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脂質マシナリーの可視化

Publicly Offered Research

Project AreaMachineries of bioactive lipids in homeostasis and diseases
Project/Area Number 23116510
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

瀬藤 光利  浜松医科大学, 医学部, 教授 (20302664)

Project Period (FY) 2011-04-01 – 2013-03-31
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2012: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2011: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Keywords脂質 / イメージング / 炎症 / 神経変性疾患 / 癌
Outline of Annual Research Achievements

脂質および脂質動態の可視化について、以下の成果を出した。
1)ヒトの腹部大動脈瘤を質量顕微鏡で解析し、動脈外膜内のvasa vasorumがトリグリセリドの異常蓄積によるアテローム硬化を起こしていることを見出した(Tanakaら)。2)パーキンソン病モデル動物を質量顕微鏡で解析し、神経変性末端におけるスルファチドの異常蓄積を見出した(Onishiら)。3)Dorfman-Chanarin症候群の皮膚を質量顕微鏡で解析し、セラミドの代謝異常の可視化に成功した(Goto-Inoueら)。4)甲状腺癌の組織を質量顕微鏡で解析し、特定のホスファチジルコリンが癌部において増加していることを発見した(Ishikawaら)。5)バナナエビの卵巣を質量顕微鏡で観察し、卵巣成熟時の脂質組成および分布の変化を明らかにした(Chanselaら)。6)脊髄損傷モデルを質量顕微鏡で解析し、リン脂質と脂質代謝物であるプロスタグランジンの時空間的な分布変化を可視化することに成功した(Hanadaら)。7)マウス骨格筋を質量顕微鏡で解析し、筋収縮時に脂質組成が劇的に変化することを発見した(Goto-Inoueら)。8)下腿部大伏在静脈の静脈瘤を質量顕微鏡で解析し、リンパ管の消失と脂質の異常蓄積を見出した(Tanakaら)。実際のヒト病理サンプルを用いた解析では、他の手法では得ることのできない疾患の本質に迫る貴重な知見を報告できた点で医学的に非常に意義深い。動物モデルを用いた解析では、ヒトサンプルでは不可能な時間変化を捉えることに成功し、生理学的および病理学的な脂質代謝の時空間動態を提示できた点に,学術的および医学的な大きな意義がある。
上記の原著報告にくわえ、質量顕微鏡による脂質解析に関する方法論の総説や解説論文を多数発表した(Miyamuraら;Saitoら;Gotoら;Nakanishiら;Setou)。

Research Progress Status

24年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

24年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (98 results)

All 2013 2012 2011 Other

All Journal Article (27 results) (of which Peer Reviewed: 24 results) Presentation (67 results) (of which Invited: 19 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] *equal contribution Adventitiavasa vasorum arteriosclerosisin abdominal aortic aneurysm2013

    • Author(s)
      Tanaka, H*., Zaima, N*., Sasaki, T., Hayasaka, T., Goto-Inoue, N., Onoue, K., Ikegami, K., Morita, Y., Yamamoto, N., Mano, Y., Sano, M., Saito, T., Sato, K., Konno, H., Setou, M
    • Journal Title

      Plos One

      Volume: 8 Issue: 2 Pages: e57398-e57398

    • DOI

      10.1371/journal.pone.0057398

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sulfatide accumulation in the dystrophic terminals of gracile axonal dystrophy mice: lipid analysis using matrix-assisted laser desorption/ionization imaging mass spectrometry.2013

    • Author(s)
      Onishi S, Tatsumi Y, Wada K, Yang HJ, Sugiura Y, Setou M, Yoshikawa H.
    • Journal Title

      Med Mol Morphol

      Volume: ー

    • NAID

      10031203183

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging mass spectrometry visualizes ceramides and the pathogenesis of dorfman-chanarin syndrome due to ceramide metabolic abnormality in the skin.2012

    • Author(s)
      Goto-Inoue N, Hayasaka T, Zaima N, Nakajima K, Holleran WM, Sano S, Uchida Y, Setou M.
    • Journal Title

      PLoS One.

