階層的生物評価系を用いた脳機能改善薬の創製

• Project Area: Chemical Biology using bioactive natural products as specific ligands: identification of molecular targets and regulation of bioactivity
• Project/Area Number: 26102704
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Tohoku University
• Principal Investigator: 福永 浩司 東北大学, 薬学研究科(研究院), 教授 (90136721)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: アルツハイマー病 / T型カルシウムチャネル / アセチルコリン / ノビレチン / L-シトルリン / 認知機能障害 / パーキンソン病 / ドパミン

Outline of Annual Research Achievements

私達は、新規アルツハイマー病治療候補薬である ST101 (spiro[imidazo[1,2-a] pyridine-3,2-indan]-2(3H)-one) が T 型電位依存性カルシウムチャネル活性化を介し、認知機能を亢進させることを報告した。本研究では、電気生理学的手法を用い、ST101 よりも強力なT 型電位依存性カルシウムチャネル活性化作用を持つ化合物を探索し、階層的生物評価系を用い、脳機能改善効果を検討した。パッチクランプ法を用い、ST101 の誘導体である spiroimidazopyridine derivatives (SAKs) の中でも特に T 型電位依存性カルシウムチャネル活性化作用が強い SAK3 を見出した。記憶・学習障害モデル動物である嗅球摘出 (OBX) マウスを用い、ST101 と SAK3 の脳機能改善効果を比較した。ST101 (0.5 mg/kg, p.o.) 急性投与では OBX マウスの記憶・学習障害は改善されないが、SAK3 (0.5 mg/kg, p.o.) 急性投与では改善した。この改善効果は T 型電位依存性カルシウムチャネル阻害薬により抑制された。さらに、SAK3 (0.5 mg/kg, p.o.) 急性投与によりアセチルコリン遊離が促進し、この促進効果は T 型電位依存性カルシウムチャネル阻害薬により完全に抑制された。以上の結果から、T 型電位依存性カルシウムチャネル活性化は脳機能の低下を改善し、記憶・学習障害を改善したと考えられる。今後は、T 型電位依存性カルシウムチャネル活性化による記憶・学習障害改善効果について詳細なメカニズムを検討し、記憶・学習に対するT 型電位依存性カルシウムチャネルの生理的な機能を明らかにする。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Valproic acid influences MTNR1A intracellular trafficking and signaling in a β-arrestin 2-dependent manner. (2016)
  • Author(s): Hong LL, Jiang Q, Long S, Wang H, Zhang LD, Tian Y, Wang CK, Cao JJ, Tao RR, Huang JY, Liao MH, Lu YM, Fukunaga K, Zhou NM, Han F.
  • Journal Title: Molecular Neurobiology Volume: 53(2) Issue: 2 Pages: 1237-1246
  • DOI: 10.1007/s12035-014-9085-y
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Stimulation of Sigma-1 Receptor Ameliorates Depressive-like Behaviors in CaMKIV Null Mice. (2015)
  • Author(s): Moriguchi, S.;Sakagami, H.;Yabuki, Y.;Sasaki, Y.;Izumi, H.;Zhang, C.;Han, F.;Fukunaga, K.
  • Journal Title: Mol Neurobiol Volume: 52 Issue: 3 Pages: 1210-1222
  • DOI: 10.1007/s12035-014-8923-2
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] ehydroepiandrosterone administration improves memory deficits following transient brain ischemia through sigma-1 receptor stimulation. (2015)
  • Author(s): Yabuki Y, Shinoda Y, Izumi H, Ikuno T, Shioda N, Fukunaga K.
