グリアアセンブリによる脳機能発現の制御と病態

• Project Area: Glial assembly: a new regulatory machinery of brain function and disorders
• Project/Area Number: 18H05199
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Research Institution: Niigata University
• Principal Investigator: 竹林 浩秀 新潟大学, 医歯学系, 教授 (60353439)
• Co-Investigator(Kenkyū-buntansha): 小泉 修一 山梨大学, 大学院総合研究部, 教授 (10280752) ; 田中 謙二 慶應義塾大学, 医学部(信濃町), 准教授 (30329700) ; 尾崎 紀夫 名古屋大学, 医学系研究科, 教授 (40281480) ; 岡部 繁男 東京大学, 大学院医学系研究科(医学部), 教授 (60204012) ; 池中 一裕 生理学研究所, 生体機能調節研究領域, 特別協力研究員 (00144527)
• Project Period (FY): 2018-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,354,000 (Direct Cost: ¥2,580,000、Indirect Cost: ¥774,000); Fiscal Year 2018: ¥3,354,000 (Direct Cost: ¥2,580,000、Indirect Cost: ¥774,000)
• Keywords: グリアアセンブリ / 最終報告書 / グリア / 精神疾患 / 神経興奮制御 / 活動電位の伝達速度

Outline of Annual Research Achievements

事後報告書をまとめるため、研究代表者（池中）と分担者（岡部、尾崎、小泉、田中、竹林）が打ち合わせを行い、その後、メールや電話で相談した。まとめた事後報告書を文部科学省に提出し、平成３０年１０月１日に岡部、小泉、久島（尾崎代理）の３名で事後評価ヒアリングに参加し、岡部がプレゼンテーションを行なった。その結果、Aの評価を得た。その後、研究代表者を池中から竹林へと交代し、業務を滞りなく引き継いだ。事後報告書に基づき、最終報告書の冊子を作成するために本領域の計画班員、公募班員から論文業績、特許、広報などに関する情報を集め、領域の最終評価書のアウトラインを作成した。以上の情報に加え、文科省からの評価書を受領し、５年間の班会議、公開シンポジウム、若手の会などの活動状況、アウトリーチ活動、ホームページを介した広報活動などをまとめ、平成３１年２月下旬に研究代表者と研究分担者で最終報告書を校正・校了した。最終報告書を１６０部印刷し、班員および関係者に広く配布した。なお、代表論文の掲載を含んだ製本を行なうと、ページ数が増えるうえにコストもかかるため、論文業績はタイトル、著者名、雑誌名、巻、ページ番号、doiのみを表記することとした。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Mechanical regulation of oligodendrocyte morphology and maturation by the mechanosensor p130Cas (2019)
  • Author(s): Shimizu Takeshi、Osanai Yasuyuki、Tanaka Kenji F.、Thai Truc Quynh、Abe Manabu、Natsume Rie、Sakimura Kenji、Ikenaka Kazuhiro
  • Journal Title: Journal of Neurochemistry Volume: 2019 Issue: 2 Pages: 158-172
  • DOI: 10.1111/jnc.14657
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Length of myelin internodes of individual oligodendrocytes is controlled by microenvironment influenced by normal and input-deprived axonal activities in sensory deprived mouse models (2018)
  • Author(s): Osanai Yasuyuki、Shimizu Takeshi、Mori Takuma、Hatanaka Nobuhiko、Kimori Yoshitaka、Kobayashi Kenta、Koyama Shinsuke、Yoshimura Yumiko、Nambu Atsushi、Ikenaka Kazuhiro
  • Journal Title: Glia Volume: 66 Issue: 11 Pages: 2514-2525
  • DOI: 10.1002/glia.23502
  • Peer Reviewed / Open Access
• [Journal Article] Dysregulation of schizophrenia-related aquaporin 3 through disruption of paranode influences neuronal viability (2018)
  • Author(s): Kunisawa Kazuo、Shimizu Takeshi、Kushima Itaru、Aleksic Branko、Mori Daisuke、Osanai Yasuyuki、Kobayashi Kenta、Taylor Anna M.、Bhat Manzoor A.、Hayashi Akiko、Baba Hiroko、Ozaki Norio、Ikenaka Kazuhiro
  • Journal Title: Journal of Neurochemistry Volume: 147 Issue: 3 Pages: 395-408
  • DOI: 10.1111/jnc.14553
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Aberrant astrocyte Ca2+ signals “AxCa signals” exacerbate pathological alterations in an Alexander disease model (2018)
  • Author(s): Saito Kozo、Shigetomi Eiji、Yasuda Rei、Sato Ryuichi、Nakano Masakazu、Tashiro Kei、Tanaka Kenji F.、Ikenaka Kazuhiro、Mikoshiba Katsuhiko、Mizuta Ikuko、Yoshida Tomokatsu、Nakagawa Masanori、Mizuno Toshiki、Koizumi Schuichi
  • Journal Title: Glia Volume: 66 Issue: 5 Pages: 1053-1067
  • DOI: 10.1002/glia.23300
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Deletion of exons encoding carboxypeptidase domain of Nna1 results in Purkinje cell degeneration (pcd) phenotype (2018)
