神経血管再生のシーズ探索と階層的生物評価系の確立

• Project Area: Chemical Biology using bioactive natural products as specific ligands: identification of molecular targets and regulation of bioactivity
• Project/Area Number: 24102505
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Tohoku University
• Principal Investigator: 福永 浩司 東北大学, 薬学研究科(研究院), 教授 (90136721)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000); Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: アルツハイマー病 / T型カルシウムチャネル / アミロイドβ / ノビレチン / 錐体外路系障害 / パーキンソン病 / ドパミン / アルツハイマー病治療薬 / 血管再生

Research Abstract

天然物創薬研究ではシーズ探索の階層的生物評価系の確立が必須である。私達はアルツハイマー病治療薬の標的分子として、T型カルシウムチャネルを同定した。T型カルシウムチャネルは中枢神経系では、主に神経終末に発現し、神経伝達物質の放出を調節している。私達は T 型カルシウムチャネルを発現するneuro2A 細胞の電気生理学的解析、細胞内カルシウム動態解析、海馬シナプス伝達解析、アルツハイマー病の原因であるアミロイドβの産生評価系を構築して、脳機能改善薬のシーズを探索した。その結果、T 型カルシウムチャネル活性化薬 ST101 が嗅球摘出マウスにおいて、アミロイドβ産生を抑制することを確認した。次に、柑橘系果皮から抽出単離したノビレチンが ST101と同様に、T 型カルシウムチャネルを活性化することを見いだした。ノビレチンはパーキンソン病モデルマウスの認知機能を改善した。さらに、線条体においてドパミン合成と遊離を促進し、錐体外路系障害も改善した。さらに、海馬において、ドパミン遊離を促進し、同時に記憶回路形成に関わるカルシウム・カルモデュリン依存性プロテインキナーゼII を活性化した。ノビレチンはアルツハイマー病の周辺症状を緩和する陳皮の有効成分である。本研究は階層的生物評価系を用いてノビレチンの標的分子の一つを同定した。

Current Status of Research Progress

Reason

25年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

25年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Fluvoxamine rescues mitochondrial Ca2+ transport and ATP production through σ1-receptor in hypertrophic cardiomyocytes. (2014)
  • Author(s): Hideaki Tagashira
  • Journal Title: Life sciences Volume: 95(2) Issue: 2 Pages: 89-100
  • DOI: 10.1016/j.lfs.2013.12.019
  • Peer Reviewed
• [Journal Article] Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice (2014)
  • Author(s): Yabuki Y, Ohizumi Y, Yokosuka A, Mimaki Y, Fukunaga K
  • Journal Title: Neuroscience Volume: 259 Pages: 126-141
  • DOI: 10.1016/j.neuroscience.2013.11.051
  • Peer Reviewed
• [Journal Article] Melatonin reverses the decreases in hippocampal protein serine/threonine kinases observed in an animal model of autism (2014)
  • Author(s): Tian Y, Yabuki Y, Moriguchi S, Fukunaga K, Mao PJ, Hong LJ, Lu YM, Wang R, Ahmed MM, Liao MH, Huang JY, Zhang RT, Zhou TY, Long S, Han F
  • Journal Title: J Pineal Res. Volume: 56 Issue: 1 Pages: 1-11
  • DOI: 10.1111/jpi.12081
  • Peer Reviewed / Open Access
• [Journal Article] CaMKII activity is essential for improvement of memory-related behaviors by chronic rivastigmine treatment. (2014)
  • Author(s): Shigeki Moriguchi
  • Journal Title: J Neurochem. Volume: 128(6) Issue: 6 Pages: 927-937
  • DOI: 10.1111/jnc.12510
  • Peer Reviewed / Open Access
• [Journal Article] Imaging Monitoring Method of CaMKII Activity by Immunohistochemical Analysis in Schizophrenic Model Rats (2013)
  • Author(s): Yabuki Y, Nakagawasai O, Tadano T, Fukunaga K
  • Journal Title: YAKUGAKU ZASSHI Volume: 133 Issue: 5 Pages: 501-506
  • DOI: 10.1248/yakushi.12-00278-3
  • NAID: 130003361942
  • ISSN: 0031-6903, 1347-5231
  • Year and Date: 2013-05-01
  • Peer Reviewed
• [Journal Article] Targeted therapy of brain ischaemia using Fas ligand antibody conjugated PEG-lipid nanoparticles (2013)
