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樹状突起における情報処理ダイナミクスの解析

Publicly Offered Research

Project AreaMesoscopic neurocircuitry: towards understanding of the functional and structural basis of brain information processing
Project/Area Number 25115701
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTohoku University

Principal Investigator

八尾 寛  東北大学, 生命科学研究科, 教授 (00144353)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywordsニューロン新生 / 海馬 / 神経幹細胞 / Ca2+チャネル / 筋細胞分化 / オプトジェネティクス / チャネルロドプシン / 大脳皮質 / 光遺伝学 / 局所回路 / トランスジェニック / Ca2+ / 光刺激
Outline of Annual Research Achievements

海馬歯状回においては、成体においても顆粒細胞が新生されている。ニューロン新生は、ネットワーク活動に依存し、アトラクター形成に関与していることが示唆されている。また、その異常がてんかん発症のメカニズムの一つとして重要である。しかし、海馬の神経幹細胞が活動依存的にニューロンに分化するメカニズムは未解明である。われわれは、成体ラット海馬歯状回からクローニングされた神経幹細胞PZ5をモデル系に用い、PZ5から産生されるニューロンがL型Ca2+チャネルの活性化により増加し、その抑制により減少することを見出した。さらに、そのプロセスの詳細を研究し、L型Ca2+チャネルが臨界期における新生ニューロンの生存と成熟を促進することを明らかにした(Teh et al., 2014)。ChRGR遺伝子をマウスの筋芽細胞C2C12に組み込んだ。この改変型チャネル遺伝子導入で、青緑色光に感受性を持つ筋細胞を作り、リズミックに照射した。その結果、青緑色光の照射を受けた細胞は、サルコメア構造の発達が促進され、光刺激に応答して収縮することを解明した(Asano et al., 2015)。オプトジェネティクスを用いたメゾスコピック研究を促進する目的で、ChR1とChR2のキメラのChRWR, ChRFRに点変異度導入し、その機能を詳細に研究した。とくにChRFR-C167Aは、膜発現効率や光電流の大きさにおいてすぐれており、大脳皮質錐体細胞など比較的大型のニューロンを微弱光で光刺激をする目的に最適化されていた(Hososhima et al., 2015)。また、バクテリア由来のNa+トランスポーター型ロドプシンをニューロンに発現させることにより、光依存的に長時間安定した活動抑制が引き起こされることを確認した(Kato et al., 2015)。

Research Progress Status

26年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

26年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (69 results)

All 2015 2014 2013 Other

All Journal Article (15 results) (of which Peer Reviewed: 12 results,  Open Access: 4 results,  Acknowledgement Compliant: 4 results) Presentation (41 results) (of which Invited: 13 results) Book (5 results) Remarks (8 results)

  • [Journal Article] Optogenetic induction of contractile ability in immature C2C12 myotubes.2015

    • Author(s)
      Asano T, Ishizuka T, Morishima K, Yawo H
    • Journal Title

      Sci Rep.

      Volume: 5 Issue: 1 Pages: 8317-8317

    • DOI

      10.1038/srep08317

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Kinetic evaluation of photosensitivity in bi-stable variants of chimeric channelrhodopsins.2015

    • Author(s)
      Hososhima S, Sakai S, Ishizuka T, Yawo H.
    • Journal Title

      PLOS ONE

      Volume: - Issue: 3 Pages: e0119558-e0119558

    • DOI

      10.1371/journal.pone.0119558

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural basis for Na+ transport mechanism by a light-driven Na+ pump2015

    • Author(s)
      H. E. Kato, K. Inoue, R. Abe-Yoshizumi, Y. Kato, H. Ono, M. Konno, S. Hososhima, T. Ishizuka, M. R. Hoque, H. Kunitomo, J. Ito, S. Yoshizawa, K. Yamashita, M. Takemoto, T. Nishizawa, R. Taniguchi, K. Kogure, A. D. Maturana, Y. Iino, H. Yawo, R. Ishitani, H. Kandori*, O. Nureki*
    • Journal Title

      Nature

      Volume: 未定 Issue: 7550 Pages: 48-53

    • DOI

      10.1038/nature14322

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chimeras of channelrhodopsin-1 and -2 from Chlamydomonas reinhardtii possess distinctive light-induced structural changes with less protonation change of a key glutamate residue for the gating behavior.2015

    • Author(s)
      Inaguma A, Tsukamoto H, Kato HE, Kimura T, Ishizuka T, Yawo H, Nureki O, Furutani Y
    • Journal Title

