相同染色体対合に必要な非コードRNAが動的クロマチン構造と相互作用する仕組み

• Project Area: Dynamic chromatin structure and function
• Project/Area Number: 26116511
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University
• Principal Investigator: 平岡 泰 大阪大学, 生命機能研究科, 教授 (10359078)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
• Keywords: 染色体

Outline of Annual Research Achievements

私たちは、分裂酵母の減数分裂において、非コードRNA であるmeiRNAが染色体の特定の部位sme2遺伝子座に蓄積し、減数分裂に必須な相同染色体の対合に寄与することを発見した。本研究は、染色体上のsme2遺伝子座に蓄積したmeiRNAの結合タンパク質を同定し、その役割を理解することによって、クロマチン機能における非コードRNAの機能を明らかにすることを目的とする。
平成26年度までに、GFP融合タンパク質ライブラリを利用してmeiRNAと共局在する因子を検索し、相同染色体の対合に影響を与えるものをいくつか同定した。この中には、RNAのポリＡ付加に関与する因子群が含まれた。平成27年度は、ゲノムワイドに約100kbp間隔でlacOリピート配列を挿入した一群の細胞株を作成し、この一群の細胞株を活用して、生細胞イメージングを行ったところ、meiRNA共局在因子が染色体上の特定の領域に結合することを明らかにした（未発表）。
また高分解能でクロマチン構造を観察するために、超分解能顕微鏡法として3D-SIM (3次元Structured Illumination Microscope)を用い、分裂酵母の減数分裂期の染色体をトレースすることを実現した。コヒーシンなどの変異体でクロマチン構造をイメージングすると共に、sme2遺伝子座の対合への影響を解析し、コヒーシンが作るクロマチン構造が相同染色体対合に必須であることを示した(Ding et al., 投稿中)。また3D-SIMを用いて、分裂酵母のテロメア近傍の高度に凝縮したクロマチン構造や、クロマチンの軸となる新規な構造を明らかにした。これらの成果は論文としてNature Communication 誌およびScientific Reports誌に掲載された(Matsuda et al., 2015；Poonperm et al., 2015)。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Uniquely designed nuclear structures of lower eukaryotes (2016)
  • Author(s): Masaaki Iwamoto, Yasushi Hiraoka, Tokuko Haraguchi
  • Journal Title: Current Opinion in Cell Biology Volume: 40 Pages: 66-73
  • DOI: 10.1016/j.ceb.2016.02.019
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing. (2016)
  • Author(s): Tashiro S, Handa T, Matsuda A, Ban T, Takigawa T, Miyasato K, Ishii K, Kugou K, Ohta K, Hiraoka Y, Masukata H, Kanoh J.
  • Journal Title: Nature Commun. Volume: 7 Issue: 1 Pages: 10393-10393
  • DOI: 10.1038/ncomms10393
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Histone H3K36 trimethylation is essential for multiple silencing mechanism in fission yeast. (2016)
  • Author(s): Shota Suzuki, Hiroaki Kato, Yutaka Suzuki, Yuji Chikashige, Yasushi Hiraoka, Hiroshi Kimura, Koji Nagao, Chikashi Obuse, Shinya Takahata and Yota Murakami
  • Journal Title: Nucleic Acids Research Volume: 44 (9) Issue: 9 Pages: 4147-4162
  • DOI: 10.1093/nar/gkw008
  • NAID: 120005819302
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Virtual nuclear envelope breakdown and its regulators in fission yeast meiosis (2016)
  • Author(s): Asakawa H, Yang H, Hiraoka Y, Haraguchi T.
  • Journal Title: Front. Cell Dev. Volume: 4 Pages: 1-8
  • DOI: 10.3389/fcell.2016.00005
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A nucleoporin that facilitates meiotic kinetochore reorganization (2016)
  • Author(s): Yang H-J, Haraguchi T, Hiraoka Y
  • Journal Title: Cell Cycle Volume: 15 Issue: 3 Pages: 307-308
  • DOI: 10.1080/15384101.2015.1125237
  • Peer Reviewed / Open Access
• [Journal Article] Cellular economy in fission yeast cells continuously cultured with limited nitrogen resources (2015)
  • Author(s): Yuji Chikashige, Shinichi Arakawa, Kenji Leibnitz, Chihiro Tsutsumi, Chie Mori, Hiroko Osakada, Masayuki Murata, Tokuko Haraguchi, Yasushi Hiraoka
  • Journal Title: Scientific Reports Volume: 5 Issue: 1
  • DOI: 10.1038/srep15617
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Nup132 modulates meiotic spindle attachment in fission yeast by regulating kinetochore assembly. (2015)
  • Author(s): Yang H-J, Asakawa H, Haraguchi T, Hiraoka Y.
