治療計画計算解剖モデルに基づく粒子線治療支援システムの開発

• Project Area: Computational anatomy for computer-aided diagnosis and therapy :Frontiers of medical image sciences
• Project/Area Number: 24103707
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Kyushu University
• Principal Investigator: 有村 秀孝 九州大学, 医学(系)研究科(研究院), 准教授 (20287353)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000); Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: image analysis / computational anatomy / particle therapy / treatment planning / machine learning / 粒子線治療 / 患者セットアップエラー / 電子密度ビーム方向像 / パワースペクトル

Research Abstract

The principal investigator developed four image analysis approaches including computational anatomy models for treatment planning in computer-assisted particle therapy. The inadequate outcome of particle therapy could be caused by several uncertainties such as inter-observer variation of target (i.e., cancerous lesion) delineations, inter-fractional position and shape variations of the targets, and patient setup errors, and so on. Furthermore, sharp dose distributions could greatly deteriorate due to the setup errors and/or organ motions depending on particle beam direction. To mitigate these issues, we have developed mainly four image analysis approaches, i.e., (1) an automated extraction of tumors using a machine learning classifier with knowledge of radiation oncologists, (2) a framework for construction of statistical clinical target volume models with inter-observer delineation and inter-fractional variations in radiation treatment planning, (3) a quantitative evaluation approach of the robustness of beam directions against patient setup errors in the particle therapy, and (4) a similar case based treatment planning system. These technologies can be organized for construction of computer-assisted particle therapy systems, which can support radiation therapy practitioners.

