脂質代謝を起点としたマイクロRNA、転写因子、エピゲノムの相互作用の解明

• Project Area: Crosstalk of transcriptional control and energy pathways by hub metabolites
• Project/Area Number: 26116716
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: 尾野 亘 京都大学, 医学(系)研究科(研究院), 准教授 (00359275)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000); Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
• Keywords: マイクロRNA / 脂質代謝 / 転写因子 / エピゲノム / 骨髄 / ゲノム編集

Outline of Annual Research Achievements

1. miR-33aおよび33bとその宿主遺伝子であるSrebp2、Srebp1の生体内での役割の解明:a) 栄養状態の変化による脂質恒常性に対する検討。miR-33bノックインマウスとmiR-33a欠損マウスの交配により、miR-33aおよびmiR-33bの有無による4種類のマウスを作製することができた。miR-33a欠損マウスにおいて最もHDLコレステロールが高く、miR-33bノックインマウスでは最もHDL-Cが低下した。また、糖・脂質の基質の流れについてメタボローム解析を行った。主成分分析において、miR-33a欠損マウス、miR-33bノックインマウス、コントロールマウスの分布が分かれ、さらにその原因追求している。また、miR-33aがラフトにおけるコレステロールを上昇させ、細胞増殖に働くことを明らかとした。b)骨髄機能の変化。マイクロRNA-33a欠損マウスでの末梢血では、炎症性のLy6Chigh monocyteが減少していた。一方、骨髄内では逆にLy6Chigh monocyteは増加していた。骨髄中では造血幹細胞のアポトーシスが減少し、Ly6Chigh monocyteの増加の原因と考えられた。一方、末梢でのLy6Chigh monocyteの減少は骨髄内の単球の末梢への移送が低下しているためと考えられた。
2.脂質代謝状態の変化におけるmiR-33/Set7/H3K4メチル化の影響の解析：miR-33aがSet7の発現制御を行っていることを明らかとした。さらに解析を続けている。
3.臓器別のmiR-33a/bの機能の解析：miR-33afloxマウス、miR-33bfloxマウスを作成し、臓器別のmiR-33a/bの解析を行った。心臓の線維化については線維芽細胞のmiR-33aが原因と考えられた。さらに肝臓、神経系での機能を解析中である。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] Mayo Clinic College of Medicine/Washington University School of Medicine/Yale University School of Medicine(米国)
• [Journal Article] Emerging Novel Biomarkers for Arteriosclerosis Obliterans (2016)
  • Author(s): Horie T, Kimura T, Ono K.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 23 Issue: 2 Pages: 171-172
  • DOI: 10.5551/jat.ED028
  • NAID: 130005122030
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Age and Sex on Clinical Outcomes after Percutaneous Coronary Intervention Relative to Coronary Artery Bypass Grafting in Patients with Triple Vessel Coronary Artery Disease. (2015)
  • Author(s): Yamaji K, Shiomi H, Morimoto T, Nakatsuma K, Toyota T, Ono K, Furukawa Y, Nakagawa Y, Kadota K, Ando K, Shirai S, Onodera T, Watanabe H, Natsuaki M, Sakata R, Hanyu M, Nishiwaki N, Komiya T, Kimura T.
  • Journal Title: Circulation. Volume: 115 Pages: 020955-020955
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] microRNAs and Cardiovascular Remodeling. (2015)
  • Author(s): Ono K
  • Journal Title: Adv Exp Med Biol. Volume: 888 Pages: 197-213
  • DOI: 10.1007/978-3-319-22671-2_10
  • ISBN: 9783319226705, 9783319226712
  • Acknowledgement Compliant
• [Journal Article] Expression Patterns of miRNA-423-5p in the Serum and Pericardial Fluid in Patients Undergoing Cardiac Surgery. (2015)
  • Author(s): Miyamoto S, Usami S, Kuwabara Y, Horie T, Baba O, Hakuno D, Nakashima Y, Nishiga M, Izuhara M, Nakao T, Nishino T, Ide Y, Nakazeki F, Wang J, Ueyama K, Kimura T, Ono K.
  • Journal Title: PLoS One. Volume: 10(11) Issue: 11 Pages: e0142904-e0142904
  • DOI: 10.1371/journal.pone.0142904
  • NAID: 120005749912
  • Peer Reviewed / Open Access
• [Journal Article] microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain. (2015)
  • Author(s): Kim J, Yoon H, Horie T, Burchett JM, Restivo JL, Rotllan N, Ramírez CM, Verghese PB, Ihara M, Hoe HS, Esau C, Fernández-Hernando C, Holtzman DM, Cirrito JR, Ono K, Kim J.