      J Biol Chem

      Volume: Mar 21

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Near-infrared (NIR) optogenetics using up-conversion system2015

    • Author(s)
      Shoko Hososhima, Hideya Yuasa, Toru Ishizuka, Hiromu Yawo
    • Journal Title

      Proc. SPIE, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II

      Volume: 9305 Pages: 93052R-93052R

    • DOI

      10.1117/12.2078875

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optogenetic patterning of whisker-barrel cortical system in transgenic rat expressing channelrhodopsin-2.2014

    • Author(s)
      Honjoh T, Ji Z-G, Yokoyama Y, Sumiyoshi A, Shibuya Y, Matsuzaka Y, Kawashima R, Mushiake H, Ishizuka T, Yawo H.
    • Journal Title

      PLoS ONE

      Volume: 9 (4) Issue: 4 Pages: 28134-28170

    • DOI

      10.1371/journal.pone.0093706

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regulation of later neurogenic stages of adult-derived neural stem/progenitor cells by L-type Ca2+ channels.2014

    • Author(s)
      Teh DBL, Ishizuka T, Yawo H
    • Journal Title

      Develop Growth Differ

      Volume: 56 Pages: 583-594

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Photofunctional nanomodulators for bioexcitation.2014

    • Author(s)
      Miyako E, Russier J, MauroM, Cebrian C, Yawo H, Menard-Moyon C, Hutchison JA, Yudasaka M, Iijima S, De Cola L, Bianco A
    • Journal Title

      Angew Chem Int Ed.

      Volume: 53 Issue: 48 Pages: 13121-13125

    • DOI

      10.1002/anie.201407169

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] オプトジェネティクスによる細胞機能の光操作.2014

    • Author(s)
      江川遼,八尾寛
    • Journal Title

      細胞

      Volume: 46 Pages: 35-38

    • NAID

      40020155660

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Optogenetic stimulation of the auditory pathway.2014

    • Author(s)
      Hernandez VH, Gehrt A, Reuter K, Jing Z, Jeschke M, Mendoza Schulz A, Hoch G, Bartels M, Vogt G, Garnham CW, Hiromu Yawo H, Fukazawa Y, Augustine GJ, Bamberg E, Kügler S, Salditt T, de Hoz L, Strenzke N, Moser T
    • Journal Title

      J Clin Invest

      Volume: 124 Issue: 3 Pages: 1114-1129

    • DOI

      10.1172/jci69050

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 光遺伝学に有用なツール開発:分子、遺伝子導入、光照射の実際.2014

    • Author(s)
      八尾 寛、江川 遼
    • Journal Title

      細胞工学

      Volume: 33 Pages: 243-248

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Optogenetically induced Seizure and the Longitudinal Hippocampal Network.2013

    • Author(s)
      Shin-ichiro Osawa, , Hajime Mushiake
    • Journal Title

      PLos One

      Volume: 8 Issue: 4 Pages: 1-1

    • DOI

      10.1371/journal.pone.0060928

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hindbrain V2a neurons in the excitation of spinal locomotor circuits during zebrafish swimming2013

    • Author(s)
      Kimura, Y., Satou, C., Fujioka, S., Shoji, W., Umeda, K., Ishizuka, T., Yawo, H., and Higashijima, S.
    • Journal Title

      Current Biology

      Volume: 23 Issue: 10 Pages: 843-849

    • DOI

      10.1016/j.cub.2013.03.066

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Optogenetic manipulation of neural and non-neural functions.2013

    • Author(s)
      Yawo H, Asano T, Sakai S, Ishizuka T
    • Journal Title

      Development, Growth & Differentiation

      Volume: 55 Issue: 4 Pages: 474-490

    • DOI

      10.1111/dgd.12053

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] オプトジェネティクスを用いたin vivoラット脳の双方向性プロービング.2013

    • Author(s)
      本城達也,八尾 寛
    • Journal Title

      実験医学

      Volume: 31 Pages: 927-933

    • Related Report
      2013 Annual Research Report
  • [Presentation] チャネルロドプシン光電変換の特性と応用2015

    • Author(s)
      八尾 寛
    • Organizer
      理研シンポジウム「細胞システムの動態と論理 Ⅶ」
    • Place of Presentation
      和光市
    • Year and Date
      2015-04-02 – 2015-04-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] A new reporter rat line which express bright red fluorescent protein (tdTomato) conditionally under Cre-loxP system.2015

    • Author(s)
      Igarashi H, Koizumi K, Kaneko R, Ikeda K, Onimaru H, Yanagawa Y, Muramatsu S-I, Ishizuka T, Yawo H
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Discrimination of optogenetic whisker pattern in channelrhodopsin-2 transgenic rat.2015