      Volume: 7 Issue: 11 Pages: e49519-e49519

    • DOI

      10.1371/journal.pone.0049519

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of phosphatidylcholine (16:0/18:1) and (16:0/18:2) in thyroid papillary cancer2012

    • Author(s)
      Ishikawa, S., Tateya, I., Hayakawa, T., Masaki, N., Takizawa, Y., Ohno, S., Kojima, T., Kitani, Y., Kitamura, M., Hirano, S., Setou, M., Ito, J
    • Journal Title

      PLoS One

      Volume: 7(11) Issue: 11 Pages: e48873-e48873

    • DOI

      10.1371/journal.pone.0048873

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] [Analysis of the regenerating murine liver by imaging mass spectrometry]2012

    • Author(s)
      Miyamura N, Setou M, Nishina H.
    • Journal Title

      Seikagaku.

      Volume: 84 Pages: 680-684

    • NAID

      10031059065

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Development of imaging mass spectrometry.2012

    • Author(s)
      Saito Y, Waki M, Hameed S, Hayasaka T, Setou M.
    • Journal Title

      Biol Pharm Bull.

      Volume: 35 Pages: 1417-1424

    • NAID

      130001872090

    • Related Report
      2012 Annual Research Report
  • [Journal Article] High-resolution multi-isotope imaging mass spectrometry enables visualisation of stem cell division and metabolism.2012

    • Author(s)
      Goto K, Waki M, Takahashi T, Kadowaki M, Setou M.
    • Journal Title

      Chembiochem.

      Volume: 13 Issue: 8 Pages: 1103-1106

    • DOI

      10.1002/cbic.201200146

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biomedical mass spectrometry.2012

    • Author(s)
      Nakanishi T, Setou M, Kuhara T.
    • Journal Title

      Anal Bioanal Chem

      Volume: 403 Issue: 7 Pages: 1775-1776

    • DOI

      10.1007/s00216-012-5922-x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] [Imaging mass spectrometry].2012

    • Author(s)
      Setou M.
    • Journal Title

      Yakugaku Zasshi.

      Volume: 132 Pages: 499-506

    • NAID

      130001888663

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Composition and localization of lipids in Penaeus merguiensis ovaries during the ovarian maturation cycle as revealed by imaging mass spectrometry.2012

    • Author(s)
      Chansela P, Goto-Inoue N, Zaima N, Hayasaka T, Sroyraya M, Kornthong N, Engsusophon A, Tamtin M, Chaisri C, Sobhon P, Setou M.
    • Journal Title

      PLoS One.

      Volume: 7 Issue: 3 Pages: e33154-e33154

    • DOI

      10.1371/journal.pone.0033154

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal alteration of phospholipids and prostaglandins in a rat model of spinal cord injury2012

    • Author(s)
      Hanada M, Sugiura Y, Shinjo R, Masaki N, Imagama S, Ishiguro N, Matsuyama Y, Setou M
    • Journal Title

      Anal Bioanal Chem

      Volume: 403巻 Issue: 7 Pages: 1873-1884

    • DOI

      10.1007/s00216-012-5900-3

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of dynamic change in contraction-induced lipid composition in mouse skeletal muscle by matrix-assisted laser desorption/ionization imaging mass spectrometry.2012

    • Author(s)
      Goto-Inoue N, Manabe Y, Miyatake S, Ogino S, Morishita A, Hayasaka T, Masaki N, Setou M, Fujii NL.
    • Journal Title

      Anal Bioanal Chem.

      Volume: 403 Issue: 7 Pages: 1863-1871

    • DOI

      10.1007/s00216-012-5809-x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging mass spectrometry reveals changes of metabolites distribution in mouse testis during testicular maturation2012

    • Author(s)
      Goto-Inoue N, Hayasaka T, Zaima N, Setou M
    • Journal Title

      Surf Interface Anal

      Volume: 44 Issue: 6 Pages: 749-754

    • DOI

      10.1002/sia.3869

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Axonal gradient of arachidonic acid-containing phosphatidylcholine and its dependence on actin dynamics2012

    • Author(s)
      Yang H, Sugiura Y, Ikegami K, Konishi Y, Setou M
    • Journal Title

      J Biol Chem

      Volume: 287巻 Issue: 8 Pages: 5290-5300

    • DOI

      10.1074/jbc.m111.316877

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanoparticle-assisted Laser Desorption/ionization [nano-PALDI]-based Imaging Mass Spectrometry [IMS] and its Application to Brain Science2012

    • Author(s)
      Hameed S, Sugiura Y, Kimura Y, Shrivas K, Setou M
    • Journal Title

      Nanomedicine and the Norvous System

      Pages: 97-118

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of lymphatic vessels and regional lipid accumulation is associated with incompetent great saphenous vein2011