  • Author(s): Zhou Li、Hossain M. Ibrahim、Yamazaki Maya、Abe Manabu、Natsume Rie、Konno Kohtaro、Kageyama Shun、Komatsu Masaaki、Watanabe Masahiko、Sakimura Kenji、Takebayashi Hirohide
  • Journal Title: Journal of Neurochemistry Volume: 147 Issue: 4 Pages: 557-572
  • DOI: 10.1111/jnc.14591
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] New roles of reactive astrocytes in the brain; an organizer of cerebral ischemia. (2018)
  • Author(s): Koizumi, S., Hirayama, Y., Morizawa, YM
  • Journal Title: Neurochem Int Volume: in press Pages: 107-114
  • DOI: 10.1016/j.neuint.2018.01.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Diencephalic progenitors contribute to the posterior septum through rostral migration along the hippocampal axonal pathway (2018)
  • Author(s): Watanabe Keisuke、Irie Koichiro、Hanashima Carina、Takebayashi Hirohide、Sato Noboru
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 1-13
  • DOI: 10.1038/s41598-018-30020-9
  • Peer Reviewed / Open Access
• [Journal Article] Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum (2018)
  • Author(s): Nakayama Hisako、Abe Manabu、Morimoto Chie、Iida Tadatsune、Okabe Shigeo、Sakimura Kenji、Hashimoto Kouichi
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 2830-2830
  • DOI: 10.1038/s41467-018-05100-z
  • Peer Reviewed / Open Access
• [Journal Article] Role of endoplasmic reticulum-mediated Ca2+ signaling in neuronal cell death (2018)
  • Author(s): Okubo Yohei、Mikami Yoshinori、Kanemaru Kazunori、Iino Masamitsu
  • Journal Title: Antioxid Redox Signal (in press) Volume: - Issue: 12 Pages: 1147-1157
  • DOI: 10.1089/ars.2018.7498
  • Peer Reviewed
• [Journal Article] Ischemic Brain Injury Leads to Brain Edema via Hyperthermia-Induced TRPV4 Activation (2018)
  • Author(s): Yutaka Hoshi, Kohki Okabe, Koji Shibasaki, Takashi Funatsu, Norio Matsuki, Yuji Ikegaya, Ryuta Koyama
  • Journal Title: Journal of Neuroscience Volume: 38 Issue: 25 Pages: 5700-5709
  • DOI: 10.1523/jneurosci.2888-17.2018
  • Peer Reviewed / Open Access
• [Journal Article] Activity-dependent functions of non-electrical glial cells (2018)
  • Author(s): Kato Daisuke、Eto Kei、Nabekura Junichi、Wake Hiroaki
  • Journal Title: The Journal of Biochemistry Volume: 印刷中 Issue: 6 Pages: 457-464
  • DOI: 10.1093/jb/mvy023
  • Peer Reviewed / Open Access
• [Journal Article] Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naive patients with major depressive disorder: an exploratory pilot case-control study. (2018)
  • Author(s): Kuwano N, Kato TA, Setoyama D, Sato-Kasai M, Shimokawa N, Hayakawa K, Ohgidani M, Sagata N, Kubo H, Kishimoto J, Kang D, Kanba S
  • Journal Title: Journal of Affective Disorders Volume: 231 Pages: 74-82
  • DOI: 10.1016/j.jad.2018.01.014
  • Peer Reviewed
• [Journal Article] Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials. (2018)
  • Author(s): Iwatsubo T, Iwata A, Suzuki K, Ihara R, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H; Japanese Alzheimer's Disease Neuroimaging Initiative, Sun CK, Beckett LA, Petersen RC, Weiner MW, Aisen PS, Donohue MC; Alzheimer's Disease Neuroimaging Initiative
  • Journal Title: Alzheimers Dement Volume: S1552-5260 Issue: 8 Pages: 1-11
  • DOI: 10.1016/j.jalz.2018.03.009
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Partial loss of function of CSF1R in a patient with white matter abnormalities. (2018)
  • Author(s): Konno T, Miura T, Harriott A, Mezaki N, Edwards ES, Ross OA, Meschia JF, Ikeuchi T, Wszolek ZK
  • Journal Title: European Journal of Neurology Volume: 印刷中 Issue: 6 Pages: 875-881