  • Author(s): Lu YM, Huang JY, Wang H, Lou XF, Liao MH, Hong LJ, Tao RR, Ahmed MM, Shan CL, Wang XL, Fukunaga K, Du YZ, Han F
  • Journal Title: Biomaterials Volume: 35 Issue: 1 Pages: 530-7
  • DOI: 10.1016/j.biomaterials.2013.09.093
  • Peer Reviewed
• [Journal Article] Vascular Endothelial σ₁-Receptor Stimulation With SA4503 Rescues Aortic Relaxation via Akt/eNOS Signaling in Ovariectomized Rats With Aortic Banding (2013)
  • Author(s): Tagashira H, Matsumoto T, Taguchi K, Zhang C, Han F, Ishida K, Nemoto S, Kobayashi T, Fukunaga K
  • Journal Title: Circulation Journal Volume: 77 Issue: 11 Pages: 2831-2840
  • DOI: 10.1253/circj.CJ-13-0256
  • NAID: 10031196838
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Diverse regulation of IP_3 and ryanodine receptors by pentazocine through σ_l-receptor in cardiomyocytes. (2013)
  • Author(s): Hideaki Tagashira
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 305(8) Issue: 8 Pages: 89-100
  • DOI: 10.1152/ajpheart.00300.2013
  • Peer Reviewed
• [Journal Article] The effect of lipid nanoparticle PEGylation on neuroinflammatory response in mouse brain (2013)
  • Author(s): Huang JY, Lu YM, Wang H, Liu J, Liao MH, Hong LJ, Tao RR, Ahmed MM, Liu P, Liu SS, Fukunaga K, Du YZ, Han F
  • Journal Title: Biomaterials Volume: 34 Issue: 32 Pages: 7960-70
  • DOI: 10.1016/j.biomaterials.2013.07.009
  • Peer Reviewed
• [Journal Article] Oral administration of glutathione improves memory deficits following transient brain ischemia by reducing brain oxidative stress (2013)
  • Author(s): Yabuki Y, Fukunaga K
  • Journal Title: Neuroscience Volume: 250 Pages: 394-407
  • DOI: 10.1016/j.neuroscience.2013.07.017
  • Peer Reviewed
• [Journal Article] Interaction of PICK1 with C-Terminus of Growth Hormone–Releasing Hormone Receptor (GHRHR) Modulates Trafficking and Signal Transduction of Human GHRHR (2013)
  • Author(s): Katsushima Y, Sato T., Yamada C., Ito M., Suzuki Y., Ogawa E., Sukegawa I., Sukegawa J., Fukunaga K., Yanagisawa T.
  • Journal Title: Journal of Pharmacological Sciences Volume: 122 Issue: 3 Pages: 193-204
  • DOI: 10.1254/jphs.12287FP
  • NAID: 10031185413
  • ISSN: 1347-8613, 1347-8648
  • Peer Reviewed
• [Journal Article] Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-asparatate receptor (2013)
  • Author(s): Moriguchi S, Tanaka T, Narahashi T, Fukunaga K
  • Journal Title: Hippocampus Volume: 23 Issue: 10 Pages: 942-51
  • DOI: 10.1002/hipo.22150
  • Peer Reviewed
• [Journal Article] Oral L-citrulline administration improves memory deficits following transient brain ischemia through cerebrovascular protection (2013)
  • Author(s): Yabuki Y, Shioda N, Yamamoto Y, Shigano M, Kumagai K, Morita M, Fukunaga K
  • Journal Title: Brain Res. Volume: 1520 Pages: 157-67
  • DOI: 10.1016/j.brainres.2013.05.011
  • Peer Reviewed
• [Journal Article] Decreased CaMKII and PKC activities in specific brain regions are associated with cognitive impairment in neonatal ventral hippocampus-lesioned rats. (2013)
  • Author(s): Yabuki Y, Nakagawasai O, Moriguchi S, Shioda N, Onogi H, Tan-No K, Tadano T, Fukunaga K.