    • Author(s)
      Tanaka H, Zaima N, Sasaki T, Yamamoto N, Sano M, Konno H, Setou M, Unno N
    • Journal Title

      J Vasc Surg

      Volume: 55 Issue: 5 Pages: 1440-8

    • DOI

      10.1016/j.jvs.2011.09.064

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal phospholipids distribution in theprefrontal cortex from a patient withschizophrenia revealed by matrix-assisted laser desorption/ionization imaging mass spectrometry2011

    • Author(s)
      Matsumoto J, Sugiura Y, Yuki D, Hayasaka T, Goto-Inoue N,Zaima N, Kunii Y, Wada A, Yang Q, Nishiura K, Akatsu H, Hori A, Hashizume Y, Yamamoto T, Ikemoto K, Setou M, Niwa SI
    • Journal Title

      Anal Bioanal Chem

      Volume: 400巻 Issue: 7 Pages: 1933-43

    • DOI

      10.1007/s00216-011-4909-3

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of phosphatidylcholine, lysophosphatidylcholine and sphing omyelin in mouse tongue body by matrix-assisted laser desorption/ionization imaging mass spectrometry2011

    • Author(s)
      Enomoto H, Sugiura Y, Setou M, Zaima N
    • Journal Title

      Anal Bioanal Chem

      Volume: 400 Issue: 7 Pages: 1913-1921

    • DOI

      10.1007/s00216-011-4924-4

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging mass spectrometry reveals characteristic changes in triglyceride and phospholipid species in regenerating mouse liver2011

    • Author(s)
      Miyamura N, Nakamura T, Goto-Inoue N, Zaima N, Hayasaka T, Yamasaki T, Terai S, Sakaida I, Setou M, Nishina H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 408 Issue: 1 Pages: 120-125

    • DOI

      10.1016/j.bbrc.2011.03.133

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging mass spectrometry-based histopathologic examination of atherosclerotic lesions2011

    • Author(s)
      Nobuhiro Zaima, Takeshi Sasaki, Hiroki Tanaka, Xian Wu Cheng, Kenji Onoue, Takahiro Hayasaka, Naoko Goto-Inoue, Hirofumi Enomoto, Naoki Unno, Masafumi Kuzuya, Mitsutoshi Setou
    • Journal Title

      Atheroslerosis

      Volume: 217 Issue: 2 Pages: 427-432

    • DOI

      10.1016/j.atherosclerosis.2011.03.044

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insufficient remodeling of membranes of mitochondria and axon terminals causes neuroaxonal dystrophy in calcium-independent phospholipase A2b deficiency.2011

    • Author(s)
      Beck, G.
    • Journal Title

      Journal of Neuroscience

      Volume: VOL. 31 Issue: 31 Pages: 11411-11420

    • DOI

      10.1523/jneurosci.0345-11.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydroxylated and non-hydroxylated sulfatide are distinctly distributed in the human cerebral cortex2011

    • Author(s)
      Yuki D, Sugiura Y, Zaima N, Akatsu H, Hashizume Y, Yamamoto T, Fujiwara M, Sugiyama K, Setou M
    • Journal Title

      Neuroscience

      Volume: 193巻 Pages: 44-53

    • DOI

      10.1016/j.neuroscience.2011.07.045

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging mass spectrometry analysis reveals an altered lipid distribution pattern in the tubular areas of hyper-IgA murine kidneys2011

    • Author(s)
      Kaneko Y, Obata Y, Nishino T, Kakeya H, Miyazaki Y, Hayasaka T, Setou M, Furusu A, Kohno S
    • Journal Title

      Exp Mol Pathol

      Volume: 91 Issue: 2 Pages: 614-621

    • DOI

      10.1016/j.yexmp.2011.07.002

    • NAID

      120006985016

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging Technology of Complex Lipid Molecular Species by a Combination of TLC-Blot and MALDI-TOF ?Special Reference to Human Brain Ganglioside Molecular Species2011

    • Author(s)
      Valdes-Gonzalez T, Goto-Inoue N, Hayasaka T, Ishiyama H, Setou M, Taki T
    • Journal Title

      J Glycom Lipidom

      Volume: 1巻 Issue: 01 Pages: 1000104-1000104

    • DOI

      10.4172/2153-0637.1000104

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation by Imaging Mass Spectrometry of Biomarker Candidates for Aging in the Hair Cortex2011

