• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

独自の合成方法論を基盤とするプローブ分子の創製

Publicly Offered Research

Project AreaChemical Biology using bioactive natural products as specific ligands: identification of molecular targets and regulation of bioactivity
Project/Area Number 26102736
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionUniversity of Shizuoka

Principal Investigator

菅 敏幸  静岡県立大学, 薬学部, 教授 (10221904)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords人工カイノイド / MFPA / 蛍光プローブ / キラルNi 触媒に / Huisgen 反応 / アクロメリン酸 / プレウロサイベルアジリジン / キノコ毒 / プローブ分子
Outline of Annual Research Achievements

本年度は、人工カイノイドである MFPAの蛍光プローブの合成を行った。MFPA は脳内のグルタミン酸受容体 (GluR) に作用し、強力な神経脱分極活性を示すことが知られている。GluR は記憶の形成に関与すると考えられており、この受容体の詳細な研究がアルツハイマー型認知症やてんかんなどの発症メカニズムの解明につながると期待できる。また、強力なMFPAに蛍光プローブ機能を付与することで細胞や生体内での動態解明が期待できる。
まず、MFPA のピロリジン環上の 3, 4 位の立体化学はニトロスチレンとα―ケトエステルとのキラルNi 触媒による縮合反応により立体化学を制御した。続いて、ラネーニッケル存在下にて高圧水素添加反応を行うことで、ニトロ基のアミンへの還元と、ケトンへの環化と生じたイミンへの還元が一挙に侵攻した MFPA の主骨格を構築した。さらに、ピロリジン環の 2 位を異性化後、芳香環上にアルキル側鎖をクロスカップリングにて導入し、末端にアジド基を有するプローブ前駆体を合成した。このプローブ前駆体は、アミノ酸部分を保護することなく、Huisgen 反応による TokyoGreen 誘導体および Triazapentalene 誘導体の連結が可能となった。合成した蛍光プローブはラットに対してカイニン酸と同程度の活性があることが明らかとなり、細胞の動態研究も可能にした。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (63 results)

All 2015 2014

All Journal Article (16 results) (of which Peer Reviewed: 16 results,  Acknowledgement Compliant: 4 results,  Open Access: 3 results) Presentation (47 results) (of which Int'l Joint Research: 1 results,  Invited: 5 results)

  • [Journal Article] A negative feedback loop controlling bHLH complexes is involved in vascular cell division and differentiation in the root apical meristem.2015

    • Author(s)
      Katayama, H., Iwamoto, K., Kariya, Y., Asakawa, T., Kan, T., Fukuda, H. and Ohashi-Ito, K.
    • Journal Title

      Curr. Biol.

      Volume: 25 Issue: 23 Pages: 3144-50

    • DOI

      10.1016/j.cub.2015.10.051

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Stereocontrolled Total Syntheses of Optically Active Furofuran Lignans2015

    • Author(s)
      M. Inai, R. Ishikawa, N. Yoshida, N. Shirakawa, Y. Akao, Y. Kawabe, T. Asakawa, M. Egi, Y. Hamashima, T. Kan
    • Journal Title

      Synthesis

      Volume: 47 Issue: 22 Pages: 3513-3521

    • DOI

      10.1055/s-0034-1378812

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of 2-Azahypoxanthine (AHX) Produced by the Fairy-Ring-Forming Fungus on the Growth and the Grain Yield of Rice2015

    • Author(s)
      T. Asai, J.-H. Choi, T. Ikka, K. Fushimi, N. Abe, H. Tanaka, Y. Yamakawa, H. Kobori, Y. Kiriiwa, R. Motohashi, V. K. Deo, T. Asakawa, T. Kan
    • Journal Title

      Japan Agricultural Research Quarterly: JARQ

      Volume: 49 Issue: 1 Pages: 45-49

    • DOI

      10.6090/jarq.49.45

    • NAID

      130004886284

    • ISSN
      0021-3551, 2185-8896
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3,3′,4′,5′-Tetrahydroxyflavone Induces Formation of Large Aggregates of Amyloid β Protein2014