Current Status of Research Progress

Reason

25年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

25年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Quantitative evaluation of the robustness of beam directions based on power spectral analysis of water-equivalent path length image in charged particle therapy (2014)
  • Author(s): Hidetaka Arimura, Genyu Kakiuchi, Yoshiyuki Shioyama, Shin-ichi Minohara, Takahiro Nakamoto, Katsumasa Nakamura, Hiroshi Honda, Mutsumi Tashiro, Tatsuaki Kanai, Hideki Hirata
  • Journal Title: nternational Journal of Intelligent Computing in Medical Sciences and Image Processing Volume: in press
  • Peer Reviewed
• [Journal Article] Similar-case-based optimization of beam arrangements in stereotactic body radiotherapy for assisting treatment planners (2013)
  • Author(s): Magome T, et al.
  • Journal Title: BioMed Research International Volume: 2013 Pages: 1-10
  • DOI: 10.1155/2013/309534
  • Peer Reviewed
• [Journal Article] 放射線治療におけるelectronic portal imaging deviceを用いた4次元線量分布推定法の開発 (2013)
  • Author(s): 溝口明日実, 有村秀孝, 塩山善之, 廣瀬貴章, 穴井重男, 本田浩, 梅津芳幸, 平田秀紀, 大喜 雅文, 中村和正, 豊福 不可依
  • Journal Title: 電子情報通信学会和文論文誌D Volume: Vol.J96-D Pages: 813-823
  • Peer Reviewed
• [Journal Article] Computer-aided beam arrangement based on similar cases in radiation treatment planning databases for stereotactic lung radiation therapy. (2013)
  • Author(s): Magome T, Arimura H, et al.
  • Journal Title: Journal of Radiation Research Volume: (In press) Issue: 3 Pages: 569-577
  • DOI: 10.1093/jrr/rrs123
  • Peer Reviewed
• [Journal Article] 放射線治療におけるelectronic portal imaging deviceを用いた4次元線量分布推定法の開発 (2013)
  • Author(s): 溝口明日実, 有村秀孝, 他
  • Journal Title: 電子情報通信学会和文論文誌 Volume: Vol.J96-D,No.4 Pages: 813-823
  • Peer Reviewed
• [Journal Article] Computerized estimation of patient setup errors in portal images based on localized pelvic templates for prostate cancer radiotherapy (2012)
  • Author(s): Arimura H, Itano W, et al.
  • Journal Title: Journal of Radiation Research Volume: 53(6) Issue: 6 Pages: 961-972
  • DOI: 10.1093/jrr/rrs043
  • Peer Reviewed
• [Journal Article] Automated estimation of number of implanted iodine-125 seeds for prostate brachytherapy based on two-view analysis of pelvicradiographs. (2012)
  • Author(s): Kawata H, Arimura H, Suefuji H, Ohkura S, Saida Y, Nashiki K, Hayashida K, Kawahara T, Ohishi A,Hayabuchi N.
  • Journal Title: J Radiat Res Volume: 53(5) Issue: 5 Pages: 742-752
  • DOI: 10.1093/jrr/rrs018
  • Peer Reviewed
• [Presentation] Computer-Assisted Particle Therapy System Based on Computational Anatomy Models for Treatment Planning (2014)
  • Author(s): Hidetaka Arimura
  • Organizer: The Fifth International Symposium on the Project Computational Anatomy
  • Place of Presentation: 東京大学，東京
• [Presentation] Local image descriptor-based searching framework of usable similar cases in a radiation treatment planning database for stereotactic body (2014)
  • Author(s): Ayumi Nonaka, Hidetaka Arimura, Katsumasa Nakamura, Yoshiyuki Shioyama, Mazen Soufi, Taiki Magome, Hiroshi Honda, Hideki Hirata
  • Organizer: SPIE Medical Imaging 2014
  • Place of Presentation: San Diego, USA
• [Presentation] Automated Method for Extraction of Lung Tumors Using a Machine Learning Classifier with Knowledge from Radiation Oncologists on Data Sets of Planning CT and FDG-PET/CT images (2013)
  • Author(s): Arimura H
  • Organizer: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: 大阪
  • Year and Date: 2013-07-05
  • Invited
• [Presentation] Optimization of robust beam direction against patient setup errors in charged particle therapy (2013)
  • Author(s): Hidetaka Arimura
  • Organizer: Medical Physics International-School & the 11Th Medical Physics Seminar
  • Place of Presentation: 大阪大学，吹田市
  • Invited
• [Presentation] Computerized Production of Statistical Clinical Target Volume Models in Prostate Cancer Radiation Treatment Planning (2013)
  • Author(s): Norimasa Matsushita, Hidetaka Arimura, Katsumasa Nakamura, Kagami Yoshikazu, Yoshiyuki Shioyama, Yasuhiko Nakamura, Hiroshi Honda, Hideki Hirata
  • Organizer: AAPM 55th Annual Meeting 2013
  • Place of Presentation: Indianapolis, USA
• [Presentation] Computer-aided Delineation of Tumour Regions for Lung Cancer in Multimodality Images by Localized Level Set Method (2013)
  • Author(s): Ze Jin, Hidetaka Arimura, Yoshiyuki Shioyama, Jumpei Kuwazuru, Taiki Magome, Katsumasa Nakamura, Hidetake Yabuuchi, Hiroshi Honda, Fukai Toyofuku, Hideki Hirata, Masayuki Sasaki
  • Organizer: International Conference on the Use of Computers in Radiation Therapy ICCR2013
  • Place of Presentation: Melbourne, Australia
• [Presentation] Computerized determination of robust beam directions against patient setup errors in hadron particle therapy (2012)
  • Author(s): Arimura H, Kakiuchi G, et al.
  • Organizer: Workshop of Image-Guidance and Multimodal Dose Planning in Radiation Therapy, MICCAI 2012
  • Place of Presentation: ニース
  • Year and Date: 2012-10-05
• [Presentation] Computer-assisted determination of the usable beam arrangement from similar treatment plans in stereotactic body radiotherapy (2012)
  • Author(s): Magome T, Arimura H, et al.
  • Organizer: Workshop of Image-Guidance and Multimodal Dose Planning in Radiation Therapy, MICCAI 2012
  • Place of Presentation: ニース
  • Year and Date: 2012-10-05
• [Book] Computational Intelligence in Biomedical Imaging (2013)
  • Author(s): Hidetaka Arimura, Taiki Magome, Genyu Kakiuchi, Jyunpei Kuwazuru, Asumi Mizoguchi
  • Total Pages: 21
  • Publisher: Springer Science+Business Media
• [Book] Springer (2013)
  • Author(s): Arimura H, Magome T, et al.
  • Total Pages: 30
  • Publisher: Computational Intelligent Image Analysis for Assisting Radiation Oncologists’ Decision Making in Radiation Treatment Planning
• [Remarks] Arimura Laboratory
  • URL: http://web.shs.kyushu-u.ac.jp/~arimura/
• [Remarks] 有村秀孝研究室
  • URL: http://web.shs.kyushu-u.ac.jp/~arimura
• [Patent(Industrial Property Rights)] 放射線ビームアングル決定システム、放射線ビームアングル決定方法及び放射線ビームアングル決定用コンピュータプログラム (2012)
  • Inventor(s): 有村秀孝，馬込大貴，塩山善之
  • Industrial Property Rights Holder: 有村秀孝，馬込大貴，塩山善之
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-04-10