  • Journal Title: Brain Reｓｅａｒｃｈ Volume: 1622 Pages: 102-113
  • DOI: 10.1016/j.brainres.2015.05.006
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Nuclear translocation of calcium/calmodulin-dependent protein kinase IIδ3 promoted by protein phosphatase-1 enhances brain-derived neurotrophic factor expression in dopaminergic neurons (2015)
  • Author(s): Shioda N, Sawai M, Ishizuka Y, Shirao T., Fukunaga K
  • Journal Title: J. Biol. Chem. Volume: 290 Issue: 35 Pages: 21663-21675
  • DOI: 10.1074/jbc.m115.664920
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Behavioral Sensitization by Methamphetamine in Junctophilin-Deficient Mice (2015)
  • Author(s): Moriguchi S, Nishi M, Sasaki Y, Takeshima H, Fukunaga K
  • Journal Title: Mol Neurobiol Volume: 51 Issue: 2 Pages: 533-542
  • DOI: 10.1007/s12035-014-8737-2
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Molecular mechanisms of synapse pathology in ATR-X syndrome (2015)
  • Author(s): Shioda N, Fukunaga K.
  • Journal Title: Folia Pharmacologica Japonica Volume: 145 Issue: 4 Pages: 174-177
  • DOI: 10.1254/fpj.145.174
  • NAID: 130005061557
  • ISSN: 0015-5691, 1347-8397
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cognitive function and calcium. cognitive improvement through T type calcium channel stimulation (2015)
  • Author(s): Fukunaga K
  • Journal Title: Clin Calcium Volume: 25 Pages: 247-254
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The role of SIGMAR1 gene mutation and mitochondrial dysfunction in amyotrophic lateral sclerosis (2015)
  • Author(s): Fukunaga K, Shinoda Y, Tagashira H
  • Journal Title: J Pharmacol Sci Volume: 127 Issue: 1 Pages: 36-41
  • DOI: 10.1016/j.jphs.2014.12.012
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Methyl pyruvate rescues mitochondrial damage caused by SIGMAR1 mutation related to amyotrophic lateral sclerosis. (2014)
  • Author(s): Tagashira, H., Shinoda, Y., Shioda, N., Fukunaga, K.
  • Journal Title: Biochim Biophys Acta. Volume: 1840 Issue: 12 Pages: 3320-3334
  • DOI: 10.1016/j.bbagen.2014.08.012
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Peroxiredoxin 1 participates in ischemia-triggered endothelial polarization (2014)
  • Author(s): Ye WF, Tao RR, Jiang Q, Huang JY, Lu NN, Lu YM, Fukunaga K, Wang H, Han F
  • Journal Title: Neurosci Ther Volume: 20 Issue: 8 Pages: 791-793
  • DOI: 10.1111/cns.12287
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] FABP3 protein promotes α-synuclein oligomerization associated with 1-methyl-1,2,3,6-tetrahydropiridine-induced neurotoxicity. (2014)
  • Author(s): Shioda N, Yabuki Y, Kobayashi Y, Onozato M, Owada Y, Fukunaga K.