  • Journal Title: J Neurosci. Volume: 35(44) Issue: 44 Pages: 14717-26
  • DOI: 10.1523/jneurosci.2053-15.2015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Influence of Sex on Long-Term Outcomes Afte Implantation of Bare-Metal Stent: A Multicenter Report From the Coronary Revascularization Demonstrating Outcome Study-Kyoto (CREDO-Kyoto) Registry Cohort-1. (2015)
  • Author(s): Yamaji K, Shiomi H, Morimoto T, Toyota T, Ono K, Furukawa Y, Nakagawa Y, Kadota K, Ando K, Shirai S, Kato M, Takatsu Y, Doi O, Kambara H, Suwa S, Onodera T, Watanabe H, Natsuaki M, Kimura T
  • Journal Title: Circulation. Volume: 132 Issue: 24 Pages: 2323-33
  • DOI: 10.1161/circulationaha.115.017168
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] MicroRNAs and High-Density Lipoprotein Cholesterol Metabolism (2015)
  • Author(s): Ono K, Horie T, Nishino T, Baba O, Kuwabara Y, Kimura T.
  • Journal Title: International Heart Journal Volume: 56 Issue: 4 Pages: 365-371
  • DOI: 10.1536/ihj.15-019
  • NAID: 130005087574
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Long-Term Outcomes After Coronary Stent Implantation in Patients Presenting With Versus Without Acute Myocardial Infarction (an Observation from Coronary Revascularization Demonstrating Outcome Study-Kyoto Registry Cohort-2). (2015)
  • Author(s): Yamaji K, Natsuaki M, Morimoto T, Ono K, Furukawa Y, Nakagawa Y, Kadota K, Ando K, Shirai S, Watanabe H, Shiomi H, Kimura T.
  • Journal Title: Am J Cardiol. Volume: 116 Issue: 1 Pages: 15-23
  • DOI: 10.1016/j.amjcard.2015.03.036
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] MicroRNA-133a in the Development of Arteriosclerosis Obliterans (2015)
  • Author(s): Ono K
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 22 Issue: 4 Pages: 342-343
  • DOI: 10.5551/jat.ED006
  • NAID: 130005066047
  • ISSN: 1340-3478, 1880-3873
  • Acknowledgement Compliant
• [Journal Article] High-density lipoprotein cholesterol levels and cardiovascular outcomes in Japanese patients after percutaneous coronary intervention: a report from the CREDO-Kyoto registry cohort-2. (2015)
  • Author(s): Izuhara M, Ono K, Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Shizuta S, Tada T, Tazaki J, Horie T, Kuwabara Y, Baba O, Nishino T, Kita T, Kimura T; CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators.
  • Journal Title: Atherosclerosis. Volume: 242(2) Issue: 2 Pages: 632-8
  • DOI: 10.1016/j.atherosclerosis.2015.05.010
  • NAID: 120005678183
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA-33a/b in Lipid Metabolism (2015)
  • Author(s): Ono K, Horie T, Nishino T, Baba O, Kuwabara Y, Yokode M, Kita T, Kimura T.
  • Journal Title: Circulation Journal Volume: 79 Issue: 2 Pages: 278-284
  • DOI: 10.1253/circj.CJ-14-1252
  • NAID: 130004927073
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Impact of Left Ventricular Outflow Tract Obstruction in Takotsubo Cardiomyopathy (2015)
  • Author(s): Kawaji T, Shiomi H, Morimoto T, Tazaki J, Imai M, Saito N, Makiyama T, Shizuta S, Ono K, Kimura T.
  • Journal Title: Circulation Journal Volume: 79 Issue: 4 Pages: 839-846
  • DOI: 10.1253/circj.CJ-14-1148
  • NAID: 130005130261
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway. (2015)
  • Author(s): Kuwabara Y, Horie T, Baba O, Watanabe S, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Otsu K, Kita T, Kimura T, Ono K.
  • Journal Title: Circulation Research Volume: 116 Issue: 2 Pages: 279-288
  • DOI: 10.1161/circresaha.116.304707
  • Peer Reviewed
• [Journal Article] Effect of Statin Therapy on Cardiovascular Outcomes after Coronary Revascularization in Patients over 80 Years of Age (2014)
  • Author(s): Natsuaki M, Morimoto T, Furukawa Y, Shiomi H, Ono K, Kimura T
  • Journal Title: Atherosclerosis Volume: 237 Issue: 2 Pages: 821-828
  • DOI: 10.1016/j.atherosclerosis.2014.10.108
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac-Specific Inhibition of Kinase Activity in Calcium/Calmodulin-Dependent Protein Kinase Kinase-β Leads to Accelerated Left Ventricular Remodeling and Heart Failure after Transverse Aortic Constriction in Mice (2014)
  • Author(s): Shin Watanabe, Takahiro Horie, Kazuya Nagao, Yasuhide Kuwabara, Osamu Baba, Hitoo Nishi, Naoya Sowa, Michiko Narazaki, Tetsuya Matsuda, Genzou Takemura, Hiromichi Wada, Koji Hasegawa, Takeshi Kimura, Koh Ono
  • Journal Title: PLoS ONE Volume: 9 Issue: 9 Pages: e108201-e108201
  • DOI: 10.1371/journal.pone.0108201
  • NAID: 120005496630
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Pre-infarction Angina Pectoris on Long-term Survival in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention (2014)
  • Author(s): Taniguchi T, Shiomi H, Toyota T, Morimoto T, Akao M, Nakatsuma K, Ono K, Makiyama T, Shizuta S, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Horie M, Kimura T.
  • Journal Title: Am J Cardiol Volume: 114 Issue: 8 Pages: 1179-1186
  • DOI: 10.1016/j.amjcard.2014.07.038
  • Peer Reviewed / Open Access
• [Journal Article] Incidence and Outcome of Surgical Procedures After Coronary Artery Bypass Grafting Compared With Those After Percutaneous Coronary Intervention (2014)
  • Author(s): Tokushige A, Shiomi H, Morimoto T, Ono K, Furukawa Y, Nakagawa Y, Kadota K, Ando K, Shizuta S, Tada T, Tazaki J, Kato Y, Hayano M, Abe M, Hamasaki S, Ohishi M, Nakashima H et al.
  • Journal Title: Circ Cardiovasc Interv. Volume: 7 Issue: 4 Pages: 482-491
  • DOI: 10.1161/circinterventions.113.001056
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo. (2014)
  • Author(s): Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Sowa N, Yahagi N, Shimano H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K.
  • Journal Title: Scientific Reports Volume: 4 Issue: 1 Pages: 5312-5312
  • DOI: 10.1038/srep05312
  • Peer Reviewed / Open Access
• [Journal Article] Anticoagulant and antiplatelet therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention. (2014)
  • Author(s): Goto K, Nakai K, Shizuta S, Morimoto T, Shiomi H, Natsaki M, Yahata M, Ota C, Ono K, Makiyama T, Nakagawa Y, Furukawa Y, Kadota K, Takatsu Y, Tamura T
  • Journal Title: Am J Cardiol. Volume: 114 Pages: 70-8
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Long-Term Efficacy and SafetyOutcomes After Unrestricted Use of Drug-Eluting Stents in Patients With AcuteCoronary Syndrome. (2014)
  • Author(s): Kawaji T, Shiomi H, Morimoto T, Tamura T, Nishikawa R, Yano M, Tazaki J, Imai M, Saito N, Makiyama T, Shizuta S, Ono K, Kimura T.
  • Journal Title: Circ J. Volume: 78 Pages: 1628-35
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Evolution in practice patterns and long-term outcomes of coronary revascularization from bare-metal stent era to drug-eluting stent era in Japan. (2014)
  • Author(s): Shiomi H, Morimoto T, Makiyama T, Ono K, Furukawa Y, Nakagawa Y, Kadota K, Onodera T, Takatsu Y, Mitsudo K, Kita T, Sakata R, Okabayashi H, Hanyu M, Komiya T, Yamazaki F, Nishiwaki N, Kimura T; CREDO-Kyoto Investigators.
  • Journal Title: Am J Cardiol. Volume: 113 Issue: 10 Pages: 1652-9
  • DOI: 10.1016/j.amjcard.2014.02.037
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] ｢miR-33a/bの生体における働きの解明と臨床応用への取り組み｣ (2016)
  • Author(s): 尾野 亘
  • Organizer: 第53回日本臨床分子医学会
  • Place of Presentation: 東京
  • Year and Date: 2016-04-15
• [Presentation] AHA-JCS Joint Symposium “Functional Importance of Immune Cells in the Heart”: MicroRNA-451 Exacerbates Lipotoxicity in Cardiomyocytes and High-Fat Diet-Induced Cardiac Hypertrophy in Mice through Suppression of the LKB1/AMPK Pathway (2016)
  • Author(s): 尾野 亘
  • Organizer: 第80回日本循環器学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
  • Invited
• [Presentation] High-density Lipoprotein Cholesterol Levels and Cardiovascular Outcomes in Japanese Patients after Percutaneous Coronary Intervention from the CREDO-Kyoto Registry Cohort-2. (2016)
  • Author(s): Masayasu Izuhara, Koh Ono, Hiroki Shiomi, Takeshi Morimoto, Yutaka Furukawa, Yoshihisa Nakagawa, Satoshi Shizuta, Tomohisa Tada, Junichi Tazaki, Takahiro Horie, Yasuhide Kuwabara, Osamu Baba, Tomohiro Nishino, Toru Kita, Takeshi Kimura
  • Organizer: 第80回日本循環器学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
• [Presentation] LincRNAs Regulated by Pressure-overload Induce Hypertrophy in Neonatal Mouse Cardiac Myocytes. (2016)
  • Author(s): Yasuhide Kuwabara, Koh Ono, Takahiro Horie, Shin Watanabe, Daihiko Hakuno, Yasuhiro Nakashima, Osamu Baba, Masayasu Izuhara, Masataka Nishiga, Shunsuke Usami, Tetsushi Nakao, Tomohiro Nishino, Yuya Ide, Fumiko Nakazeki, Satoshi Koyama, Toru Kita, Takeshi Kimura
  • Organizer: 第80回日本循環器学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
• [Presentation] Expression Patterns of miRNA-423-5p in the Serum and Pericardial Fluid in Patients Undergoing Cardiac Surgery. (2016)
  • Author(s): Shunsuke Usami, Shoichi Miyamoto, Yasuhide Kuwabara, Takahiro Horie, Osamu Baba, Daihiko Hakuno, Yasuhiro Nakashima, Masataka Nishiga, Masayasu Izuhara, Tetsushi Nakao, Tomohiro Nishino, Yuya Ide, Fumiko Nakazeki, Koji Ueyama, Takeshi Kimura, Koh Ono
  • Organizer: 第80回日本循環器学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18
• [Presentation] Serum HDL cholesterol decreases in microRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor1 (Srebf1) (2015)
  • Author(s): Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Sowa N, Nakashima Y, Hakuno D, Kimura T, Ono K.
  • Organizer: American Heart Association Annual Scientific Sessions 2015
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] High-density lipoprotein cholesterol levels and cardiovascular outcomes in Japanese patients after percutaneous coronary intervention: A report from the CREDO-Kyoto registry cohort-2. (2015)
  • Author(s): Izuhara M, Ono K, Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Shizuta S, Tada T, Tazaki J, Horie T, Kuwabara Y, Baba O, Nishino T, Kita T, Kimura T; CREDO-Kyoto PCI/CABG Registry Cohort-2Investigators.
  • Organizer: American Heart Association Annual Scientific Sessions 2015
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] 桑原康秀、堀江貴裕、馬場理、出原正康、宇佐美俊輔、西賀雅隆、西野共達、北徹、木村剛、尾野亘 (2015)
  • Author(s): マウス大動脈縮窄モデルにより増加するlincRNAはマウス心筋細胞において心肥大を誘導する
  • Organizer: 第19回 日本心不全学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-10-22
• [Presentation] ｢microRNA-33a/bの脂質代謝における働き｣ (2015)
  • Author(s): 尾野 亘
  • Organizer: 動脈硬化Update 2015
  • Place of Presentation: 東京
  • Year and Date: 2015-09-05
  • Invited
• [Presentation] Organ memory achieved by the interaction of miR-33a/b and SREBP2/1 (2015)
  • Author(s): 尾野 亘
  • Organizer: “臓器の記憶”国際シンポジウム2015
  • Place of Presentation: 東京
  • Year and Date: 2015-08-23
  • Int'l Joint Research / Invited
• [Presentation] MicroRNA-451 Aggravates Lipotoxic Cardiomyopathy through Suppression of the LKB1/AMPK Pathway. (2015)
  • Author(s): Yasuhide Kuwabara, Takahiro Horie, Osamu Baba, Toru Kita, Takeshi Kimura, Koh Ono.
