RNA : Evf2 in the Endothelin signaling in branchial arch development (2012)
  • Author(s): Yukiko Kurihara,
  • Organizer: Keystone Symposia Canference Non-Coding RNAs
  • Place of Presentation: スノウバード・クリフロツジ(米国)
  • Year and Date: 2012-04-02
• [Presentation] Ex vivo血管新生における血管内皮細胞の集団的運動 (2012)
  • Author(s): Koichi Nishiyama
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学(山梨県 甲府市)(招待講演)
  • Year and Date: 2012-03-26
• [Presentation] Novel roles of the neural crest in coronary artery formation through the Endothelin-1/Endothelin A receptor signaling. (2012)
  • Author(s): Yuichiro Arima
  • Organizer: 第76回 日本循環器学会学術集会
  • Place of Presentation: 福岡国際会議場(福岡県福岡市)
  • Year and Date: 2012-03-18
• [Presentation] Hox gene function and possible crosstalk with Dlx genes in craniofacial morphogenesis (2012)
  • Author(s): Taro Kitazawa
  • Organizer: Gordon Research Conference Craniofacial Morphogenesis & Tissue Regeneration
  • Place of Presentation: フォーポイント・バイ・シェラトン・ロサンゼルス(米国)
• [Presentation] Angiogenic morphogenesis driven by collective endothelial cell behavior (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: 第34回分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県 横浜市)(招待講演)
  • Year and Date: 2011-12-13
• [Presentation] 下顎形成におけるエンドセリンシグナルにおけるnon-coding RNAとパラスペックル蛋白の作用 (2011)
  • Author(s): 栗原由紀子
  • Organizer: 第34回分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県 横浜市)
  • Year and Date: 2011-12-13
• [Presentation] Hox gene function and possible crosstalk with Dlx genes in craniofacial morphogenesis (2011)
  • Author(s): Taro Kitazawa
  • Organizer: 第34回分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県 横浜市)
  • Year and Date: 2011-12-13
• [Presentation] The first heart field subdomain defined by endothelin receptor type-A expression contributes to conduction system development (2011)
  • Author(s): Rieko Asai
  • Organizer: 第34回分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県 横浜市)
  • Year and Date: 2011-12-13
• [Presentation] Endothelin-l/Endothelin A receptor signaling are required for proper coronary artery development. (2011)
  • Author(s): Yuichiro Arima
  • Organizer: 第34回分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県 横浜市)
  • Year and Date: 2011-12-13
• [Presentation] Neural crest cells contribute to coronary artery development through endothelin signaling. (2011)
  • Author(s): Yuichiro Arima
  • Organizer: 第19回日本血管生物医学会学術集会
  • Place of Presentation: 東京ステーションコンファレンス(東京都 千代田区)
  • Year and Date: 2011-12-10
• [Presentation] Endothelin-l/Endothelin type-A receptor signaling regulates pharyngeal arch artery development through Dlx5/6-independent pathway. (2011)
  • Author(s): Ki-Sung Kim
  • Organizer: 第19回日本血管生物医学会学術集会
  • Place of Presentation: 東京ステーションコンファレンス(東京都 千代田区)
  • Year and Date: 2011-12-10
• [Presentation] Mechanism involving dynamic and heterogeneous endothelial cell movement during angiogenesis. (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: 第19回日本血管生物医学会学術集会
  • Place of Presentation: 東京ステーションコンファレンス(東京都 千代田区)(招待講演)
  • Year and Date: 2011-12-09
• [Presentation] Collective endothelial cell movement in angiogenic morphogenesis (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: オーランドコンベンションセンター(米国)
  • Year and Date: 2011-11-15
• [Presentation] Coronary artery anomalies in Endothelin-1 and Endothel in A receptor knockout mice. (2011)
  • Author(s): Yuichiro Arima
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: オーランドコンペンションセンター(米国)
