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慢性的エネルギー飢餓環境におけるDNA脱メチル化経路を介したがん転移機構の解明

Publicly Offered Research

Project AreaCrosstalk of transcriptional control and energy pathways by hub metabolites
Project/Area Number 26116722
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKumamoto University

Principal Investigator

尾池 雄一  熊本大学, 大学院生命科学研究部 (医), 教授 (90312321)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Keywordsがん微小環境 / 転移 / エピゲノム / DNA脱メチル化 / ヒストン修飾
Outline of Annual Research Achievements

がん原発巣におけるがん細胞のエピゲノム変化と転移との関連解明実験において、腫瘍微小環境においてがん細胞で発現誘導されるDNA脱メチル化酵素が、解糖系関連酵素遺伝子の発現誘導に関与していることを見出した。現在、DNA脱メチル化酵素をノックダウンしたがん細胞株を用いた移植実験を実施しており、がん原発巣における低酸素環境がDNA脱メチル化酵素を介したエピゲノム変化やこれに伴う細胞代謝の変化を引き起こし、がん細胞の増殖や生存に寄与している可能性を検討している。移植前のがん細胞と移植後に肺転移したがん細胞間で細胞代謝を比較したところ、肺転移したがん細胞では、解糖系が亢進していることを見出した。さらに、移植前のがん細胞に比べ移植後に肺転移したがん細胞では解糖系関連酵素遺伝子の発現が亢進していることが明らかとなった。そこで、肺転移したがん細胞における解糖系関連酵素遺伝子の発現亢進のメカニズムを検討したところ、肺転移した骨肉腫細胞ではMEK-ERK-HIF経路が活性化し、細胞代謝が解糖系にシフトしていることが明らかとなった。また、移植前のがん細胞と移植後に肺転移したがん細胞をそれぞれ経静脈的にマウスに投与し、肺におけるがん細胞の増殖を検討すると、移植前のがん細胞ではほとんど増殖が認められないのに対し、肺転移したがん細胞では肺組織における増殖が認められた。以上より、原発巣におけるがん細胞のエピゲノム変化とこれに伴う細胞代謝変化が転移したがん細胞においても記憶として維持され、その増殖や生存に寄与している可能性が示唆された。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(56 results)

All 2016 2015 2014 Other

All Journal Article (20 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 20 results,  Acknowledgement Compliant: 15 results,  Open Access: 16 results) Presentation (23 results) (of which Int'l Joint Research: 1 results,  Invited: 21 results) Book (12 results) Remarks (1 results)

  • [Journal Article] Angiopoietin-like protein 2 increases renal fibrosis by accelerating transforming growth factor-β signaling in chronic kidney disease.2016

    • Author(s)
      Jun Morinaga, Tsuyoshi Kadomatsu, Keishi Miyata, Motoyoshi Endo, Kazutoyo Terada, Zhe Tian, Taichi Sugizaki, Hiroki Tanigawa, Jiabin Zhao, Shunshun Zhu, Michio Sato, Kimi Araki, Ken-ichi Iyama, Kengo Tomita, Masashi Mukoyama, Kimio Tomita, Kenichiro Kitamura, Yuichi Oike
    • Journal Title

      Kidney Int

      Volume: 89 Pages: 327-341

    • DOI

      10.1016/j.kint.2015.12.021

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Excess Lymphangiogenesis Cooperatively Induced by Macrophages and CD4D T Cells Drives the Pathogenesis of Lymphedema2016

    • Author(s)
      Ogata F
    • Journal Title

      J Invest Dermatol

      Volume: 136 Pages: 706-714

    • DOI

      10.1016/j.jid.2015.12.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Angiopoietin-like protein 2 is a multistep regulator of inflammatory neovascularization in a murine model of age-related macular degeneration.2016

    • Author(s)
      M. Hirasawa, K. Takubo, H. Osada, S. Miyake, E. Toda, M. Endo, K. Umezawa, K. Tsubota, Y. Oike and Y. Ozawa
    • Journal Title

      J Biol Chem.

      Volume: 291 Pages: 7373-7385

    • DOI

      10.1074/jbc.m115.710186

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Persistent activation of cGMP-dependent protein kinase by a nitrated cyclic nucleotide via site specific protein S-guanylation2016

    • Author(s)
      Akashi S, Ahmed KA, Sawa T, Ono K, Tsutsuki H, Burgoyne JR, Ida T, Horio E, Prysyazhna O, Oike Y, Rahaman MM, Eaton P, Fujii S, Akaike T.
    • Journal Title

      Biochemistry.

