異なる感覚様式の記憶による行動制御と神経回路

• Project Area: Elucidation of neural computation for prediction and decision making: toward better human understanding and applications
• Project/Area Number: 26120705
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Tohoku University
• Principal Investigator: 谷本 拓 東北大学, 生命科学研究科, 教授 (70714955)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2015: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000); Fiscal Year 2014: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
• Keywords: 神経科学

Outline of Annual Research Achievements

記憶には、色や音、匂い、味、手触りといった様々な感覚成分が一体となって結びついている。これらの感覚と紐付けられた記憶は、同じ報酬や罰によって形成されるにも関わらず、それぞれの強度や性質が全く異なる。記憶によって導かれる予測価値の差異が、どのような神経メカニズムによるのかの解明は、適応的行動の発現を理解するうえで重要である。本研究では、ショウジョウバエの砂糖報酬・電気ショック罰情報と感覚情報の統合の場である脳構造キノコ体に焦点を当て、色と匂いという2つの感覚情報が処理される神経回路の比較を通じて、このような予測価値の差異が生じる要因を探った。
平成27年度は、訓練時にキノコ体の標的細胞を単一細胞レベルで機能阻害することで、視覚・嗅覚記憶における報酬・罰回路を構成するドーパミン神経をそれぞれ同定し、これらの解剖学的、行動学的な比較を行った。この結果、報酬や罰を伝達する神経細胞の機能を妨げると、嗅覚と視覚の両者ともに、連合記憶の形成に支障が生じることが確認された。すなわち、色と匂いについては独立した記憶中枢で処理されるのではなく、両者とも同じ神経回路において一括で処理されるということが明らかとなった。この成果は、Vogt et al,. eLife, 2016に代表される4編の原著論文として報告した。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] Max Planck Institute of Neurobiology/University of Munich(Germany)
• [Int'l Joint Research] HHMI Janelia Research Campus/Cold Spring Harbor Laboratory(米国)
• [Journal Article] Direct neural pathways convey distinct visual information to Drosophila mushroom bodies. (2016)
  • Author(s): Vogt K, Aso Y, Hige T, Knapek S, Ichinose T, Friedrich AB, Turner GC, Rubin GM, Tanimoto H.
  • Journal Title: eLife Volume: in press
  • DOI: 10.7554/elife.14009
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Functional dissociation in sweet taste receptor neurons between and within taste or- gans of Drosophila. (2016)
  • Author(s): Thoma V, Knapek S, Arai S, Hartl M, Kohsaka H, Sirigrivatanawong P, Abe A, Hashimoto K, Tanimoto H.
  • Journal Title: Nature Communications Volume: 7 Issue: 1 Pages: 10678-10678
  • DOI: 10.1038/ncomms10678
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reward signal in a recurrent circuit drives appetitive long-term memory formation. (2015)
  • Author(s): Ichinose T, Aso Y, Yamagata N, Abe A, Rubin GM, Tanimoto H.
  • Journal Title: eLife Volume: 4 Pages: 1-18
  • DOI: 10.7554/elife.10719
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Reversing Stimulus Timing in Visual Conditioning Leads to Memories with Opposite Valence in Drosophila. (2015)
  • Author(s): Vogt K, Yarali A, Tanimoto H.
  • Journal Title: PLoS One Volume: 10(10) Issue: 10 Pages: e0139797-e0139797
  • DOI: 10.1371/journal.pone.0139797
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Distinct dopamine neurons mediate reward signals for short- and long-term memories (2015)
  • Author(s): Yamagata N, Ichinose T, Aso Y, Placais P, Friedrich AB, Sima RJ, Preat T, Rubin GM, Tanimoto H
  • Journal Title: PNAS Volume: 112 Issue: 2 Pages: 578-583
  • DOI: 10.1073/pnas.1421930112
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014)
  • Author(s): Aso Y, Sitaraman D, Ichinose T, Kaun KR, Vogt K, Belliart-Guerin G, Placais PY, Robie AA, Yamagata N, Schnaitmann C, Rowell WJ, Johnston RM, Ngo TT, Chen N, Korff W, Nitabach MN, Heberlein U, Preat T, Branson KM, Tanimoto H, Rubin GM
  • Journal Title: Elife Volume: 4
  • DOI: 10.7554/elife.04580
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The neuronal architecture of the mushroom body provides a logic for associative learning. (2014)