  • Journal Title: The Journal of Biological Chemistry. Volume: 289(27) Issue: 27 Pages: 18957-18965
  • DOI: 10.1074/jbc.m113.527341
  • Peer Reviewed / Open Access
• [Journal Article] Rivastigmine restores 5-HT1A receptor levels in the hippocampus of olfactory bulbectomized mice. (2014)
  • Author(s): Muhammad Rashedul Islam, Shigeki Moriguchi, Hideaki Tagashira and Kohji Fukunaga
  • Journal Title: Advances in Alzheimer’s disease Volume: 3 Issue: 03 Pages: 128-136
  • DOI: 10.4236/aad.2014.33012
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Ultrasonic visualization of propagation of myocardial vibration driven by electrical excitation of myocardium of rat in ex vivo experiment (2014)
  • Author(s): Fujita Y, Tagashira H, Hasegawa H, Fukunaga K, Kanai H
  • Journal Title: Jpn J Appl Physics Volume: 53 Issue: 7S Pages: 07KF25-07KF25
  • DOI: 10.7567/jjap.53.07kf25
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Rivastigmine improves hippocampal neurogenesis and depressive-like behaviors via 5-HT1A receptor stimulation in olfactory bulbectomized mice. (2014)
  • Author(s): Muhammad Rashedul Islam, Shigeki Moriguchi, Hideaki Tagashira and Kohji Fukunaga
  • Journal Title: Neuroscience Volume: 272 Pages: 116-130
  • DOI: 10.1016/j.neuroscience.2014.04.046
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Orphan receptor and chaperon functions of sigma-1 receptor (2014)
  • Author(s): Fukunaga K
  • Journal Title: Folia Pharmacologica Japonica Volume: 143 Issue: 5 Pages: 263-264
  • DOI: 10.1254/fpj.143.263
  • NAID: 130004827701
  • ISSN: 0015-5691, 1347-8397
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Atg5 deficit exaggerates the lysosome formation and cathepsin B activation in mice brain after lipid nanoparticles injection (2014)
  • Author(s): Lu NN, Liu J, Tian Y, Liao MH, Wang H, Lu YM, Tao RR, Hong LJ, Liu SS, Fukunaga K, Du YZ, Han F
  • Journal Title: Nanomedicine Volume: 10 Issue: 8 Pages: 1843-1852
  • DOI: 10.1016/j.nano.2014.03.019
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] In vivo two-photon fluorescence microscopy reveals disturbed cerebral capillary blood flow and increased susceptibility to ischemic insults in diabetic mice (2014)
  • Author(s): Huang JY, Li LT, Wang H, Liu SS, Lu YM, Liao MH, Tao RR, Hong LJ, Fukunaga K, Chen Z, Wilcox CS, Lai EY, Han F
  • Journal Title: CNS Neurosci Ther Volume: 20 Issue: 9 Pages: 816-822
  • DOI: 10.1111/cns.12268
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Aberrant CaMKII activity in the medial prefrontal cortex is associated with cognitive dysfunction in ADHD model rats. (2014)
  • Author(s): Yabuki Y, Shioda N, Maeda T, Hiraide S, Togashi H, Fukunaga K.
  • Journal Title: Brain Research. Volume: 1557 Pages: 90-100
  • DOI: 10.1016/j.brainres.2014.02.025
  • Peer Reviewed
• [Journal Article] Nitrosative stress induces peroxiredoxin 1 ubiquitination during ischemic insult via E6AP activation in endothelial cells both in vitro and in vivo (2014)
  • Author(s): Tao RR, Wang H, Hong LJ, Huang JY, Lu YM, Liao MH, Ye WF, Lu NN, Zhu DY, Huang Q, Fukunaga K, Lou YJ, Shoji I, Wilcox CS, Lai EY, Han F
  • Journal Title: Antioxid Redox Signal Volume: (in press) Issue: 1 Pages: 1-16
  • DOI: 10.1089/ars.2013.5381
  • Peer Reviewed / Open Access
• [Journal Article] Cardioprotective Effect of the Selective Sigma-1 Receptor Agonist, SA4503 (2014)
  • Author(s): Hirano K, Tagashira H, Fukunaga K