  • Journal Title: Neuroscience Volume: 234 Pages: 103-115
  • DOI: 10.1016/j.neuroscience.2012.12.048
  • Peer Reviewed
• [Journal Article] Stimulation of the Sigma-1 Receptor by DHEA Enhances Synaptic Effic acy and Neurogenesis in the Hippocampal Dentate Gyrus of Olfactory Bulbectomized Mice. (2013)
  • Author(s): Shigeki Moriguchi
  • Journal Title: PLoS One. Volume: 8(4) Issue: 4 Pages: e60863-e60863
  • DOI: 10.1371/journal.pone.0060863
  • Peer Reviewed
• [Journal Article] Stimulation of σ(1)-receptor restores abnormal mitochondrial Ca(2+) mobilization and ATP production following cardiac hypertrophy. (2013)
  • Author(s): Hideaki Tagashira
  • Journal Title: Biochimica et Biophysica Acta- General Subjects Volume: 1830(4) Issue: 4 Pages: 3082-3094
  • DOI: 10.1016/j.bbagen.2012.12.029
  • Peer Reviewed
• [Journal Article] Crucial Interactions Between Selective Serotonin Uptake Inhibitors and Sigma-1 Receptor in Heart Failure (2013)
  • Author(s): Bhuiyan MS, Tagashira H, Fukunaga K
  • Journal Title: Journal of Pharmacological Sciences Volume: 121 Issue: 3 Pages: 177-184
  • DOI: 10.1254/jphs.12R13CP
  • NAID: 10031165462
  • ISSN: 1347-8613, 1347-8648
  • Peer Reviewed
• [Journal Article] Influence of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on socioemotional behaviors in offspring rats. (2013)
  • Author(s): Nguyen AT, Nishijo M, Hori E, Nguyen NM, Pham TT, Fukunaga K, Nakagawa H, Tran AH, Nishijo H.
  • Journal Title: Environ Health Insights Volume: 7 Pages: 1-14
  • DOI: 10.4137/ehi.s10346
  • Peer Reviewed
• [Journal Article] The Disturbance of Hippocampal CaMKII/PKA/PKC Phosphorylation in Early Experimental Diabetes Mellitus. (2013)
  • Author(s): Liao MH, Xiang YC, Huang JY, Tao RR, Tian Y, Ye WF, Zhang GS, Lu YM, Ahmed MM, Liu ZR, Fukunaga K, Han F.
  • Journal Title: CNS Neurosci Ther. Volume: - Issue: 5 Pages: 329-36
  • DOI: 10.1111/cns.12084
  • Peer Reviewed
• [Journal Article] The Novel Cognitive Enhancer ST101 Enhances Acetylcholine Release in Mouse Dorsal Hippocampus Through T-type Voltage-Gated Calcium Channel Stimulation. (2013)
  • Author(s): Yamamoto Y, Shioda N, Han F, Moriguchi S, Fukunaga K.
  • Journal Title: J Pharmacol Sci. Volume: 121 Pages: 212-226
  • Peer Reviewed
• [Journal Article] Crucial interactions between selective serotonin uptake inhibitors and sigma-1 receptor in heart failure. (2013)
  • Author(s): Bhuiyan S, Tagashira H, Fukunaga K. Crucial interactions between selective serotonin uptake inhibitors and sigma-1 receptor in heart failure.
  • Journal Title: J Pharmacol Sci. Volume: 121 Pages: 177-184
  • Peer Reviewed
• [Journal Article] Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice. (2013)
  • Author(s): Moriguchi S, Tanaka T, Tagashira H, Narahashi T, Fukunaga K.
  • Journal Title: Behav Brain Res. Volume: 242 Pages: 150-157
  • DOI: 10.1016/j.bbr.2012.12.054
  • Peer Reviewed
• [Journal Article] The γ-secretase blocker DAPT reduces the permeability of the blood-brain barrier by decreasing the ubiquitination and degradation of occludin during permanent brain ischemia. (2013)
  • Author(s): Zhang GS, Tian Y, Huang JY, Tao RR, Liao MH, Lu YM, Ye WF, Wang R, Fukunaga K, Lou YJ, Han F.
  • Journal Title: CNS Neurosci Ther. Volume: 19(1) Issue: 1 Pages: 53-60
  • DOI: 10.1111/cns.12032
  • Peer Reviewed
• [Journal Article] Tao RR, Huang JY, Shao XJ, Ye WF, Tian Y, Liao MH, Fukunaga K, Lou YJ, Han F, Lu YM. Ischemic injury promotes Keap1 nitration and disturbance of antioxidative responses in endothelial cells: a potential vasoprotective effect of melatonin. (2013)
  • Author(s): Tao RR, Huang JY, Shao XJ, Ye WF, Tian Y, Liao MH, Fukunaga K, Lou YJ, Han F, Lu YM.
  • Journal Title: J Pineal Res. Volume: 54(3) Issue: 3 Pages: 271-281
  • DOI: 10.1111/jpi.12009
  • Peer Reviewed
• [Journal Article] Acyl-CoA binding domain containing 3 (ACBD3) recruits the protein phosphatase PPM1L to ER-Golgi membrane contact sites. (2012)
  • Author(s): Shinoda Y, Fujita K, Saito S, Matsui H, Kanto Y, Nagaura Y, Fukunaga K, Tamura S, Kobayashi T.
  • Journal Title: FEBS Lett. Volume: 586 Pages: 3024-3029
  • Peer Reviewed
• [Journal Article] P2X(7) signaling promotes microsphere embolism-triggered microglia activation bymaintaining elevation of Fas ligand (2012)
  • Author(s): Lu YM, Tao RR, Huang JY, Li LT, Liao MH, Li XM, Fukunaga K, Hong ZH, Han F
  • Journal Title: J Neuroinflammation Volume: 9 Issue: 1 Pages: 172-172
  • DOI: 10.1186/1742-2094-9-172
  • Peer Reviewed
• [Journal Article] Expression of a truncated form of the endoplasmic reticulum chaperone protein, sigma-1 receptor, promotes mitochondrial energy depletion and apoptosis. (2012)
  • Author(s): Norifumi Shioda
  • Journal Title: J Biol Chem. Volume: 287(28) Issue: 28 Pages: 23318-23331
  • DOI: 10.1074/jbc.m112.349142
  • Peer Reviewed
• [Journal Article] Benefit of vanadium compound in therapy for cardiovascular diseases. (2012)
  • Author(s): Fukunaga K.
  • Journal Title: Yakugaku Zasshi. Volume: 132 Pages: 279-284
  • NAID: 130001872021
  • Peer Reviewed
• [Journal Article] The T-type voltage-gated calcium channel as a molecular target of the novel cognitive enhancer ST101 : Enhancement of long-term potentiation and CaMKll autophosphorylation in rat cortical slices. (2012)
  • Author(s): Shigeki Moriguchi
  • Journal Title: J Neurochem. Volume: 121(1) Issue: 1 Pages: 44-53
  • DOI: 10.1111/j.1471-4159.2012.07667.x
  • Peer Reviewed
• [Journal Article] Cardioprotective effect of fluvoxamine, sigma-1 receptor high affinity agonist. (2012)
  • Author(s): Tagashira H, Fukunaga K.
  • Journal Title: Yakugaku Zasshi. Volume: 132(2) Pages: 167-172
  • NAID: 130001872003
  • Peer Reviewed
• [Presentation] Sigma-1受容体による心筋リアノジン受容体の機能調節 (2014)
  • Author(s): 田頭秀章、福永浩司
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本
• [Presentation] パーキンソンモデル動物の運動・認知機能障害に対する nobiletin の改善作用 (2014)
  • Author(s): 矢吹 悌、大泉 康、福永 浩司
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本
• [Presentation] 抗精神病薬ハロペリドールによる心毒性のメカニズム (2014)
  • Author(s): 篠田康晴、田頭秀章、福永浩司
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本
• [Presentation] FABP3は介在神経のGAD67発現を調節する (2014)
  • Author(s): 山本由似、福永浩司、大和田祐二
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本
• [Presentation] The memory improvement by T-type Ca2+ channel stimulation (2014)
  • Author(s): Kohji Fukunaga
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
• [Presentation] Molecular mechanisms of synapse pathology in ATR-X syndrome (2014)
  • Author(s): Norifumi Shioda, Masahiro Sawai, Misaki Onozato, Kouya Yamaguchi and Kohji Fukunaga
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
• [Presentation] The molecular mechanisms of neurodegeneration caused by ALS-related sigma-1 receptor mutation (2014)
  • Author(s): Hideaki Tagashira, Yasushi Yabuki, Norifumi Shioda and Kohji Fukunaga
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
• [Presentation] Role of Na+/Ca2+ exchanger in Alzheimer’s disease (2014)
