HLAクラスIIによって提示される細胞内ミスフォールド蛋白質の機能解明

• Project Area: HLA polymorphism, disease and evolution
• Project/Area Number: 25133705
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University
• Principal Investigator: 荒瀬 尚 大阪大学, 微生物病研究所, 教授 (10261900)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000); Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: 抗原提示 / ミスフォールド蛋白質 / MHCクラスII / 自己免疫疾患 / 関節リウマチ / 自己抗体 / HLA-DR

Outline of Annual Research Achievements

MHCクラスII分子は様々な自己免疫疾患の感受性に最も強く関与している分子である。しかし、特定のMHCクラスII分子がどのように疾患感受性を決定するかは長年明らかになっていない。一方、我々は、細胞内のミスフォールド蛋白質を細胞外へ輸送する分子としてMHCクラスII分子を同定した。さらに解析を進めることによってクラスIIに提示されたミスフォールド蛋白質は、抗原特異的なB細胞を活性化する。そこで、関節リウマチや抗リン脂質抗体症候群等の自己免疫疾患で認められるいくつかの自己抗体を解析すると、それらは、MHCクラスII分子に提示されたミスフォールド蛋白質（抗体重鎖やβ２グライコプロテインI）に対して高い親和性を示すことが判明した(Jin et al. PNAS 2014, Tanimura et al. Blood 2015)。さらに、MHCクラスII分子に提示されたミスフォールド蛋白質に対する自己抗体の結合性は、MHCクラスII分子による関節リウマチ等の自己免疫疾患の感受性と高い相関を示すことが判明した(Jin et al. PNAS 2014)。これらのことから、細胞内のミスフォールド蛋白質がMHCクラスII分子によって、細胞外へ輸送されると、その複合体が異物として異常な免疫応答を誘導するのではないかという今までに考えられてきたのとは異なる新たな自己免疫疾患の発症機構が明らかになった。すなわち、MHCクラスII分子に提示されたミスフォールド蛋白質は、自己抗体の標的分子として、自己免疫疾患の発症に関わるという新たな自己免疫疾患の分子機序が明らかになった。

Research Progress Status

26年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

26年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] β2-glycoprotein I/ HLA class II complexes are novel autoantigens in antiphospholipid syndrome. (2015)
  • Author(s): Tanimura K, Jin H, Suenaga T, Morikami S, Arase N, Kishida K, Hirayasu K, Kohyama M, Ebina Y, Yasuda S, Horita T, Takasugi K, Ohmura K, Yamamoto K, Katayama I, Sasazuki T, Lanier LL, Atsumi T, Yamada H, Arase H.
  • Journal Title: Blood Volume: 125 Issue: 18 Pages: 2835-2844
  • DOI: 10.1182/blood-2014-08-593624
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] ミスフォールド蛋白質／MHCクラスII分子複合体による新たな自己免疫疾患発症機構 (2015)
  • Author(s): 荒瀬 尚
  • Journal Title: 臨床免疫・アレルギー科 Volume: 63(2) Pages: 187-192
• [Journal Article] Negative regulation of DSS-induced experimental colitis by PILRα. (2015)
  • Author(s): Kishida, K., Kohyama, M., Kurashima, Y., Kogure, Y., Wang, J., Hirayasu, K., Suenaga, T., Kiyono, H., Kunisawa, J. and Arase, H.
  • Journal Title: Int. Immunol. Volume: - Issue: 6 Pages: 307-314
  • DOI: 10.1093/intimm/dxv004
  • Peer Reviewed / Open Access
• [Journal Article] 自己免疫疾患におけるMHC(HLA)クラスⅡ分子のあらたな機能 (2014)
  • Author(s): 荒瀬 尚
  • Journal Title: 週刊医学のあゆみ 「HLAのブレイクスルー ー臨床応用と疾患研究の進歩」 Volume: 251(4) Pages: 283-288
• [Journal Article] Engineering large viral DNA genomes using the CRISPR-Cas9 system. (2014)
  • Author(s): Suenaga T, Kohyama M, Hirayasu K, Arase H.