    • Author(s)
      Waki ML, et al
    • Journal Title

      PLoS One

      Volume: 6 Issue: 10 Pages: e26721-e26721

    • DOI

      10.1371/journal.pone.0026721

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging Mass Spectrometry Evaluation of the Effects of Various Irrigation Fluids in a Rat Model of Postoperative Cerebral Edema.2011

    • Author(s)
      Koizumi S, Hayasaka T, Goto-Inoue N, Doi K, Setou M, Namba H
    • Journal Title

      World Neurosurq

      Volume: 77巻 Issue: 1 Pages: 153-159

    • DOI

      10.1016/j.wneu.2011.03.039

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging mass spectrometry for lipidomics2011

    • Author(s)
      Goto-Inoue N, Hayasaka T, Zaima N, Setou M
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1811 Issue: 11 Pages: 961-969

    • DOI

      10.1016/j.bbalip.2011.03.004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] IMSオーバービュー2013

    • Author(s)
      瀬藤光利
    • Organizer
      2013年度農芸化学会大会シンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 質量顕微鏡法による生体機能の解明と応用について2013

    • Author(s)
      瀬藤光利
    • Organizer
      生体機能の解明とその応用に関する研究会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Novel analytical approches by new high space resolutional imaging mass spectrometry2013

    • Author(s)
      瀬藤光利
    • Organizer
      Mass Spectrometry 2013
    • Place of Presentation
      シンガポール
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] イメージングマススペクトロメトリーによる皮膚の観察2013

    • Author(s)
      瀬藤光利
    • Organizer
      LO皮膚科学研究会 冬季プログラム
    • Place of Presentation
      沼津
    • Related Report
      2012 Annual Research Report
  • [Presentation] 質量顕微鏡法について(質量分析イメージング)2013

    • Author(s)
      瀬藤光利
    • Organizer
      第37回 分析機器展
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] 質量顕微鏡法による癌のバイオマーカー研究の基礎と応用2013

    • Author(s)
      瀬藤光利
    • Organizer
      第1回婦人科がんバイオマーカー研究会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Distribution of lipids analyzed by imaging mass spectrometry2013

    • Author(s)
      瀬藤光利
    • Organizer
      Seminar at MPI-CBG
    • Place of Presentation
      ドレスデン
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development and application of imaging mass spectrometry2013

    • Author(s)
      瀬藤光利
    • Organizer
      超領域日中韓国際シンポジウム
    • Place of Presentation
      静岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 質量分析イメージングデータの定量生物学的解析法2012

    • Author(s)
      瀬藤光利
    • Organizer
      第35回 日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] Anatomy With Imaging Mass Spectrometry2012

    • Author(s)
      瀬藤光利
    • Organizer
      the 2nd International Anatomical Sciences and Cell Biology Conference
    • Place of Presentation
      タイ
    • Year and Date
      2012-12-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cell Biology of Aging Process2012

    • Author(s)
      瀬藤光利
    • Organizer
      the 2nd International Anatomical Sciences and Cell Biology Conference
    • Place of Presentation
      タイ
    • Year and Date
      2012-12-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] 質量顕微鏡による乳がんの循環腫瘍細胞のメタボローム解析2012

    • Author(s)
      瀬藤光利
    • Organizer
      第43回高松宮妃癌研究基金国際シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-11-14
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 脂質マシナリーの可視化2012

    • Author(s)
      瀬藤光利
    • Organizer
      新学術領域研究「生命応答を制御する脂質マシナリー」第3回班会議
    • Place of Presentation
      秋田
    • Year and Date
      2012-11-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] イメージングマススペクトロメトリーによる骨格筋収縮に伴う代謝物変動の可視化2012

    • Author(s)
      井上菜穂子、眞鍋康子、宮武正太、森下愛、荻野慎也、瀬藤光利、藤井宣晴
    • Organizer
      第37回日本医用マススペクトル学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-10-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] イメージングマススペクトロメトリーによる歯牙及び歯周組織の臨床組織切片の解析2012

    • Author(s)
      平野裕一、早坂孝宏、正木紀隆、渡辺賀子、増本一真、長田哲次、加藤文度、瀬藤光利
    • Organizer
      第37回日本医用マススペクトル学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-10-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] 質量分析イメージングを用いたヒト口腔扁平上皮癌のホスファチジルコリンの分布解析2012

    • Author(s)
      内山佳之、早坂孝宏、正木紀隆、長田哲次、加藤文度、瀬藤光利
    • Organizer
      第37回日本医用マススペクトル学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-10-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mass Microscopeを用いたヒト網膜組織の脂質イメージング解析2012

    • Author(s)
      早坂孝宏、井上菜穂子、正木紀隆、小川倫弘、兼坂岳志、堀映、赤津裕康、瀬藤光利
    • Organizer
      第37回日本医用マススペクトル学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-10-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] Meta analysis of histopathological lipidomics2012

    • Author(s)
      瀬藤光利
    • Organizer
      2012 Tecan Symposium
    • Place of Presentation
      ボストン
    • Year and Date
      2012-10-23
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Imaging mass spectrometry of Sphingolipids2012

    • Author(s)
      瀬藤光利
    • Organizer
      EMBO Workshop on Molecular Medicine of Sphingolipids
    • Place of Presentation
      イスラエル
    • Year and Date
      2012-10-16
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Imaging mass spectrometry provides the comprehensive analysis of the dynamic change of phospholipids in selective white matter injury of the rat model2012

    • Author(s)
      小野 秀明, 今井 英明, 早坂 孝宏, 宮脇 哲, 堀川 弘吏, 越智 崇, 伊藤 明博, 瀬藤 光利, 齊藤 延人
    • Organizer
      Neuroscience 2012 SFN's 42nd annual meeting
    • Place of Presentation
      ニューオリンズ
    • Year and Date
      2012-10-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] Molecular imaging of rat hippocampus after transit global ischemia using imaging mass spectrometry2012

    • Author(s)
      Satoru Miyawaki, Takahiro Hayasaka, Hideaki, Imai, Hideaki Ono, Hiroshi, Horikawa, Ochi Takashi, Akihiro Ito, Hirofumi Nakatomi, Mitsutoshi Setou, Nobuhito Saito
    • Organizer
      Neuroscience 2012 SFN's 42nd annual meeting
    • Place of Presentation
      ニューオリンズ
    • Year and Date
      2012-10-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] イメージングマススペクトロメトリーによって初めて明らかになった、細胞内の脂質分布の分子種特異的な極性について2012

    • Author(s)
      瀬藤光利
    • Organizer
      日本生物物理学会 第50回年会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] リン脂質リモデリング酵素LPCAT1は肝癌の脂質組成を変化させ、癌の進展に関与している2012

    • Author(s)
      森田剛文、坂口孝宣、瀬藤光利、今野弘之
    • Organizer
      第71回日本癌学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] 胃癌におけるLPCAT1発現亢進および脂質変化2012

    • Author(s)
      菊池寛利、宮崎真一郎、平松良浩、馬場恵、神谷欣志、坂口孝宣、瀬藤光利、森弘樹、椙村春彦、今野弘之
    • Organizer
      第71回日本癌学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] Glycolipidomics by TLC-Blot / MALDI-TOF MS- Gangliosides in Alzheimer's Disease -2012

    • Author(s)
      Takao Taki , Wakao Hirano , Takahiro Hayasaka , Mitsutoshi Setou , Naoko Goto-Inoue
    • Organizer
      26th International Carbohydrate Symposium
    • Place of Presentation
      マドリード
    • Year and Date
      2012-07-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] 乳癌循環腫瘍細胞のフローサイトメトリー法による精製と質量顕微鏡法による解析2012

    • Author(s)
      脇紀彦、井手佳美、高橋司、後藤健介、古川省悟、高橋郁太、佐藤哲朗、白井祐輔、門脇慎、稲見勝朗、大畑健次、椎谷紀彦 、瀬藤光利
    • Organizer
      第22回日本サイトメトリー学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2012-06-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] TLC-Blot MALDI-TOF MS Lipidomics2012

    • Author(s)
      瀧孝雄、平野稚子、櫻井一志、早坂孝宏、瀬藤光利、井上菜穂子
    • Organizer
      第54回日本脂質生化学会
    • Place of Presentation
      九州
    • Year and Date
      2012-06-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] Intracellular distribution of Phosphatidylcholine molecular species.2012

    • Author(s)
      瀬藤光利
    • Organizer
      文部科学省新学術領域研究 「脂質マシナリー」 主催 国際シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2012-06-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] ラット損傷脊髄における炎症反応の質量顕微鏡による解析およびprostaglandinとリゾリン脂質を用いた評価との比較2012