    • Author(s)
      Abe K, Ishizuka T, Yawo H
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Opt-fMRI study of whisker-barrel cortical responses using channelrhodopsin-2 expressing rat.2015

    • Author(s)
      Yokoyama Y, Sumiyoshi A, Kawashima R, Yawo H
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 八尾寛. チャネルロドプシンの分子ダイナミクス.2015

    • Author(s)
      八尾寛
    • Organizer
      蛋白研セミナー「光運動反応・光センサー蛋白質・光遺伝学」
    • Place of Presentation
      吹田
    • Year and Date
      2015-03-10 – 2015-03-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Near-infrared (NIR) optogenetics using up-conversion system.2015

    • Author(s)
      Hososhima S, Yuasa H, Ishizuka T, Yawo H
    • Organizer
      SPIE Photonics West-Bios
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2015-02-07 – 2015-02-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 光で生命機能に干渉する ~オプトジェネティクス(光遺伝学)の現況と展望~(チュートリアル).2014

    • Author(s)
      八尾寛
    • Organizer
      応用物理学会 量子エレクトロニクス研究会
    • Place of Presentation
      軽井沢
    • Year and Date
      2014-12-19 – 2014-12-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 触覚時空間パターン脳内表現のオプトジェネティクス.2014

    • Author(s)
      八尾寛
    • Organizer
      第35 回日本レーザー医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-29 – 2014-11-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ランタニドナノ粒子のアップコンバージョン効果を応用した生体の近赤外光操作.2014

    • Author(s)
      細島頌子, 湯浅英哉, 石塚徹, 八尾寛
    • Organizer
      第36回日本バイオマテリアル学会大会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-17 – 2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Developmental connectomics of axonal reorganization in avian ciliary ganglion.2014

    • Author(s)
      R. Egawa, S. Hososhima, T. Ishizuka, H. Yawo
    • Organizer
      Neuroscience 2014
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Evaluation of a novel reporter rat line which conditionally expresses red fluorescent protein (tdTomato).2014

    • Author(s)
      H. Igarashi, K. Koizumi, R. Kaneko, K. Ikeda, H. Onimaru, Y. Yanagawa, S.-I. Muramatsu, T. Ishizuka, H. Yawo
    • Organizer
      Neuroscience 2014
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 感覚の遺伝子工学.2014

    • Author(s)
      八尾寛
    • Organizer
      第5回感性センシング応用ロードマップ技術分科会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Optogenetic patterning of touch perception -- sensing light by skin.2014

    • Author(s)
      Yawo H. Yokoyama Y, Sumiyoshi A, Abe A, Koizumi K, Egawa R, Liu Y, Ohshiro T, Matsuzaka Y, Kawashima R, Mushiake H, Ishizuka T
    • Organizer
      The 16th International Conference on Retinal Proteins (ICRP2014)
    • Place of Presentation
      Nagahama, Japan
    • Year and Date
      2014-10-05 – 2014-10-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Bi-stable variants of chimeric channelrhodopsins - kinetics-dependent activation of neurons2014

    • Author(s)
      Hososhima S, Ishizuka T, Yawo H.
    • Organizer
      The 16th International Conference on Retinal Proteins (ICRP2014)
    • Place of Presentation
      Nagahama, Japan
    • Year and Date
      2014-10-05 – 2014-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Light-induced membrane depolarization by two-component optogenetic.2014

    • Author(s)
      A. Zamani, T. Ishizuka, H. Yawo
    • Organizer
      The 16th International Conference on Retinal Proteins (ICRP2014)
    • Place of Presentation
      Nagahama, Japan
    • Year and Date
      2014-10-05 – 2014-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional MRI signal to optogenetic tactile pattern of channelrhodopsin-2 expressing rat in barrel cortex.2014

    • Author(s)
      Y. Yokoyama, A. Sumiyoshi, R. Kawashima, H. Yawo
    • Organizer
      The 16th International Conference on Retinal Proteins (ICRP2014)
    • Place of Presentation
      Nagahama, Japan
    • Year and Date
      2014-10-05 – 2014-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 触覚パターンのオプトジェネティクス制御.2014

    • Author(s)
      八尾寛, 横山超一, 住吉晃, 阿部健太, 小泉協, 江川遼, 劉越人, 大城朝一, 松坂義哉, 川島隆太, 虫明元, 石塚徹
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ニワトリ胚毛様体神経節の発達期におけるカスパーゼ6依存的なシナプスリモデリング.2014