  • Journal Title: YAKUGAKU ZASSHI Volume: 134 Issue: 6 Pages: 707-713
  • DOI: 10.1248/yakushi.13-00255-3
  • NAID: 130004427994
  • ISSN: 0031-6903, 1347-5231
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 筋萎縮性側索硬化症に関連するシグマ１受容体変異体の神経細胞毒性の検討 (2016)
  • Author(s): 篠田康晴、田頭秀章、福永浩司
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-27
• [Presentation] 不正論文に対するＪＰＳ編集委員会の取り組み (2016)
  • Author(s): 福永浩司
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-09
• [Presentation] 海馬Ｔ型カルシウムチャネルによるCaMKII活性化と認知機能障害 (2016)
  • Author(s): 福永浩司
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-09
• [Presentation] 心疾患に伴う鬱症状とSigma-1受容体 (2016)
  • Author(s): 福永浩司、篠田康晴
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-09
• [Presentation] ドパミンD2L受容体機能低下はセロトニン神経過活動によりストレス脆弱性を引き起こす (2016)
  • Author(s): 塩田 倫史、杉本航、福永 浩司
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-09
• [Presentation] CaMキナーゼII賦活化による新しい記憶学習機構 (2016)
  • Author(s): 森口茂樹、福永浩司
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-09
• [Presentation] SAK3 のT 型電位依存性カルシウムチャネル活性化による認知機能改善作用 (2016)
  • Author(s): 矢吹悌、福永浩司
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-09
• [Presentation] 一過性脳虚血に対するT型カルシウムチャンネル活性化薬SAK3の神経保護効果 (2016)
  • Author(s): 許晶、矢吹悌、福永浩司
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-09
• [Presentation] バルプロ酸誘発自閉症様行動はオキシトシンによって改善される (2016)
  • Author(s): 松尾和哉、矢吹悌、福永浩司
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-09
• [Presentation] T-type Ca2+ channel activation by spiroimidazopyridine compound. (2015)
  • Author(s): Yasushi Yabuki, Minoru Wakamori, Kohji Fukunaga.
  • Organizer: Pharmaceutical Science Symposium 2015 in Sendai.
  • Place of Presentation: 仙台
  • Year and Date: 2015-11-16
  • Int'l Joint Research
• [Presentation] Post-traumatic stress disorder-like behaviors in FABP3 null mice. (2015)
  • Author(s): Ibuki Takahata, Yasushi Yabuki, Yuji Owada, Kohji Fukunaga
  • Organizer: Pharmaceutical Science Symposium 2015 in Sendai.
  • Place of Presentation: 仙台
  • Year and Date: 2015-11-16
  • Int'l Joint Research
• [Presentation] Post-traumatic stress disorder-like behaviors in FABP3 null mice. (2015)
  • Author(s): Kohji Fukunaga, Yasushi Yabuki, Ibuki Takahata, Yuji Owada, Norifumi Shioda
  • Organizer: Neuroscience 2015.
  • Place of Presentation: Chicago, USA
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Sigma-1 receptor mediates depressive behaviors induced by cardiovascular diseases. (2015)
  • Author(s): Kohji Fukunaga, Yasuharu Shinoda
  • Organizer: Neuroscience 2015.
  • Place of Presentation: Chicago, USA
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Sigma-1 receptor stimulation improves depressive-like behaviors and adult hippocampal neurogenesis in CaMKIV null mice. (2015)
  • Author(s): Shigeki Moriguchi, Hiroyuki Sakagami, Kohji Fukunaga.
  • Organizer: Neuroscience 2015.
  • Place of Presentation: Chicago, USA
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Alzheimer disease drug candidate SAK3 stimulates Cav3.1 and Cav3.3 T-type Ca2+ channels. (2015)
  • Author(s): Yasushi Yabuki, Minoru Wakamori, Kohji Fukunaga.
  • Organizer: Neuroscience 2015.
  • Place of Presentation: Chicago, USA
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Inhibition of Amyloid beta accumulation by SAK3 as an Alzheimer's disease drug candidate. (2015)
  • Author(s): Hisanao Izumi, Yasushi Yabuki, Yasuharu Shinoda, Kohji Fukunaga
  • Organizer: Neuroscience 2015.