  • Author(s): Shigeki Moriguchi, Satomi Kita, Takahiro Iwamoto and Kohji Fukunaga
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
• [Presentation] Sigma-1 receptor stimulation improves NO-mediated aortic relaxation in pressure overload-induced vascular injury (2014)
  • Author(s): Hideaki Tagashira, Takayuki Matsumoto, Kumiko Taguchi, Tsuneo Kobayashi and Kohji Fukunaga
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
• [Presentation] Oral glutathione administration improves memory deficits following transient brain ischemia (2014)
  • Author(s): Yasushi Yabuki and Kohji Fukunaga
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
• [Presentation] The impairment of σ1 receptor by haloperidol promotes the progression of heart failure (2014)
  • Author(s): Yasuharu Shinoda, Hideaki Tagashira and Kohji Fukunaga
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
• [Presentation] Sigma-1 receptor stimulation ameliorates transverse aortic constriction-induced depressive-like behaviors (2014)
  • Author(s): Koga Hirano, Hideaki Tagashira, Chen Zhang, Feng Han and Kohji Fukunaga
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
• [Presentation] Sigma-1 receptor stimulation improves depressive-like behaviors in CaMKIV null mice (2014)
  • Author(s): Yuzuru Sasaki, Shigeki Moriguchi, Hiroyuki Sakagami and Kohji Fukunaga
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
• [Presentation] FABP3 regulates GABA signaling in cingulate cortical neurons (2014)
  • Author(s): Yui Yamamoto, Kohji Fukunaga and Yuji Owada
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
• [Presentation] Aripiprazole, a dopamine D2 receptor partial agonist activates nuclear CaMKII in dopaminergic neurons (2014)
  • Author(s): Masahiro Sawai, Norifumi Shioda and Kohji Fukunaga
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
• [Presentation] FABP3 promotes α-Syn oligomerization in dopaminergic neurons (2014)
  • Author(s): Misaki Onozato, Norifumi Shioda, Yasushi Yabuki, Yuji Owada and Kohji Fukunaga
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
• [Presentation] Molecular mechanism of dopamine-induced activation of intracellular D2L receptor (2014)
  • Author(s): Eriko Ishida, Norifumi Shioda and Kohji Fukunaga
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
• [Presentation] Fatty acid-binding protein 3 promotes α-Synuclein oligomerization (2014)
  • Author(s): Norifumi Shioda, Yuji Owada and Kohji Fukunaga
  • Organizer: International symposium ‘’New Frontier of Molecular Neuropathology 2014’’
  • Place of Presentation: 東京
• [Presentation] 神経変性疾患治療における sigma-1 受容体リガンドの臨床的意義 (2013)
  • Author(s): 福永浩司
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-21
• [Presentation] ノビレチンはパーキンソン病モデルマウスの認知障害を改善する (2013)
  • Author(s): 福永浩司、矢吹悌、大泉康
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-21
• [Presentation] 海馬歯状回におけるDHEAによるsigma-1受容体の賦活化と抗うつ作用 (2013)
  • Author(s): 森口茂樹、山本由似、佐々木譲、宮嶋晃輔、田頭秀章、福永浩司
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-21
• [Presentation] 心筋細胞におけるSigma-1 受容体を介するミトコンドリアATP 産生の制御 (2013)
  • Author(s): 田頭秀章、塩田倫史、福永浩司
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-21
• [Presentation] 認知機能改善薬 ST101 は統合失調症モデルラットの認知機能を改善する (2013)
  • Author(s): 矢吹悌、中川西修、丹野孝一、福永浩司
