海馬歯状回の恒常性維持機能の理解とその神経細胞内メカニズムの解明

• Project Area: Brain Environment
• Project/Area Number: 24111546
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Fujita Health University
• Principal Investigator: 宮川 剛 藤田保健衛生大学, 総合医科学研究所, 教授 (10301780)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000); Fiscal Year 2013: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2012: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
• Keywords: 脳・神経 / 神経科学 / 脳神経疾患

Research Abstract

海馬歯状回の神経細胞の成熟度は各種の実験操作により双方向性に変化する。この細胞レベルでの成熟度変化は、ストレス下での脳のシステムの恒常性維持に重要な役割を果たしていると考えられるが、その機能的役割については未だ不明な点が多い。25年度は、非成熟歯状回を持つ遺伝子改変マウスを対象にデキサメタゾン（DEX）抑制テストを行い、海馬によるHPA系反応の抑制的な調節機能を評価した。これまでに調べた2系統のマウスでは、DEXを投与しても血中コルチコステロン濃度が高いままで低下しないことから、HPA系反応の抑制機能に障害があることが示唆された。この結果は、非成熟歯状回が恒常性維持機能の破綻に関連している可能性があることを示している。しかし、非成熟歯状回を引き起こす抗うつ薬の慢性投与が前頭皮質の特定の抑制性神経細胞も成熟前の状態に戻す作用があることが最近明らかとなり、歯状回以外の脳細胞の成熟度変化がHPA系反応の異常を引き起こしている可能性についても考慮する必要が出てきた。そこで、光遺伝学的手法を用いて歯状回神経細胞特異的に成熟度を操作する方法を確立するため、チャネルロドプシン2（ChR 2）を発現するfloxマウスを歯状回特異的Cre 発現マウスと交配し、歯状回神経細胞にのみChR 2を発現するマウスを作製した。このマウスの歯状回に複数回の光刺激を与えたところ、歯状回神経細胞が脱成熟したことを示唆する遺伝子発現変化が確認された。このように、歯状回神経細胞の成熟度と脳の恒常性維持機能との直接的な関係を明らかにするための解析系を確立した。また、本領域の他の班員との共同研究（10件）も実施し、複数の神経疾患モデルマウスの歯状回で成熟度変化を確認した。これは、歯状回の成熟度異常を伴う脳内環境の恒常性の維持機能の破綻が、様々な精神・神経疾患に関与している可能性があることを示唆している。

Current Status of Research Progress

Reason

25年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

25年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders (2014)
  • Author(s): Kobayashi M, Nakatani T, Koda T, Matsumoto K,I, Ozaki R, Mochida N, Takao K, Miyakawa T, Matsuoka I
  • Journal Title: Molecular brain Volume: 7(1) Issue: 1 Pages: 12-12
  • DOI: 10.1186/1756-6606-7-12
  • Peer Reviewed / Open Access
• [Journal Article] Increased Behavioral and Neuronal Responses to a Hallucinogenic Drug in PACAP Heterozygous Mutant Mice. (2014)
  • Author(s): Keisuke Hazama
  • Journal Title: PLoS ONE Volume: 20 Issue: 2 Pages: 89153-89153
  • DOI: 10.1371/journal.pone.0089153
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive behavioral analysis of cluster of differentiation 47 knockout mice (2014)
  • Author(s): Koshimizu H, Takao K, Matozaki T, Ohnishi H, Miyakawa T
  • Journal Title: PLoSOne Volume: 9 Issue: 2 Pages: e89584-e89584
  • DOI: 10.1371/journal.pone.0089584
  • Peer Reviewed / Open Access
• [Journal Article] Contextual and cued fear conditioning test using a video analyzing system in mice. (2014)
  • Author(s): Shoji H, Takao K, Hattori S, Miyakawa T.
