Identifying a microendophenotype of post-traumatic stress disorder

• Project Area: Unraveling micro-endophenotypes of psychiatric disorders at the molecular, cellular and circuit levels.
• Project/Area Number: 25116531
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: JOHANSEN JOSHUA 独立行政法人理化学研究所, 脳科学総合研究センター, チームリーダー (80625351)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: fear / prediction error / periaqueductal gray / subregion specificity / anxiety disorders / amygdala / PTSD / associative learning / memory

Outline of Annual Research Achievements

We have made continued progress in Heisei 26 on delineating a circuit mechanism for setting fear learning levels. Following up on our previous work from Heisei, we have discovered that central nucleus of the amygdala (CeA) inputs to the periaqueductal gray (PAG) regulates prediction error neural coding and memory strength through differential modulation of distinct subregions of the PAG.Specifically we found that optogenetic inhibition of CE inputs to ventrolateral PAG (vlPAG) inhibited auditory conditioned stimulus (CS) processing in vlPAG without affecting shock unconditioned stimulus (US) processing.In contrast, the same optogenetic manipulation disinhibited shock US processing, but had no effect on CS processing in dorsolateral PAG neurons.

Research Progress Status

26年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

26年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Hebbian and neuromodulatory mechanisms interact to trigger associative memory formation (2014)
  • Author(s): Johansen, J.P., Diaz-Mataix, L., Hamanaka, H. Ozawa, T., Ycu, E., Koivumaa, J., Kumar, A., Hou, M., Deisseroth, K., Boyden, E. & LeDoux, J.E.
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 111(51)
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Encoding of fear learning and memory in distributed neural circuits (2014)
  • Author(s): Herry, C. & Johansen, J.P.
  • Journal Title: Nature Neuroscience Volume: 17(12) Pages: 1644-54
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Neural circuits: interacting interneurons regulate fear learning (2014)
  • Author(s): Takaaki Ozawa & Johansen, J.P.
  • Journal Title: Current Biology Volume: 24 (15)
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Anxiety is the sum of its parts (2013)
  • Author(s): Johansen Joshua Patrick
  • Journal Title: Nature Volume: 496 Issue: 7444 Pages: 174-175
  • DOI: 10.1038/nature12087
  • Peer Reviewed
• [Presentation] A distributed circuit mechanism for controlling associative memory strength (2015)
  • Author(s): Joshua Johansen
  • Organizer: Invited talk: Universite Paris Descartes
  • Place of Presentation: Universite Paris Descartes, France
  • Year and Date: 2015-01-26
  • Invited
• [Presentation] A distributed circuit mechanism for controlling associative memory strength (2015)
  • Author(s): Joshua Johansen
  • Organizer: Wiezmann Institute of Science
  • Place of Presentation: Wiezmann Institute of Science, Israel
  • Year and Date: 2015-01-21
  • Invited
• [Presentation] A neural circuit mechanism for triggering and setting the strength of fear memories (2014)
  • Author(s): Joshua Johansen
  • Organizer: New Directions in Pain Neuroscience
  • Place of Presentation: Center for Information and Neural Networks (CiNet), Japan
  • Year and Date: 2014-12-04
  • Invited
• [Presentation] A neural circuit mechanism for triggering and setting the strength of fear memories (2014)
  • Author(s): Joshua Johansen
  • Organizer: Friedrich Miescher Institute
  • Place of Presentation: Friedrich Miescher Institute, Switzerland
  • Year and Date: 2014-10-28
  • Invited
• [Presentation] A neural circuit mechanism for triggering and setting the strength of fear memories (2014)
  • Author(s): Joshua Johansen
  • Organizer: University of Geneva
  • Place of Presentation: University of Geneva, Switzerland
  • Year and Date: 2014-10-27
  • Invited
• [Presentation] A neural circuit mechanism for triggering and setting the strength of fear memories (2014)
  • Author(s): Joshua Johansen
  • Organizer: Pavlovian Society
  • Place of Presentation: Seattle, Washington
  • Year and Date: 2014-09-19
  • Invited
• [Presentation] A neural circuit mechanism for triggering and setting the strength of fear memories (2014)
  • Author(s): Joshua Johansen
  • Organizer: Japan Neuroscience Society Meeting
  • Place of Presentation: Yokohama, Pacifico Yokohama, Japan
  • Year and Date: 2014-09-11
  • Invited
• [Presentation] A neural circuit mechanism for triggering and setting the strength of fear memories (2014)
  • Author(s): Joshua Johansen
  • Organizer: Asian-Pacific Society for Neurochemistry Meeting
  • Place of Presentation: Kaosiung, Taiwan
  • Year and Date: 2014-08-26
  • Invited
• [Presentation] Teaching the brain to fear: from neural circuits and coding to behavior (2014)
  • Author(s): Joshua Johansen
  • Organizer: Tokyo University
  • Place of Presentation: Tokyo University, Bioscience Research Bldg, Japan
  • Year and Date: 2014-07-08
  • Invited
• [Presentation] A neural circuit mechanism for triggering and setting the strength of fear memories (2014)
  • Author(s): Joshua Johansen
  • Organizer: iCeMS conference
  • Place of Presentation: Kyoto, iCeMS Main bldg (#77), 2F seminar room, Japan
  • Year and Date: 2014-06-13
  • Invited
• [Presentation] A neural circuit mechanism for triggering and setting the strength of fear memories (2014)
  • Author(s): Joshua Johansen
  • Organizer: Biological Psychiatry Meeting
  • Place of Presentation: New York, USA
  • Year and Date: 2014-05-09
  • Invited
• [Presentation] A neural circuit mechanism for triggering and setting the strength of fear memories (2014)
  • Author(s): Joshua Johansen
  • Organizer: Korea Advanced Institute of Science and Technology
  • Place of Presentation: Daejeon, Korea
  • Year and Date: 2014-05-01
  • Invited
• [Presentation] A neural circuit mechanism for triggering and setting the strength of fear memories (2014)
  • Author(s): Joshua Johansen
  • Organizer: Korea Institute of Science and Technology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2014-04-29
  • Invited
• [Presentation] A neural circuit mechanism for triggering and setting the strength of fear memories (2014)
  • Author(s): Johansen Joshua Patrick
  • Organizer: 38th Annual Winter Conference
  • Place of Presentation: Park City Marriot Hotel, USA
  • Invited
• [Presentation] Amygdala prediction error coding triggers associative learning and sets memory strength (2013)
  • Author(s): Johansen Joshua Patrick
  • Organizer: Spring Hippocampal Research Conference 2013
  • Place of Presentation: The hotel Imperiale, Italy
  • Invited
• [Presentation] Teaching signals for amygdala plasticity mediating fear learning (2013)
  • Author(s): Johansen Joshua Patrick
  • Organizer: Molecular and Cellular Cognition Society for Neuroscience Sattellite Symposium
  • Place of Presentation: Westin Gaslamp Quarter Hotel, USA
  • Invited
• [Presentation] A neural circuit mechanism for triggering and setting the strength of fear memories (2013)
  • Author(s): Johansen Joshua Patrick
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸コンベンションセンター
  • Invited
• [Presentation] Teaching the Amygdala to Fear
  • Author(s): Johansen Joshua Patrick
  • Organizer: Gordon Conference: Amygdala in Health and Disease
  • Place of Presentation: Stonehill college, USA
  • Invited
• [Presentation] Teaching the amygdala to fear: a role for multiple learning rules
  • Author(s): Johansen Joshua Patrick
  • Organizer: Pavlovian Society Meeting 2013
  • Place of Presentation: Hilton Garden Inn, USA
  • Invited
• [Presentation] A neural circuit mechanism for triggering and setting the strength of fear memories
  • Author(s): Johansen Joshua Patrick
  • Organizer: 第16回神経科学領域における分子モニタリングシンポジウム
  • Place of Presentation: ウインクあいち
  • Invited
• [Presentation] A neural circuit mechanism for triggering and setting the strength of fear memories
  • Author(s): Johansen Joshua Patrick
  • Organizer: 第14回『脳と心のメカニズム』冬のワークショップ
  • Place of Presentation: ルスツリゾート
  • Invited
• [Remarks] Lab webpage
  • URL: http://jlab.brain.riken.jp/