  • Journal Title: Microbiol Immunol. Volume: 58（9） Issue: 9 Pages: 513-522
  • DOI: 10.1111/1348-0421.12180
  • NAID: 40020207309
  • Peer Reviewed
• [Journal Article] A motif in LILRB2 critical for Angptl2 binding and activation. (2014)
  • Author(s): Deng M, Lu Z, Zheng J, Wan X, Chen X, Hirayasu K, Sun H, Lam Y, Chen L, Wang Q, Song C, Huang N, Gao GF, Jiang Y, Arase H, Zhang CC.
  • Journal Title: Blood. Volume: 124(6) Issue: 6 Pages: 924-935
  • DOI: 10.1182/blood-2014-01-549162
  • Peer Reviewed
• [Journal Article] 自己免疫疾患の新たな発症メカニズム (2014)
  • Author(s): 荒瀬 規子、金 暉、荒瀬 尚
  • Journal Title: 感染・炎症・免疫 Volume: 44(2) Pages: 67-69
• [Journal Article] 自己免疫疾患の新たな発症メカニズム (2014)
  • Author(s): 荒瀬 規子、金 暉、荒瀬 尚
  • Journal Title: 細胞工学 Volume: 33(7) Pages: 762-763
• [Journal Article] Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILRα. (2014)
  • Author(s): Kuroki K, Wang J, Ose T, Yamaguchi M, Tabata S, Maita N, Nakamura S, Kajikawa M, Kogure A, Satoh T, Arase H, Maenaka K.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 111(24) Issue: 24 Pages: 8877-8882
  • DOI: 10.1073/pnas.1324105111
  • Peer Reviewed / Open Access
• [Journal Article] Regulation of immune responses by neutrophils (2014)
  • Author(s): Jing, W., Arase, H.
  • Journal Title: Ann. N. Y. Acad. Sci Volume: in press
  • Peer Reviewed
• [Journal Article] Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility (2014)
  • Author(s): Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H
  • Journal Title: Proceedings of National Academy of Science USA Volume: 111 Issue: 10 Pages: 3787-3792
  • DOI: 10.1073/pnas.1401105111
  • Peer Reviewed / Open Access
• [Journal Article] Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages. (2014)
  • Author(s): Haldar, M., Kohyama, M., So, A.Y., Kc, W., Wu, X., Briseno, C.G., Satpathy, A.T., Kretzer, N.M., Arase, H., Rajasekaran, N.S., Wang, L., Egawa, T., Igarashi, K., Baltimore, D., Murphy, T.L., and Murphy, K.M.
  • Journal Title: Cell Volume: 156 Issue: 6 Pages: 1223-1234
  • DOI: 10.1016/j.cell.2014.01.069
  • Peer Reviewed
• [Journal Article] Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis. (2013)
  • Author(s): Minami T, Kijima T, Kohmo S, Arase H, Otani Y, Nagatomo I, Takahashi R, Miyake K, Higashiguchi M, Morimura O, Ihara S, Tsujino K, Hirata H, Inoue K, Takeda Y, Kida H, Tachibana I, Kumanogoh A.
  • Journal Title: Scientific Reports Volume: 3 Issue: 1 Pages: 2669-2669
  • DOI: 10.1038/srep02669
  • Peer Reviewed
• [Journal Article] Us3 kinase encoded by herpes simplex virus 1 mediates down regulation of cell surface major histocompatibility complex class Iand evasion of CD8+ T cells. (2013)
  • Author(s): Imai, T., et al.