  • Place of Presentation: Chicago, USA
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] アルツハイマー病モデルマウスを用いた認知機能改善薬SAK3の創薬研究 (2015)
  • Author(s): 泉久尚、矢吹悌、篠田康晴、福永浩司
  • Organizer: 第54回日本薬学会東北支部大会
  • Place of Presentation: 岩手
  • Year and Date: 2015-09-26
• [Presentation] Abnormal fear memory via enhancement of CaM kinase II and IV activities in Na+/Ca2+ exchanger type-1 heterozygous mice (2015)
  • Author(s): 森口茂樹、泉久尚、喜多紗斗美、阪上洋行、岩本隆宏、福永浩司
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-24
• [Presentation] Anxiety and PTSD-like behaviors in FABP3 null mice. (2015)
  • Author(s): Yasushi Yabuki, Ibuki Takahata, Ryo Inagaki, Yuji Owada, Kohji Fukunaga
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-24
• [Presentation] 細胞内小器官におけるドパミン D2 受容体の機能解析 (2015)
  • Author(s): 塩田 倫史、福永 浩司
  • Organizer: 第66回日本薬理学会北部会
  • Place of Presentation: 富山
  • Year and Date: 2015-09-18
• [Presentation] NCKX2欠損マウスにおける認知機能障害の細胞内機序 (2015)
  • Author(s): 森口茂樹、喜多紗斗美、矢吹悌、泉久尚、堀江恭二、竹田潤二、岩本隆宏、福永浩司
  • Organizer: 第66回日本薬理学会北部会
  • Place of Presentation: 富山
  • Year and Date: 2015-09-18
• [Presentation] T型カルシウム活性化薬SAK3によるマウス海馬内グルタミン酸遊離の調節 (2015)
  • Author(s): 稲垣良、矢吹悌、田中智哉、福永浩司
  • Organizer: 第66回日本薬理学会北部会
  • Place of Presentation: 富山
  • Year and Date: 2015-09-18
• [Presentation] Novel intracellular D2LR signaling is critical for dendritic spine formation. (2015)
  • Author(s): Norifumi Shioda, Kohji Fukunaga
  • Organizer: 第58回日本神経化学会大会
  • Place of Presentation: 大宮
  • Year and Date: 2015-09-11
• [Presentation] Dysregulation of fear memory and CaM kinase II activity in NCX1 heterozygous mice (2015)
  • Author(s): 森口茂樹、泉久尚、喜多紗斗美、阪上洋行、岩本隆宏、福永浩司
  • Organizer: 第58回日本神経化学会大会
  • Place of Presentation: 大宮
  • Year and Date: 2015-09-11
• [Presentation] Effect of a novel cognitive enhancer ST101 on decreased CaMKII activity in schizophrenia model rats. (2015)
  • Author(s): Yasushi Yabuki, Kohji Fukunaga
  • Organizer: 第58回日本神経化学会大会
  • Place of Presentation: 大宮
  • Year and Date: 2015-09-11
• [Presentation] ATP supplementation therapy for ALS with SIGMAR1 mutation. (2015)
  • Author(s): Yasuharu Shinoda, Hideaki Tagashira, Kohji Fukunaga
  • Organizer: 第58回日本神経化学会大会
  • Place of Presentation: 大宮
  • Year and Date: 2015-09-11
• [Presentation] アルツハイマー病モデルマウスを用いた新規認知機能改善薬SAK3創薬研究 (2015)
  • Author(s): 泉久尚、矢吹悌、篠田康晴、福永浩司
  • Organizer: 第17回 応用薬理シンポジウム
  • Place of Presentation: 新潟
  • Year and Date: 2015-09-04
• [Presentation] 脂肪酸結合蛋白質3欠損マウスの PTSD 様行動とその病態解明 (2015)
  • Author(s): 高畑伊吹、矢吹悌、福永浩司
  • Organizer: 次世代を担う創薬・医療薬理シンポジウム2015
  • Place of Presentation: 東京
  • Year and Date: 2015-08-29
• [Presentation] FABP3 KO マウスにおける PTSD 様行動障害の解析 (2015)
  • Author(s): 高畑伊吹、矢吹悌、福永浩司
  • Organizer: 生体機能と創薬シンポジウム2015
  • Place of Presentation: 千葉
  • Year and Date: 2015-08-27
• [Presentation] Effect of a novel cognitive enhancer on decreased CaMKII activity in schizophrenia model rats. (2015)
  • Author(s): Yasushi Yabuki, Kohji Fukunaga.