  • Year and Date: 2011-11-15
• [Presentation] (2011)
  • Author(s): Yuichiro Arima
  • Organizer: 日蘭二国間交流セミナーFrontiers Angiogenesis: Development and Diseases
  • Place of Presentation: 昭和薬科大学(東京都 町田市)
  • Year and Date: 2011-11-05
• [Presentation] Morphogenetic cell movement in sprouting angiogenesis (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: 日蘭二国間交流セミナーFrontiers Angiogenesis : Development and Diseases
  • Place of Presentation: 昭和薬科大学(東京都 町田市)(招待講演)
  • Year and Date: 2011-11-04
• [Presentation] Dynamic and Heterogeneous collective endothelial cell movement driving angiogenic morphogenesis (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: The Second Pacific Symposium on Vascular Biology
  • Place of Presentation: 済州新羅ホテル(韓国)
  • Year and Date: 2011-10-30
• [Presentation] Ex vivoにおける定量的血管新生評価系の開発 (2011)
  • Author(s): 西山功一
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 栃木県総合文化センター(栃木県 宇都宮市)
  • Year and Date: 2011-10-22
• [Presentation] エンドセリンシグナルによる咽頭弓動脈リモデリング機構の解明 (2011)
  • Author(s): 金基成
  • Organizer: 第10回心臓血管発生研究会
  • Place of Presentation: ホテル華の湯(福島県 郡山市)
  • Year and Date: 2011-10-07
• [Presentation] The first heart field subdomain defined by endothelin receptor type-A expression contributes to conduction system development (2011)
  • Author(s): Rieko Asai
  • Organizer: ESC Working Group on Developmental Anatomy and Pathology
  • Place of Presentation: リブリツェ・キャッスル(チェコ共和国)
  • Year and Date: 2011-09-24
• [Presentation] Idl modulates sprouting angiogenesis possibly via spatiotemporal regulation of the Notch signal specification (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: 第84回日本生化学大会
  • Place of Presentation: 国立京都国際会館(京都府京都市)
  • Year and Date: 2011-09-22
• [Presentation] Collective endothelial cell movement in angiogenic morphogenesis (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: The 9th Japan-Korea Joint Symposium on vascular biology
  • Place of Presentation: ウエスティン朝鮮ホテル釜山(韓国)(招待講演)
  • Year and Date: 2011-08-25
• [Presentation] Analysis of Hox genes' functions in craniofacial morphogenesis using recombinase mediated cassette exchange system that induces ectopic expression of Hoxgenes (2011)
  • Author(s): Taro Kitazawa
  • Organizer: 第44回日本発生生物学会年会
  • Place of Presentation: 沖縄コンベンションセンター(沖縄県 宜野湾市)
  • Year and Date: 2011-05-20
• [Presentation] Endothelin receptor type-A expression defines a distinct subpopulation within the heart field and contributes to chamber myocardium formation (2011)
  • Author(s): Rieko Asai
  • Organizer: 第44回日本発生生物学会年会
  • Place of Presentation: 沖縄コンベンションセンター(沖縄県 宜野湾市)
  • Year and Date: 2011-05-19
• [Presentation] Endothelin receptor type-A expression defines a distinct subdomain within the heart field and contributes to chamber myocardium (2011)
  • Author(s): Rieko Asai
  • Organizer: Weinstein Cardiovascular Development Conference 2011
  • Place of Presentation: ヒルトンシンシナティネーデルラントプラザ(米国)
  • Year and Date: 2011-05-06
• [Presentation] Endothelin-l/Endothel in type-A receptor signaling regulates pharyngeal arch artery development through Dlx5/6-independent pathway. (2011)
  • Author(s): Ki-Sung Kim
  • Organizer: 2011 Pediatric Academic Societies and Asian Society for Pediatric Research joint meeting
  • Place of Presentation: Denver Convention Center, (Denver, USA)
  • Year and Date: 2011-05-01
• [Remarks]
  • URL: http://bio.m.u-kyoto.ac.jp/home-j.html
• [Remarks]
  • URL: http://bio.m.u-tokyo.ac.jp/home-j.html