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タンパク質天然変性領域の分類と機能予測

Publicly Offered Research

Project AreaTarget recognition and expression mechanism of intrinsically disordered protein
Project/Area Number 24113704
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

PATIL Ashwini (Patil Ashwini)  東京大学, 医科学研究所, 助教 (30572193)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords生体生命情報学 / プロテオーム / 生物物理 / 蛋白質 / 国際情報交換
Research Abstract

In this study, a novel classification scheme was defined for intrinsically disordered regions using their chemical composition. It was shown that the functions of proteins containing intrinsically disordered regions are related, at least in part, with the chemical nature of the disordered regions.
Since the chemical composition of disordered regions by itself was found to be insufficient as a predictor of protein function, several possible sequence features of disordered regions were identified. These sequence features included information about the amino acid composition, chemical composition, amino acid pair frequencies and features associated with predicted secondary structure of the intrinsically disordered region. These sequence features were extracted from disordered regions within proteins and were rigorously tested for their ability to predict protein function.
The study showed that sequence features from intrinsically disordered regions can be used to predict protein function with a combination of features performing better than single ones. Additionally, different combinations of features perform best for the prediction of different functional terms. Further investigation needs to be performed to identify the best combinations of sequence features from disordered regions that are good predictors of protein function. The study also highlighted the inadequate nature of the current functional annotation schemes, specifically Gene Ontology terms, and their inability to capture the various functions of intrinsically disordered regions.

Current Status of Research Progress
Reason

25年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

25年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2013 Annual Research Report
  • 2012 Annual Research Report

Research Products

(5 results)

All 2014 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (2 results) (of which Invited: 1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Evaluation of Sequence Features from Intrinsically Disordered Regions for the Estimation of Protein Function2014

    • Author(s)
      Alok Sharma, Abdollah Dehzangi, James Lyons, Seiya Imoto, Satoru Miyano, Kenta Nakai, Ashwini Patil
    • Journal Title

      PLOS ONE

      Volume: 9(2)

    • DOI

      10.1371/journal.pone.0089890

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemical composition is maintained in poorly conserved intrinsically disordered regions and suggests a means for their classification2012

    • Author(s)
      Harry Amri Moesa, Shunichi Wakabayashi, Kenta Nakai and Ashwini Patil
    • Journal Title

      Molecular BioSystems

      Volume: 8 Pages: 3262-3273

    • DOI

      10.1039/c2mb25202c

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] The conservation of chemical composition in intrinsically disordered regions and its utility in their functional classification2013

    • Author(s)
      Ashwini Patil
    • Organizer
      【新学術領域研究「天然変性タンパク質の分子認識機構と機能発現」】 第2回国際シンポジウム
    • Place of Presentation
      理化学研究所 横浜研
    • Year and Date
      2013-01-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] Classification and conservation of intrinsically disordered regions in proteins.2013

    • Author(s)
      Ashwini Patil
    • Organizer
      Annual meeting of the Protein Science Society of Japan
    • Place of Presentation
      とりぎん文化会館(鳥取県鳥取市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Patent(Industrial Property Rights)] A scheme to represent and classify protein domains using their chemical composition2012

    • Inventor(s)
      Ashwini Patil
    • Industrial Property Rights Holder
      Ashwini Patil
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-10-02
    • Related Report
      2012 Annual Research Report
    • Overseas

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Published: 2013-05-15   Modified: 2019-07-29  

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