  • Journal Title: PLos One Volume: 8 Issue: 8 Pages: e72050-e72050
  • DOI: 10.1371/journal.pone.0072050
  • Peer Reviewed
• [Journal Article] Herpesvirus 6 glycoproteins B (gB), gH, gL, and gQ are necessary and sufficient for cell-to-cell fusion. (2013)
  • Author(s): Tanaka Y, Suenaga T, Matsumoto M, Seya T, Arase H.
  • Journal Title: J Virol. Volume: 87(19) Issue: 19 Pages: 10900-10903
  • DOI: 10.1128/jvi.01427-13
  • Peer Reviewed
• [Journal Article] CD1a-positive familial cutaneous mastocytosis without germ-line or somatic mutations in c-kit (2013)
  • Author(s): Arase, N., Wataya-Kaneda, M., Oiso, N., Arase, H., Katayama, I.
  • Journal Title: Br. J. Dermatol. Volume: 169 Issue: 1 Pages: 201-204
  • DOI: 10.1111/bjd.12265
  • Peer Reviewed
• [Presentation] Cellular misfolded proteins rescued from protein degradation by MHC class II molecules are targets for autoantibodies in autoimmune diseases (2015)
  • Author(s): Hisashi Arase
  • Organizer: Immunology at the Forefront, the 6th IFReC International Symposium
  • Place of Presentation: KNOWLEDGE THEATER, Grand Front Osaka, Japan
  • Year and Date: 2015-02-23 – 2015-02-24
  • Invited
• [Presentation] 自己免疫疾患の新たな標的分子：ミスフォールド蛋白質／MHCクラスⅡ分子複合体 (2015)
  • Author(s): 荒瀬 尚
  • Organizer: 第22回自己抗体と自己免疫シンポジウム
  • Place of Presentation: 丸ビルホール（東京）
  • Year and Date: 2015-02-07
  • Invited
• [Presentation] Cellular misfolded proteins rescued from protein degradation by MHC class II molecules are targets for autoantibodies in autoimmune diseases (2015)
  • Author(s): Hui Jin, Lewis L. Lanier and Hisashi Arase
  • Organizer: Keystone Symposia on Autoimmunity and Tolerance
  • Place of Presentation: Keystone (U.S.A)
  • Year and Date: 2015-02-02 – 2015-02-08
• [Presentation] Cellular misfolded proteins complexed with MHC class II molecules are targets for autoimmune diseases (2015)
  • Author(s): 荒瀬 尚
  • Organizer: 第4回眉山免疫シンポジウム
  • Place of Presentation: 徳島大学（徳島）
  • Year and Date: 2015-01-29 – 2015-01-30
  • Invited
• [Presentation] Myeloperoxidase/HLA class II complexes are targets for autoantibodies in microscopic polyangiitis. (2014)
  • Author(s): Hiwa Ryosuke, Ohmura Koichiro, Arase Noriko, Jin Hui, Hirayasu Kouyuki, Kohayama Masako, Suenaga Tadahiro, Matsuoka Sumiko, Iwatani Hirotsugu, Atsumi Tatsuya, Terao Chikashi, Mimori Tsuneyo, Arase Hisashi
  • Organizer: 第43回日本免疫学会学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Processing of cellular misfolded protein complexed with MHC class II molecules (2014)
  • Author(s): Kishida Kazuki, Arase Hisashi
  • Organizer: 第43回日本免疫学会学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] PILRα negatively regulates size of adipose tissue by controlling monocyte mobility (2014)
  • Author(s): Kohyama Masako, Kishida Kazuki, Arase Hisashi
  • Organizer: 第43回日本免疫学会学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] MHC class II-restricted recognition of self-antigen/MHC class II complexes by autoantibodies (2014)
  • Author(s): Jin Hui, Arase Noriko, Matsuoka Sumiko, Hirayasu Kouyuki, Kohayama Masako, Suenaga Tadahiro, Nakamaru Yuji, Imatani Yoshinori, Katayama Ichiro, Arase Hisashi
  • Organizer: 第43回日本免疫学会学術集会
  • Place of Presentation: 国立京都国際会館（京都）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] ペア型レセプターPILRによる糖鎖認識を介した免疫制御機構 (2014)
  • Author(s): 荒瀬 尚
  • Organizer: 第12回糖鎖学コンソーシアムシンポジウム
