非定型炎症を伴う精神疾患モデル動物を活用したマイクロ精神病態の同定と分子機序解明

• Project Area: Unraveling micro-endophenotypes of psychiatric disorders at the molecular, cellular and circuit levels.
• Project/Area Number: 25116526
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Fujita Health University
• Principal Investigator: 宮川 剛 藤田保健衛生大学, 総合医科学研究所, 教授 (10301780)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000); Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
• Keywords: 脳・神経 / 脳神経疾患 / 細胞・組織 / シグナル伝達 / 海馬歯状回 / 未成熟神経細胞 / ストレス / HPA系 / 精神・神経疾患

Outline of Annual Research Achievements

各種精神疾患モデルマウスの系統のうちヒト遺伝学的解析や死後脳解析での知見を考慮の上、最も妥当性の高いと考えられるSchnurri-2 KOマウスに特に注目し引き続き以下の解析を進めた。
(1) 遺伝的・環境的要因が脳の軽度慢性炎症を引き起こすメカニズムの解明：ジーンチップデータに基づいたバイオインフォマティクス解析により、炎症・神経過活動・「未成熟歯状回」の遺伝子発現パターンが非常に似ていることがわかってきた。環境的要因が脳の軽度慢性炎症を引き起こすメカニズムを調べるためストレス負荷モデルおよび神経過活動モデルマウスにおいて脳内分子発現変化の予備的解析を行った。今後匹数を増やして詳細な検討を行う。
(2) 脳の軽度慢性炎症が原因となって生じるマイクロエンドフェノタイプの同定：Schnurri-2 KOマウスを用いた3D電顕（電子顕微鏡）によるコネクトーム解析により、スパインレベルでの変化がわかりつつある。また、統合失調症患者とそのモデルマウスでは、DNAメチル化などのエピゲノム異常が生じている可能性が示唆されている。慢性炎症を呈するモデルマウスの脳においてどのようなエピジェネティクス変化が生じているか調べるためメチローム解析を行い、現在データの解析中である。さらに海馬のジーンチップデータのバイオインフォマティクス解析により炎症を始めとした各種の分子レベルでの表現型を正常化する可能性が考えられる薬剤を複数選定し、実際にマウスに投与した。現段階では行動レベルでのスクリーニングで顕著な効果はまだ得られていないが、今後さらに別の薬剤や複数の薬剤の併用などの検討を行う。
また、当初の計画以上の進展としてジーンチップデータのインフォマティクス解析により統合失調症患者の前頭皮質が擬似的未成熟状態にある可能性があることが分かった。新たなマイクロエンドフェノタイプ同定への一助になると考えられる。

Research Progress Status

26年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

26年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Comprehensive behavioral study of mGluR3 knockout mice: implication in schizophrenia related endophenotypes. (2014)
  • Author(s): Fujioka R, Nii T, Iwaki A, Shibata A, Ito I, Kitaichi K, Nomura M, Hattori S, Takao K, Miyakawa T, Fukumaki Y.
  • Journal Title: Mol Brain Volume: 7 Issue: 1 Pages: 31-31
  • DOI: 10.1186/1756-6606-7-31
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hippocampal neurogenesis regulates forgetting during adulthood and infancy. (2014)
  • Author(s): Akers KG, Martinez-Canabal A, Restivo L, Yiu AP, De Cristofaro A, Hsiang HL, Wheeler AL, Guskjolen A, Niibori Y, Shoji H, Ohira K, Richards BA, Miyakawa T, Josselyn SA, Frankland PW.
  • Journal Title: Science Volume: 344(6184) Issue: 6184 Pages: 598-602
  • DOI: 10.1126/science.1248903
  • Peer Reviewed / Open Access
• [Journal Article] Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia. (2014)
  • Author(s): Hagihara H, Ohira K, Takao K, Miyakawa T.