    • Author(s)
      Hiroko Ushikubo, Yui Tanimoto, Kazuho Abe, Tomohiro Asakawa, Toshiyuki Kan Tatsuhiro Akaishi
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 37 Issue: 5 Pages: 748-754

    • DOI

      10.1248/bpb.b13-00709

    • NAID

      130004147321

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural specificity of electric potentials in the coulometric-array analysis of catechins and theaflavins2014

    • Author(s)
      Matsuura, K., Usui, Y., Kan, T., Ishii, T., and Nakayama, T.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 55 Issue: 2 Pages: 103-109

    • DOI

      10.3164/jcbn.13-101

    • NAID

      130004678427

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Total Syntheses of (+)-Sesamin and (+)-Sesaminol2014

    • Author(s)
      Ryo Ishikawa, Naoto Yoshida, Yusuke Akao, Yusuke Kawabe, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, and Toshiyuki Kan
    • Journal Title

      Chemistry Letters

      Volume: 43 Issue: 10 Pages: 1572-1574

    • DOI

      10.1246/cl.140613

    • NAID

      130004427220

    • ISSN
      0366-7022, 1348-0715
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Practical synthesis of natural plant-growth regulator 2-azahypoxanthine, its derivatives, and biotin-labeled probes2014

    • Author(s)
      Kazutada Ikeuchi, Ryosuke Fujii, Shimpei Sugiyama, Tomohiro Asakawa, Makoto Inai, Yoshitaka Hamashima, Jae-Hoon Choi, Tomohiro Suzuki, Hirokazu Kawagishi and Toshiyuki Kan
    • Journal Title

      Org. Biomol. Chem

      Volume: 12 Issue: 23 Pages: 3813-3815

    • DOI

      10.1039/c4ob00705k

    • NAID

      120005596545

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Neuroprotective effect of nobiletin on cerebral ischemia-reperfusion injury in transient middle cerebral artery-occluded rats.2014

    • Author(s)
      Yasuda N, Ishii T, Oyama D, Fukuta T, Agato Y, Sato A, Shimizu K, Asai T, Asakawa T, Kan T, Yamada S, Ohizumi Y, Oku N.
    • Journal Title

      Brain Res.

      Volume: 1559 Pages: 46-54

    • DOI

      10.1016/j.brainres.2014.02.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 2-Azahypoxanthine and Imidazole-4-carboxamide produced by the fairy-ring-forming fungus increase yields of wheat2014

    • Author(s)
      H. Tobina, J-H. Choi, T. Asai, Y. Kiriiwa, T. Asakawa, T. Kan, A. Morita, H. Kawagishi
    • Journal Title

      Field Crop Res

      Volume: 162 Pages: 6-11

    • DOI

      10.1016/j.fcr.2014.03.008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Practical Total Syntheses of Acromelic Acids A and B2014

    • Author(s)
      Hitoshi Ouchi, Aya Asahina, Tomohiro Asakawa, Makoto Inai, Yoshitaka Hamashima and Toshiyuki Kan
    • Journal Title

      Org. Lett.

      Volume: 16 Issue: 7 Pages: 1980-1980

    • DOI

      10.1021/ol500529w

    • NAID

      130005160054

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereocontrolled Total Synthesis of Hedyotol A2014

    • Author(s)
      Yusuke Kawabe, Ryo Ishikawa, Yusuke Akao, Atsushi Yoshida, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima and Toshiyuki Kan
    • Journal Title

      Org. Lett.

      Volume: 16 Issue: 7 Pages: 1976-1976

    • DOI

      10.1021/ol500524y

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enantioselective Synthesis of SB-2032072014

    • Author(s)
      Yasuo Hirooka, Kazutada Ikeuchi, Yuichiro Kawamoto, Yusuke Akao, Takumi Furuta, Tomohiro Asakawa, Makoto Inai, Toshiyuki Wakimoto, Tohru Fukuyama and Toshiyuki Kan
    • Journal Title

      Org. Lett.