  • Place of Presentation: 東京医科歯科大学鈴木章夫記念講堂（東京）
  • Year and Date: 2014-12-04 – 2014-12-05
  • Invited
• [Presentation] ペア型レセプターを介した宿主病原体相互作用 (2014)
  • Author(s): 荒瀬 尚
  • Organizer: 千葉大学感染症グローバルネットワークフォーラム2014
  • Place of Presentation: 千葉大学医学部記念講堂（千葉）
  • Year and Date: 2014-11-15
  • Invited
• [Presentation] CRISPR/Cas9システムを用いた DNA ウイルスのゲノム改変 (2014)
  • Author(s): 末永忠広、 荒瀬尚
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川）
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] Cellular misfolded proteins complexed with MHC class II molecules are targets for autoantibodies in autoimmune diseases (2014)
  • Author(s): Hisashi Arase
  • Organizer: France-Japan Workshop
  • Place of Presentation: The conference room in Cassis is l'Oustau Calendal, Cassis (France)
  • Year and Date: 2014-10-22 – 2014-10-23
  • Invited
• [Presentation] Paired receptors in host pathogen interaction (2014)
  • Author(s): Hisashi Arase
  • Organizer: 2014 NHRI/IBMS Joint International Conference on Inflammation & Disease
  • Place of Presentation: Institute of Biomedical Sciences, Academia Sinica(Taiwan)
  • Year and Date: 2014-10-16 – 2014-10-18
  • Invited
• [Presentation] Cellular misfolded proteins transported to the cell surface by MHC class II molecules are targets for autoantibodies (2014)
  • Author(s): 荒瀬 尚
  • Organizer: Novo Nordisk Innovation Summit 2014
  • Place of Presentation: 東京大学（東京）
  • Year and Date: 2014-10-01 – 2014-10-02
  • Invited
• [Presentation] Engineering of large viral DNA genomes using the CRISPR-Cas9 system (2014)
  • Author(s): Tadahiro Suenaga, Hisashi Arase
  • Organizer: 第13回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 奈良県新公会堂（奈良）
  • Year and Date: 2014-09-23 – 2014-09-26
• [Presentation] Immune sensing system for bacterially degraded immunoglobulin via activating receptor DIR (2014)
  • Author(s): Kouyuki Hirayasu, Fumiji Saito, Hiroki Nagai, Kyoko Shida, Noriko Arase, Yasuhiko Horiguchi, Yuji Nakamaru, Ichiro Katayama, Hisashi Arase
  • Organizer: 第13回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 奈良県新公会堂（奈良）
  • Year and Date: 2014-09-23 – 2014-09-26
• [Presentation] ミスフォールド蛋白質／MHCクラスII分子複合体による新たな自己免疫疾患発症機構 (2014)
  • Author(s): 荒瀬 尚
  • Organizer: 第57回日本臨床検査医学会近畿支部総会
  • Place of Presentation: 神戸国際会議場（兵庫）
  • Year and Date: 2014-09-20
  • Invited
• [Presentation] Regulation of Immune Response by Paired Receptors (2014)
  • Author(s): Hisashi Arase
  • Organizer: Taishan Academic Forum on Cancer & Immune Singnaling Pathways And First Session Stem Cell Immunology Qilu International Forum
  • Place of Presentation: Yantai,China
  • Year and Date: 2014-08-09 – 2014-08-11
  • Invited
• [Presentation] Sialic Acids on N-glycosylated VZV gB are Required for Membrane Fusion Mediated by Myelin-associated Glycoprotein (MAG) (2014)
  • Author(s): Tadahiro Suenaga, Fuminori Arisawa, Maki Matsumoto, Hisashi Arase
  • Organizer: The 39th Annual International Herpesvirus Workshop (IHW2014)
  • Place of Presentation: Kobe International Exhibition Hall, Kobe
  • Year and Date: 2014-07-19 – 2014-07-23
  • Invited
• [Presentation] Autoantibodies in Rheumatoid Arthritis Specifically Recognize IgG Heavy Chain Complexed with HLA-DR, Which is Strongly Associated with Rheumatoid Arthritis Susceptibility. (2014)
  • Author(s): Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H.