  • Organizer: Basic Cardiovascular Sciences 2015
  • Place of Presentation: New Orleans, Louisiana, USA
  • Year and Date: 2015-07-13
  • Int'l Joint Research
• [Presentation] 心血管疾患の創薬分子標的と再生・発生｢脂質恒常性維持におけるマイクロRNA-33の働き｣ (2015)
  • Author(s): 尾野 亘
  • Organizer: 第1回J-ISCP学術集会
  • Place of Presentation: 京都
  • Year and Date: 2015-06-21
  • Invited
• [Presentation] 脂質代謝を起点としたmicroRNA-33a/bの作用の解明 (2015)
  • Author(s): 尾野 亘、堀江貴裕、桑原康秀、馬場 理、西野共達、中尾哲史、西賀雅隆、木村 剛
  • Organizer: 生命素子による転写環境とエネルギー代謝のクロストーク制御｢転写代謝システム｣ 平成27年度 領域班会議
  • Place of Presentation: 熊本
  • Year and Date: 2015-06-14
• [Presentation] シンポジウム25 脂質代謝研究の最前線 「microRNA-33a/bによる細胞・臓器レベルの脂質代謝制御機構」 (2015)
  • Author(s): 尾野 亘
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 下関
  • Year and Date: 2015-05-23
  • Invited
• [Presentation] ①プレナリーセッション: Future Perspective in Atherosclerosis Research: Seeking for Novel Therapeutic Targets against Cardiovascular Diseases ‘miR-33a/b as novel therapeutic targets for the treatment of cardiovascular diseases’ (2015)
  • Author(s): 尾野 亘
  • Organizer: 第79回日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24
  • Invited
• [Presentation] Kuwabara Y, Ono K, Horie T, Baba O, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Ide Y, Nakazeki F, Koyama S, Kita T, Kimura T (2015)
  • Author(s): MicroRNA-451 is Involved in Diabetic Cardiomyopathy through LKB1/AMPK Pathwa
  • Organizer: 第79回日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24
• [Presentation] microRNA-451はLKB1-AMPK経路を抑制することで、ラット心筋細胞において細胞障害を、生体においては高脂肪食誘導性心肥大を誘導する (2015)
  • Author(s): 桑原康秀、堀江貴裕、馬場理、出原正康、宇佐美俊輔、中尾哲史、西賀雅隆、西野共達、北徹、木村剛、尾野亘
  • Organizer: 第52回 日本臨床分子医学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2015-04-10
• [Presentation] 高血圧における臓器連関 ｢miR-33a/bによる細胞・臓器レベルの脂質代謝制御機構｣ (2015)
  • Author(s): 尾野 亘
  • Organizer: 第44回日本心脈管作動物質学会
  • Place of Presentation: 高松
  • Year and Date: 2015-02-07
  • Invited
• [Presentation] Microrna-33, Located Within Srebf2 Intron, Regulate Fatty Acid Synthesis via Targeting SREBP-1 in vivo (2014)
  • Author(s): 1)Nishino T, Horie T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Ide Y, Nakazeki F, Koyama S, Yokode M, Kita T, Kimura T, Ono K.
  • Organizer: American Heart Association Annual Scientific Sessions 2014
  • Place of Presentation: Chicago
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] MicroRNA-33b Knock-in Mice for an Intron of Sterol Regulatory Element-Binding Factor 1 (Srebf1) Exhibit Reduced HDL-C in vivo (2014)
  • Author(s): 2)Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Ide Y, Nakazeki F, Koyama S, Yokode M, Kita T, Kimura T, Ono K.
  • Organizer: American Heart Association Annual Scientific Sessions 2014
  • Place of Presentation: Chicago
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Self-rating Depression Scale Score as an Inverse and Independent Predictor of Successful Smoking Cessation with a Pharmacological Treatment for Nicotine Addiction (2014)
  • Author(s): 3)Wada H, Satoh-Asahara N, Akao M, Abe M, Ono K, Morimoto M, Shimatsu A, Takahashi Y, Hasegawa K.
  • Organizer: American Heart Association Annual Scientific Sessions 2014
  • Place of Presentation: Chicago
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Serum HDL-C decreases in microRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1). (2014)
  • Author(s): Horie T, Nishino T, Baba O, Kuwabara Y, Nakano T, Nishiga M, Usami S, Izuhara M, Kimura T, Ono K.
  • Organizer: 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
  • Place of Presentation: Kyoto
  • Year and Date: 2014-09-12 – 2014-09-14
• [Presentation] MicroRNA-33 deficiency reduces atherosclerotic plaque progression in apoE knockout mice. (2014)
  • Author(s): Baba O, Horie T, Ono K, Kuwabara Y, Sowa N, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T.