      Volume: 55 Pages: 751-61

    • DOI

      10.1021/acs.biochem.5b00774

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Angiopoietin-like protein 2 promotes inflammatory conditions in the ligamentum flavum in the pathogenesis of lumbar spinal canal stenosis by activating interleukin-6 expression.2015

    • Author(s)
      Nakamura T, Okada T, Endo M, Nakamura T, Oike Y & Mizuta H.
    • Journal Title

      Eur Spine J

      Volume: 24 Pages: 2001-2009

    • DOI

      10.1007/s00586-015-3835-z

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The exacerbating roles of CCAAT/enhancer-binding protein homologous protein (CHOP) in the development of bleomycin-induced pulmonary fibrosis and the preventive effects of tauroursodeoxycholic acid (TUDCA) against pulmonary fibrosis in mice.2015

    • Author(s)
      Tanaka Y, Ishitsuka Y, Hayasaka M, Yamada Y, Miyata K, Endo M, Kondo Y, Moriuchi H, Irikura M, Tanaka K, Mizushima T, Oike Y, Irie T.
    • Journal Title

      Pharmacological Research

      Volume: 99 Pages: 52-62

    • DOI

      10.1016/j.phrs.2015.05.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ANGPTL2 increases bone metastasis of breast cancer cells through enhancing CXCR4 signaling.2015

    • Author(s)
      Masuda T, Endo M, Yamamoto Y, Odagiri H, Kadomatsu T, Nakamura T, Tanoue H, Ito H, Yugami M, Miyata K, Morinaga J, Horiguchi H, Motokawa I, Terada K, Morioka MS, Manabe I, Iwase H, Mizuta H, Oike Y.
    • Journal Title

      Sci. Rep.

      Volume: 5 Pages: 9170-9170

    • DOI

      10.1038/srep09170

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Muscle-liver-fat signaling axis is essential for central control of adaptive adipose remodeling2015

    • Author(s)
      Shimizu N, Maruyama T, Yoshikawa N, Matsumiya R, Ma Y, Ito N, Tasaka Y, Kuribara-Souta A, Miyata K, Oike Y, Berger S, Schutz G, Takeda S & Tanaka H
    • Journal Title

      Nat Commun.

      Volume: - Pages: 6693-6693

    • DOI

      10.1038/ncomms7693

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs protein translation and contributes to myopathy in mice and humans.2015

    • Author(s)
      Wei FY, Zhou B, Suzuki T, Miyata K, Ujihara Y, Horiguchi H, Takahashi N, Xie P, Michiue H, Fujimura A, Kaitsuka T, Matsui H, Koga Y, Mohri S, Suzuki T, Oike Y, Tomizawa K.
    • Journal Title

      Cell Metabolism

      Volume: 21 Pages: 428-42

    • DOI

      10.1016/j.cmet.2015.01.019

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] IRAP deficiency attenuates diet-induced obesity in mice through increased energy expenditure.2015

    • Author(s)
      Niwa M, Numaguchi Y, Ishii M, Kuwahata T, Kondo M, Shibata R, Miyata K, Oike Y, Murohara T.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 457(1) Pages: 12-18

    • DOI

      10.1016/j.bbrc.2014.12.071

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiopoietin-like protein 2 renders colorectal cancer cells resistant to chemotherapy by activating spleen tyrosine kinase-phosphoinositide 3-kinase-dependent anti-apoptotic signaling.2014

    • Author(s)
      Horiguchi H, Endo M, Miyamoto Y, Sakamoto Y, Odagiri H, Masuda T, Kadomatsu T, Tanoue H, Motokawa I, Terada K, Morioka MS, Manabe I, Baba H, Oike Y.
    • Journal Title

      Cancer Sci

      Volume: 105 Pages: 1550-1559

    • DOI

      10.1111/cas.12554

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Protection afforded by pre- or post-treatment with 4-phenylbutyrateagainst liver injury induced by acetaminophen overdose in mice2014

    • Author(s)
      Daisuke Shimizua, Yoichi Ishitsuka, Keishi Miyata, Yoshiro Tomishima, Yuki Kondo, Mitsuru Irikura, Takao Iwawaki, Yuichi Oike, Tetsumi Irie
    • Journal Title

      Pharmacol Res.