  • Organizer: The 15th Annual European Congress of Rheumatology EULAR 2014
  • Place of Presentation: Paris(France)
  • Year and Date: 2014-06-11 – 2014-06-14
• [Presentation] 病原体とペア型レセプター (2014)
  • Author(s): 荒瀬 尚
  • Organizer: 第31回日本産婦人科感染症研究会 学術集会
  • Place of Presentation: 神戸国際会議場（兵庫）
  • Year and Date: 2014-06-07 – 2014-06-08
  • Invited
• [Presentation] MHCクラスⅡ分子によって細胞外へ輸送された細胞内ミスフォールド蛋白質が自己抗体の標的分子である (2014)
  • Author(s): 金暉、荒瀬規子、平安恒幸、香山雅子、末永忠広、松岡須美子、斉藤隆、Lewis L. Lanier、荒瀬尚
  • Organizer: 第24回Kyoto T cell Conference
  • Place of Presentation: 京都大学（京都）
  • Year and Date: 2014-05-16 – 2014-05-17
• [Presentation] PILRαの糖鎖認識機構と機能
  • Author(s): 荒瀬 尚
  • Organizer: 糖鎖免疫2014
  • Place of Presentation: 東京医科歯科大学（東京）
  • Invited
• [Presentation] Regulation of Immune Response by Paired Receptors
  • Author(s): Hisashi Arase
  • Organizer: The 3rd NIF Winter School on Advanced Immunology
  • Place of Presentation: Awaji (Japan)
  • Invited
• [Presentation] Rheumatoid factor binding to IgG heavy chain presented on HLA-DR is associated with Rheumatoid Arthritis susceptibility
  • Author(s): Jin Hui, Arase Noriko, Kohayama Masako, Saito Fumiji, Hirayasu Kouyuki, Matsumoto Maki, Shida Kyoko, Suenaga Tadahiro, Saito Takashi, Katayama Ichiro, Lanier Lewis L., Arase Hisashi
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ（千葉市）
• [Presentation] β2-glycoprotein I presented on MHC class II molecules are recognized by autoantibodies in antiphospholipid syndrome
  • Author(s): Tanimura Kenji, Suenaga Tadahiro, Jin Hui, Hirayasu Kouyuki, Arase Noriko, Kohayama Masako, Ebina Yasuhiko, Yasuda Shinsuke, Horita Tetsuya, Katayama Ichiro, Atsumi Tatsuya, Yamada Hideo, Arase Hisashi
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ（千葉市）
• [Presentation] PILRα negatively regulates DSS induced experimental colitis
  • Author(s): Kishida Kazuki, Kohyama Masako, Kurashima Yosuke, Wang Jing, Hirayasu Kouyuki, Suenaga Tadahiro, Kiyono Hiroshi, Kunisawa Jun, Arase Hisashi
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ（千葉市）
• [Presentation] Thymic epithelial cell-derived exsomes are responsible for MHC class II expression on thymoyctess
  • Author(s): Arisawa Fuminori, Arase Hisashi
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ（千葉市）
• [Presentation] Immune sensing system for immunoglobulin degradation by bacteria
  • Author(s): Hirayasu Kouyuki, Saito Fumiji, Horiguchi Yasuhiko, Nagai Hiroki, Arase Hisashi
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ（千葉市）