  • Author(s): Aso Y, Hattori D, Yu Y, Johnston R, Iyer N, Ngo T, Dionne H, Abbott L, Axel R, Tanimoto H, Rubin G.
  • Journal Title: eLife Volume: 3
  • DOI: 10.7554/elife.04577
  • Peer Reviewed / Open Access
• [Journal Article] Shared mushroom body circuits operate visual and olfactory memories in Drosophila. (2014)
  • Author(s): Vogt K, Schnaitmann C, Dylla K, Knapek S, Aso Y, Rubin GM, Tanimoto H.
  • Journal Title: eLife Volume: 3
  • Peer Reviewed / Open Access
• [Presentation] Neural pathways for the formation, consolidation, and retrieval of memory in the fly brain. (2016)
  • Author(s): Tanimoto H.
  • Organizer: The 6th International Symposium on "Biology of Decision Making"
  • Place of Presentation: Ecole Normale Superieure & Institut du Cerveau et de la Moelle epiniere, Paris (France)
  • Year and Date: 2016-05-25
  • Int'l Joint Research / Invited
• [Presentation] Dopamine circuits and memory formation. (2015)
  • Author(s): Tanimoto H.
  • Organizer: 14th European Symposium for Insect Taste and Olfaction
  • Place of Presentation: Residence Hotel Cormoran, Cagliari (Italy)
  • Year and Date: 2015-09-20
  • Int'l Joint Research / Invited
• [Presentation] Mushroom body reward circuits. (2015)
  • Author(s): Tanimoto H.
  • Organizer: The EMBO-Kavli Workshop on Neural Circuits and Behaviour of Drosophila
  • Place of Presentation: Orthodox academy of Crete, Hania (Greece)
  • Year and Date: 2015-07-05
  • Int'l Joint Research / Invited
• [Presentation] Dopamine circuits for memory formation. (2015)
  • Author(s): Tanimoto H.
  • Organizer: 3rd Asia-Pacific Drosophila Research Conference
  • Place of Presentation: Beijing Conference Center, Beijing (China)
  • Year and Date: 2015-05-11
  • Int'l Joint Research / Invited
• [Presentation] Mashroom body circuits and memory formation. (2014)
  • Author(s): Tanimoto H.
  • Organizer: The Genetics Society Autumn Meeting 2014
  • Place of Presentation: The Royal Society, London (UK)
  • Year and Date: 2014-11-27 – 2014-11-28
  • Invited
• [Presentation] Mashroom body circuits and memory formation. (2014)
  • Author(s): Tanimoto H.
  • Organizer: Neurofly 2014
  • Place of Presentation: Convention Center Crete Maris, Crete (Greece)
  • Year and Date: 2014-10-05 – 2014-10-09
  • Invited
• [Presentation] Distinct dopamine neurons mediate reward signals for short- and long-term memories. (2014)
  • Author(s): Tanimoto H.
  • Organizer: Janelia Farm 2014 Fall Conference
  • Place of Presentation: Janelia Farm Reserch Campus, Ashburn (USA)
  • Year and Date: 2014-09-21 – 2014-09-24
  • Invited
• [Presentation] Neural circuits for memory formation. (2014)
  • Author(s): Tanimoto H.
  • Organizer: The 85th Annual Meeting of the Zoological Society of Japan
  • Place of Presentation: Tohoku University Kawauchi Campus, Sendai
  • Year and Date: 2014-09-11 – 2014-09-13
  • Invited
• [Presentation] Neural circuits for colour discrimination and learning. (2014)
  • Author(s): Tanimoto H, Vogt K, Schnaitmann C, Aso Y, Rubin GM, Wachtler T, Garbers C.
  • Organizer: 11th International Congress of Neuroethology and 36th Annual Meeting of The Japanese Society for Comparative Physiology and Biochemistry
  • Place of Presentation: Sapporo Convention Center, Sapporo
  • Year and Date: 2014-07-29 – 2014-08-01
  • Invited
• [Presentation] Functional diversity of the Drosophila mushroom body. (2014)
  • Author(s): Tanimoto H.
  • Organizer: Janelia Farm 2014 Spring Conference
  • Place of Presentation: Janelia Farm Reserch Campus, Ashburn (USA)
  • Year and Date: 2014-04-27 – 2014-05-01
  • Invited