  • Journal Title: Mol Brain Volume: 7 Issue: 1 Pages: 41-41
  • DOI: 10.1186/1756-6606-7-41
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Enhanced stability of hippocampal place representation caused by reduced magnesium block of NMDA receptors in the dentate gyrus (2014)
  • Author(s): Yuichiro Hayashi, Yoko Nabeshima, Katsunori Kobayashi, Tsuyoshi Miyakawa, Koichi Tanda, Keizo Takao, Hidenori Suzuki, Eisaku Esumi, Shigeru Noguchi, Yukiko Matsuda, Toshikuni Sasaoka, Tesuo Noda, Jun-ichi Miyazaki, Masayoshi Mishina, Kazuo Funabiki and Yo-ichi Nabeshima
  • Journal Title: Molecular Brain Volume: 7 Issue: 1 Pages: 44-44
  • DOI: 10.1186/1756-6606-7-44
  • Peer Reviewed / Open Access
• [Journal Article] Mechanisms for interferon-α-induced depression and neural stem cell dysfunction. (2014)
  • Author(s): Zheng LS, Hitoshi S, Kaneko N, Takao K, Miyakawa T, Tanaka Y, Xia H, Kalinke U, Kudo K, Kanba S, Ikenaka K, Sawamoto K.
  • Journal Title: Stem Cell Reports Volume: 3(1) Issue: 1 Pages: 73-84
  • DOI: 10.1016/j.stemcr.2014.05.015
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Genomic responses in mouse models greatly mimic human inflammatory diseases. (2014)
  • Author(s): Takao K, Miyakawa T
  • Journal Title: Proc Natl Acad Sci USA Volume: 112(4) Issue: 4 Pages: 1167-72
  • DOI: 10.1073/pnas.1401965111
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system. (2014)
  • Author(s): Watanabe S, Ageta-Ishihara N, Nagatsu S, Takao K, Komine O, Endo F, Miyakawa T, Misawa H, Takahashi R, Kinoshita M, Yamanaka K.
  • Journal Title: Mol Brain Volume: 7 Issue: 1 Pages: 62-62
  • DOI: 10.1186/s13041-014-0062-1
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] IL1RAPL1 knockout mice show learning deficiency, memory decline, hyperactivity and reduced anxiety-like behaviours. (2014)
  • Author(s): Misato Yasumura, Tomoyuki Yoshida, Maya Yamazaki, Manabu Abe, Rie Natsume, Kouta Kanno, Takeshi Uemura, Keizo Takao, Kenji Sakimura, Takefumi Kikusui, Tsuyoshi Miyakawa, Masayoshi Mishina
  • Journal Title: Scientific Reports Volume: 4: 6613 Issue: 1 Pages: 6613-6613
  • DOI: 10.1038/srep06613
  • Peer Reviewed / Open Access
• [Journal Article] Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders (2014)
  • Author(s): Kobayashi M, Nakatani T, Koda T, Matsumoto K,I, Ozaki R, Mochida N, Takao K, Miyakawa T, Matsuoka I
  • Journal Title: Molecular brain Volume: 7(1) Issue: 1 Pages: 12-12
  • DOI: 10.1186/1756-6606-7-12
  • Peer Reviewed / Open Access
• [Journal Article] Contextual and cued fear conditioning test using a video analyzing system in mice. (2014)
  • Author(s): Shoji H, Takao K, Hattori S, Miyakawa T.
  • Journal Title: J Vis Exp Volume: 85 Issue: 85 Pages: 85-85
  • DOI: 10.3791/50871
  • Peer Reviewed / Open Access
• [Journal Article] Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia (2014)
  • Author(s): Takanori Onouchi, Katsunori Kobayashi, Kazuyoshi Sakai, Atsushi Shimomura, Ron Smits, Chiho Sumi-Ichinose, Masafumi Kurosumi Keizo Takao, Ryuji Nomura, Akiko Iizuka-Kogo, Hidenori Suzuki,Kazunao Kondo, Tetsu Akiyama Tsuyoshi Miyakawa Riccardo Fodde and Takao Senda, Riccardo Fodde, Takao
  • Journal Title: Molecular Brain Volume: 7 Issue: 1 Pages: 21-21
  • DOI: 10.1186/1756-6606-7-21
  • Peer Reviewed / Open Access
• [Journal Article] In vivo evaluation of cellular activity in αCaMKII heterozygous knockout mice using manganese-enhanced magnetic resonance imaging (MEMRI) (2013)
  • Author(s): Hattori S, Hagihara H, Ohira K, Aoki I, Saga T, Suhara T, Higuchi M, Miyakawa T.