  • Journal Title: J. Cell Biol. Volume: 211 Issue: 2 Pages: 295-308
  • DOI: 10.1083/jcb.201501035
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Fission yeast meets a legend in Kobe: report of the Eighth International Fission Yeast Meeting. (2015)
  • Author(s): Asakawa H, Yamamoto TG, Hiraoka Y.
  • Journal Title: Genes Cells Volume: 20 Issue: 12 Pages: 967-971
  • DOI: 10.1111/gtc.12307
  • Peer Reviewed / Open Access
• [Journal Article] Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation (2015)
  • Author(s): Megumi Tsuchiya, Shin Isogai, Hiroaki Taniguchi, Hidehito Tochio, Masahiro Shirakawa, Ken-ichirou Morohashi, Yasushi Hiraoka, Tokuko Haraguchi & Hidesato Ogawa
  • Journal Title: Scientific Report Volume: 5 Issue: 1 Pages: 14498-14498
  • DOI: 10.1038/srep14498
  • NAID: 120005820894
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The nuclear pore complex acts as a master switch for nuclear and cell differentiation (2015)
  • Author(s): Masaaki Iwamoto, Yasushi Hiraoka, Tokuko Haraguchi
  • Journal Title: Communicative and Integrative Biology Volume: 8 Issue: 4 Pages: e1056950-e1056950
  • DOI: 10.1080/19420889.2015.1056950
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Histone H4 acetylation required for chromatin decompaction during DNA replication (2015)
  • Author(s): Ruan K, Yamamoto TG, Asakawa H, Chikashige Y, Kimura H, Masukata H, Haraguchi T, Hiraoka Y.
  • Journal Title: Sci Rep Volume: 5 Issue: 1 Pages: 1-10
  • DOI: 10.1038/srep12720
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Highly condensed chromatins are formed adjacent to subtelomeric and decondensed silent chromatin in fission yeast. (2015)
  • Author(s): Matsuda A, Chikashige Y, Ding DQ, Ohtsuki C, Mori C, Asakawa H, Kimura H, Haraguchi T, Hiraoka Y.
  • Journal Title: Nature Communication Volume: 6 Issue: 1 Pages: 1-12
  • DOI: 10.1038/ncomms8753
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Chromosome Scaffold is a Double-Stranded Assembly of Scaffold Proteins. (2015)
  • Author(s): Poonperm R, Takata H, Hamano T, Matsuda A, Uchiyama S, Hiraoka Y, Fukui K
  • Journal Title: Sci. Rep. Volume: 5 Issue: 1 Pages: 11916-11916
  • DOI: 10.1038/srep11916
  • NAID: 120006995010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Recent advancements in structured-illumination microscopy toward live-cell imaging. (2015)
  • Author(s): Hirano Y, Matsuda A, Hiraoka Y
  • Journal Title: Microscopy (Oxf) Volume: 64 Issue: 4 Pages: 237-249
  • DOI: 10.1093/jmicro/dfv034
  • Peer Reviewed / Open Access
• [Journal Article] Uncleavable Nup98-Nup96 is functional in the fission yeast Schizosaccharomyces pombe (2015)
  • Author(s): Haruhiko Asakawa, Chie Mori, Chizuru Ohtsuki, Masaaki Iwamoto, Yasushi Hiraoka, Tokuko Haraguchi
  • Journal Title: FEBS Open Bio Volume: 5 Issue: 1 Pages: 508-514
  • DOI: 10.1016/j.fob.2015.06.004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] BAF is a cytosolic DNA sensor that leads to exogenous DNA avoiding autophagy. (2015)
  • Author(s): Kobayashi,S., Koujin, T., Kojidani, T., Osakada, H., Mori, C., Hiraoka, Y., Haraguchi, T.
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 印刷中 Issue: 22 Pages: 7027-7032
  • DOI: 10.1073/pnas.1501235112
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Biased assembly of the nuclear pore complex is required for somatic and germline nuclear differentiation in Tetrahymena (2015)
  • Author(s): Masaaki Iwamoto, Takako Koujin, Hiroko Osakada, Chie Mori, Tomoko Kojidani, Atsushi Matsuda, Haruhiko Asakawa, Yasushi Hiraoka, Tokuko Haraguchi
  • Journal Title: Journal of Cell Science Volume: 128 Pages: 1812-1823
  • DOI: 10.1242/jcs.167353
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Fission Yeast Scp3 Potentially Maintains Microtubule Orientation through Bundling (2015)
  • Author(s): Ozaki K, Chikashige Y, Hiraoka Y, Matsumoto T.
  • Journal Title: PLoS One Volume: 10 Issue: 3 Pages: e0120109-e0120109
  • DOI: 10.1371/journal.pone.0120109
  • NAID: 120005745675
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Meiotic nuclear movements in fission yeast are regulated by the transcription factor Mei4 downstream of a Cds1-dependent replication checkpoint pathway. (2014)
  • Author(s): Ruan K, Yamamoto TG, Asakawa H, Chikashige Y, Masukata H, Haraguchi T, Hiraoka Y.
  • Journal Title: Genes Cells Volume: 20 Issue: 3 Pages: 160-172
  • DOI: 10.1111/gtc.12207
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A method of correlative light and electron microscopy for yeast cells (2014)
  • Author(s): Asakawa H, Hiraoka Y, Haraguchi T
  • Journal Title: Micron Volume: 61 Pages: 53-61
  • DOI: 10.1016/j.micron.2014.02.007
  • Peer Reviewed / Open Access
• [Journal Article] Chromosomes Rein Back the Spindle Pole Body during Horsetail Movement in Fission Yeast Meiosis (2014)
  • Author(s): Yuji Chikashige, Miho Yamane, Kasumi Okamasa, Chie Mori, Noriko Fukuta, Atsushi Matsuda, Tokuko Haraguchi, Yasushi Hiraoka
  • Journal Title: Cell Structure and Function Volume: 39 Issue: 2 Pages: 93-100
  • DOI: 10.1247/csf.14007
  • NAID: 130004053902
  • ISSN: 0386-7196, 1347-3700
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Roles for inner nuclear membrane proteins Lem2 and Bqt4 in chromosome organization (2015)
  • Author(s): Yasushi Hiraoka
  • Organizer: 4th International Symposium of the Mathematics on Chromatin Live Dynamics
  • Place of Presentation: 広島市国際青年会館（広島県・広島市）
  • Year and Date: 2015-12-07
  • Int'l Joint Research / Invited
• [Presentation] Chromosomes and nuclear structures in fission yeast (2015)
  • Author(s): Yasushi Hiraoka
  • Organizer: Cold Spring Harbor Laboratory Meeting “Cell Biology of Yeasts”
  • Place of Presentation: Cold Spring Harbor（USA）
  • Year and Date: 2015-11-03
  • Int'l Joint Research / Invited
• [Presentation] Role for the fission yeast Lem2 protein in chromosome segregation and genome stability (2015)
  • Author(s): Yasushi Hiraoka
  • Organizer: Nuclear Transport Meeting
  • Place of Presentation: Sant Feliu de Guixols (Spain)
  • Year and Date: 2015-09-20
  • Int'l Joint Research / Invited
• [Presentation] A Role of Chromatin-Nuclear Membrane Protein Interaction on the Nuclear Envelope Assembly (2015)
  • Author(s): Tokuko Haraguchi, Shouhei Kobayashi, Takako Koujin, Hiroko Osakada,Tomoko Kojidani, Chie Mori, Yasushi Hiraoka
  • Organizer: International Symposium on Chromatin Structure, Dynamics, and Function
  • Place of Presentation: 淡路島夢舞台国際会議場（兵庫県・淡路市）
  • Year and Date: 2015-08-25
  • Int'l Joint Research
• [Presentation] Chromosome Segregation is Impaired by Loss of Lem2 (2015)
  • Author(s): Yoshie Tange, Yuji Chikashige, Yasuhiro Hirano, Tokuko Haraguchi, Yasushi Hiraoka
  • Organizer: International Symposium on Chromatin Structure, Dynamics, and Function
  • Place of Presentation: 淡路島夢舞台国際会議場（兵庫県・淡路市）
  • Year and Date: 2015-08-25
  • Int'l Joint Research / Invited
• [Presentation] Highly condensed chromatins are formed adjacent to subtelomeric and decondensed silent chromatin in fission yeast (2015)
  • Author(s): Atsushi Matsuda, Tokuko Haraguchi, Yasushi Hiraoka
  • Organizer: International Symposium on Chromatin Structure, Dynamics, and Function
  • Place of Presentation: 淡路島夢舞台国際会議場（兵庫県・淡路市）
  • Year and Date: 2015-08-24
  • Int'l Joint Research
• [Presentation] Nup132 modulates meiotic spindle attachment in fission yeast by regulating kinetochore reassembly (2015)
  • Author(s): Hui-Ju Yang, Haruhiko Asakawa, Tokuko Haraguchi, Yasushi Hiraoka
  • Organizer: 8th International Fission Yeast Meeting
  • Place of Presentation: 生田神社会館（兵庫県・神戸市）
  • Year and Date: 2015-06-25
  • Int'l Joint Research
• [Presentation] Shugoshin forms a specialized chromatin domain at subtelomeres, repressing transcription and replication (2015)
  • Author(s): Sanki Tashiro, Tetsuya Handa, Atsushi Matsuda, Takuto Ban, Toru Takigawa, Kazumi Miyasato, Kojiro Ishii, Kazuto Kugou, Kunihiro Ohta, Yasushi Hiraoka, Hisao Masukata, Junko Kanoh
  • Organizer: 8th International Fission Yeast Meeting
  • Place of Presentation: 生田神社会館（兵庫県・神戸市）
  • Year and Date: 2015-06-24
  • Int'l Joint Research
• [Presentation] Chromosome segregation is impaired by loss of LEM-domain nuclear membrane protein Lem2 (2015)
  • Author(s): Yasushi Hiraoka, Yoshie Tange, Yuji Chikashige, Tokuko Haraguchi
  • Organizer: 8th International Fission Yeast Meeting
  • Place of Presentation: 生田神社会館（兵庫県・神戸市）
  • Year and Date: 2015-06-24
  • Int'l Joint Research / Invited
• [Presentation] Super-resolution microscopy reveals highly condensed chromatin adjacent to subtelomeric, decondensed silent chromatin (2015)
  • Author(s): Atsushi Matsuda, Tokuko Haraguchi, Yasushi Hiraoka
  • Organizer: 8th International Fission Yeast Meeting
  • Place of Presentation: 生田神社会館（兵庫県・神戸市）
  • Year and Date: 2015-06-24
  • Int'l Joint Research
• [Presentation] Replication timing control by telomere-adjacent nuclear localization in fission yeast (2015)
  • Author(s): Hisao Masukata, Yuta Nakamura, Hidesato Ogawa, Haruhiko Asakawa Tatsuro S Takahashi, Takuro Nakagawa, Yasushi Hiraoka, Shiho Ogawa
  • Organizer: 8th International Fission Yeast Meeting
  • Place of Presentation: 生田神社会館（兵庫県・神戸市）
  • Year and Date: 2015-06-22
  • Int'l Joint Research / Invited
• [Presentation] Actin-dependent redistribution of lipid droplets confers the stress resistance of a yeast ascospore (2015)
  • Author(s): Yang HJ, Kojidani T, Osakada H, Asakawa H, Haraguchi T, Hiraoka Y
  • Organizer: Cold Spring Harbor Asia Conferences “Lipid Metabolism and Human Metabolic Disorders”
  • Place of Presentation: Suzhou (China)
  • Year and Date: 2015-06-04
  • Int'l Joint Research
• [Presentation] Roles for the inner nuclear membrane in genome stability (2015)
  • Author(s): 平岡 泰
  • Organizer: 蛋白研セミナー “Nuclear organization and actin-dependent mechanisms in genome stability”
  • Place of Presentation: 大阪大学蛋白質研究所（大阪府・吹田市）
  • Year and Date: 2015-05-18
  • Invited
• [Presentation] 相同染色体対合に必要な非コード RNAが動的クロマチン構造と相互作用する仕組み (2015)
  • Author(s): 平岡 泰
  • Organizer: クロマチン動構造第３回班会議
  • Place of Presentation: ルスツリゾート（北海道・虻田郡）
  • Year and Date: 2015-05-09
• [Presentation] Nup132 modulates monopolar spindle attachment through regulating outer kinetochore disassembly at meiotic prophase (2014)
  • Author(s): Yang H-J, Asakawa H, Haraguchi T, Hiraoka Y.
  • Organizer: 第32回染色体ワークショップ・第13回核ダイナミクス研究会
  • Place of Presentation: 安芸グランドホテル、広島県
  • Year and Date: 2014-12-16
• [Presentation] BAF による外来DNA のオートファジー回避 (2014)
  • Author(s): 小林 昇平, 荒神 尚子, 糀谷 知子, 小坂田 裕子, 森 知栄, 平岡 泰, 原口 徳子
  • Organizer: 第32回染色体ワークショップ・第13回核ダイナミクス研究会
  • Place of Presentation: 安芸グランドホテル、広島県
  • Year and Date: 2014-12-16
• [Presentation] 分裂酵母の核膜孔複合体蛋白質Nup131, Nup132の機能解析 (2014)
  • Author(s): 淺川東彦, Hui-ju Yang, 大槻千鶴, 糀谷知子, 森知栄, 小坂田裕子, 長尾恒治, 小布施力史, 平岡泰, 原口徳子
  • Organizer: 第32回染色体ワークショップ・第13回核ダイナミクス研究会
  • Place of Presentation: 安芸グランドホテル、広島県
  • Year and Date: 2014-12-16
• [Presentation] A role for chromosomal RNA bodies in fission yeast meiosis (2014)
  • Author(s): 丁 大橋、原口 徳子、平岡 泰
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜、神奈川県
  • Year and Date: 2014-11-27
• [Presentation] 分裂酵母減数分裂期前期染色体構造の解析 (2014)
  • Author(s): 丁 大橋、松田 厚志、原口 徳子、平岡 泰
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜、神奈川県
  • Year and Date: 2014-11-26
• [Presentation] 繊毛虫の大核と小核を分ける核膜孔複合体の構造と機能 (2014)
  • Author(s): 岩本 政明、荒神 尚子、小坂田 裕子、森 知栄、平岡 泰、原口 徳子
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜、神奈川県
  • Year and Date: 2014-11-25
• [Presentation] 細胞内導入人工ビーズで明らかになったクロマチン-核膜タンパク質相互作用の役割 (2014)
  • Author(s): 原口 徳子, 小林 昇平, 荒神 尚子, 小坂田 裕子, 糀谷 知子, 森 知栄, 平岡 泰
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都国際会館、京都府
  • Year and Date: 2014-10-18
• [Presentation] 核膜形成における核膜タンパク質とクロマチンの動的相互作用の役割 (2014)
  • Author(s): 原口 徳子, 小林 昇平, 荒神 尚子, 小坂田 裕子, 糀谷 知子, 森 知栄, 平岡 泰
  • Organizer: 第52回日本生物物理学会年会
  • Place of Presentation: 札幌コンベンションセンター、北海道
  • Year and Date: 2014-09-26
• [Presentation] 塩濃度変化に対する天然クロマチンファイバーの高次構造変化の直接観察 (2014)
  • Author(s): 小穴 英廣, 西川 香里, 松原 央達, 山本 歩, 山本 孝治, 原口 徳子, 平岡 泰, 鷲津 正夫
  • Organizer: 第52回日本生物物理学会年会
  • Place of Presentation: 札幌コンベンションセンター、北海道
  • Year and Date: 2014-09-26
• [Presentation] テトラヒメナのヒストン修飾の観察 (2014)
  • Author(s): 丸山顕史、岩本政明、平岡泰、原口徳子
  • Organizer: 第6回光塾
  • Place of Presentation: 未来ICT研究所、兵庫県
  • Year and Date: 2014-09-06
• [Presentation] BAFによる外来物質のオートファジー回避 (2014)
  • Author(s): 小林昇平、荒神尚子、糀谷知子、小坂田裕子、森 知栄、平岡 泰、原口徳子
  • Organizer: 第6回光塾
  • Place of Presentation: 未来ICT研究所、兵庫県
  • Year and Date: 2014-09-06
• [Presentation] The detailed localization of meiotic cohesin subunits, REC8 and RAD21L, in mouse spermatocytes (2014)
  • Author(s): Mei R, Matsuda A, Hiraoka Y, Lee J.
