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体内時計によるグリアネットワーク調節に注目した「精神-疼痛」連関メカニズムの解明

Publicly Offered Research

Project AreaGlial assembly: a new regulatory machinery of brain function and disorders
Project/Area Number 26117507
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKanazawa University

Principal Investigator

宝田 剛志  金沢大学, 薬学系, 助教 (30377428)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywordsグリア / Neurovascular Unit / 血液脳関門 / 時計遺伝子 / アストロサイト
Outline of Annual Research Achievements

グリア病である神経障害性疼痛は、精神的ストレスや精神疾患との関連性が臨床上指摘されている(うつを伴う慢性痛、統合失調症や自閉スペクトラム症での痛覚鈍麻など)。しかし、この「精神と疼痛(痛み)」の関連性(連関)の分子基盤は未解明である。

我々の解析結果より、睡眠障害等の精神疾患との関連性が深い体内時計システムが破綻したマウスでは、行動・疼痛機能の異常とともに、脳・脊髄組織でのアストロサイトでの異常活性化が認められる。これにより、血管周囲に存在するアストロサイト-ペリサイトアセンブリが異常をきたす可能性を提唱した。つまり、BBB恒常性は体内時計システムによるグリアネットワークの上に成り立つことを示唆するものである。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (15 results)

All 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 7 results,  Acknowledgement Compliant: 3 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Int'l Joint Research] Columbia University/The Albert Einstein College of Medicine,(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Genetic analysis of Runx2 function during intramembranous ossification.2016

    • Author(s)
      Takeshi Takarada, Ryota Nakazato, Azusa Tsuchikane, Koichi Fujikawa, Takashi Iezaki, Yukio Yoneda, Eiichi Hinoi
    • Journal Title

      Development

      Volume: 143 Pages: 211-218

    • DOI

      10.1242/dev.128793

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Upregulation of Slc38a1 gene along with promotion of neurosphere growth and subsequent neuronal specification in undifferentiated neural progenitor cells exposed to theanine.2016

    • Author(s)
      Takeshi Takarada, Masato Ogura, Noritaka Nakamichi, Takami Kakuda, Ryota Nakazato, Hiroshi Kokubo, Shinsuke Ikeno, Saki Nakamura, Takaya Kutsukake, Eiichi Hinoi and Yukio Yoneda
    • Journal Title

      Neurochem Res

      Volume: 41 Issue: 1-2 Pages: 5-15

    • DOI

      10.1007/s11064-015-1591-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Potential interactions of calcium-sensitive reagents with zinc ion in different cultured cells.2015

    • Author(s)
      Koichi Fujikawa, Ryo Fukumori, Saki Nakamura, Takaya Kutsukake, Takeshi Takarada and Yukio Yoneda
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 5 Pages: e0127421-e0127421

    • DOI

      10.1371/journal.pone.0127421

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation.2015

    • Author(s)
      Jianwen Wei, Junko Shimazu, Munevver P. Makinistoglu, Antonio Maurizi, Daisuke Kajimura, Haihong Zong, Takeshi Takarada, Takashi Iezaki, Jeffrey E. Pessin, Eiichi Hinoi and Gerard Karsenty
    • Journal Title

      Cell

      Volume: 161 Issue: 7 Pages: 1576-1591

    • DOI

      10.1016/j.cell.2015.05.029

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Daily oral intake of theanine prevents the decline of 5-bromo-2'-deoxyuridine incorporation in hippocampal dentate gyrus with concomitant alleviation of behavioral abnormalities in adult mice with severe traumatic stress.2015

    • Author(s)
      Takeshi Takarada, Noritaka Nakamichi, Takami Kakuda, Ryota Nakazato, Hiroshi Kokubo, Shinsuke Ikeno, Saki Nakamura, Eiichi Hinoi and Yukio Yoneda
    • Journal Title

      J Pharmacol Sci

      Volume: 127 Issue: 3 Pages: 292-297

    • DOI

      10.1016/j.jphs.2014.12.018

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Upregulation of runt-related transcription factor-2 through CCAAT enhancer binding protein-beta signaling pathway in microglial BV-2 cells exposed to ATP.2015

    • Author(s)
      Ryota Nakazato*, Takeshi Takarada*, Shinsuke Ikeno, Saki Nakamura, Takaya Kutsukake, Eiichi Hinoi and Yukio Yoneda *Equally contributed.
    • Journal Title

      J Cell Physiol. in press

      Volume: - Issue: 10 Pages: 2510-2521

    • DOI

      10.1002/jcp.24988

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Constitutive and functional expression of runt-related transcription factor-2 by microglial cells.2014

    • Author(s)
      Ryota Nakazato, Takeshi Takarada, Takumi Watanabe, Binh Thanh Nguyen, Shinsuke Ikeno, Eiichi Hinoi, Yukio Yoneda
    • Journal Title

      Neurochemistry International

      Volume: 74 Pages: 24-35

    • DOI

      10.1016/j.neuint.2014.04.010

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 緑茶アミノ酸テアニンによる神経系前駆細胞の機能制御2015

    • Author(s)
      宝田 剛志
    • Organizer
      生体機能と創薬シンポジウム2015
    • Place of Presentation
      千葉
    • Year and Date
      2015-08-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] The role of Runx2 in endochondral and intramembranous ossification during skeletogenesis.2015

    • Author(s)
      Takeshi Takarada
    • Organizer
      The 3rd Seoul Symposium on Bone Health
    • Place of Presentation
      Seoul (Korea)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 神経細胞毒性におけるグルタミントランスポーターSlc38a1の役割2015

    • Author(s)
      宝田 剛志、中里 亮太、中村 早希、藤川 晃一、高 巳奇、檜井 栄一、米田 幸雄
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 体内時計によるグリアネットワーク調節に注目した「精神-疼痛」連関メカニズムの解明2015

    • Author(s)
      宝田 剛志
    • Organizer
      新学術領域研究「グリアアセンブリによる脳機能発現の制御と病態」2014年度班会議
    • Place of Presentation
      東京
    • Year and Date
      2015-01-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] ミクログリア時計システムの入出力機構に関する解析2014

    • Author(s)
      宝田 剛志
    • Organizer
      包括脳ネットワーク2014年冬のシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脳梗塞後神経細胞障害におけるグルタミントランスポーターSlc38a1の役割2014

    • Author(s)
      宝田 剛志、中里 亮太、中村 早希、藤川 晃一、高 巳奇、檜井 栄一、米田 幸雄
    • Organizer
      第126回日本薬理学会近畿部会
    • Place of Presentation
      和歌山
    • Year and Date
      2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 体内時計によるグリアネットワーク調節に注目した「精神-疼痛」連関メカニズムの解明2014

    • Author(s)
      宝田 剛志
    • Organizer
      「グリアアセンブリによる脳機能発現の制御と病態」第1回夏のワークショップ
    • Place of Presentation
      京都
    • Year and Date
      2014-08-08 – 2014-08-09
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2022-01-28  

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