  • Journal Title: J Vis Exp Volume: 85 Issue: 85 Pages: 85-85
  • DOI: 10.3791/50871
  • Peer Reviewed / Open Access
• [Journal Article] Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia (2014)
  • Author(s): Takanori Onouchi, Katsunori Kobayashi, Kazuyoshi Sakai, Atsushi Shimomura, Ron Smits, Chiho Sumi-Ichinose, Masafumi Kurosumi Keizo Takao, Ryuji Nomura, Akiko Iizuka-Kogo, Hidenori Suzuki,Kazunao Kondo, Tetsu Akiyama Tsuyoshi Miyakawa Riccardo Fodde and Takao Senda, Riccardo Fodde, Takao
  • Journal Title: Molecular Brain Volume: 7 Issue: 1 Pages: 21-21
  • DOI: 10.1186/1756-6606-7-21
  • Peer Reviewed / Open Access
• [Journal Article] Post-natal therapeutic intervention for lissencephaly using a blood-brain-barrier permeable calpain inhibitor (2013)
  • Author(s): Shiori Toba, Yasuhisa Tamura, Kanako Kumamoto, Masami Yamada, Keizo Takao, Satoko Hattori, Tsuyoshi Miyakawa, Yosky Kataoka, Mitsuyoshi Azuma, Kiyoshi Hayasaka, Masano Amamoto, Keiko Tominaga, Anthony Wynshaw-Boris, Mitsuhiro Kato and Shinji Hirotsune
  • Journal Title: SNJ1945 Scientific Reports Volume: 3 Issue: 1 Pages: 1224-1224
  • DOI: 10.1038/srep01224
  • Peer Reviewed
• [Journal Article] Fluoxetine-induced cortical adult neurogenesis. (2013)
  • Author(s): Ohira K, Takeuchi R, Shoji H, Miyakawa T.
  • Journal Title: Neuropsychopharmacology Volume: 38（6） Issue: 6 Pages: 909-20
  • DOI: 10.1038/npp.2013.2
  • Peer Reviewed
• [Journal Article] Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia. (2013)
  • Author(s): Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T.
  • Journal Title: Neuropsychopharmacology Volume: 38(8) Issue: 8 Pages: 1409-25
  • DOI: 10.1038/npp.2013.38
  • Peer Reviewed / Open Access
• [Journal Article] ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response. (2013)
  • Author(s): Umemori J, Takao K, Koshimizu H, Hattori S, Furuse T, Wakana S, Miyakawa T.
  • Journal Title: BMC Res Notes Volume: 6(1) Issue: 1 Pages: 203-203
  • DOI: 10.1186/1756-0500-6-203
  • Peer Reviewed / Open Access
• [Journal Article] Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice (2013)
  • Author(s): Ageta-Ishihara N, Yamakado H, Morita T, Hattori S, Takao K, Miyakawa T, Takahashi R, Kinoshita M
  • Journal Title: Mol Brain Volume: 6 Issue: 1 Pages: 35-35
  • DOI: 10.1186/1756-6606-6-35
  • Peer Reviewed / Open Access
• [Journal Article] Orexin receptor-1 in the locus coeruleus plays an important role in cue- dependent fear memory consolidation. (2013)
  • Author(s): Soya S, Shoji H, Hasegawa E, Hondo M, Miyakawa T, Yanagisawa M, Mieda M, Sakurai T.
  • Journal Title: J Neurosci. Volume: 33 Issue: 36 Pages: 14549-57
  • DOI: 10.1523/jneurosci.1130-13.2013
  • Peer Reviewed / Open Access
• [Journal Article] Point Mutation in Syntaxin-1A Causes Abnormal Vesicle Recycling, Behaviors, and Short-term Plasticity. (2013)
  • Author(s): Yumi Watanabe, Norikazu Kata yama, Kosei Takeuchi, et. al.
  • Journal Title: J. Biol. Chem. Volume: 288 Issue: 48 Pages: 34906-34919
  • DOI: 10.1074/jbc.m113.504050
  • Peer Reviewed / Open Access
• [Journal Article] Chronic fluoxetine treatment reduces parvalbumin expression and perineuronal nets in gamma-aminobutyric acidergic interneurons of the frontal cortex in adult mice. (2013)
  • Author(s): Ohira K, Takeuchi R, Iwanaga T, Miyakawa T
  • Journal Title: Mol Brain Volume: 6 Issue: 1 Pages: 43-43
  • DOI: 10.1186/1756-6606-6-43
  • Peer Reviewed / Open Access
• [Journal Article] In vivo evaluation of cellular activity in αCaMKII heterozygous knockout mice using manganese-enhanced magnetic resonance imaging (MEMRI) (2013)
  • Author(s): Hattori S, Hagihara H, Ohira K, Aoki I, Saga T, Suhara T, Higuchi M, Miyakawa T.
