「リポクオリティ」領域研究の推進

• Project Area: Quality of lipids in biological systems
• Project/Area Number: 20H05613
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: 有田 誠 国立研究開発法人理化学研究所, 生命医科学研究センター, チームリーダー (80292952)
• Project Period (FY): 2020-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: 成果取りまとめ / 領域マネジメント / 脂質

Outline of Research at the Start

国内・国際学会発表、冊子体ならびにDVD形式での報告書作成、領域ホームページ、を通じて、本研究で得られたリポクオリティに関する研究成果を、広く社会に発信する。

Outline of Annual Research Achievements

これまでにリポクオリティ領域から生み出された多くの連携研究について、その研究成果をとりまとめて複数の英文原著論文、および英文・和文総説として発表し、国内外に向けて幅広く周知活動を行った。さらに本領域で得られたリポクオリティに関する研究成果を広く社会に発信するために、DVD形式での「リポクオリティ研究成果報告書」をとりまとめ、国内外の主要な研究機関や幅広い分野の研究者および一般の方々への配布作業を行った。また、リポクオリティ領域事務局を整理・整頓するに当たり、各研究班の研究業績や国際連携室、データベース情報など、ホームページ上のコンテンツの最終のアップデート作業および業務関係書類の整理・保管作業を行った。また、当初予定していた海外に直接出向いての学会発表（オランダ・ユトレヒトで2021年10月に開催された61st Internatiolnal Conference on the Bioscience of Lipids）はコロナ禍の影響で残念ながら叶わなかったが、リポクオリティ領域の研究成果の周知については、シンガポールで開催された9th & 10th International Singapore Lipid Symposium （2021年３月、2022年３月)や、日本学術会議食料科学委員会・農学委員会合同公開シンポジウム（2021年12月）をはじめ、国内外の招待講演やシンポジウムにおいてオンライン発表および国内学会での発表を積極的に行うことで、概ねその目的を達成することが出来た。

Research Progress Status

令和2年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和2年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Lipid diversity and disease control revealed by advanced lipidomics (2022)
  • Author(s): 有田誠
  • Journal Title: 生化学 Volume: 94 Issue: 1 Pages: 5-13
  • DOI: 10.14952/SEIKAGAKU.2022.940005
  • ISSN: 0037-1017
  • Year and Date: 2022-02-25
  • Peer Reviewed / Open Access
• [Journal Article] The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation (2022)
  • Author(s): Dore E、Joly-Beauparlant C、Morozumi S、Mathieu A、Levesque T、Allaeys I、Duchez A、Cloutier N、Leclercq M、Bodein A、Payre C、Martin C、Petit-Paitel A、Gelb MH.、Rangachari M、Murakami M、Davidovic L、Flamand N、Arita M、Lambeau G、Droit A、Boilard E
  • Journal Title: JCI Insight Volume: 7 Issue: 2
  • DOI: 10.1172/jci.insight.152638
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota (2022)
  • Author(s): Miki Yoshimi、Taketomi Yoshitaka、Kidoguchi Yuh、Yamamoto Kei、Muramatsu Kazuaki、Nishito Yasumasa、Park Jonguk、Hosomi Koji、Mizuguchi Kenji、Kunisawa Jun、Soga Tomoyoshi、Boilard Eric、B. Gowda Siddabasave Gowda、Ikeda Kazutaka、Arita Makoto、Murakami Makoto
  • Journal Title: JCI Insight Volume: 7 Issue: 2
  • DOI: 10.1172/jci.insight.152611
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques (2022)
  • Author(s): Nagatake T, Kishino S, Urano E, et al.
  • Journal Title: Mucosal Immunology Volume: 15 Issue: 2 Pages: 289-300
  • DOI: 10.1038/s41385-021-00477-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Structures and functions of the gut microbial lipidome (2022)
  • Author(s): Morozumi Satoshi、Ueda Masahiro、Okahashi Nobuyuki、Arita Makoto
  • Journal Title: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Volume: 1867 Issue: 3 Pages: 159110-159110
  • DOI: 10.1016/j.bbalip.2021.159110
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of the Structural Diversity and Structure-Specific Behavior of Oxidized Phospholipids by LC-MS/MS (2021)
  • Author(s): Aoyagi Ryohei、Yamamoto Takahiro、Furukawa Yuuki、Arita Makoto
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 69 Issue: 10 Pages: 953-961
  • DOI: 10.1248/cpb.c21-00274
  • NAID: 130008095521
  • ISSN: 0009-2363, 1347-5223
  • Year and Date: 2021-10-01
  • Peer Reviewed / Open Access
• [Journal Article] Oxidized Phospholipids and Neutrophil Elastase Coordinately Play Critical Roles in NET Formation (2021)
  • Author(s): Tokuhiro Takuto、Ishikawa Akane、Sato Haruka、Takita Shunya、Yoshikawa Ayuri、Anzai Ryoko、Sato Shinichi、Aoyagi Ryohei、Arita Makoto、Shibuya Takumi、Aratani Yasuaki、Shimizu Shigeomi、Tanaka Masato、Yotsumoto Satoshi
  • Journal Title: Frontiers in Cell and Developmental Biology Volume: 9 Pages: 718586-718586
  • DOI: 10.3389/fcell.2021.718586
  • Peer Reviewed / Open Access
• [Journal Article] Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s. (2021)
  • Author(s): Kong WS, Tsuyama N, