Publicly Offered Research
Grant-in-Aid for Transformative Research Areas (A)
Immune cell differentiation and proliferation are known to be synchronized with sleep. However, the molecular and cellular mechanisms by which sleep regulates immune system function and the contribution of glia to the regulation of sleep (gliosomnia) are an enigma. Gene expression in nucleus accumbens glia and leukocytes from wild-type mice, sleep-deprived mice, and mutant mice with high sleep need will be analyzed using single-cell gene expression analysis and identify molecules that interfere with the regulation of the immune system.