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-21
• [Presentation] マウス脳虚血におけるL-シトルリン経口投与による脳血管保護作用 (2013)
  • Author(s): 志賀野美幸、矢吹悌、塩田倫史、熊谷弘太、森田匡彦、福永浩司
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-21
• [Presentation] ドパミンD2受容体を介したCaMKIIdelta;3核内移行制御機構 (2013)
  • Author(s): 塩田倫史、澤井優広、福永浩司
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-21
• [Presentation] Synergic induction of cardiac hypertrophy by CaMKII and calcineurin activities (2013)
  • Author(s): Kohji Fukunaga
  • Organizer: The 2nd Taiwan-Japan Bilateral Conference on Protein phosphatases
  • Place of Presentation: 台湾・竹南
• [Presentation] Sigma-1 receptor mutation in Amyotrophic Lateral Sclerosis causes neuronal inclusion of TDP-43 (2013)
  • Author(s): Shigeki Moriguchi, Yuzuru Sasaki, Hiroyuki Sakagami and Kohji Fukunaga
  • Organizer: 43th Society for Neuroscience; Annual Meeting
  • Place of Presentation: アメリカ・サンディエゴ
• [Presentation] Stimulation of sigma-1 receptor improves depressive-like behaviors in CaMKIV null mice (2013)
  • Author(s): Shigeki Moriguchi, Yuzuru Sasaki, Hiroyuki Sakagami and Kohji Fukunaga
  • Organizer: 43th Society for Neuroscience; Annual Meeting
  • Place of Presentation: アメリカ・サンディエゴ
• [Presentation] FABP3 expression aggravates neuronal α-synuclein accumulation in Parkinson’s model mice (2013)
  • Author(s): Norifumi Shioda, Yasushi Yabuki, Yuji Owada and Kohji Fukunaga
  • Organizer: 43th Society for Neuroscience; Annual Meeting
  • Place of Presentation: アメリカ・サンディエゴ
• [Presentation] Novel CaM kinase II activator, ST101 improves the cognition in Schizophrenia model rats (2013)
  • Author(s): Yasushi Yabuki, Motohiro Morioka and Kohji Fukunaga
  • Organizer: 43th Society for Neuroscience; Annual Meeting
  • Place of Presentation: アメリカ・サンディエゴ
• [Presentation] 一過性脳虚血発作マウスにおけるグルタチオン経口投与による脳機能改善作用 (2013)
  • Author(s): 矢吹 悌、福永 浩司
  • Organizer: 第25回脳循環代謝学会
  • Place of Presentation: 札幌
• [Presentation] Neurochemical methods for evaluating the cognition-enhancing drugs using schizophrenia model rats (2013)
  • Author(s): Kohji Fukunaga and Yasushi Yabuki
  • Organizer: The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
  • Place of Presentation: 横浜
• [Presentation] 循環器疾患に対するフルボキサミンの有用性 (2013)
  • Author(s): 福永浩司
  • Organizer: 第43回日本神経精神薬理学会
  • Place of Presentation: 沖縄
• [Presentation] Sigma-1受容体活性化によるCaMKIV欠損マウスにおけるうつ様症状の改善効果 (2013)
  • Author(s): 森口茂樹、佐々木譲、阪上洋行、福永浩司
  • Organizer: 第43回日本神経精神薬理学会
  • Place of Presentation: 沖縄
• [Presentation] Rivastigmineによる嗅球摘出（OBX）マウスの海馬歯状回における神経新生および抗うつ様作用の改善効果 (2013)
  • Author(s): Islam Md. Rashedul、森口茂樹、田頭秀章、福永浩司
  • Organizer: 第43回日本神経精神薬理学会
  • Place of Presentation: 沖縄
• [Presentation] Sigma-1受容体の賦活化によるCaMKIV欠損マウスにおけるうつ様行動の改善効果 (2013)
  • Author(s): 森口茂樹、佐々木譲、阪上洋行、福永浩司
  • Organizer: 第15回応用薬理シンポジウム
  • Place of Presentation: 品川
• [Presentation] パーキンソン病モデル動物における nobiletin による学習・認知改善作用のメカニズム (2013)
  • Author(s): 矢吹 悌、大泉 康、福永 浩司
  • Organizer: 第15回応用薬理シンポジウム
  • Place of Presentation: 品川
• [Presentation] 脂肪酸結合タンパク質FABP3は黒質ドパミン神経細胞におけるαシヌクレイン凝集体形成を促進する (2013)
  • Author(s): 塩田倫史、福永浩司
  • Organizer: 第40回日本脳科学会
  • Place of Presentation: 浜松
• [Presentation] ST101, a novel cognitive enhancer stimulates CaMKII and PKC activities in the cognition-related brain regions in schizophrenia model rats (2013)
