報酬予測をつくるネットワークの解明

• Project Area: Elucidation of neural computation for prediction and decision making: toward better human understanding and applications
• Project/Area Number: 24120510
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Doshisha University
• Principal Investigator: 藤山 文乃 同志社大学, 脳科学研究科, 教授 (20244022)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000); Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
• Keywords: 大脳基底核 / 神経解剖学

Research Abstract

1997 年のSchultz の報告から、ドーパミンが報酬の予測誤差を担っているという知見が積み重ねられてきた。しかしこのドーパミンニューロンを直接興奮もしくは抑制しうる因子に何があり得るのかは未だ完全には解明されていない。応募者らは2011年に線条体のストリオソーム（パッチ）領域の直接路ニューロンはドーパミンニューロンが存在する黒質緻密部に投射していることを報告した(Fujiyama et al., 2011)。しかし技術的な限界のために、この報告も黒質緻密部への投射軸索が直接ドーパミンニューロンにシナプスを作成していることの証明までは至らなかった。一方、応募者らはH24～25年の公募研究で、「報酬予測をつくるネットワークの解明」のために大脳基底核の中継核である視床下核および淡蒼球外節に対し、ウイルスベクタを用いた単一神経トレース等を行った (視床下核：Koshimizu et al., 2013; 淡蒼球外節： Fujiyama et al., Neurosci2013報告)。この研究の過程で、淡蒼球外節の単一ニューロンの軸索がドーパミンニューロンが存在する黒質緻密部に投射していることを偶然発見した(Fujiyama et al., Neurosci2013報告)。