      Volume: 16 Issue: 6 Pages: 1646-1646

    • DOI

      10.1021/ol5002973

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of positron emission tomography for real-time imaging of biodistribution of green tea catechin2014

    • Author(s)
      Kosuke Shimizu, Tomohiro Asakawa, Norihiro Harada, Dai Fukumoto, Hideo Tsukada, Tomohiro Asai, Shizuo Yamada, Toshiyuki Kan, and Naoto Oku
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 2 Pages: e85520-e85520

    • DOI

      10.1371/journal.pone.0085520

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The source of "fairy rings": 2-azahypoxanthine and its metabolite found in a novel purine metabolic pathway in plants2014

    • Author(s)
      J-H. Choi, T. Ohnishi, Y. Yamakawa, S. Takeda, S. Sekiguchi, W. Maruyama, K. Yamashita, T. Suzuki, A. Morita, T. Ikka, R. Motohashi, Y. Kiriiwa, H. Tobina, T. Asai, S. Tokuyama, H. Hirai, N. Yasuda, K. Noguchi, T. Asakawa, S. Sugiyama, T. Kan, H. Kawagishi
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 53 Issue: 6 Pages: 1552-1555

    • DOI

      10.1002/anie.201308109

    • NAID

      120006727084

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Practical synthesis of kainoids : a new chemical probe precursor and a fluorescent probe2014

    • Author(s)
      Sasaki, S.; Suzuki, H.; Ouchi, H.; Asakawa, T.; Inai, M.; Sakai, R.; Shimamoto, K.; Hamashima, Y.; Kan, T.
    • Journal Title

      Org Lett

      Volume: 16 Issue: 2 Pages: 564-7

    • DOI

      10.1021/ol403434e

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthetic Studies of Fisetin, Myricetin and Nobiletin Analogs and Related Probe Molecules2014

    • Author(s)
      Aiki Hiza, Yuta Tsukaguchi, Takahiro Ogawa, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, and Toshiyuki Kan
    • Journal Title

      HETEROCYCLES

      Volume: 88 Issue: 2 Pages: 1371-1371

    • DOI

      10.3987/com-13-s(s)107

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Practical synthesis of natural plant-growth regulator 2-azahypoxanthine, its derivatives, and biotin-labeled probes2015

    • Author(s)
      Kazutada Ikeuchi
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Hawaii
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ソホラフラバノン H の合成研究2015

    • Author(s)
      村松義浩
    • Organizer
      第46回中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      三重
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 第46回中部化学関係学協会支部連合秋季大会2015

    • Author(s)
      後藤篤実
    • Organizer
      第46回中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      三重
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] テアデノール A 及び B の全合成2015

    • Author(s)
      稲井誠
    • Organizer
      第41回反応と合成の進歩シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2015-11-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 機能解明を指向した植物成長調整化合物の合成研究2015

    • Author(s)
      藤井涼介
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部 合同学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-11-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] プリンセピンの合成研究2015

    • Author(s)
      吉田直人
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部 合同学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-11-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] ドウモイ酸の合成研究2015

    • Author(s)
      大八木悠
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部 合同学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-11-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] フェアリー化合物の代謝産物に関する生物有機化学的研究2015

    • Author(s)
      松崎信生
    • Organizer
      第57回天然有機化合物討論会
    • Place of Presentation
      神奈川
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] カイノイド蛍光プローブの合成研究2015

    • Author(s)
      新宅彩也加
    • Organizer
      第61日本薬学会東海支部総会・大会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] フロフラン天然物の合成研究2015

    • Author(s)
      白川奈菜
    • Organizer
      第61日本薬学会東海支部総会・大会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] フロフラン天然物の合成研究2015