  • Journal Title: Frontiers in Integrative Neuroscience Volume: 40 Pages: 125-132
  • DOI: 10.3389/fnint.2013.00076
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response. (2013)
  • Author(s): Umemori J, Takao K, Koshimizu H, Hattori S, Furuse T, Wakana S, Miyakawa T.
  • Journal Title: BMC Res Notes Volume: 6(1) Issue: 1 Pages: 203-203
  • DOI: 10.1186/1756-0500-6-203
  • Peer Reviewed / Open Access
• [Journal Article] Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice (2013)
  • Author(s): Ageta-Ishihara N, Yamakado H, Morita T, Hattori S, Takao K, Miyakawa T, Takahashi R, Kinoshita M
  • Journal Title: Mol Brain Volume: 6 Issue: 1 Pages: 35-35
  • DOI: 10.1186/1756-6606-6-35
  • Peer Reviewed / Open Access
• [Journal Article] Orexin receptor-1 in the locus coeruleus plays an important role in cue- dependent fear memory consolidation. (2013)
  • Author(s): Soya S, Shoji H, Hasegawa E, Hondo M, Miyakawa T, Yanagisawa M, Mieda M, Sakurai T.
  • Journal Title: J Neurosci. Volume: 33 Issue: 36 Pages: 14549-57
  • DOI: 10.1523/jneurosci.1130-13.2013
  • Peer Reviewed / Open Access
• [Journal Article] Point Mutation in Syntaxin-1A Causes Abnormal Vesicle Recycling, Behaviors, and Short-term Plasticity. (2013)
  • Author(s): Yumi Watanabe, Norikazu Kata yama, Kosei Takeuchi, et. al.
  • Journal Title: J. Biol. Chem. Volume: 288 Issue: 48 Pages: 34906-34919
  • DOI: 10.1074/jbc.m113.504050
  • Peer Reviewed / Open Access
• [Journal Article] Chronic fluoxetine treatment reduces parvalbumin expression and perineuronal nets in gamma-aminobutyric acidergic interneurons of the frontal cortex in adult mice. (2013)
  • Author(s): Ohira K, Takeuchi R, Iwanaga T, Miyakawa T
  • Journal Title: Mol Brain Volume: 6 Issue: 1 Pages: 43-43
  • DOI: 10.1186/1756-6606-6-43
  • Peer Reviewed / Open Access
• [Journal Article] PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders. (2013)
  • Author(s): Paemka L, Mahajan VB, Skeie JM, Sowers LP, Ehaideb SN, Gonzalez-Alegre P, Sasaoka T, Tao H, Miyagi A, Ueno N, Takao K, Miyakawa T, Wu S, Darbro BW, Ferguson PJ, Pieper AA, Britt JK, Wemmie JA, Rudd DS, Wassink T, El-Shanti H, Mefford HC, Carvill GL, Manak JR, Bassuk AG
  • Journal Title: PLoS One Volume: 8(12) Issue: 12 Pages: e80737-e80737
  • DOI: 10.1371/journal.pone.0080737
  • Peer Reviewed / Open Access
• [Journal Article] Mice lacking collapsin response mediator protein 1 manifest hyperactivity, impaired leaming and memory, and impaired prepulse inhibition (2013)
  • Author(s): Yamashita N, Takahashi A, Takao K, Yamamoto T, Kolattukudy P, Miyakawa T, Goshima Y
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 7巻 Pages: 216-226
  • DOI: 10.3389/fnbeh.2013.00216
  • Peer Reviewed / Open Access
• [Presentation] 精神疾患の中間表現型としての未成熟脳 (2015)
  • Author(s): 宮川剛
  • Organizer: 第88回日本薬理学会年会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-03-18 – 2015-03-20
• [Presentation] Transcriptomic effects of antidepressant treatment and glucocorticoid receptor-overexpression on the maturational status of brain cells in mice (2014)
  • Author(s): Tsuyoshi Miyakawa
  • Organizer: ACNP 53rd Annual Meeting