Current Status of Research Progress

Reason

25年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

25年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Long-lasting single-neuron labeling by in vivo electrop oration without microscopic guidance (2013)
  • Author(s): Kei Oyama, Shinya Ohara, Sho Satoa, Fuyuki Karube, Fumino Fujiyama, Yoshikazu Isomura, Hajime Mushiake, Toshio Iijima, Ken-Ichiro Tsutsui
  • Journal Title: Journal of Neuroscience Methods Volume: 218 Issue: 2 Pages: 139-147
  • DOI: 10.1016/j.jneumeth.2013.06.004
  • Peer Reviewed
• [Journal Article] A quantitative analy- sis of axon bouton distribution of subthal- amic nucleus neurons in the rat by single neuron visualization with a viral vector. (2013)
  • Author(s): Koshimizu Y, Fujiyama F, Nakamura KC, Furuta T, Kaneko T
  • Journal Title: The Journal of Comparative Neurology Volume: vol. 521(no. 9) Issue: 9 Pages: 2125-2146
  • DOI: 10.1002/cne.23277
  • Peer Reviewed
• [Journal Article] Cell type-specific inhibitory inputs to dendritic and somatic compartments of parvalbumin-expressing neocortical interneuron. (2013)
  • Author(s): Hioki H, Okamoto S, Konno M, Kameda H, Sohn J, Kuramoto E, Fujiyama F, Kaneko T
  • Journal Title: The Journal of Neuroscience Volume: vol. 33 (no. 2) Issue: 2 Pages: 544-555
  • DOI: 10.1523/jneurosci.2255-12.2013
  • NAID: 120005300466
  • Peer Reviewed
• [Journal Article] Cell Type-Specific Inhibitory Inputs to Dendritic and Somatic Compartments of Parvalbumin-Expressing Neocortical Interneuron. (2013)
  • Author(s): Hioki H
  • Journal Title: J Neurosci Volume: 33 Pages: 544-55
  • Peer Reviewed
• [Journal Article] Morphological analysis of thalamocortical axon fibers of rat posterior thalamic nuclei: A single neuron tracing study with viral vectors (2012)
  • Author(s): Ohno S, Kuramoto E, Furuta T, Hioki,H Tanaka YR, Fujiyama F, Sonomura T,Uemura M, Sugiyama K, Kaneko T
  • Journal Title: Cerebral Cortex Volume: vol. 22 Issue: 12 Pages: 2840-2857
  • DOI: 10.1093/cercor/bhr356
  • NAID: 120005243652
  • Peer Reviewed
• [Journal Article] Parvalbumin-Producing Cortical Interneurons Receive Inhibitory Inputs on Proximal Portions and Cortical Excitatory Inputs on Distal Dendrites. (2012)
  • Author(s): Kameda H
  • Journal Title: Eur J Neurosci Volume: 35 Pages: 838-54
  • Peer Reviewed
• [Presentation] Neural connection pattern in the basal ganglia, with relation to cortico-sub thalamic pathway (2013)
  • Author(s): Karube F
  • Organizer: Neuro2013
  • Place of Presentation: 京都
  • Year and Date: 2013-06-20
• [Presentation] ラット淡蒼球外節と直接路・間接路との関係を形態学的に解析する (2013)
  • Author(s): Mizutani K
  • Organizer: Neuro2013
  • Place of Presentation: 京都
  • Year and Date: 2013-06-20
• [Presentation] ラット淡蒼球外節の投射様式を領域ごとに解析する (2013)
  • Author(s): Fujiyama F
  • Organizer: Neuro2013
  • Place of Presentation: 京都
  • Year and Date: 2013-06-20
• [Presentation] Axonal arborization of midbrain non-dopaminergic neurons: single-cell (2013)
  • Author(s): Matsuda W
  • Organizer: Neuro2013
  • Place of Presentation: 京都
  • Year and Date: 2013-06-20
• [Presentation] Excitatory and Inhibitory Inputs to Parvalbumin-Expressing Interneurons in t he Mouse Primary Motor Cortex. (2013)
  • Author(s): Hioki H
  • Organizer: Neuro2013
  • Place of Presentation: 京都
  • Year and Date: 2013-06-20
• [Presentation] Quantitative analysis of single cell projection from midline and intralamina r thalamic nuclei to striosome and matrix compartments of rat striatum (2013)
  • Author(s): Unzai T
  • Organizer: Neuro2013
  • Place of Presentation: 京都
  • Year and Date: 2013-06-20
• [Presentation] Excitatory and Inhibitory Inputs to Parvalbumin-Expressing Interneurons in the Mouse Primary Motor Cortex. (2013)
  • Author(s): Hioki H
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: 高松
  • Year and Date: 2013-03-28
• [Presentation] Regional Difference in Network between the Striatum and Globus Pallidus. (2013)
  • Author(s): Fujiyama F
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: 高松
  • Year and Date: 2013-03-28
• [Presentation] 運動系視床皮質投射の神経回路 (2013)
  • Author(s): Kuramoto E
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: 高松
  • Year and Date: 2013-03-28
• [Presentation] Innervation of pallidal neurons by a striatal direct and indirect neurons in the rat. (2013)
  • Author(s): Mizutani K, Karube F, Takahashi S, Unzai T, Fujiyama F.
  • Organizer: The 36th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Kyoto
• [Presentation] Neural connection pattern in the rat basal ganglia, with relation to cortico-subthalamic pathway. (2013)
  • Author(s): Karube F, Fujiyama F
  • Organizer: The 36th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Kyoto
• [Presentation] Quantitative analysis of single cell projection from midline and intralaminar thalamic nuclei to striosome and matrix compartments of rat striatum. (2013)
  • Author(s): Unzai T, Kuramoto E, Kaneko T, Fujiyama F
  • Organizer: The 36th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Kyoto
• [Presentation] Regional Difference in Network between the Striatum and Globus Pallidus. (2013)
  • Author(s): Fujiyama F, Nakano T, Matsuda W, Oh YM, Mizutani K, Furuta T, Karube F, Takahashi S, Unzai T, Udagawa J, Kaneko T
  • Organizer: The 36th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Kyoto
• [Presentation] Axonal arborization of midbrain non-dopaminergic neurons: single-cell study. (2013)
  • Author(s): Matsuda W, Furuta T, Kuramoto E, Hioki H, Fujiyama F, Kaneko T
  • Organizer: The 36th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Kyoto
• [Presentation] Excitatory and Inhibitory Inputs to Parvalbumin-Expressing Interneurons in the Mouse Primary Motor Cortex. (2013)
  • Author(s): Hioki H, Sohn J, Kuramoto E, Okamoto S, Wang T, Kameda H, Fujiyama F, Kaneko T
  • Organizer: The 36th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Kyoto
• [Presentation] Types of rat pallidofugal projection system revealed by single-neuron tracing study with a viral vector (2012)
  • Author(s): Fujiyama F
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-18
• [Presentation] Quantitative analysis of single cell projection from midline and intralamina thalamic nuclei to striosome and matrix compartments of rat striatum. (2012)
  • Author(s): Unzai T
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-18
• [Book] Clinical Neuroscience (2014)
  • Author(s): 藤山文乃
  • Total Pages: 3
  • Publisher: 中外医学社
• [Book] 生体の科学 (2013)
  • Author(s): 藤山文乃
  • Total Pages: 5
  • Publisher: 医学書院
• [Book] 脳神経科学イラストレイテッド (2013)
  • Author(s): 藤山文乃
  • Total Pages: 6
  • Publisher: 羊土社
• [Book] 生体の科学 (2013)
  • Author(s): 藤山文乃
  • Total Pages: 4
  • Publisher: 金原一郎記念医学医療振興財団
• [Book] 脳神経科学イラストレイテッド 改訂第三版 (2012)
  • Author(s): 藤山文乃
  • Total Pages: 6
  • Publisher: 羊土社
• [Book] 機能的脳神経外科 (2012)
  • Author(s): 松田和郎
  • Total Pages: 6
  • Publisher: 日本定位・機能神経外科学会
• [Remarks] 同志社大学脳科学研究科神経回路形態部門藤山文乃研究室
  • URL: http://ncircuit.doshisha.ac.jp/
• [Remarks] 同志社大学脳科学研究科神経回路形態部門
  • URL: http://brainscience.doshisha.ac.jp/introduction/sys/nc.html
• [Remarks] Laboratory of Neural Circuitry
  • URL: http://ncircuit.doshisha.ac.jp/
• [Remarks] 同志社大学脳科学研究科
  • URL: http://brainscience.doshisha.ac.jp/introduction/sys/nc.html