    • Author(s)
      白川奈菜
    • Organizer
      新規素材探索研究会 第14回セミナー
    • Place of Presentation
      横浜
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] カイノイド蛍光プローブの合成研究2015

    • Author(s)
      新宅彩也加
    • Organizer
      新規素材探索研究会 第14回セミナー
    • Place of Presentation
      横浜
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] テアデノール A 及び B の全合成2015

    • Author(s)
      稲井誠
    • Organizer
      有機合成シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] アクロメリン酸 A,B の全合成2015

    • Author(s)
      浅川倫宏
    • Organizer
      次世代を担う有機化学シンポジウム
    • Place of Presentation
      滋賀
    • Year and Date
      2015-05-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 潜在的対称性に注目した生理活性天然物の全合成2014

    • Author(s)
      菅敏幸
    • Organizer
      平成26年度日本化学会東海支部地区講演会
    • Place of Presentation
      静岡
    • Year and Date
      2014-12-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] MFPAの短段階合成と蛍光プローブ化2014

    • Author(s)
      佐々木真吾,鈴木寛人,大内仁志,稲井誠,浅川倫宏,酒井隆一,島本啓子,濱島義隆,菅敏幸
    • Organizer
      第 40 回反応と合成の進歩シンポジウム
    • Place of Presentation
      宮城
    • Year and Date
      2014-11-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヘジオトール A の合成研究2014

    • Author(s)
      石川諒,河辺佑介,吉田直人,稲井誠,浅川倫宏,濱島義隆,菅敏幸
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部 合同学術大会 2014
    • Place of Presentation
      静岡
    • Year and Date
      2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] スギヒラタケの毒成分プローブ分子を目指した合成研究2014

    • Author(s)
      野田和宏,吉野友美,鈴木智大,河岸洋和,浅川倫宏,稲井誠,江木正浩,菅敏幸
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部 合同学術大会 2014
    • Place of Presentation
      静岡
    • Year and Date
      2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Stereocontrolled Total Synthesis of Teadenols A and B2014

    • Author(s)
      Hitoshi Ouchi, Ryunosuke Yoshida, Aya Asahina, Atsushi Yoshida, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
    • Organizer
      The 2nd International Conference on Pharma-Food
    • Place of Presentation
      静岡
    • Year and Date
      2014-11-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Synthetic Study on Furofuran Lignans2014

    • Author(s)
      Ryo Ishikawa, Yusuke Kawabe, Yusuke Akao, Atsushi Yoshida, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
    • Organizer
      The 2nd International Conference on Pharma-Food
    • Place of Presentation
      静岡
    • Year and Date
      2014-11-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Practical Synthesis of Nobiletin and its PET Imaging Study2014

    • Author(s)
      Tomohiro Asakawa, Aiki Hiza, Yuta Tsukaguchi, Makoto Inai, Yoshitaka Hamashima, Toshiyuki Kan
    • Organizer
      The 2nd International Conference on Pharma-Food
    • Place of Presentation
      静岡
    • Year and Date
      2014-11-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Efficient Synthesis of Catechin Probe and its Molecular Dynamics2014

    • Author(s)
      Toshiyuki Kan, Tomohiro Asakawa, Kosuke Shimizu, Norihiro Harada, Hideo Tsukada, Makoto Inai, Masahiro Egi, Yoshitaka Hamashima, Naoto Oku
    • Organizer
      The 2nd International Conference on Pharma-Food
    • Place of Presentation
      静岡
    • Year and Date
      2014-11-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Probe Molecule Synthesis based on Total Synthesis of Natural Product2014

    • Author(s)
      Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Hirokazu Kawagishi, Toshiyuki Kan
    • Organizer
      The 3rd International Symposium on Chemical Biology of Natural Products
    • Place of Presentation
      大阪
    • Year and Date
      2014-10-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] アクロメリン酸A, Bの全合成2014