• [Presentation] PILRα negatively regulates monocyte mobility
  • Author(s): Kohyama Masako, Wang Jing Kishida Kazuki, Arase Hisashi
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ（千葉市）
• [Presentation] Misfolded proteins complexed with MHC class II molecules are targeted by autoantibodies
  • Author(s): Hisashi Arase
  • Organizer: 日独免疫セミナー
  • Place of Presentation: 日本平ホテル (Japan)
  • Invited
• [Presentation] 水痘帯状疱疹ウイルス（VZV）の膜融合メカニズムの解析
  • Author(s): 末永忠広、森康子、荒瀬尚
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸国際会議場（神戸市）
• [Presentation] 病原体とペア型レセプター
  • Author(s): 荒瀬尚
  • Organizer: 第67回日本細菌学会東北支部総会
  • Place of Presentation: 東北大学（仙台市）
  • Invited
• [Presentation] MHCクラスII分子と自己抗体
  • Author(s): 荒瀬尚
  • Organizer: 免疫サマースクール2013
  • Place of Presentation: ザ・ルイガンズ(福岡)
  • Invited
• [Presentation] Herpesvirus 6 Glycoprotein B (gB), gH, gL and gQ are Necessary and Sufficient for Cell-to-Cell Fusion
  • Author(s): Tadahiro Suenaga, Yuki Tanaka, Misako Matsumoto, Tsukasa Seya, Hisashi Arase
  • Organizer: 38th International Herpesvirus Workshop
  • Place of Presentation: Grand Rapids, Michigan (USA)
• [Presentation] 水痘帯状疱疹ウイルス（VZV）glycoprotein H (gH)受容体の解析
  • Author(s): 末永忠広、松本麻紀、有澤史倫、森康子、荒瀬尚
  • Organizer: 第28回ヘルペスウイルス研究会
  • Place of Presentation: 淡路夢舞台国際会議場（淡路市）
• [Presentation] Misfolded ER proteins transported to the cell surface by MHC class II molecules are targeted by autoantibodies
  • Author(s): Hisashi Arase
  • Organizer: Immune Regulation by Immunoreceptors
  • Place of Presentation: 筑波大学（つくば市）
• [Book] 細胞工学 (2013)
  • Author(s): 荒瀬 尚
  • Publisher: 秀潤社
• [Book] 臨床・免疫アレルギー科 (2013)
  • Author(s): 王 静、荒瀬 尚
  • Publisher: 科学評論社
• [Book] 血液フロンティア (2013)
  • Author(s): 荒瀬 規子、荒瀬 尚
  • Publisher: 医薬ジャーナル社
• [Book] 週刊 医学のあゆみ「免疫グロブリン様受容体による免疫制御と疾患」 (2013)
  • Author(s): 王 静、荒瀬 尚
  • Publisher: 医歯薬出版株式会社
• [Remarks] 免疫学分野
  • URL: http://immchem.biken.osaka-u.ac.jp
• [Remarks] 免疫化学分野ホームページ
  • URL: http://immchem.biken.osaka-u.ac.jp/
• [Patent(Industrial Property Rights)] 免疫用ペプチド、それを含む免疫疾患用医薬組成物、および免疫疾患の予防または治療方法 (2015)
  • Inventor(s): 荒瀬 尚, 岸田 一輝
  • Industrial Property Rights Holder: 荒瀬 尚, 岸田 一輝
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-068043
  • Filing Date: 2015-03-30
• [Patent(Industrial Property Rights)] 自己抗体の検出方法、自己免疫疾患の罹患の可能性を試験する方法、自己抗体の検出試薬および自己免疫疾患用の試験試薬 (2013)
  • Inventor(s): 荒瀬尚, 谷村憲司, 金,暉, 荒瀬規子
  • Industrial Property Rights Holder: 荒瀬尚, 谷村憲司, 金,暉, 荒瀬規子
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-148833
  • Filing Date: 2013-07-17