  • DOI: 10.1111/ene.13611
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Familial and sporadic chronic progressive degenerative parietal ataxia (2018)
  • Author(s): Morihara Ryuta、Yamashita Toru、Deguchi Kentaro、Kurata Tomoko、Nomura Emi、Sato Kota、Nakano Yumiko、Ohta Yasuyuki、Hishikawa Nozomi、Ikeuchi Takeshi、Kitaguchi Masataka、Abe Koji
  • Journal Title: Journal of the Neurological Sciences Volume: 387 Pages: 70-74
  • DOI: 10.1016/j.jns.2018.01.031
  • Peer Reviewed
• [Journal Article] A novel presenilin 1 mutation (Leu418Trp) associated with spasticity, parkinsonism, and white matter lesion in a dominant Alzheimer's family (2018)
  • Author(s): Takahashi Yoshiaki、Ohta Yasuyuki、Sasaki Ryo、Tadokoro Kou、Sato Kota、Shang Jingwei、Takemoto Mami、Hishikawa Nozomi、Yamashita Toru、Haraguchi Takashi、Ikeuchi Takeshi、Abe Koji
  • Journal Title: Journal of the Neurological Sciences Volume: 387 Pages: 166-169
  • DOI: 10.1016/j.jns.2018.01.006
  • Peer Reviewed
• [Journal Article] 1.Imamaki R. Ogawa K, Kizuka Y, Komi Y, Kojima S, Kotani N, Honke K, Honda T, Taniguchi N, and Kitazume S (2018)
  • Author(s): 1.Imamaki R. Ogawa K, Kizuka Y, Komi Y, Kojima S, Kotani N, Honke K, Honda T, Taniguchi N, and Kitazume S
  • Journal Title: Oncogene Volume: - Issue: 31 Pages: 4287-4299
  • DOI: 10.1038/s41388-018-0271-7
  • Peer Reviewed / Open Access
• [Journal Article] Gene expression of A6-like subgroup of ATP-binding cassette transporters in mouse brain parenchyma and microvessels (2018)
  • Author(s): Tachikawa M, Toki H, Watanabe M, Tomi M, Hosoya K, Terasaki T.
  • Journal Title: Anat Sci Int Volume: - Issue: 4 Pages: 456-463
  • DOI: 10.1007/s12565-018-0435-0
  • Peer Reviewed
• [Journal Article] Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like receptor 3 cascade (2018)
  • Author(s): Okada Ryo、Zhang Xinwen、Harada Yuka、Wu Zhou、Nakanishi Hiroshi
  • Journal Title: Inflammation Research Volume: 67 Issue: 5 Pages: 371-374
  • DOI: 10.1007/s00011-018-1136-9
  • Peer Reviewed
• [Journal Article] Neonatal Seizure Models to Study Epileptogenesis (2018)
  • Author(s): Kasahara Yuka、Ikegaya Yuji、Koyama Ryuta
  • Journal Title: Frontiers in Pharmacology Volume: 9
  • DOI: 10.3389/fphar.2018.00385
  • Peer Reviewed / Open Access
• [Journal Article] TRPV4 is functionally expressed in oligodendrocyte precursor cells and increases their proliferation (2018)
  • Author(s): Ohashi Kana、Deyashiki Ayane、Miyake Takahito、Nagayasu Kazuki、Shibasaki Koji、Shirakawa Hisashi、Kaneko Shuji
  • Journal Title: Pflugers Archiv - European Journal of Physiology Volume: 470 Issue: 5 Pages: 705-716
  • DOI: 10.1007/s00424-018-2130-3
  • NAID: 120007006244
  • Peer Reviewed
• [Journal Article] Molecular membrane dynamics: Insights into synaptic function and neuropathological disease (2018)
  • Author(s): Bannai Hiroko
  • Journal Title: Neuroscience Research Volume: 129 Pages: 47-56
  • DOI: 10.1016/j.neures.2017.07.007
  • Peer Reviewed
• [Journal Article] NDE1 positively regulates oligodendrocyte morphological differentiation (2018)
  • Author(s): Shimizu Shoko、Ishino Yugo、Tohyama Masaya、Miyata Shingo
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 7644-7644
  • DOI: 10.1038/s41598-018-25898-4
  • Peer Reviewed / Open Access
• [Journal Article] MARCKSL1 regulates spine formation in the amygdala and controls the hypothalamic-pituitary-adrenal axis and anxiety-like behaviors. (2018)
  • Author(s): Tanaka T, Shimizu S, Ueno M, Fujihara Y, Ikawa M, Miyata S.
  • Journal Title: EBioMedicine Volume: 30 Pages: 62-73
  • DOI: 10.1016/j.ebiom.2018.03.018
  • NAID: 120006957428
  • Peer Reviewed / Open Access
• [Journal Article] SLO potassium channels antagonize premature decision making in C. elegans (2018)
  • Author(s): Aoki I, Tateyama M, Shimomura T, Ihara K, Kubo Y, Nakano S, Mori I.
  • Journal Title: Commun Biol. Volume: 1 Issue: 1 Pages: 123-123
  • DOI: 10.1038/s42003-018-0124-5
  • Peer Reviewed / Open Access
• [Journal Article] CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration. (2018)
  • Author(s): Ageta-Ishihara N, Konno K, Yamazaki M, Abe M, Sakimura K, Watanabe M, Kinoshita M.
  • Journal Title: Neurochem Int Volume: S0197-0186 Issue: 17 Pages: 30442-4
  • DOI: 10.1016/j.neuint.2018.01.003
  • Peer Reviewed / Open Access
• [Journal Article] Hypersomnia with ADHD: a possible subtype of narcolepsy type 2 (2018)
  • Author(s): Ito W, Honda M, Ueno T, Kato N
  • Journal Title: Sleep and Biological Rhythms Volume: in press Pages: 205-210
  • DOI: 10.1007/s41105-017-0139-1
  • NAID: 40021518704
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Inequity aversion is observed in common marmosets but not in marmoset models of autism induced by prenatal exposure to valproic acid. (2018)
  • Author(s): Yasue M, Nakagami A, Nakagaki K, Ichinohe N, Kawai N
  • Journal Title: Behav Brain Res. Volume: 234 Pages: 36-40
  • DOI: 10.1016/j.bbr.2018.01.013
  • Peer Reviewed / Open Access
• [Journal Article] Developmental defects and aberrant accumulation of endogenous psychosine in oligodendrocytes in a murine model of Krabbe disease. (2018)
  • Author(s): Inamura N, Kito M, Go S, Kishi S, Hosokawa M, Asai K, Takakura N, Takebayashi H, Matsuda J, Enokido Y.
  • Journal Title: Neurobiology of Disease Volume: 120 Pages: 51-62
  • DOI: 10.1016/j.nbd.2018.08.023
  • Peer Reviewed / Open Access
• [Journal Article] A collagen-coated PGA conduit for interpositional-jump graft with end-to-side neurorrhaphy for treating facial nerve paralysis in rat (2018)
  • Author(s): Niimi Yosuke、Matsumine Hajime、Takeuchi Yuichi、Osaki Hironobu、Tsunoda Satoshi、Miyata Mariko、Yamato Masayuki、Sakurai Hiroyuki
  • Journal Title: Microsurgery Volume: Epub ahead of print Issue: 1 Pages: 70-80
  • DOI: 10.1002/micr.30291
  • Peer Reviewed / Open Access
• [Journal Article] Neuronal Origin of the Temporal Dynamics of Spontaneous BOLD Activity Correlation. (2018)
  • Author(s): T. Matsui, T. Murakami, K. Ohki
  • Journal Title: Cerebral Cortex Volume: in press Issue: 4 Pages: 4500-5000
  • DOI: 10.1093/cercor/bhy045
  • Peer Reviewed
• [Journal Article] Development of stereotaxic recording system for awake marmosets (Callithrix jacchus). (2018)
  • Author(s): Wakabayashi M, Koketsu D, Kondo H, Sato S, Ohara K, Polyakova Z, Chiken S, Hatanaka N, Nambu A
  • Journal Title: Neurosci Res Volume: in press Pages: 37-45
  • DOI: 10.1016/j.neures.2018.01.001
  • Peer Reviewed / Open Access
• [Journal Article] Motoneuron degeneration in the trigeminal motor nucleus innervating the masseter muscle in Dystonia musculorum mice (2017)
  • Author(s): Hossain M. Ibrahim、Horie Masao、Yoshioka Nozomu、Kurose Masayuki、Yamamura Kensuke、Takebayashi Hirohide