    • Author(s)
      大内仁志,朝比奈彩,浅川倫宏,稲井誠,濱島義隆,菅敏幸
    • Organizer
      第56回天然有機化合物討論会
    • Place of Presentation
      高知
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Hedyotol Aの全合成2014

    • Author(s)
      稲井誠,河辺佑介,石川諒,吉田直人,赤尾祐介,吉田篤史,浅川倫宏,濱島義隆,菅敏幸
    • Organizer
      第 44 回 複素環化学討論会
    • Place of Presentation
      札幌
    • Year and Date
      2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Practical Synthesis of Nobiletin and its PET Imaging Study2014

    • Author(s)
      Tomohiro Asakawa, Aiki Hiza, Yuta Tsukaguchi, Makoto Inai, Yoshitaka Hamashima, Toshiyuki Kan
    • Organizer
      The XXVIIth International Conference on Polyphenols & The 8th Tannin Conference
    • Place of Presentation
      名古屋
    • Year and Date
      2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Efficient Synthesis of Catechin Probe and its Molecular Dynamics2014

    • Author(s)
      Toshiyuki Kan, Tomohiro Asakawa, Kosuke Shimizu, Norihiro Harada, Hideo Tsukada, Makoto Inai, Masahiro Egi, Yoshitaka Hamashima, Naoto Oku
    • Organizer
      The XXVIIth International Conference on Polyphenols & The 8th Tannin Conference
    • Place of Presentation
      名古屋
    • Year and Date
      2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Synthetic Studies of Tea Polyphenols and its Probes2014

    • Author(s)
      Yusuke Kawabe, Atsushi Yoshida, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
    • Organizer
      The XXVIIth International Conference on Polyphenols & The 8th Tannin Conference
    • Place of Presentation
      名古屋
    • Year and Date
      2014-09-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Stereocontrolled Total Synthesis of Teadenols A and B2014

    • Author(s)
      Makoto Inai, Ryunosuke Yoshida, Aya Asahina, Atsushi Yoshida, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
    • Organizer
      The XXVIIth International Conference on Polyphenols & The 8th Tannin Conference
    • Place of Presentation
      名古屋
    • Year and Date
      2014-09-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Synthetic Study on Furofuran Lignans2014

    • Author(s)
      Ryo Ishikawa, Yusuke Kawabe, Yusuke Akao, Atsushi Yoshida, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
    • Organizer
      The XXVIIth International Conference on Polyphenols & The 8th Tannin Conference
    • Place of Presentation
      名古屋
    • Year and Date
      2014-09-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Synthetic Investigation on Natural Products from Mushroom2014

    • Author(s)
      Toshiyuki Kan
    • Organizer
      ITbM-RCMS-IGER Seminar
    • Place of Presentation
      名古屋
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 効率的カテキンプローブ合成を基盤とする動態解析2014

    • Author(s)
      菅敏幸
    • Organizer
      農芸化学会北海道東北支部例会
    • Place of Presentation
      北海道
    • Year and Date
      2014-08-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Synthetic Study on Heterocyclic Natural Products2014

    • Author(s)
      Toshiyuki Kan
    • Organizer
      Applied Chemistry Lecture, Changchun Institute of Applied Chemistry, Chinese Academy of Science
    • Place of Presentation
      Chaina
    • Year and Date
      2014-08-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] フロフラン天然物の合成研究2014

    • Author(s)
      吉田直人, 河辺佑介, 石川諒,稲井誠,浅川倫宏,濱島義隆,菅敏幸
    • Organizer
      創薬懇話会 2014 in 岐阜
    • Place of Presentation
      岐阜
    • Year and Date
      2014-07-10 – 2017-07-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] MFPAの短段階合成と蛍光プローブ化2014

    • Author(s)
      大八木悠,佐々木真吾,鈴木寛人,大内仁志,稲井誠,浅川倫宏,濱島義隆,菅敏幸
    • Organizer
      創薬懇話会 2014 in 岐阜
    • Place of Presentation
      岐阜
    • Year and Date
      2014-07-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 植物成長因子のプローブ合成研究2014

    • Author(s)
      藤井涼介,池内和忠,稲井誠,浅川倫宏,江木正浩,濱島義隆,崔宰熏,河岸洋和,菅敏幸
    • Organizer
      創薬懇話会 2014 in 岐阜
    • Place of Presentation
      岐阜
    • Year and Date
      2014-07-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] MFPAの短段階合成と蛍光プローブ化2014

    • Author(s)
      大八木悠,佐々木真吾,鈴木寛人,大内仁志,稲井誠,浅川倫宏,酒井隆一,島本啓子,濱島義隆,菅敏幸
    • Organizer
      第 60 回日本薬学会東海支部総会・大会
    • Place of Presentation
      三重
    • Year and Date
      2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 植物成長因子のプローブ合成研究2014

    • Author(s)
      藤井涼介,池内和忠,稲井誠,浅川倫宏,江木正浩,濱島義隆,崔宰熏,河岸洋和,菅敏幸
    • Organizer
      第 60 回日本薬学会東海支部総会・大会
    • Place of Presentation
      三重
    • Year and Date
      2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] フロフラン天然物の合成研究2014

    • Author(s)
      吉田直人,河辺佑介,石川諒, 稲井誠,浅川倫宏,濱島義隆,菅敏幸
    • Organizer
      第 60 回日本薬学会東海支部総会・大会
    • Place of Presentation
      三重
    • Year and Date
      2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 興味深い生物活性を有する天然物の合成研究2014

    • Author(s)
      稲井誠
    • Organizer
      第49回 天然物化学談話会
    • Place of Presentation
      岡山
    • Year and Date
      2014-07-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 効率的カテキンプローブ合成を基盤とする動態解析2014

    • Author(s)
      菅敏幸
    • Organizer
      化学生態学研究会
    • Place of Presentation
      北海道
    • Year and Date
      2014-06-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ヘジオトール A の合成研究2014

    • Author(s)
      石川諒,河辺佑介,赤尾祐介,吉田篤史,稲井誠,浅川倫宏,濱島義隆,菅敏幸
    • Organizer
      新規素材探索研究会 第13回セミナー
    • Place of Presentation
      横浜
    • Year and Date
      2014-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 植物成長因子のプローブ合成研究2014

    • Author(s)
      藤井涼介,池内和忠,稲井誠,浅川倫宏,江木正浩,濱島義隆,崔宰熏,河岸洋和,菅敏幸
    • Organizer
      新規素材探索研究会 第13回セミナー
    • Place of Presentation
      横浜
    • Year and Date
      2014-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Teadenol A 及び B の全合成2014

    • Author(s)
      稲井誠,吉田龍之介,朝比奈彩,吉田篤史,浅川倫宏,濱島義隆,菅敏幸
    • Organizer
      新規素材探索研究会 第13回セミナー
    • Place of Presentation
      横浜
    • Year and Date
      2014-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] アクロメリン酸 A, B の全合成2014

    • Author(s)
      大内仁志,浅川倫宏,稲井誠,濱島義隆,菅敏幸
    • Organizer
      新規素材探索研究会 第13回セミナー
    • Place of Presentation
      横浜
    • Year and Date
      2014-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] カイノイドの合成とプローブ分子化2014

    • Author(s)
      稲井誠,濱島義隆,菅敏幸
    • Organizer
      新学術領域研究「天然物ケミカルバイオロジー~分子標的と活性制御~」 第 6 回公開シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2014-05-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Hedyotol A の全合成2014

    • Author(s)
      河辺佑介,石川諒,吉田直人,赤尾祐介,吉田篤史,稲井誠,浅川倫宏,濱島義隆,菅敏幸
    • Organizer
      第12回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi