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ヒトの質感認知の脳神経メカニズムに関する臨床的研究

Publicly Offered Research

Project AreaIntegrative studies of neural mechanisms and advanced information technologies for perception of material and surface qualities
Project/Area Number 23135502
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionYamagata University

Principal Investigator

鈴木 匡子  山形大学, 医学(系)研究科(研究院), 教授 (20271934)

Project Period (FY) 2011-04-01 – 2013-03-31
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Keywords質感 / 鮮度 / 認知症 / 視覚性認知 / 視覚性失認 / 局所脳損傷 / 触覚性失認 / 後頭葉
Outline of Annual Research Achievements

ヒトの質感認知の脳神経メカニズムを知るために、これまでは局所脳損傷患者において質感認知障害の検討を進め、視覚性質感認知に両側後頭葉が重要な働きをしていることを明らかにしてきた。一方、認知症患者では傷んだ食品を食べたり、人に勧めたりする行動が見られることがあり、質感を含めた物の質的な変化の認知に何らかの異常がある可能性が示唆される。そこで、今年度は本領域の岡嶋克典氏(横浜国立大学)が作成した生鮮食品の画像刺激をご提供いただいて鮮度判断課題を作成し、認知症患者を対象に施行した。
【対象】変性性認知症患者20名(軽度アルツハイマー病15名、その他5名;女性10名)。健常対照群 5名
【方法】鮮度判断課題;野菜(キャベツ、人参、小松菜)を0から66時間まで系統的に劣化させた画像刺激を用い、野菜毎に鮮度の異なる2枚の刺激対を各10組作って、より新鮮な方を選択させた。輝度判断課題;同一鮮度の小松菜の輝度を6段階に変化させた画像刺激を用い、輝度の異なる2枚の刺激対を30組作って、より明るく見える方を選択させた。また、他の認知機能を評価するために標準的な神経心理学的検査を施行した。
【結果】認知症群では鮮度判断課題の正答数21.3±4.5、輝度判断課題28.7±2.1と鮮度判断課題が有意に低下していたのに対し、健常群は両者に差がなかった。鮮度判断課題の成績は、認知症群が健常群に比べ有意に低下していた。また、認知症群の鮮度判断課題の成績は、輝度判断課題の成績と有意な相関を認めたが(r=0.45, p0.05)、全般的認知機能や視運動性課題の速度の指標とは相関がなかった。
【考察】アルツハイマー病を中心とする変性性認知症患者では、画像における野菜の鮮度判断機能が低下していると考えられた。鮮度判断には種々の機能が関与しており、今後、影響する要因やその神経基盤を検討していく必要がある。

Research Progress Status

24年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

24年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (18 results)

All 2013 2012 2011

All Journal Article (10 results) (of which Peer Reviewed: 8 results) Presentation (6 results) Book (2 results)

  • [Journal Article] Comparison of caregiver strain in Parkinson's disease between Yamagata, Japan, and Maryland, The United States.2013

    • Author(s)
      Tanji H, Koyama S, Wada M, Kawanami T, Kurita K, Tamiya G, Saito N, Suzuki K, Kato T, Anderson KE, Gruber-Baldini AL, Fishman PS, Reich SG, Weiner WJ, Shulman LM.
    • Journal Title

      Parkinsonism Relat Disord

      Volume: 19 Issue: 6 Pages: 628-633

    • DOI

      10.1016/j.parkreldis.2013.02.014

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Face specific breadband electrocorticographic spectral power change in the rhinal cortex2012

    • Author(s)
      Tanji K, Iwasaki M, Nakasato N, Suzuki K.
    • Journal Title

      Neuroscience Letters

      Volume: 515 Issue: 1 Pages: 66-70

    • DOI

      10.1016/j.neulet.2012.03.020

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson's disease : a 3-year longitudinal study2012

    • Author(s)
      BabaT, Kikuchi A, Hirayama K, Nishio Y, Hosokai Y, Kanno S, Hasegawa T, Sugeno N, Konno M, Suzuki K, et al
    • Journal Title

      Brain

      Volume: 135 Issue: 1 Pages: 162-169

    • DOI

      10.1093/brain/awr321

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered cognitive function of prefrontal cortex during error feedback in patients with irritable bowel syndrome, based on FMRI and dynamic causal modeling2012

    • Author(s)
      Aizawa E, Sato Y, Kochiyama T, Saito N, Izumiyama M, Morishita J, Kanazawa M, Shima K, Mushiake H, Hongo M, Fukudo S
    • Journal Title

      Gastroenterology

      Volume: 143(5) Issue: 5 Pages: 1188-1198

    • DOI

      10.1053/j.gastro.2012.07.104

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 視覚性認知障害2012

    • Author(s)
      鈴木匡子
    • Journal Title

      神経心理学

      Volume: 28 Pages: 23-28

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Neural substrates for writing impairments in Japanese patients with mild Alzheimer's disease : A SPECT study2011

    • Author(s)
      Hayashi A, Nomura H, Mochizuki R Ohmuma A, Kinpara T, Ohtomo K, Hosokai Y, Ishioka T, Suzuki K, Mori E
    • Journal Title

      Neuropsychologia

      Volume: 49 Issue: 7 Pages: 1962-1968

    • DOI

      10.1016/j.neuropsychologia.2011.03.024

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Illusory misidentifications and cortical hypometabolism in Parkinson's disease2011

    • Author(s)
      Ishioka T, Hirayama K, Hosokai Y, Takeda A, Suzuki K, et al
    • Journal Title

      Movement disorder

      Volume: 26 Issue: 5 Pages: 837-843

    • DOI

      10.1002/mds.23576

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of olfactory dysfunction and brain metabolism in Parkinson's disease2011

    • Author(s)
      Baba T, Takeda A, Kikuchi A, Hishio Y, Hosokai Y, Hirayama K, Hasegawa T, Sugeno N, Suzuki K, et al
    • Journal Title

      Movement disorder

      Volume: 26 Issue: 4 Pages: 621-628

    • DOI

      10.1002/mds.23602

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired Glucose Metabolism Slows Executive Function Independent of Cerebral Ischemic Lesions in Japanese Elderly: The Takahata Study2011

    • Author(s)
      Takahashi Y, Iseki C, Wada M, Momma T, Ueki M, Kawanami T, Daimon M, Suzuki K, et al
    • Journal Title

      Internal Medicine

      Volume: 50 Issue: 16 Pages: 1671-1678

    • DOI

      10.2169/internalmedicine.50.4871

    • NAID

      130000969367

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 非典型認知症への臨床的アプローチ2011

    • Author(s)
      鈴木匡子
    • Journal Title

      臨床神経学

      Volume: 51 Pages: 930-933

    • Related Report
      2011 Annual Research Report
  • [Presentation] Face specific broadband electrocorticographic spectral power change in the rhinal cortex2012

    • Author(s)
      Tanji K,Iwasaki M, Nakasato N,Suzuki K
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      Earnest N Morial Convention Center, New Orleans, USA
    • Year and Date
      2012-10-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] Neuronal Bases of Texture Discrimination and Identification2012

    • Author(s)
      Suzuki K, Uno Y
    • Organizer
      The 2012 International Neuropsychological Society Mid-Year Meeting
    • Place of Presentation
      Radisson Blu Scandinavia Hotel, Oslo, Norway
    • Year and Date
      2012-06-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] Impaired discourse after aneurysmal subarachnoid haemorrhage.2012

    • Author(s)
      Uno Y, Kondo R, Saito S, Suzuki K
    • Organizer
      The 2012 International Neuropsychological Society Mid-Year Meeting
    • Place of Presentation
      Radisson Blu Scandinavia Hotel, Oslo, Norway
    • Year and Date
      2012-06-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] Writing Impairments in Japanese Patients with Mild Cognitive Impairments and with Mild Alzheimer’s Disease2012

    • Author(s)
      Hayashi A, Nomura H, Mochizuki R, Ohnuma A, Suzuki K, Mori E
    • Organizer
      The 2012 International Neuropsychological Society Mid-Year Meeting
    • Place of Presentation
      Radisson Blu Scandinavia Hotel, Oslo, Norway
    • Year and Date
      2012-06-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] 非定型認知症への臨床的アプローチ2011

    • Author(s)
      鈴木匡子
    • Organizer
      第52回日本神経学会総会
    • Place of Presentation
      名古屋名古屋国際会議場(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 視覚性認知障害2011

    • Author(s)
      鈴木匡子
    • Organizer
      第35回日本神経心理学会
    • Place of Presentation
      宇都宮栃木県総合文化センター(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Book] 中山書店2012

    • Author(s)
      斎藤尚宏,鈴木匡子 (分担)
    • Total Pages
      432
    • Publisher
      認知症 神経心理学的アプローチ
    • Related Report
      2012 Annual Research Report
  • [Book] 認知症学上その解明と治療の最新知見2011

    • Author(s)
      鈴木匡子(分担)
    • Total Pages
      620
    • Publisher
      日本臨床社
    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2018-03-28  

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