    • Author(s)
      加藤秀理,江川遼,細島頌子,石塚徹,八尾寛.
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] ニワトリ胚毛様体神経節における軸索再編成の発達期コネクトミクス研究.2014

    • Author(s)
      江川遼,細島頌子,石塚徹,八尾寛
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] オプトジェネティックスを用いた触覚パターンによるバレル野のfMRI応答.2014

    • Author(s)
      横山超一,住吉晃,川島隆太,八尾寛
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 赤色蛍光タンパク質tdTomatoをCre-loxPコンディショナルに発現するレポーターラットの評価.2014

    • Author(s)
      五十嵐敬幸,小泉協,金子涼輔,池田啓子,鬼丸洋,柳川右千夫,村松 慎一,石塚 徹,八尾寛
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 光を触覚として感じるラット.2014

    • Author(s)
      八尾寛
    • Organizer
      光操作研究会シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2014-08-21 – 2014-08-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Target-dependent direction of Muse cell differentiation -- a proposal of in vitro model system.2014

    • Author(s)
      H. Igarashi, T. Morita, T. Murakami, Y. Matsuzaki, A. Konno, T. Ishizuka, M. Dezawa, H. Yawo
    • Organizer
      5th International Congress on Stem Cells and Tissue Formation
    • Place of Presentation
      Dresden, Germany
    • Year and Date
      2014-07-08 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 発達期ニワトリ胚毛様体神経節で見られるプレシナプス刈り込みへのカスパーゼ6の関与.2014

    • Author(s)
      加藤秀理,江川遼,細島頌子,石塚徹,八尾寛
    • Organizer
      第47回発生生物学会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-05-27 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Rat-Based Systems for Basic and Clinical Optogenetics.2014

    • Author(s)
      Yawo H.
    • Organizer
      Gordon Research Conference on Photosensory Receptors and Signal Transduction
    • Place of Presentation
      Lucca (Barga), Italy
    • Year and Date
      2014-04-06 – 2014-04-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The molecular determinants involved in the Gd3+-dependent channel block of channelrhodopsins.2014

    • Author(s)
      Yawo H, Watanabe S, Ishizuka T
    • Organizer
      Gordon Research Conference on Photosensory Receptors and Signal Transduction
    • Place of Presentation
      Lucca (Barga), Italy
    • Year and Date
      2014-04-06 – 2014-04-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Optogenetic Patterning of Somatosensory Perception2014

    • Author(s)
      Yawo H
    • Organizer
      "International Institute for Advanced Studies" Conference
    • Place of Presentation
      木津川市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Light-Evoked Touch Sense with Channelrhodopsin-Optogenetics2013

    • Author(s)
      Yawo H
    • Organizer
      NIH-Tohoku University-JSPS Symposium
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Optogenetic delivery of touch sense into peripheral and central nervous systems2013

    • Author(s)
      Yawo H
    • Organizer
      IUPS2013
    • Place of Presentation
      Birmingham, イギリス
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Optogenetic patterning of whisker-barrel tactile perception2013

    • Author(s)
      Yawo H
    • Organizer
      A symposium organized by the WCI Center for Functional Connectomics “lluminating brain function: New tools and new applications”
    • Place of Presentation
      Seoul, 韓国
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The molecular determinants involved in ion flux regulation of channelrhodopsins2013

    • Author(s)
      Yawo H
    • Organizer
      International Symposium Optogenetics 2013
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Optogenetic manipulation of presynaptic activity in the ciliary ganglion during embryogenesis of the chick2013

    • Author(s)
      Shoko Hososhima, Toru lshizuka, Hiromu Yawo
    • Organizer
      IUPS 2013
    • Place of Presentation
      Birmingham, イギリス
    • Related Report
      2013 Annual Research Report
  • [Presentation] A DMD-based multicolor irradiation system for the optogenetic analysis of neural circuits2013

    • Author(s)
      Seiichiro Sakai, Takaaki Mishima, Toru lshizuka, Hiromu Yawo
    • Organizer
      IUPS 2013
    • Place of Presentation
      Birmingham, イギリス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Whisker photostimulation evokes barrel cortical response of ChR2 transgenic rat2013

    • Author(s)
      Tatsuya Honjoh, Akira Sumiyoshi, Yukinobu Yokoyama, Zhi-Gang Ji, Toru lshizuka, Ryuta Kawashima, Hiromu Yawo
    • Organizer
      IUPS 2013
    • Place of Presentation
      Birmingham, イギリス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Involvement of caspases in the synaptogenesis of chick ciliary ganglion2013