  • Organizer: World Congress of Reproductive Biology 2014
  • Place of Presentation: Edinburgh, Scotland
  • Year and Date: 2014-09-04
• [Presentation] ３D imaging (2014)
  • Author(s): 平岡泰
  • Organizer: 第23回細胞生物学ワークショップ
  • Place of Presentation: 未来ICT研究所、兵庫県
  • Year and Date: 2014-08-05
• [Presentation] 蛍光顕微鏡の基礎 (2014)
  • Author(s): 平岡泰
  • Organizer: 第23回細胞生物学ワークショップ
  • Place of Presentation: 未来ICT研究所、兵庫県
  • Year and Date: 2014-08-04
• [Presentation] 相同染色体対合に必要な非コードRNAが動的クロマチン構造と相互作用する仕組み (2014)
  • Author(s): 平岡泰
  • Organizer: 新学術領域「動的クロマチン構造と機能」第2回班会議
  • Place of Presentation: 十勝サホロリゾート、北海道
  • Year and Date: 2014-07-04
• [Presentation] 繊毛虫テトラヒメナの核膜孔複合体：その構造の進化的な共通性と特殊性 (2014)
  • Author(s): 岩本政明, 小坂田裕子, 森知栄, 福田康弘, 長尾恒治, 小布施力史, 平岡泰, 原口徳子
  • Organizer: 第66回日本細胞生物学会大会
  • Place of Presentation: 奈良県新公会堂、奈良県
  • Year and Date: 2014-06-12
• [Presentation] 蛍光顕微鏡下におけるクロマチンファイバーの単離および高次構造制御 (2014)
  • Author(s): 小穴英廣, 西川香里, 松原央達, 山本歩, 山本孝治, 原口徳子, 平岡泰, 鷲津正夫
  • Organizer: 第66回日本細胞生物学会大会
  • Place of Presentation: 奈良県新公会堂、奈良県
  • Year and Date: 2014-06-12
• [Presentation] 微小核の形成・維持の仕組みの解析から明らかになった核膜の役割 (2014)
  • Author(s): 原口徳子, 荒神尚子, 小坂田裕子, 糀谷知子, 小林昇平, 舛本寛, 平岡泰
  • Organizer: 第66回日本細胞生物学会大会
  • Place of Presentation: 奈良県新公会堂、奈良県
  • Year and Date: 2014-06-11
  • Invited
• [Presentation] BAF依存的な膜集合による外来DNAのオートファジー回避 (2014)
  • Author(s): 小林昇平, 荒神尚子, 糀谷知子, 小坂田裕子, 森知栄, 平岡泰, 原口徳子
  • Organizer: 第66回日本細胞生物学会大会
  • Place of Presentation: 奈良県新公会堂、奈良県
  • Year and Date: 2014-06-11
• [Presentation] 分裂酵母における核膜孔複合体の構成と機能 (2014)
  • Author(s): 淺川東彦, Yang H-J, 山本孝治, 大槻千鶴, 近重裕次, 十川久美子, 徳永万喜洋, 岩本政明, 平岡泰, 原口徳子
  • Organizer: 第66回日本細胞生物学会大会
  • Place of Presentation: 奈良県新公会堂、奈良県
  • Year and Date: 2014-06-11
• [Presentation] Meiotic progression is impaired in a nuclear envelope tethered-Rpnll mutant (2014)
  • Author(s): Yang H-J ，Asakawa H，Ohtsuki C，Hiraoka Y.
  • Organizer: 第66回日本細胞生物学会大会
  • Place of Presentation: 奈良県新公会堂、奈良県
  • Year and Date: 2014-06-11
• [Presentation] Fine structures of meiosis-specific chromosome and homologous chromosome pairing in S. pombe (2014)
  • Author(s): Ding D-Q, Matusda A, Haraguchi T, Hiraoka Y.
  • Organizer: Gordon Research Conferences Meiosis From Meiotic Entry to Gamete Production
  • Place of Presentation: New London, USA
  • Year and Date: 2014-06-02
• [Presentation] A role for chromosomal RNA bodies as an epigenetic mark (2014)
  • Author(s): Hiraoka Y.
  • Organizer: IIAS Research Conference 2014 “Chromatin Decording”
  • Place of Presentation: International Institute for Advanced Studies, Kyoto, Japan.
  • Year and Date: 2014-05-14
  • Invited
• [Book] 新・生細胞蛍光イメージング (2015)
  • Author(s): 原口徳子・木村宏・平岡泰（編著）
  • Total Pages: 352
  • Publisher: 共立出版
• [Remarks] Hiraoka Laboratory
  • URL: http://www.fbs.osaka-u.ac.jp/labs/hiraoka/index.html
• [Patent(Industrial Property Rights)] 核酸導入促進剤 (2016)
  • Inventor(s): 小川英知、原口徳子、土屋惠、平岡泰
  • Industrial Property Rights Holder: 大阪大学、情報通信研究機構
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-006937
  • Filing Date: 2016-01-18