Novel Chiral Bifunctional Heterogeneous Catalysts for Asymmetric Tandem Reactions
Publicly Offered Research
| Project Area | Advanced Molecular Transformations by Organocatalysts |
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| Project/Area Number |
26105711
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ユー ウージン 東京大学, 理学(系)研究科(研究院), 助教 (70626077)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | heterogeneous catalysis / organocatalysis / asymmetric catalysis / aerobic oxidation / metal nanoparticles / aerobic oxidaiton |
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| Outline of Annual Research Achievements |
Over the fiscal year, we have been investigating the fabrication of a chiral heterogeneous bifunctional catalyst that is capable of performing an asymmetric tandem oxidation process (TOP). We were able to combine gold/palladium nanoparticles (NPs) with a polymer-supported chiral phosphoric acid (CPA) catalyst, and this composite material possessed the capacity to catalyze the sequential aerobic oxidation-asymmetric aza-Friedel Crafts reaction. We were able to perform this asymmetric TOP to obtain various chiral piperazines in high yields and enantioselectivites. In addition, we were able to recover and reuse the heterogeneous several times without significant loss in yields and enantioselectivites.
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| Research Progress Status |
27年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
27年度が最終年度であるため、記入しない。
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Report
(2 results)
Research Products
(4 results)