    • Author(s)
      花田充、杉浦悠毅、新城龍一、石黒直樹、瀬藤光利、松山幸弘
    • Organizer
      第85回 整形外科学会学術総会
    • Place of Presentation
      京都
    • Year and Date
      2012-05-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] 質量顕微鏡法によるヒト毛髪皮質中の加齢マーカー分子の探索2012

    • Author(s)
      脇 紀彦、高橋 司、後藤 健介、早坂 孝宏、下村 裕、瀬藤 光利
    • Organizer
      日本顕微鏡学会 第68回学術講演会
    • Place of Presentation
      つくば
    • Year and Date
      2012-05-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] 質量顕微鏡による内耳の解析2012

    • Author(s)
      杉山健一、瀧澤義徳、水田邦博、大和谷崇、岡村純、中西啓、泉智沙子、早坂孝宏、瀬藤光利、峯田周幸
    • Organizer
      第113回 日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      新潟
    • Year and Date
      2012-05-09
    • Related Report
      2012 Annual Research Report
  • [Presentation] Ceramide deficiency in the epidermis leads to development of psoriasis-like lesions associated with IL-23-dependent proliferation of γδ-17 cells2012

    • Author(s)
      Nakajima K,Kataoka S,Goto-Inoue N,Terao M, Murota H,Azukizawa H,Setou M, Katayama I,Takeda J,Sano S.
    • Organizer
      2012 SID Annual Meeting and Celebration of the SID's 75th Aniversary
    • Place of Presentation
      North Carolina
    • Year and Date
      2012-05-09
    • Related Report
      2012 Annual Research Report
  • [Presentation] 我が国で見いだされた新規疾患単位、中性脂肪蓄積心筋血管症 ー希少難病からcommon diseaseへの展開ー2012

    • Author(s)
      平野 賢一、財満 信宏、 池田 善彦、眞能正幸、 小林 邦久、神崎 秀明、北風 政史、小室一成、瀬藤 光利、友池 仁暢
    • Organizer
      第109回日本内科学会講演会
    • Place of Presentation
      京都
    • Year and Date
      2012-04-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] Overexpression of LPCAT1 and concomitant alteration of lipid in gastric cancer2012

    • Author(s)
      Kikuchi H, Uehara T, Yamamoto M, Baba M, Ohta M, Kamiya K, Baba S, Setou M, Sugimura H and Konno H.
    • Organizer
      American Association for Cancer Research
    • Place of Presentation
      シカゴ
    • Year and Date
      2012-04-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] Biochemical Mapping with MALDI Imaging Mass Spectrometry2012

    • Author(s)
      Mitsutoshi Setou
    • Organizer
      2012春季第59回応用物理学関係連合講演会
    • Place of Presentation
      早稲田大学(東京)(招待講演)
    • Year and Date
      2012-03-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Axonal distribution of lipids revealed by imaging mass spectrometry2012

    • Author(s)
      Mitsutoshi Setou
    • Organizer
      第42回生理研国際シンポジウム生理研・新潟脳研合同シンポジウム
    • Place of Presentation
      生理学研究所(岡崎)(招待講演)
    • Year and Date
      2012-03-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] 質量顕微鏡法によるヒト毛髪皮質における加齢マーカー分子の探索2012

    • Author(s)
      脇紀彦、瀬藤光利
    • Organizer
      新学術領域研究脂質マシナリ班若手ワークショップ
    • Place of Presentation
      東京大学(東京)(ポスター発表)
    • Year and Date
      2012-02-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 質量顕微鏡法の開発と応用について2012

    • Author(s)
      瀬藤光利
    • Organizer
      Oncology 領域における基礎研究およびトラン スレーショナルリサーチ 定期講演会
    • Place of Presentation
      神奈川
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 脂質を「見る」質量顕微鏡の進歩2012

    • Author(s)
      瀬藤光利
    • Organizer
      千里ライフサイエンスセミナー
    • Place of Presentation
      豊中市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] イメージング質量分析の最近の進展2012

    • Author(s)
      瀬藤光利
    • Organizer
      第7回北海道大学大学院医学研究科連携研究センターシンポジウム
    • Place of Presentation
      北海道
    • Related Report
      2012 Annual Research Report
  • [Presentation] 質量顕微鏡法による動脈硬化の観察2012

    • Author(s)
      瀬藤光利
    • Organizer
      第19回 動脈硬化若手研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 質量顕微鏡を用いた選択的白質障害におけるリン脂質の動態解析2012