  • Author(s): Yasushi Yabuki, Osamu Nakagawasai and Kohji Fukunaga
  • Organizer: The 3rd congress of asian college of neuropsychopharmacology (AsCNP)
  • Place of Presentation: 中国・北京
• [Presentation] 細胞内小器官おけるドパミンD2受容体の機能解析 (2013)
  • Author(s): 塩田倫史、笹原正清、森寿、福永浩司
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] ドパミン神経細胞におけるCaMKIIδ3核内移行制御機構の解析 (2013)
  • Author(s): 澤井優広、塩田倫史、福永浩司
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] ドパミン神経細胞における脂肪酸結合蛋白質によるαシヌクレイン凝集体形成の分子機構 (2013)
  • Author(s): 小野里美咲、塩田倫史、矢吹悌、大和田祐二、福永浩司
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] A mutation of sigma-1 receptor associated with ALS causes neuronal mitochondrial dysfunction (2013)
  • Author(s): Kohji Fukunaga
  • Organizer: The 11th Korea-Japan Joint Symposium of Brain Sciences and Cardiac and Smooth Muscle Sciences
  • Place of Presentation: 浜松
  • Invited
• [Presentation] 筋萎縮性側索硬化症ALSにおけるミトコンドリア障害と創薬ターゲット (2013)
  • Author(s): 福永浩司
  • Organizer: 生体機能と創薬シンポジウム2013
  • Place of Presentation: 福岡
• [Presentation] Impact of sigma-1 receptor in cardiovascular and neurodegenerative diseases (2013)
  • Author(s): Kohji Fukunaga
  • Organizer: The 12th Meeting of the Asia Pacific Federation of Pharmacologists (MAPFP)
  • Place of Presentation: 中国・上海
  • Invited
• [Presentation] L-citrulline投与によるマウス両総頸動脈閉塞モデルにおける eNOS 保護作用と記憶改善作用 (2013)
  • Author(s): 矢吹悌、塩田倫史、志賀野美幸、福永浩司
  • Organizer: 第13回日本NO学会学術集会
  • Place of Presentation: 沖縄
• [Presentation] Aberrant behavioral sensitization by methamphetamine in junctophilin deficient mice (2013)
  • Author(s): Shigeki Moriguchi, Miyuki Nisi, Hiroshi Takeshima and Kohji Fukunaga
  • Organizer: 第56回日本神経化学会大会 Neuro2013
  • Place of Presentation: 京都
• [Presentation] Dopamine-induced endocytosis activates the intracellular D2L receptor at golgi apparatus (2013)
  • Author(s): Norufumi Shioda, Masakiyo Sasahara, Hisashi Mori and Kohji Fukunaga
  • Organizer: 第56回日本神経化学会大会 Neuro2013
  • Place of Presentation: 京都
• [Presentation] FABP3 aggravates a-synuclein accumulation in the dopaminergic neurons (2013)
  • Author(s): Yasushi Yabuki, Norifumi Shioda, Yuka Kobayashi, Yuji Owada and Kohji Fukunaga
  • Organizer: 第56回日本神経化学会大会 Neuro2013
  • Place of Presentation: 京都
• [Presentation] The mechanisms of nuclear translocation of CaMKIIdelta3 in dopaminergic neurons (2013)
  • Author(s): Masahiro Sawai, Norifumi Shioda and Kohji Fukunaga
  • Organizer: 第56回日本神経化学会大会 Neuro2013
  • Place of Presentation: 京都
• [Presentation] Impaired cognitive function and anxiety-like behaviors in FABP3 null mice (2013)
  • Author(s): Yui Yamamoto, Kohji Fukunaga and Yuji Owada
  • Organizer: 第56回日本神経化学会大会 Neuro2013
  • Place of Presentation: 京都
• [Presentation] 統合失調症モデルラットにおける認知機能障害メカニズムの解明と新規認知機能改善薬の探索 (2013)
  • Author(s): 矢吹悌、中川西修、福永浩司
  • Organizer: 第15回ブレインサイエンス研究会
  • Place of Presentation: 福岡
• [Presentation] 柑橘系果皮由来ノビレチンのドパミン神経機能改善作用 (2013)
  • Author(s): 矢吹悌、大泉康、福永浩司
  • Organizer: 第4回公開シンポジウム 天然物ケミカルバイオロジー～分子標的と活性制御～
  • Place of Presentation: つくば
• [Presentation] Development of potent T-VGCC activator SAK3 as Alzheimer therapeutics (2013)
  • Author(s): Kohji Fukunaga, Hideaki Tagashira and Akikazu Kakei
  • Organizer: The 11th International Conference on Alzheimer’s and Parkinson’s diseases