  • Journal Title: Frontiers in Integrative Neuroscience Volume: 40 Pages: 125-132
  • DOI: 10.3389/fnint.2013.00076
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders. (2013)
  • Author(s): Paemka L, Mahajan VB, Skeie JM, Sowers LP, Ehaideb SN, Gonzalez-Alegre P, Sasaoka T, Tao H, Miyagi A, Ueno N, Takao K, Miyakawa T, Wu S, Darbro BW, Ferguson PJ, Pieper AA, Britt JK, Wemmie JA, Rudd DS, Wassink T, El-Shanti H, Mefford HC, Carvill GL, Manak JR, Bassuk AG
  • Journal Title: PLoS One Volume: 8(12) Issue: 12 Pages: e80737-e80737
  • DOI: 10.1371/journal.pone.0080737
  • Peer Reviewed / Open Access
• [Journal Article] Mice lacking collapsin response mediator protein 1 manifest hyperactivity, impaired leaming and memory, and impaired prepulse inhibition (2013)
  • Author(s): Yamashita N, Takahashi A, Takao K, Yamamoto T, Kolattukudy P, Miyakawa T, Goshima Y
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 7巻 Pages: 216-226
  • DOI: 10.3389/fnbeh.2013.00216
  • Peer Reviewed / Open Access
• [Journal Article] M4 muscarinic receptor knockout mice display abnormal social behavior and decreased prepulse inhibition (2012)
  • Author(s): Koshimizu H, Leiter LM, Miyakawa T
  • Journal Title: Mol Brain Volume: Volume 5, 10 Issue: 1 Pages: 10-10
  • DOI: 10.1186/1756-6606-5-10
  • Peer Reviewed
• [Journal Article] DRPLA transgenic mouse substrains carrying single copy of full-length mutant human DRPLA gene with variable sizes of expanded CAG repeats exhibit CAG repeat length- and age-dependent changes in behavioral abnormalities and gene expression profiles. (2012)
  • Author(s): Suzuki K, Zhou J, Sato T, Takao K, Miyakawa T, Oyake M, Yamada M, Takahashi H, Takahashi Y, Goto J, Tsuji S.
  • Journal Title: Neurobiol Dis Volume: 46(2) Issue: 2 Pages: 336-50
  • DOI: 10.1016/j.nbd.2012.01.014
  • Peer Reviewed
• [Journal Article] α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion. (2012)
  • Author(s): Yamakado H
  • Journal Title: Neurosci Res Volume: 73(2) Issue: 2 Pages: 173-7
  • DOI: 10.1016/j.neures.2012.03.010
  • Peer Reviewed
• [Journal Article] Detection of an immature dentate gyrus feature in human schizophrenia/bipolar patients. (2012)
  • Author(s): Walton NM, Zhou Y, Kogan JH, Shin R, Webster M, Gross AK, Heusner CL, Chen Q, Miyake S, Tajinda K, Tamura K, Miyakawa T, Matsumoto M
  • Journal Title: Transl Psychiatry Volume: 2 Issue: 7 Pages: e135-e135
  • DOI: 10.1038/tp.2012.56
  • Peer Reviewed
• [Journal Article] Comprehensive behavioral analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) knockout mice. (2012)
  • Author(s): Hattori S, Takao K, Tanda K, Toyama K, Shintani N, Baba A, Hashimoto H, Miyakawa T.
  • Journal Title: Front Behav Neurosci Volume: 6 Pages: 58-58
  • DOI: 10.3389/fnbeh.2012.00058
  • Peer Reviewed
• [Journal Article] Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice. (2012)
  • Author(s): Nagura H, Ishikawa Y, Kobayashi K, Takao K, Tanaka T, Nishikawa K, Tamura H, Shiosaka S, Suzuki H, Miyakawa T, Fujiyoshi Y, Doi T.
  • Journal Title: Mol Brain Volume: 5 Issue: 1 Pages: 43-43
  • DOI: 10.1186/1756-6606-5-43
  • NAID: 120005323021
  • Peer Reviewed
• [Journal Article] Behavioral abnormalities observed in Zfhx2-deficient mice (2012)
  • Author(s): Yuriko Komine, Keizo Takao, Tsuyoshi Miyakawa, Tetsuo Yamamori
  • Journal Title: PLoS One Volume: 7 Issue: 12 Pages: 12-12
  • DOI: 10.1371/journal.pone.0053114
  • Peer Reviewed
• [Journal Article] Increased astrocytic ATP release results in enhanced excitability of the hippocampus. (2012)
  • Author(s): Lee HU, Yamazaki Y, Tanaka KF, Furuya K, Sokabe M, Hida H, Takao K, Miyakawa T, Fujii S, Ikenaka K.