    • Author(s)
      小野 秀明、今井 英明、早坂 孝宏、宮脇 哲、堀川 弘吏、越智 崇、伊藤 明博、瀬藤 光利、 齊藤 延人
    • Organizer
      日本脳神経外科学会第71回学術総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] 質量顕微鏡法の新技術と創薬への利用2012

    • Author(s)
      瀬藤光利
    • Organizer
      ヒューマンサイエンス振興財団 WG勉強会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 一過性全脳虚血後の海馬神経細胞死の分子imaging -質量顕微鏡法を用いた分子動態解析-2012

    • Author(s)
      宮脇哲、早坂孝宏、今井英明、小野秀明、堀川弘吏、越智崇、伊藤明博、中富浩文、瀬藤光利、斉藤延人
    • Organizer
      第13回日本分子脳神経外科学会
    • Place of Presentation
      熊本
    • Related Report
      2012 Annual Research Report
  • [Presentation] Diagnostic application of Imaging Mass Spectrometry2012

    • Author(s)
      Mitsutoshi Setou, Kiyoshi Ogawa, Akiko Kubo, Ikuko Yao, Masaaki Matsuura
    • Organizer
      IMSC2012 19th International Mass Spectrometry Conference
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Introduction to Imaging Mass Spectrometry2012

    • Author(s)
      瀬藤光利、矢尾育子、早坂孝宏、正木紀隆、Cecilia Eriksson
    • Organizer
      IMSC2012 19th International Mass Spectrometry Conference
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mass spectro imaging2012

    • Author(s)
      瀬藤光利
    • Organizer
      the 14th International Congress of Histochemistry and Cytochemistry (ICHC 2012)
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 質量顕微鏡 質量分析を利用したバイオイメージング2012

    • Author(s)
      瀬藤光利 矢尾育子
    • Organizer
      第21回 日本バイオイメージング学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 質量顕微鏡法によるバイオマーカー研究の基礎と応用2012

    • Author(s)
      瀬藤光利
    • Organizer
      第16回薬物動態談話会セミナー
    • Place of Presentation
      三島
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Development and application of imaging mass spectrometry2012

    • Author(s)
      瀬藤 光利
    • Organizer
      Postech セミナー
    • Place of Presentation
      韓国
    • Related Report
      2012 Annual Research Report
  • [Presentation] 質量顕微鏡の開発と応用2012

    • Author(s)
      瀬藤光利
    • Organizer
      大阪大学大学院医学系研究科 老年・腎臓内科学講座セミナー
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 質量顕微鏡の耳鼻咽喉科学応用について2012

    • Author(s)
      瀬藤光利
    • Organizer
      第60回日本耳鼻咽喉科学会中部地方部会連合会
    • Place of Presentation
      浜松
    • Related Report
      2012 Annual Research Report
  • [Presentation] 質量分析イメージング法の開発と応用2012

    • Author(s)
      瀬藤光利
    • Organizer
      静岡県立大学院薬学研究院 月例セミナー
    • Place of Presentation
      静岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 質量顕微鏡法の研究開発2012

    • Author(s)
      瀬藤光利
    • Organizer
      東京大学グローバルCOE・CMSI「ナノバイオ工学」
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Cell Imaging and signaling research using mass spectrometry2012

    • Author(s)
      瀬藤光利
    • Organizer
      The 34th conference of the Korean Society of Cell Biology
    • Place of Presentation
      ウルサン
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 質量顕微鏡を用いた解析例と今後の展開2012

    • Author(s)
      瀬藤光利
    • Organizer
      島津サイエンス西日本(株)主催 講演
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 生体サンプルのMALDIイメージング質量分析に関する研究2012

    • Author(s)
      瀬藤光利
    • Organizer
      日本質量分析学会総会 日本質量分析学会奨励賞受賞講演
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Biomolecular imaging of C. elegans by MALDI-IMS2012

    • Author(s)
      Saira Hameed, Yoshishige Kimura, Yuki Sugiura, Takahiro Hayasaka, Naoko_Goto Inoue, Mitsutoshi Setou
    • Organizer
      Joint meeting of The 45th Annual Meeting of the Japanaese Society of Developmental Biologists The 64th Annual Meeting of the Japan Society for Cell Biology
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] maging mass spectrometry reveals changes of testicular lipids during seminiferous tubule maturation of the giant freshwater prawn Macrobrachium rosenbergii2012