  • Place of Presentation: Arizona, USA
  • Year and Date: 2014-12-07 – 2014-12-11
• [Presentation] ranscriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia (2014)
  • Author(s): Hideo Hagihara, Koji Ohira, Keizo Takao, Tsuyoshi Miyakawa
  • Organizer: Neuroscience 2014
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Contrasting expression patterns for immaturity and maturity marker genes in the dentate gyrus between mouse line with ‘immature dentate gyrus’ and mice overexpressing glucocorticoid receptor (2014)
  • Author(s): Hisatsugu Koshimizu, Hideo Hagihara, Keizo Takao, Tsuyoshi Miyakawa
  • Organizer: Neuroscience 2014
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Cohort removal induces hyperthermia, increased pain sensitivity, and decreased anxiety-like behavior (2014)
  • Author(s): Keizo Takao, Satoko Hattori, Hirotaka Shoji, Tsuyoshi Miyakawa
  • Organizer: Neuroscience 2014
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Transcriptomic evidence for immaturity in the frontal cortex and dentate gyrus of mice treated with antidepressants (2014)
  • Author(s): Koji Ohira, Hideo Hagihara, Rika Takeuchi, Tsuyoshi Miyakawa
  • Organizer: Neuroscience 2014
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia (2014)
  • Author(s): Hideo Hagihara, Koji Ohira, Keizo Takao, Tsuyoshi Miyakawa
  • Organizer: Molecular and Cellular Cognition Society
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2014-11-14
• [Presentation] Contrasting expression patterns for immaturity and maturity marker genes in the dentate gyrus between mouse line with ‘immature dentate gyrus’ and mice overexpressing glucocorticoid receptor (2014)
  • Author(s): Hisatsugu Koshimizu, Hideo Hagihara, Keizo Takao, Tsuyoshi Miyakawa
  • Organizer: Molecular and Cellular Cognition Society
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2014-11-14
• [Presentation] 遺伝子改変マウスの行動解析を起点とする精神疾患の研究―マウスはモデルになりますー (2014)
  • Author(s): 宮川剛
  • Organizer: 第36回日本生物学的精神医学会・第57回日本神経化学会大会
  • Place of Presentation: 奈良県文化会館、奈良県新公会堂
  • Year and Date: 2014-09-29 – 2014-10-01
• [Presentation] 統合失調症の脳内中間表現型としての軽度慢性炎症―マウスモデルを用いた研究― (2014)
  • Author(s): 宮川剛
  • Organizer: 第36回日本生物学的精神医学会・第57回日本神経化学会大会
  • Place of Presentation: 奈良県文化会館、奈良県新公会堂
  • Year and Date: 2014-09-29 – 2014-10-01
• [Presentation] Bidirectional change of maturation status of cells in the brain: Relevance to neuropsychiatric disorder (2014)
  • Author(s): Tsuyoshi Miyakawa
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Genomic responses in mouse models greatly mimic human inflammatory diseases: In defense of mouse models for studying human disorders (2014)
  • Author(s): Keizo Takao, Tsuyoshi Miyakawa
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Comprehensive behavioral analysis of forebrain and dentate gyrus-specific Schnurri-2 knockout mice (2014)
  • Author(s): Satoko Hattori, Keizo Takao, Maya Yamazaki, Keiko Toyama, Juzoh Umemori, Kenji Sakimura, Tsuyoshi Miyakawa
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia (2014)
  • Author(s): Hideo Hagihara, Koji Ohira, Keizo Takao, Tsuyoshi Miyakawa