  • Journal Title: These^† authors contributed equally to this work Volume: 61 Issue: 2 Pages: 210-224
  • DOI: 10.1002/glia.22427
  • Peer Reviewed
• [Presentation] Bidirectional change of maturation status of cells in the brain: Relevance to neuropsychiatric disorders (2014)
  • Author(s): Tsuyoshi Miyakawa
  • Organizer: Frontier International Symposium for Neuron and Disease
  • Place of Presentation: Xian, Chaina
  • Invited
• [Presentation] Bidirectional change of maturation status of dentate gyrus neurons: Relevance to neuropsychiatric disorders. (2013)
  • Author(s): Tsuyoshi Miyakawa
  • Organizer: 15th Annual Genes, Brain and Behavior Meeting of the International Behavioural and Neural Genetics Society
  • Place of Presentation: Leuven, Belgium
• [Presentation] マンガン造影MRI法を用いたalpha-CaMKIIへテロノックアウトマウスの脳機能解析 (2013)
  • Author(s): 服部聡子、米山操、齊藤茂芳、青木伊知男、佐賀恒夫、須原哲也、樋口真人、宮川剛
  • Organizer: Neuro2013
  • Place of Presentation: 国立京都国際会館
• [Presentation] 抗うつ薬によって引き起こされる成体マウス前頭皮質内側部の脱成熟 (2013)
  • Author(s): 大平耕司、竹内理香、宮川剛
  • Organizer: Neuro2013
  • Place of Presentation: 国立京都国際会館
• [Presentation] Shunurri-2 マウスで見られる精神疾患の中間表現型としても未成熟歯状回は成育後に出現する (2013)
  • Author(s): 高雄啓三、萩原英雄、大平耕司、昌子浩孝、服部聡子、小清水久嗣、梅森十三、高木豪、石井俊輔、宮川剛
  • Organizer: Neuro2013
  • Place of Presentation: 国立京都国際会館
• [Presentation] 歯状回ニューロンの成熟異常を示すマウスの海馬におけるBDNF-MAPK シグナル経路の調整異常 (2013)
  • Author(s): 小清水久嗣、大平耕司、萩原英雄、高雄啓三、高木豪、片岡正和、石井俊輔、高橋正身、宮川剛
  • Organizer: Neuro2013
  • Place of Presentation: 国立京都国際会館
• [Presentation] 統合失調症モデルマウスの前頭前野におけるパルバルブミン陽性細胞の減少とペリニューロナルネット発現の変化 (2013)
  • Author(s): 萩原英雄、高木豪、石井俊輔、Isabella A Greaf、Gerald R Crabtree、宮川剛
  • Organizer: Neuro2013
  • Place of Presentation: 国立京都国際会館
• [Presentation] Bidirectional change of maturation statue of dentate gyrus neurons: relevance to neuropsychiatric diseases (2013)
  • Author(s): Tsuyoshi Miyakawa
  • Organizer: The 8th International Conference for Neurons and Brain Disease
  • Place of Presentation: Singapore
• [Presentation] 遺伝子・脳・行動：遺伝子改変マウスを用いた研究 (2013)
  • Author(s): 宮川剛
  • Organizer: 日本心理学会第77回大会
  • Place of Presentation: 札幌コンベンションセンター、札幌市産業振興センター
• [Presentation] Immature dentate gyrus and mild chronic inflammation: Candidate endophenotype of neuropsychiatric disorders (2013)
  • Author(s): Tsuyoshi Miyakawa
  • Organizer: 4th European Coference on Schizophrenia Research
  • Place of Presentation: Berlin, Germany
  • Invited
• [Presentation] 精神疾患の中間表現型としての未成熟脳 (2013)
  • Author(s): 宮川剛
  • Organizer: 第23回日本臨床精神神経薬理学会 第43回日本神経精神薬理学会合同年会
  • Place of Presentation: 沖縄コンベンションセンター
• [Presentation] 成体マウスの前頭皮質と海馬において、抗うつ薬の長期投与によって抑制性神経細胞のパルブアルブミンとペリニューロナルネットが減少した (2013)
  • Author(s): 大平耕司、竹内理香、岩永剛、宮川剛
  • Organizer: 第23回日本臨床精神神経薬理学会 第43回日本神経精神薬理学会合同年会
  • Place of Presentation: 沖縄コンベンションセンター
• [Presentation] マンガン造影MRI法を用いたalpha-CaMKIIへテロノックアウトマウスの脳画像解析 (2013)
  • Author(s): 服部聡子、米山操、齊藤茂芳、青木伊知男、佐賀恒夫、須原哲也、樋口真人、宮川剛