  • Journal Title: Neurochem Int Volume: - Pages: 159-170
  • DOI: 10.1016/j.neuint.2017.10.009
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Copy Number Variant in the Region of Adenosine Kinase (ADK) and Its Possible Contribution to Schizophrenia Susceptibility (2017)
  • Author(s): Kimura Hiroki、Kushima Itaru、Yohimi Akira、Aleksic Branko、Ozaki Norio
  • Journal Title: Int J Neuropsychopharmacol Volume: - Issue: 5 Pages: 1-5
  • DOI: 10.1093/ijnp/pyx103
  • Peer Reviewed
• [Journal Article] Possible involvement of a cell adhesion molecule, Migfilin, in brain development and pathogenesis of autism spectrum disorders (2017)
  • Author(s): Ishizuka Kanako、Tabata Hidenori、Ito Hidenori、Kushima Itaru、Noda Mariko、Yoshimi Akira、Usami Masahide、Watanabe Kyota、Morikawa Mako、Uno Yota、Okada Takashi、Mori Daisuke、Aleksic Branko、Ozaki Norio、Nagata Koh-ichi
  • Journal Title: Journal of Neuroscience Research Volume: 96 Issue: 5 Pages: 789-802
  • DOI: 10.1002/jnr.24194
  • Peer Reviewed / Open Access
• [Journal Article] Upregulation of Vesicular Glutamate Transporter 2 and STAT3 Activation in the Spinal Cord of Mice Receiving 3,3′-Iminodipropionitrile (2017)
  • Author(s): Ohgomori Tomohiro、Yamasaki Ryo、Kira Jun-ichi、Jinno Shozo
  • Journal Title: Neurotox Res. Volume: 未定 Issue: 4 Pages: 768-780
  • DOI: 10.1007/s12640-017-9822-x
  • Peer Reviewed
• [Presentation] Effects of a novel Olig2-binding protein 2 (Obp2) deficiency on the oligodendrocytes differentiation and myelination in murine spinal cord. (2019)
  • Author(s): Anna Simankova, Norihisa Bizen, Manabu Abe, Kenji Sakimura, Hirohide Takebayashi
  • Organizer: N-hybrid conference
• [Presentation] Analysis of the effect of a novel Olig2-Binding Factor on the oligodendrocyte differentiation and myelination in central nervous system. (2019)
  • Author(s): Norihisa Bizen, Anna Simankova, Nobuhiro Ohno, Manabu Abe, Kenji Sakimura, Hirohide Takebayashi
  • Organizer: The 66th NIBB Conference ABiS International Symposium
• [Presentation] 新規Olig2結合因子によるオリゴデンドロサイト前駆細胞維持機構の解明 (2019)
  • Author(s): 備前典久、矢野真人、周麗、阿部学、﨑村建司、竹林浩秀
  • Organizer: 第124回日本解剖学会総会全国学術集会
• [Presentation] Neural and systemic pathogenesis of dystonia musculorum mice. (2018)
  • Author(s): Hirohide Takebayashi
  • Organizer: 2018 Korea-Japan Joint Symposium on Neurodevelopment
  • Int'l Joint Research / Invited
• [Presentation] Motoneuron degeneration in the trigeminal motor nucleus and atrophy of the masseter muscle in Dystonia musculorum mice. (2018)
  • Author(s): Hirohide Takebayashi, MD Ibrahim Hossain, Masao Horie, Nozomu Yoshioka, Masayuki Kurose, Kensuke Yamamura
  • Organizer: FENS2018
  • Int'l Joint Research
• [Presentation] オリゴデンドロサイトの分化と脳機能 (2018)
  • Author(s): 竹林浩秀
  • Organizer: 脳研夏期セミナー
  • Invited
• [Presentation] Myelin lipid分解経路の破綻がもたらす脳白質脳症の病態解析とその治療応用 (2018)
  • Author(s): 榎戸靖、鬼頭もも子、郷慎司、細川昌則、浅井清文、竹林浩秀、松田純子、稲村直子
  • Organizer: 第61回日本神経化学会大会
• [Book] 脳神経化学 （第1章） (2018)
  • Author(s): 竹林浩秀
  • Total Pages: 368
  • Publisher: 化学同人
  • ISBN: 9784759817263
• [Remarks] グリアアセンブリによる脳機能発現の制御と病態
  • URL: http://square.umin.ac.jp/glialassembl/