    • Author(s)
      Tanapan Siangcham, Piyachat Chansela, Takahiro Hayasaka, Noritaka Masaki, Morakot Sroyraya, Saowaros Suwansa-ard, Attakorn Engsusophon, Prasert Sobhon, Mitsutoshi Setou
    • Organizer
      Joint meeting of The 45th Annual Meeting of the Japanaese Society of Developmental Biologists The 64th Annual Meeting of the Japan Society for Cell Biology
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] 質量顕微鏡法を用いたラット遅発性神経細胞死における分子動態解析2012

    • Author(s)
      宮脇哲、早坂孝宏、小野秀明、今井英明、堀川弘吏、越智崇、伊藤明博、中富浩文、瀬藤光利、斉藤延人
    • Organizer
      第37回日本脳卒中学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 質量顕微鏡によるバイオイメージング:現状と将来展望2012

    • Author(s)
      瀬藤 光利
    • Organizer
      ナノプローブテクノロジー第167委員会 第66 回研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Overexpression of LPCAT1 and concomitant lipid alterations in gastric cancer2012

    • Author(s)
      Hirotoshi Kikuchi1, Takashi Uehara 1, Tomohiko Setoguchi1, Masayoshi Yamamoto1, Manabu Ohta1, Kinji Kamiya1, Satoshi Baba2, Mitsutoshi Setou3, Haruhiko Sugimura2 and Hiroyuki Konno1
    • Organizer
      AACR Annual Meeting
    • Place of Presentation
      シカゴ
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] オーム研究と解析技術/神経2011

    • Author(s)
      瀬藤光利
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都)(一般講演)
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Distinct Distribution of Hydroxylated and Non-hydroxylated Sulfatide in Human Carebral Cortex2011

    • Author(s)
      Dai Yuuki, Yuki Sugiura, Nobuhiro Zaima, Hiroyasu Akatsu, Masami Fujiwara, Keikichi Sugiyama, Mitsutoshi Setou
    • Organizer
      59th Conference on Mass Spectrometry and Allied Topics
    • Place of Presentation
      Denver(アメリカ)(ポスター発表)
    • Year and Date
      2011-06-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 質量顕微鏡による5つのホスファチジルコリンの蝸牛における局在2011

    • Author(s)
      瀧澤義徳、水田邦博、中西啓、橋本泰幸、大和谷崇、岡村純、杉山健一、木村桃子、鈴木高広、早坂孝宏、瀬藤光利、峯田周幸
    • Organizer
      日本耳鼻咽喉科学会総会
    • Place of Presentation
      国立京都国際会館(京都)(一般講演)
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Changes of lipid molecules in perivascular tissues due to incompetence of lipid drainage by lymphatic vessel cause vein wall thickening2011

    • Author(s)
      Hiroki Tanaka, Nobuhiro Zaima, Takeshi Sasaki, Naoto Yamamoto, Masaki Sano, Hiroyuki Konno, Naoki Unno, Mitsutoshi Setou
    • Organizer
      Arteriosclerosis, Thrombosis, and Vascular Biology
    • Place of Presentation
      Chicago(アメリカ)(ポスター発表)
    • Year and Date
      2011-04-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腹部大動脈瘤と外膜の脂肪細胞化2011

    • Author(s)
      瀬藤光利、田中宏樹、財満信宏、海野直樹、今野弘之
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)(特別講演)
    • Year and Date
      2011-04-30
    • Related Report
      2011 Annual Research Report
  • [Remarks] 浜松医科大学 解剖学講座 細胞生物学分野

    • URL

      http://www.hama-med.ac.jp/university/chair/setou/ja/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.hama-med.ac.jp/university/chair/setou/ja/index.html

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 質量分析データ処理方法及び装置2012

    • Inventor(s)
      松浦正明、牛嶋大、涌井昌俊、瀬藤光利、梶原茂樹、小河潔
    • Industrial Property Rights Holder
      松浦正明、牛嶋大、涌井昌俊、瀬藤光利、梶原茂樹、小河潔
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-04-27
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 大動脈瘤モデル動物2011

    • Inventor(s)
      海野直樹、田中宏樹、眞野勇記、佐野真規、財満信宏、瀬藤光利、佐々木健
    • Industrial Property Rights Holder
      浜松医科大学
    • Filing Date
      2011-05-10
    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2018-03-28  

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