  • Organizer: 第23回日本臨床精神神経薬理学会 第43回日本神経精神薬理学会合同年会
  • Place of Presentation: 沖縄コンベンションセンター
• [Presentation] Dysregulation of BDNF-MAPK signaling pathway in the hippocampus of mice with “immature dentate gyrus. (2013)
  • Author(s): Hisatsugu Koshimizu, Koji Ohira, Hideo Hagihara, Keizo Takao, Tsuyoshi Takagi, Masakazu Kataoka, Shunsuke Ishii, Masami Takahashi, Tsuyoshi Miyakawa
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego
• [Presentation] Decreased parvalbumin immunoreactivity and altered perineuronal net labeling in the frontal cortex of schizophrenia model mice (2013)
  • Author(s): Hideo Hagihara, Tsuyoshi Takagi, Shunsuke Ishii, Isabella A Graef, Gerald R Crabtree, and Tsuyoshi Miyakawa
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego
• [Presentation] “Immature dentate gyrus”, a candidate endophenotype for psychotic disorders, emerges after adolescence in Schnurri-2 KO mice. (2013)
  • Author(s): Keizo Takao, Hideo Hagihara, Koji Ohira, Hirotaka Shoji, Satoko Hattori, Hisatsugu Koshimizu, Juzoh Umemori, Tsuyoshi Takagi, Shunsuke Ishii, Tsuyoshi Miyakawa
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego
• [Presentation] Neuronal dematuration induced by antidepressant treatment in medial frontal cortex of adult mice. (2013)
  • Author(s): Koji Ohira, Rika Takeuchi, and Tsuyoshi Miyakawa
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego
• [Presentation] Immature dentate gyrus as a candidate endophenotype of neuropsychiatric disorders (2013)
  • Author(s): Tsuyoshi Miyakawa
  • Organizer: ACNP 52nd Annual Meeting
  • Place of Presentation: Hollywood, Florida
  • Invited
• [Presentation] Bidirectional change of maturation status of dentate gyrus neurons: Relevance to neuropsychiatric disorders. (2013)
  • Author(s): Tsuyoshi Miyakawa, Keizo Takao, Koji Ohira, Hideo Hagihara
  • Organizer: Keystone Symposia Neurogenesis
  • Place of Presentation: Santa Fe, New Maxico, USA
• [Presentation] The SNAP-25-PKC site mutation causes immaturity of the dentate granule cells in adult mice. (2012)
  • Author(s): Koji Ohira, Keiko Toyama, Hironori K. Nakamura, Hirotaka Shoji, Masakazu Kataoka, Masami Takahashi, Tsuyoshi Miyakawa
  • Organizer: 14th Annual Meeting of the International Behavioural and Neural Genetics Society
  • Place of Presentation: Colorado, USA
• [Presentation] Deficiency of Schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia (2012)
  • Author(s): Takao K, Kobayashi K, Hagihara H, Ohira K, Toyama K, Shoji H, Nakamura HK, Esaki K, Furuya S, Takagi T, Walton N, Hayashi N, Suzuki H, Matsumoto M, Ishii S, Miyakawa T
  • Organizer: 14th Annual Meeting of the International Behavioural and Neural Genetics Society
  • Place of Presentation: Colorado, USA
• [Presentation] Chronic fluoxetine treatment increases neurogenesis in the cortex of adult mice (2012)
  • Author(s): Koji Ohira, Rika Takeuch, Tsuyoshi Miyakawa.