  • Place of Presentation: イタリア・フローレンス
• [Presentation] Yasushi Yabuki, Osamu Nakagawasai and Kohji Fukunaga (2013)
  • Author(s): Yasushi Yabuki, Osamu Nakagawasai and Kohji Fukunaga
  • Organizer: The 24th Biennial Meeting of the International Society for Neurochemistry and the American Society for Neurochemistry
  • Place of Presentation: メキシコ・カンクン
• [Presentation] 新規アルツハイマー治療候補薬 ST101 による認知機能改善のメカニズム (2012)
  • Author(s): 福永浩司、山本由似
  • Organizer: 第42回日本神経精神薬理学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-10-18
• [Presentation] 脂肪酸結合蛋白質FABP 欠損マウスにおける不安様行動とシグナル伝達異常 (2012)
  • Author(s): 山本由似、塩田倫史、大和田裕二、福永浩司
  • Organizer: 第42回日本神経精神薬理学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-10-18
• [Presentation] T型カルシウムチャネル賦活化と認知機能調節 (2012)
  • Author(s): 森口茂樹、塩田倫史、田頭秀章、福永浩司
  • Organizer: 第42回日本神経精神薬理学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-10-18
• [Presentation] 新生仔期腹側海馬損傷ラットの統合失調症様認知機能障害モデル動物としての有用性 (2012)
  • Author(s): 矢吹悌、森口茂樹、塩田倫史、中川西修、小野木弘志、丹野孝一、只野武、福永浩司
  • Organizer: 第42回日本神経精神薬理学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-10-18
• [Presentation] Sigma-1 受容体の構造と心臓機能 (2012)
  • Author(s): 福永浩司、田頭秀章、塩田倫史
  • Organizer: 生体機能と創薬シンポジウム 2012
  • Place of Presentation: 神戸
  • Year and Date: 2012-08-30
• [Presentation] The mitochondrial Ca2+ transport and ATP production though sigma-1 receptor in heart. (2012)
  • Author(s): Fukunaga K, Tagashira H
  • Organizer: Basic Cardiovascular Sciences 2012 Scientific Sessions
  • Place of Presentation: New Orleans, Louisiana, USA
  • Year and Date: 2012-07-23
• [Presentation] Novel Alzheimer’s therapeutics, ST101 enhances acetylcholine release through T-type voltage-gated calcium channel. (2012)
  • Author(s): Fukunaga K, Yamamoto Y, Moriguchi S
  • Organizer: Alzheimer’s Association of International Conference
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2012-07-14
• [Presentation] ADHD モデル動物における認知機能障害のメカニズム
  • Author(s): 矢吹悌、塩田倫史、前田智美、平出幸子、富樫廣子、福永浩司
  • Organizer: 第23回神経行動薬理若手研究者の集い
  • Place of Presentation: 仙台
• [Presentation] CaMKIV欠損マウスのうつ様行動と海馬神経新生異常との関連性
  • Author(s): 佐々木譲、森口茂樹、阪上洋行、福永浩司
  • Organizer: 第23回神経行動薬理若手研究者の集い
  • Place of Presentation: 仙台
• [Presentation] アルツハイマー病におけるNa+/Ca2+交換体の役割
  • Author(s): 森口茂樹
  • Organizer: 第4回福岡薬理・生理系研究会
  • Place of Presentation: 福岡
• [Presentation] 神経変性疾患におけるニコチン受容体を介する神経保護
  • Author(s): 福永浩司
  • Organizer: 喫煙科学研究財団シンポジウム2013「脳内ニコチン受容体と神経保護・再生」
  • Place of Presentation: 東京
• [Presentation] CaM kinase II研究から精神疾患を考える
  • Author(s): 福永浩司
  • Organizer: 第26回鹿児島ブレインサイエンスカンファレンス
  • Place of Presentation: 鹿児島
  • Invited
• [Presentation] 海馬歯状回におけるDHEAによるsigma-1受容体の賦活化による神経新生促進作用と抗うつ効果
  • Author(s): 森口茂樹、佐々木譲、田頭秀章、福永浩司
  • Organizer: 第64回日本薬理学会北部会
  • Place of Presentation: 旭川
• [Presentation] CaMKIV欠損マウスのうつ様行動とsigma-1受容体アゴニストの改善作用
  • Author(s): 佐々木譲、森口茂樹、阪上洋行、福永浩司
  • Organizer: 第64回日本薬理学会北部会
  • Place of Presentation: 旭川
• [Presentation] 脂肪酸結合蛋白質は黒質ドパミン神経細胞におけるαシヌクレイン凝集体形成を促進する
  • Author(s): 塩田倫史、矢吹悌、小野里美咲、福永浩司
  • Organizer: 日本生化学会東北支部 第79回例会・シンポジウム
  • Place of Presentation: 仙台
• [Presentation] セリン・スレオニンホスファターゼPP2Cεのゴルジ体局在タンパク質GCP60との機能連関
  • Author(s): 篠田康晴、福永浩司、藤田宏介、永浦裕子、田村眞理、小林孝安
  • Organizer: 日本生化学会東北支部 第79回例会・シンポジウム
  • Place of Presentation: 仙台