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Transcriptomic evidence for the immaturity in the frontal cortex of mice treated with antidepressants (2014)
  • Author(s): Koji Ohira, Hideo Hagihara, Rika Takeuchi, Tsuyoshi Miyakawa
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Contrasting expression pattern for immaturity and maturity marker genes in the dentate gyrus between mouse lines with “immature dentate gyrus” and mice overexpressing glucocorticoid receptor (2014)
  • Author(s): Hisatsugu Koshimizu, Hideo Hagihara, Keizo Takao, Tsuyoshi Miyakawa
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Remote memory deficit in three strains of mutant mice immature dentate gyrus phenotype (2014)
  • Author(s): Hirotaka Shoji, Tsuyoshi Miyakawa, Shunsuke Ishii, Isabella A Graef, Gerald R Crabtree, Paul W Frankland, Tsuyoshi Miyakawa
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Bidirectional change of maturation status of cells in the brain: relevant to neuropsychiatric disorders (2014)
  • Author(s): Tsuyoshi Miyakawa
  • Organizer: 9th International Conference for Neurons and Brain Disease
  • Place of Presentation: スペイン、マドリード
  • Year and Date: 2014-07-11 – 2014-07-16
• [Presentation] 精神疾患の中間表現型としての未成熟脳 (2014)
  • Author(s): 宮川剛
  • Organizer: 第110回日本精神神経学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-06-26 – 2014-06-28
• [Presentation] Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia (2014)
  • Author(s): Hideo Hagihara, Koji Ohira, Keizo Takao, Tsuyoshi Miyakawa
  • Organizer: 29th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2014-06-22 – 2014-06-26
• [Presentation] Retrospective prediction of behavioral state by hippocampal transcriptomes (2014)
  • Author(s): Hideo Hagihara, Tomoyasu Horikawa, Hironori K. Nakamura, Hirotaka Shoji, Yukiyasu Kamitani, Tsuyoshi Miyakawa
  • Organizer: 29th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2014-06-22 – 2014-06-26
• [Presentation] Bidirectional change of maturation status of cells in the brain: Relevance to neuropsychiatric disorders (2014)
  • Author(s): Tsuyoshi Miyakawa
  • Organizer: Frontier International Symposium for Neuron and Disease
  • Place of Presentation: 西安、中国
  • Year and Date: 2014-03-10 – 2014-03-12
• [Presentation] Immature dentate gyrus as a candidate endophenotype of neuropsychiatric disorders (2013)
  • Author(s): Tsuyoshi Miyakawa
  • Organizer: ACNP 52nd Annual Meeting
  • Place of Presentation: Florida, USA
  • Year and Date: 2013-12-08 – 2013-12-12
  • Invited
• [Presentation] Dysregulation of BDNF-MAPK signaling pathway in the hippocampus of mice with “immature dentate gyrus. (2013)
  • Author(s): Hisatsugu Koshimizu, Koji Ohira, Hideo Hagihara, Keizo Takao, Tsuyoshi Takagi, Masakazu Kataoka, Shunsuke Ishii, Masami Takahashi, Tsuyoshi Miyakawa
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-09 – 2013-11-13
• [Presentation] Decreased parvalbumin immunoreactivity and altered perineuronal net labeling in the frontal cortex of schizophrenia model mice (2013)
  • Author(s): Hideo Hagihara, Tsuyoshi Takagi, Shunsuke Ishii, Isabella A Graef, Gerald R Crabtree, and Tsuyoshi Miyakawa