  • Organizer: 25th international society for neurochemistry (ISN), 13th the Asian-Pacific Society for Neurochemistry (APSN) and 35th the Australasian Neuroscience Society (ANS)
  • Place of Presentation: Cairns, Australia
  • Year and Date: 2015-08-23
  • Int'l Joint Research
• [Presentation] シグマ1受容体変異による筋萎縮性側索硬化症のミトコンドリア障害の機序 (2015)
  • Author(s): 篠田康晴、田頭秀章、福永浩司
  • Organizer: 第26回霧島神経薬理フォーラム
  • Place of Presentation: 鹿児島
  • Year and Date: 2015-08-16
• [Presentation] アルツハイマー病モデルマウスを用いた認知機能改善薬SAK3の研究 (2015)
  • Author(s): 泉久尚、矢吹悌、福永浩司
  • Organizer: 第26回霧島神経薬理フォーラム
  • Place of Presentation: 鹿児島
  • Year and Date: 2015-08-16
• [Presentation] ATR-X症候群における分子病態の解明と治療薬開発 (2015)
  • Author(s): 塩田倫史、和田敬仁、福永浩司
  • Organizer: 第36回グアニジノ化合物研究会
  • Place of Presentation: 仙台
  • Year and Date: 2015-08-08
• [Presentation] アルツハイマー病治療候補化合物 SAK3 による T 型電位依存性 Ca2+ チャネル活性化作用 (2015)
  • Author(s): 矢吹悌、福永浩司
  • Organizer: 第10回年会 日本ケミカルバイオロジー
  • Place of Presentation: 仙台
  • Year and Date: 2015-06-10
• [Presentation] アルツハイマー病治療薬 SAK3 による T 型電位依存性 Ca2+ チャネル活性化作用 (2015)
  • Author(s): 矢吹 悌、福永 浩司
  • Organizer: 第17回ブレインサイエンス研究会
  • Place of Presentation: 福岡
  • Year and Date: 2015-06-06
• [Presentation] FABP3 KO マウスにおける PTSD 様症状はメラトニン受容体アゴニストにより軽減される (2015)
  • Author(s): 高畑伊吹、矢吹悌、福永浩司
  • Organizer: 第17回ブレインサイエンス研究会
  • Place of Presentation: 福岡
  • Year and Date: 2015-06-06
• [Presentation] シグマ1受容体のALS関連遺伝子変異はミトコンドリア障害を誘導する (2015)
  • Author(s): 篠田康晴、田頭秀章、福永浩司
  • Organizer: 生化学会東北支部81回例会・シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2015-05-09
• [Presentation] Sigma-1 receptor agonist and fluvoxamine rescue depressive behaviors in CaMKIV null mice (2015)
  • Author(s): Fukunaga K, Sakagami H, Moriguchi S
  • Organizer: Experimental Biology 2015
  • Place of Presentation: Boston, USA
  • Year and Date: 2015-03-28 – 2015-04-01
• [Presentation] Disease-modifying therapeutics for Parkinson’s disease and amyotrophic lateral sclerosis (2015)
  • Author(s): Fukunaga K
  • Organizer: 日本薬学会 第135年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] 心疾患に伴ううつ症状のメカニズムと治療 (2015)
  • Author(s): 福永浩司
  • Organizer: 第88回日本薬理学会年会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-03-18 – 2015-03-20
• [Presentation] FABP3 promotes α-synuclein oligomerization in dopaminergic neurons (2014)
  • Author(s): Fukunaga K, Shioda N, Morioka M, Owada Y
  • Organizer: Neuroscience 2014
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Remarks] 東北大学大学院 薬学研究科 薬理学分野
  • URL: http://www.pharm.tohoku.ac.jp/~yakuri/yakuri_top.html