    • Author(s)
      Hidetaka Katow, Ryo Egawa, Shoko Hososhima, Toru lshizuka, Hiromu Yawo
    • Organizer
      IUPS 2013
    • Place of Presentation
      Birmingham, イギリス
    • Related Report
      2013 Annual Research Report
  • [Presentation] Optogenetically-evoked Ca2+ release from intracellular store in the calyx-type presynaptic terminal of the embryonic chick ciliary ganglion2013

    • Author(s)
      Ryo Egawa, Shoko Hososhima, Hidetaka Katow, Toru Ishizuka, Hiromu Yawo
    • Organizer
      IUPS 2013
    • Place of Presentation
      Birmingham, イギリス
    • Related Report
      2013 Annual Research Report
  • [Presentation] 光遺伝学的に誘起された杯状シナプス前終末小胞体ストアからのCa2+放出2013

    • Author(s)
      江川遼、細島頌子、加藤秀理、石塚徹、八尾寛
    • Organizer
      第45回東北生理談話会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] オプトジェネティクスを利用したラットウィスカ光刺激パターニング2013

    • Author(s)
      八尾 寛、本城達也、姫 志剛、横山超一、石塚 徹
    • Organizer
      生理研シナプス研究会「シナプス・神経ネットワークの機能ダイナミクス」
    • Place of Presentation
      岡崎
    • Related Report
      2013 Annual Research Report
  • [Presentation] 歯状回門苔状細胞のバースト活動を光で誘導する2013

    • Author(s)
      三嶋孝知、八尾 寛、石塚徹
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] ニワトリ胚毛様体神経節杯状シナプス前終末における光遺伝学的操作・計測2013

    • Author(s)
      江川遼、細島頌子、侯旭濱、加藤秀理、石塚徹、仲村春和、八尾 寛
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] ウイスカ光触覚刺激に対するパレル野の応答解析2013

    • Author(s)
      本城達也、住吉晃、横山超一、姫志剛、川島隆太、八尾 寛
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Book] Optogenetics: Light-Sensing Proteins and Their Applications2015

    • Author(s)
      Yawo H, Kandori H, Koizumi Eds.
    • Total Pages
      512
    • Publisher
      Springer, Tokyo
    • Related Report
      2014 Annual Research Report
  • [Book] Chaptor 8. General description: Future prospects of optogenetics. “Optogenetics: Light-Sensing Proteins and Their Applications”2015

    • Author(s)
      Yawo, H., Egawa, R., Hososhima, S., Wen, L
    • Total Pages
      22
    • Publisher
      Springer, Tokyo
    • Related Report
      2014 Annual Research Report
  • [Book] Chaptor 21. Strategies to probe mechanoreception: from mechanical to optogenetic approaches. “Optogenetics: Light-Sensing Proteins and Their Applications”2015

    • Author(s)
      Ji, Z.-G., Ishizuka, T., Yawo, H
    • Total Pages
      10
    • Publisher
      Springer, Tokyo
    • Related Report
      2014 Annual Research Report
  • [Book] オプトジェネティクス―光工学と遺伝学による行動制御技術の最前線2013

    • Author(s)
      八尾 寛、他
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2013 Annual Research Report
  • [Book] Optogenetics2013

    • Author(s)
      Oertner TG, Helmchen F, de Lecea L, Beck H, Konnerth A, Kaupp B, Knpfel T, Yawo H, Musser M
    • Publisher
      De Gruyter, Berlin
    • Related Report
      2013 Annual Research Report
  • [Remarks] 東北大学研究者紹介

    • URL

      http://db.tohoku.ac.jp/whois/detail/0684d30b13c056e926b65120463918fb.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東北大学大学院生命科学研究科

    • URL

      http://www.lifesci.tohoku.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 脳機能解析分野

    • URL

      http://neuro.med.tohoku.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東北大学脳科学センター

    • URL

      http://www.bsc.tohoku.ac.jp/contents/c2_32/c2_32_yao_h.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東北大学プレスリリース

    • URL

      http://www.tohoku.ac.jp/japanese/2015/02/press20150205-01.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東北大学研究者紹介

    • URL

      http://db.tohoku.ac.jp/whois/detail/0684d30b13c056e926b65120463918fb.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東北大学大学院生命科学研究科

    • URL

      http://www.lifesci.tohoku.ac.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 脳機能解析分野

    • URL

      http://neuro.med.tohoku.ac.jp/

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-15   Modified: 2019-07-29  

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