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-09 – 2013-11-13
• [Presentation] “Immature dentate gyrus”, a candidate endophenotype for psychotic disorders, emerges after adolescence in Schnurri-2 KO mice. (2013)
  • Author(s): Keizo Takao, Hideo Hagihara, Koji Ohira, Hirotaka Shoji, Satoko Hattori, Hisatsugu Koshimizu, Juzoh Umemori, Tsuyoshi Takagi, Shunsuke Ishii, Tsuyoshi Miyakawa
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-09 – 2013-11-13
• [Presentation] Neuronal dematuration induced by antidepressant treatment in medial frontal cortex of adult mice. (2013)
  • Author(s): Koji Ohira, Rika Takeuchi, and Tsuyoshi Miyakawa
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-09 – 2013-11-13
• [Presentation] Dysregulation of BDNF-MAPK signaling pathway in the hippocampus of mice with “immature dentate gyrus” (2013)
  • Author(s): Hisatsugu Koshimizu, Koji Ohira, Hideo Hagihara, Keizo Takao, Tsuyoshi Takagi, Masakazu Kataoka, Shunsuke Ishii, Masami Takahashi, Tsuyoshi Miyakawa
  • Organizer: 12th Annual Molecular and Cellular Congnition Society Meeting
  • Place of Presentation: San Diego , USA
  • Year and Date: 2013-11-07 – 2013-11-08
• [Presentation] Decreased parvalbumin immunoreactivity and altered perineuronal net labeling in the frontal cortex of schizophrenia model mice (2013)
  • Author(s): Hideo Hagihara, Tsuyoshi Takagi, Shunsuke Ishii, Isabella A Graef, Gerald R Crabtree, and Tsuyoshi Miyakawa
  • Organizer: 12th Annual Molecular and Cellular Congnition Society Meeting
  • Place of Presentation: San Diego , USA
  • Year and Date: 2013-11-07 – 2013-11-08
• [Presentation] “Immature dentate gyrus”, a candidate endophenotype for psychotic disorders, emerges after adolescence in Schnurri-2 KO mice. (2013)
  • Author(s): Keizo Takao, Hideo Hagihara, Koji Ohira, Hirotaka Shoji, Satoko Hattori, Hisatsugu Koshimizu, Juzoh Umemori, Tsuyoshi Takagi, Shunsuke Ishii, Tsuyoshi Miyakawa
  • Organizer: 12th Annual Molecular and Cellular Congnition Society Meeting
  • Place of Presentation: San Diego , USA
  • Year and Date: 2013-11-07 – 2013-11-08
• [Presentation] 精神疾患の中間表現型としての未成熟脳 (2013)
  • Author(s): 宮川剛
  • Organizer: 第23回日本臨床精神神経薬理学会 第43回日本神経精神薬理学会合同年会
  • Place of Presentation: 沖縄コンベンションセンター
  • Year and Date: 2013-10-24 – 2013-10-26
• [Presentation] 成体マウスの前頭皮質と海馬において、抗うつ薬の長期投与によって抑制性神経細胞のパルブアルブミンとペリニューロナルネットが減少した (2013)
  • Author(s): 大平耕司、竹内理香、岩永剛、宮川剛
  • Organizer: 第23回日本臨床精神神経薬理学会 第43回日本神経精神薬理学会合同年会
  • Place of Presentation: 沖縄コンベンションセンター
  • Year and Date: 2013-10-24 – 2013-10-26
• [Presentation] マンガン造影MRI法を用いたalpha-CaMKIIへテロノックアウトマウスの脳画像解析 (2013)
  • Author(s): 服部聡子、米山操、齊藤茂芳、青木伊知男、佐賀恒夫、須原哲也、樋口真人、宮川剛
  • Organizer: 第23回日本臨床精神神経薬理学会 第43回日本神経精神薬理学会合同年会
  • Place of Presentation: 沖縄コンベンションセンター
  • Year and Date: 2013-10-24 – 2013-10-26
• [Presentation] Immature dentate gyrus and mild chronic inflammation: Candidate endophenotype of neuropsychiatric disorders (2013)
  • Author(s): Tsuyoshi Miyakawa
  • Organizer: 4th European Coference on Schizophrenia Research
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2013-09-26 – 2013-09-28
  • Invited