      Volume: 87 Pages: 26-41

    • DOI

      10.1016/j.phrs.2014.06.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.2014

    • Author(s)
      Sato H, Taketomi Y, Ushida A, Isogai Y, Kojima T, Hirabayashi T, Miki Y, Yamamoto K, Nishito Y, Kobayashi T, Ikeda K, Taguchi R, Hara S, Ida S, Miyamoto Y, Watanabe M, Baba H, Miyata K, Oike Y, Gelb MH, Murakami M.
    • Journal Title

      Cell Matabolism

      Volume: 20 Pages: 119-132

    • DOI

      10.1016/j.cmet.2014.05.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Diverse roles of ANGPTL2 in physiology and pathophysiology.2014

    • Author(s)
      Kadomatsu T, Endo M, Miyata K, Oike Y.
    • Journal Title

      Trends Endocrinol. Metab.

      Volume: 25(5) Pages: 245-254

    • DOI

      10.1016/j.tem.2014.03.012

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tissue Inhibitor of Metalloproteinase-3 Knockout Mice Exhibit Enhanced Energy Expenditure through Thermogenesis2014

    • Author(s)
      Hanaoka Y, Yasuda O, Soejima H, Miyata K, Yamamoto E, Izumiya Y, Maeda N, Ohishi M, Rakugi H, Oike Y, Kim-Mitsuyama S, Ogawa H
    • Journal Title

      PLoS One.

      Volume: 9

    • DOI

      10.1371/journal.pone.0094930

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] TMEM65 is a mitochondrial inner-membrane protein.2014

    • Author(s)
      Naotaka Nishimura, Tomomi Gotoh, Yuichi Oike, Masato Yano
    • Journal Title

      Peer J.

      Volume: 2

    • DOI

      10.7717/peerj.349

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.2014

    • Author(s)
      Yoshizawa T, Karim Md. F, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Kakeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K.
    • Journal Title

      Cell metab

      Volume: 9 Pages: 712-21

    • DOI

      10.1016/j.cmet.2014.03.006

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions.2014

    • Author(s)
      Swain L, Wottawa M, Oike Y, et al.
    • Journal Title

      J. Leukoc. Biol.

      Volume: 96 Pages: 365-375

    • DOI

      10.1189/jlb.2hi1013-533r

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum ANGPTL2 levels reflect clinical features of breast cancer patients: implications for the pathogenesis of breast cancer metastasis.2014

    • Author(s)
      Endo M, Yamamoto Y, Nakano M, Masuda T, Odagiri H, Horiguchi H, Miyata K, Kadomatsu T, Motokawa I, Okada S, Iwase H, Oike Y.
    • Journal Title

      Int. J. Biol. Markers

      Volume: 印刷中 Pages: 0-0

    • DOI

      10.5301/jbm.5000080

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression.2014

    • Author(s)
      Horio E, Kadomatsu T, Miyata K, Arai Y, Hosokawa K, Doi Y, et al.
    • Journal Title

      Arterioscler. Thromb. Vasc. Biol.

      Volume: 34 Pages: 790-800

    • DOI

      10.1161/atvbaha.113.303116

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 生活習慣病の分子基盤解明と治療戦略~健康寿命延伸に挑む~2016

    • Author(s)
      尾池 雄一
    • Organizer
      糖尿病と肥満における最新知見
    • Place of Presentation
      名古屋市
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Introduction for Cutting Edge in Advanced Genomic Medicine to Elucidate the Molecular Basis of the Cardiovascular System: From Development to Disease2016

    • Author(s)
      尾池 雄一
    • Organizer
      第80回日本循環器学会学術集会 シンポジウム21 「最新ゲノム医学から探る心血管システムの分子基盤~発生から病態まで~」
    • Place of Presentation
      東北大学百周年記念会館(宮城県仙台市青葉区)
    • Year and Date
      2016-03-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 生活習慣病・がんの共通分子機構とSASPとしてのアンジオポエチン様因子2シグナル2015

    • Author(s)
      門松 毅、尾池 雄一
    • Organizer
      BMB2015(第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(神戸市中央区)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] がんと心血管疾患の共通分子基盤解明2015

    • Author(s)
      尾池 雄一
    • Organizer
      脳心血管抗加齢研究会 2015 シンポジウム3「炎症・免疫応答を機軸とした癌・血管病の000新規治療
    • Place of Presentation
      梅田スカイビル(大阪市北区大淀中)
    • Year and Date
      2015-11-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Tumor dell-derived Angiopoietin-like protein 2 is a crucial driver of metastasis2015

    • Author(s)
      Endo M & Oike Y
    • Organizer
      2015 Annual Meeting of Vascular Science & Medicine Organization Session II " Tumor Angiogenesis and Metastasis"
    • Place of Presentation
      MBC Samjoo Art Hall (韓国釜山)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生活習慣病とがんの共通分子病態~健康長寿社会実現化を目指して~2015

    • Author(s)
      尾池 雄一
    • Organizer
      東北エイジングサミット ―加齢制御研究から臨床まで―
    • Place of Presentation
      仙台国際センター(宮城県仙台市青葉区)
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 生活習慣病の分子基盤解明と治療戦略~健康長寿社会実現へ向けて~2015

    • Author(s)
      尾池 雄一
    • Organizer
      第4回 MetS Forum 徳島 ~メタボリックシンドロームの克服に向けて~
    • Place of Presentation
      ホテルクレメント徳島(徳島市寺島本町西)
    • Year and Date
      2015-08-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] がん組織内血管代謝ニッシェによる分子記憶形成とがん病態進展の分子機構The mechanisms of tumor progression through molecular memory constituted by vasculo-metabolic niche in tumor tissue2015

    • Author(s)
      尾池 雄一
    • Organizer
      ”臓器の記憶” 国際シンポジウム2015
    • Place of Presentation
      東京コンベンションホール(東京都中央区京橋)
    • Year and Date
      2015-08-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Role of ANGPTL2 in Obesity/Diabetes and Cardiovascular Diseases2015

    • Author(s)
      尾池 雄一
    • Organizer
      第9回 Hypertension and Metabolic Syndrome Symposium
    • Place of Presentation
      ヒルトン大阪(大阪市北区梅田)
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 心血管病の分子病態解明~健康長寿社会を目指して~2015

    • Author(s)
      尾池 雄一
    • Organizer
      第2回仙台先進循環器研究会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-06-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 慢性的エネルギー飢餓環境におけるDNA脱メチル化経路を介したがん転移機構の解明2015

    • Author(s)
      尾池 雄一
    • Organizer
      新学術領域「転写代謝システム」2015領域班会議
    • Place of Presentation
      菊南温泉 ユウベルホテル(熊本市)
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] 生活習慣病とがんの共通分子病態~健康長寿社会を目指して~2015

    • Author(s)
      尾池 雄一
    • Organizer
      第78回神奈川県内科医学会集談会共催セミナー
    • Place of Presentation
      横須賀市医師会館 大会議室(横須賀市新港町)
    • Year and Date
      2015-02-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] アンジオポエチン様因子と生活習慣関連疾患2014

    • Author(s)
      尾池 雄一
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      シーガイアコンベンションホール(宮崎県宮崎市山崎町)
    • Year and Date
      2014-10-24 – 2014-10-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Role of ANGPTL2 in obesity and insulin resistance2014

    • Author(s)
      尾池 雄一
    • Organizer
      ICDM2014 (International Conference on Diabetes and Metabolism)
    • Place of Presentation
      KINTEX Exhibition Center Ⅱ, Gyeonggido, Korea(京畿道高陽市, 韓国)
    • Year and Date
      2014-10-16 – 2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis2014

    • Author(s)
      尾池 雄一
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市西区みなとみらい)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 生体恒常性とその変容による疾患発症の分子機構解明~健康長寿社会を目指して~2014

    • Author(s)
      尾池 雄一
    • Organizer
      第七回香川脳心腎GOCR研究会
    • Place of Presentation
      リーガホテルゼスト高松 3階 「ダイヤモンド」(高松市古新町)
    • Year and Date
      2014-08-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Diverse roles of ANGPTL2 signaling in physiology and patho-physiology2014

    • Author(s)
      尾池 雄一
    • Organizer
      Taishan Academic Forum on Cancer & Immune Signaling Pathways And First Session Stem Cell Immunology Qilu International Forum
    • Place of Presentation
      Dongshan Hotel Building 6, Yantai,China (烟台市,中国)
    • Year and Date
      2014-08-09 – 2014-08-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 慢性的エネルギー飢餓環境におけるDNA脱メチル化経路を介したがん転移機構の解明2014

    • Author(s)
      尾池 雄一
    • Organizer
      文部科学省 科学研究費補助金「新学術領域研究」平成23年度~27年度 生命素子による転写環境とエネルギー代謝のクロストーク制御(転写代謝システム)ー班会議ー
    • Place of Presentation
      仙台 秋保温泉 岩沼屋(宮城県仙台市太白区秋保町湯元字薬師)
    • Year and Date
      2014-07-11 – 2014-07-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] アンジオポエチン様因子2による生体の恒常性維持と疾患2014

    • Author(s)
      尾池 雄一
    • Organizer
      第35回日本炎症・再生医学会
    • Place of Presentation
      万国津梁館(沖縄県名護市喜瀬)
    • Year and Date
      2014-07-01 – 2014-07-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 心血管病の分子病態 ~慢性炎症の観点から~2014