  • Organizer: 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
  • Place of Presentation: Kyoto
  • Year and Date: 2014-09-12 – 2014-09-14
• [Presentation] MicroRNA-451 is involved in diabetic cardiomyopathy through suppression of the LKB1/AMPK pathway. (2014)
  • Author(s): Kuwabara Y, Horie T, Baba O, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Kita T, Kimura T, Ono K.
  • Organizer: 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
  • Place of Presentation: Kytoto
  • Year and Date: 2014-09-12 – 2014-09-14
• [Presentation] MicroRNA-33, embedded in Srebf2 intron, regulate fatty acid synthesis through targeting SREBP-1 in vivo. (2014)
  • Author(s): Nishino T, Horie T, Baba O, Kuwabara Y, YOkode M, Kita T, Kimura T, Ono K.
  • Organizer: 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
  • Place of Presentation: Kyoto
  • Year and Date: 2014-09-12 – 2014-09-14
• [Presentation] MicroRNA-33, embedded in Srebf2 intron, regulate fatty acid synthesis through targeting SREBP-1 in vivo. (2014)
  • Author(s): Nishino T, Horie T, Baba O, Kuwabara Y, YOkode M, Kita T, Kimura T, Ono K.
  • Organizer: European Society of Cardiology Congress 2014
  • Place of Presentation: Barcerona
  • Year and Date: 2014-08-30 – 2014-09-04
• [Presentation] MicroRNA-33 deficiency leads to high fat diet- induced obesity and insulin resistance in vivo. (2014)
  • Author(s): Horie T, Nishino T, Baba O, Kuwabara Y, Nakano T, Nishiga M, Usami S, Izuhara M, Kimura T, Ono K.
  • Organizer: European Society of Cardiology Congress 2014
  • Place of Presentation: Barcerona
  • Year and Date: 2014-08-30 – 2014-09-04
• [Presentation] 第9回五島雄一郎賞受賞講演 ｢High impact of microRNA-33 on atherosclerosis and lipid metabolism｣ (2014)
  • Author(s): 尾野 亘
  • Organizer: 第46回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-11
  • Invited
• [Presentation] Featured Session：最先端の病態研究 ｢microRNA-33の動脈硬化・脂質制御における役割｣ (2014)
  • Author(s): 尾野 亘
  • Organizer: 第46回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-10
  • Invited
• [Presentation] MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein-2 (Srebp2) regulates Srebp1 in vivo. (2014)
  • Author(s): Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Hasegawa K, Kume N Yokode M, Kita T, Kimura T, Ono K.
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Kyoto
  • Year and Date: 2014-04-14
• [Presentation] MicroRNA-33 deficiency reduces atherosclerotic plaque progression in apoE knockout mice. (2014)
  • Author(s): Baba O, Horie T, Kuwabara Y, Chujo Y, Watanabe S, Kinoshita M, Horiguchi M, Nakamura T, Chonabayashi K, Hishizawa M, Hasegawa K, Kume N Yokode M, Kita T, Kimura T, Ono K.
  • Organizer: The 18th International Vascular Biology Meeting
  • Place of Presentation: Kyoto
  • Year and Date: 2014-04-14
• [Presentation] SREBP-2のイントロンに存在するマイクロRNA-33はSREBP-1の発現を制御する (2014)
  • Author(s): 堀江貴裕
  • Organizer: 第51回日本臨床分子医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-11
• [Presentation] icroRNA-451はLKB1-AMPK経路を抑制することで、ラット心筋細胞において細胞障害を、生体においては高脂肪食誘導性心肥大を誘導する (2014)
  • Author(s): 桑原康秀
  • Organizer: 第51回日本臨床分子医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-11
• [Presentation] アポE欠損マウスにおいてマイクロRNA-33欠損は動脈硬化進展を抑制する (2014)
  • Author(s): 馬場 理
  • Organizer: 第51回日本臨床分子医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-11
• [Book] ｢生活習慣病とmiRNA｣ 実験医学 ノンコーディングRNAテキストブック (2015)
  • Author(s): 尾野 亘
  • Total Pages: 251
  • Publisher: 羊土社
• [Book] Annual Review 循環器2014 (2014)
  • Author(s): 尾野 亘
  • Total Pages: 315
  • Publisher: 中外医学社
• [Remarks] 心血管疾患分子機構解明グループ
  • URL: http://kyoto-u-cardio.jp/kisokenkyu/metabolic/
• [Remarks] 京都大学循環器内科 心血管疾患分子機構解明グループ
  • URL: http://kyoto-u-cardio.jp/kisokenkyu/metabolic/