• [Presentation] 遺伝子・脳・行動：遺伝子改変マウスを用いた研究 (2013)
  • Author(s): 宮川剛
  • Organizer: 日本心理学会第77回大会
  • Place of Presentation: 札幌コンベンションセンター、札幌市産業振興センター
  • Year and Date: 2013-09-19 – 2013-09-21
• [Presentation] Bidirectional change of maturation statue of dentate gyrus neurons: relevance to neuropsychiatric diseases (2013)
  • Author(s): Tsuyoshi Miyakawa
  • Organizer: The 8th International Conference for Neurons and Brain Disease
  • Place of Presentation: Singapore
  • Year and Date: 2013-07-02 – 2013-07-04
• [Presentation] マンガン造影MRI法を用いたalpha-CaMKIIへテロノックアウトマウスの脳機能解析 (2013)
  • Author(s): 服部聡子、米山操、齊藤茂芳、青木伊知男、佐賀恒夫、須原哲也、樋口真人、宮川剛
  • Organizer: Neuro2013
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2013-06-20 – 2013-06-23
• [Presentation] 抗うつ薬によって引き起こされる成体マウス前頭皮質内側部の脱成熟 (2013)
  • Author(s): 大平耕司、竹内理香、宮川剛
  • Organizer: Neuro2013
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2013-06-20 – 2013-06-23
• [Presentation] Shunurri-2 マウスで見られる精神疾患の中間表現型としても未成熟歯状回は成育後に出現する (2013)
  • Author(s): 高雄啓三、萩原英雄、大平耕司、昌子浩孝、服部聡子、小清水久嗣、梅森十三、高木豪、石井俊輔、宮川剛
  • Organizer: Neuro2013
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2013-06-20 – 2013-06-23
• [Presentation] 歯状回ニューロンの成熟異常を示すマウスの海馬におけるBDNF-MAPK シグナル経路の調整異常 (2013)
  • Author(s): 小清水久嗣、大平耕司、萩原英雄、高雄啓三、高木豪、片岡正和、石井俊輔、高橋正身、宮川剛
  • Organizer: Neuro2013
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2013-06-20 – 2013-06-23
• [Presentation] 統合失調症モデルマウスの前頭前野におけるパルバルブミン陽性細胞の減少とペリニューロナルネット発現の変化 (2013)
  • Author(s): 萩原英雄、高木豪、石井俊輔、Isabella A Greaf、Gerald R Crabtree、宮川剛
  • Organizer: Neuro2013
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2013-06-20 – 2013-06-23
• [Presentation] マンガン造影MRI法を用いたalpha-CaMKIIへテロノックアウトマウスの脳機能解析 (2013)
  • Author(s): 服部聡子、米山操、齊藤茂芳、青木伊知男、佐賀恒夫、須原哲也、樋口真人、宮川剛
  • Organizer: MCCS-Asia 6th Annual Meeting
  • Place of Presentation: 京都
  • Year and Date: 2013-06-19
• [Presentation] 抗うつ薬によって引き起こされる成体マウス前頭皮質内側部の脱成熟 (2013)
  • Author(s): 大平耕司、竹内理香、宮川剛
  • Organizer: MCCS-Asia 6th Annual Meeting
  • Place of Presentation: 京都
  • Year and Date: 2013-06-19
• [Presentation] Shunurri-2 マウスで見られる精神疾患の中間表現型としても未成熟歯状回は成育後に出現する (2013)
  • Author(s): 高雄啓三、萩原英雄、大平耕司、昌子浩孝、服部聡子、小清水久嗣、梅森十三、高木豪、石井俊輔、宮川剛
  • Organizer: MCCS-Asia 6th Annual Meeting
  • Place of Presentation: 京都
  • Year and Date: 2013-06-19
• [Presentation] 歯状回ニューロンの成熟異常を示すマウスの海馬におけるBDNF-MAPK シグナル経路の調整異常 (2013)
  • Author(s): 小清水久嗣、大平耕司、萩原英雄、高雄啓三、高木豪、片岡正和、石井俊輔、高橋正身、宮川剛
  • Organizer: MCCS-Asia 6th Annual Meeting
  • Place of Presentation: 京都
  • Year and Date: 2013-06-19
• [Presentation] 統合失調症モデルマウスの前頭前野におけるパルバルブミン陽性細胞の減少とペリニューロナルネット発現の変化 (2013)
  • Author(s): 萩原英雄、高木豪、石井俊輔、Isabella A Greaf、Gerald R Crabtree、宮川剛
  • Organizer: MCCS-Asia 6th Annual Meeting
  • Place of Presentation: 京都
  • Year and Date: 2013-06-19
• [Presentation] Bidirectional change of maturation status of dentate gyrus neurons: Relevance to neuropsychiatric disorders. (2013)
  • Author(s): Tsuyoshi Miyakawa
  • Organizer: 15th Annual Genes, Brain and Behavior Meeting of the International Behavioural and Neural Genetics Society
  • Place of Presentation: Leuven, Belgium
  • Year and Date: 2013-05-20 – 2013-05-24