    • Author(s)
      尾池 雄一
    • Organizer
      千葉心血管病研究会 2014
    • Place of Presentation
      ホテル ザ・マンハッタン 2階「ルーナ」(千葉市美浜区ひび野)
    • Year and Date
      2014-06-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 生体恒常性維持機構とアンチエイジング2014

    • Author(s)
      尾池 雄一
    • Organizer
      第14回日本抗加齢医学会総会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市北区中之島)
    • Year and Date
      2014-06-06 – 2014-06-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] アンジオポエチン様因子の観点からインスリン抵抗性の分子基盤を考える2014

    • Author(s)
      尾池 雄一
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪国際会議場(10F Room 1003)(大阪府大阪市北区中之島)
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Metabolic alterations in the tumor microenvironment accelerates tumor cell invasivity and metastasis through epigenetic regulation of ANGPTL22014

    • Author(s)
      尾池 雄一
    • Organizer
      第18回国際血管生物学会
    • Place of Presentation
      京都みやこめっせ(京都府京都市左京区岡崎成勝寺町)
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Book] Thyroid Cancer Explore 2(1)2016

    • Author(s)
      遠藤元誉、尾池雄一
    • Total Pages
      6
    • Publisher
      メディカルレビュー社
    • Related Report
      2015 Annual Research Report
  • [Book] 膨大なデータを徹底整理する サイトカイン・増殖因子キーワード事典2015

    • Author(s)
      門松 毅、尾池雄一
    • Total Pages
      3
    • Publisher
      洋土社
    • Related Report
      2015 Annual Research Report
  • [Book] series モデル動物利用マニュアル 疾患モデルの作製と利用 脂質代謝異常と関連疾患 下巻2015

    • Author(s)
      宮田敬士、尾池雄一
    • Total Pages
      8
    • Publisher
      エル・アイ・シー
    • Related Report
      2015 Annual Research Report
  • [Book] series モデル動物利用マニュアル 疾患モデルの作製と利用-脂質代謝異常と関連疾患 下巻2015

    • Author(s)
      尾池雄一
    • Total Pages
      2
    • Publisher
      エル・アイ・シー
    • Related Report
      2015 Annual Research Report
  • [Book] 血管医学 16(4)2015

    • Author(s)
      門松毅、尾池雄一
    • Total Pages
      8
    • Publisher
      メディカルレビュー社
    • Related Report
      2015 Annual Research Report
  • [Book] 別冊 BIO Clinica 慢性炎症と疾患「慢性炎症制御による加齢関連疾患治療の展望」 Perspectives of therapeutic strategy for age-related disease by modulating chronic inflammation 4(2)2015

    • Author(s)
      門松毅、尾池雄一
    • Total Pages
      7
    • Publisher
      北隆館 ニュー・サイエンス社
    • Related Report
      2015 Annual Research Report
  • [Book] Inflamm Regen 352015

    • Author(s)
      Oike Y, Kadomatsu T & Endo M.
    • Total Pages
      10
    • Publisher
      日本炎症・再生医学会
    • Related Report
      2015 Annual Research Report
  • [Book] Inflamm Regen 352015

    • Author(s)
      Oike Y
    • Total Pages
      10
    • Publisher
      日本炎症・再生医学会
    • Related Report
      2015 Annual Research Report
  • [Book] 産科と婦人科 Vol.82(2)2015

    • Author(s)
      遠藤 元誉,尾池 雄一
    • Total Pages
      106
    • Publisher
      診断と治療社
    • Related Report
      2014 Annual Research Report
  • [Book] 医学のあゆみ Vol.250(9)2015

    • Author(s)
      門松 毅, 尾池 雄一
    • Total Pages
      251
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2014 Annual Research Report
  • [Book] series モデル動物利用マニュアル 疾患モデルの作製と利用-脂質代謝異常と関連疾患 上巻2015

    • Author(s)
      尾池 雄一, 佐々木 雄彦, 村上 誠, 矢作 直也
    • Total Pages
      477
    • Publisher
      株式会社エル・アイ・シー
    • Related Report
      2014 Annual Research Report
  • [Book] Medical Science Digest Vol.40(11)2014

    • Author(s)
      門松 毅, 尾池 雄一
    • Total Pages
      45
    • Publisher
      ニューサイエンス社
    • Related Report
      2014 Annual Research Report
  • [Remarks] 熊本大学大学院生命科学研究部 分子遺伝学分野

    • URL

      http://molegene.kumamoto-u.ac.jp

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-28  

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