Publicly Offered Research
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
During the FY2014 we have achieved the following:(1)Given results from other laboratories we have focused on the neural circuit between the hypothalamus and CA2 as a mediator for social behaviors. Using viral expression of the optogenetic ChR2 channel we have obtained behavioral data indicating these inputs are sufficient to alter hippocampal-dependent social behaviors. In parallel we have identified this input as a strong mediator of inhibitory input to CA2 pyramidal cells, suggesting the pathway may play a key role in the hippocampal phenotypes associated with the CA2-disinhibition model of schizophrenia. The inputs from the hypothalamus to CA2 contain at least two distinct neurotransmitters, glutamate and substance P. In the in vitro slice preparation we have dissociated a fast (glutamate) and slow (substance P) physiological response to optogenetic stimulation of these inputs. Currently we are trying to map these disparate responses to different components of the behavioral changes we observe.(2)We have conducted in vivo physiological recordings in the CA1 and CA2 of mice during social interaction and social memory paradigms. This work is a crucial first step in defining the parameters we can use to correlate abnormal activity in the hippocampi of schizophrenia-model mice. Further, we are combining these recordings with in vivo optical stimulation of the hypothalamic inputs to examine changes in hippocampal excitability associated with social learning.
26年度が最終年度であるため、記入しない。
All 2014
All Presentation (1 results) (of which Invited: 1 results)