  • Organizer: 28th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Stockholm, Sweden
• [Presentation] Deficiency of Schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia (2012)
  • Author(s): Takao K, Kobayashi K, Esaki K, Furuya S, Takagi T, Hayashi N, Walton N, Suzuki H, Matsumoto M, Ishii S, Miyakawa T
  • Organizer: 28th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Stockholm, Sweden
• [Presentation] Fluoxetine-induced cortical adult neurogenesis and its neuroprotective effects against ischemi. (2012)
  • Author(s): Koji Ohira, Rika Takeuch, Tsuyoshi Miyakawa
  • Organizer: International Conference of Neurons and Brain Diseases
  • Place of Presentation: Montreal, Canada
• [Presentation] 抗うつ薬による成熟大脳皮質の神経新生と虚血に対する神経保護作用 (2012)
  • Author(s): 大平耕司、竹内理香、宮川剛
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] 双極性気分障害モデルマウスにおける脳内遺伝子発現パターンおよび血中メタボロームパターンからの活動量の推定 (2012)
  • Author(s): 梅森十三、萩原英雄、中村寛則、堀川友慈、昌子浩孝、遠山桂子、入野康宏、吉田優、神谷之康、宮川剛
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] 前脳特異的カルシニューリンノックアウトによる海馬歯状回顆粒細胞の未成熟化 (2012)
  • Author(s): 萩原英雄、遠山桂子、Graef A Isabella、Crabtree R Gerald、宮川剛
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] 歯状回ニューロンの成熟異常を示すマウスの海馬における成熟型BDNFおよびcarboxypeptidase E の発現上昇とTrkBの異所性発現 (2012)
  • Author(s): 小清水久嗣、大平耕司、萩原英雄、高雄啓三、宮川剛
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] 慢性拘束ストレスはBALB/cマウスの海馬歯状回における未成熟神経細胞マーカーの変動を惹起する (2012)
  • Author(s): 昌子浩孝、萩原英雄、宮川剛
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Deficiency of Schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia (2012)
  • Author(s): Takao K, Kobayashi K, Hagihara H, Ohira K, Toyama K, Shoji H, Nakamura HK, Esaki K, Furuya S, Takagi T, Walton N, Yamaguchi S, Hayashi N, Suzuki H, Matsumoto M, Ishii S, Miyakawa T.
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, USA
• [Presentation] Behavioral state of model mice of bipolar disorder can be retrospectively predicted by gene expression in dentate gyrus and plasma metabolites (2012)
  • Author(s): Umemori J, Hagihara H, Nakamura HK, Horikawa T, Shoji H, Toyama K, Irino Y, Yoshida M, Kamitani Y, Miyakawa T.
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, USA
• [Presentation] Upregulation of mature form brain-derived neurotrophic factor and carboxypeptidase E, and ectopic expression of tyrosine kinase receptor B in the hippocampus of mice with maturation failure in dentate gyrus neurons (2012)
  • Author(s): Koshimizu H, Ohira K, Hagihara H, Takao K, Takagi T, Kataoka M, Ishii S, Takahashi M, Miyakawa T.
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, USA
• [Presentation] Fluoxetine-induce cortical neurogenesis and its neurorotetive effects again ischemia (2012)
  • Author(s): Ohira K, Takeuchi R, Miyakawa T.
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, USA
• [Presentation] Maturation deicits of dentate granule cells in forebrain-specific calcineurin KO mice is rescued by PDE4 inhibitor treatment (2012)
  • Author(s): Hagihara H, Toyama K, Graef IA, Crabtree GR, Miyakawa T.
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, USA
• [Presentation] Deficiency of Schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia. (2012)
  • Author(s): Tsuyoshi Miyakawa, Keizo Takao, Katsunori Kobayashi, Hideo Hagihara, Koji Ohira, Hirotaka Shoji, Satoko Hattori, Hisatsugu Koshimizu, Juzoh Umemori, Shun Yamaguchi, Tsuyoshi Takagi, Noah Walton, Hidenori Suzuki, Mitsuyuki Matsumoto, Shunsuke, Ishii
  • Organizer: ACNP 51st Annual Meeting
  • Place of Presentation: Hollywood, Florida USA
• [Presentation] Deficiency of Schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia. (2012)
  • Author(s): Tsuyoshi Miyakawa, Keizo Takao, Hideo Hagihara, Koji Ohira, Hirotaka Shoji, Satoko Hattori, Hisatsugu Koshimizu, Juzoh Umemori, Tsuyoshi Takagi, Shunsuke Ishii.
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場、マリンメッセ福岡
• [Remarks] 藤田保健衛生大学総合医科学研究所システム医科学研究部門ホームページ
  • URL: http://www.fujita-hu.ac.jp/ICMS/research_category/res06/index.html
• [Remarks] 藤田保健衛生大学総合医科学研究所システム医科学研究部門ホームページ
  • URL: http://www.fujita-hu.ac.jp/ICMS/research_category/res06/index.html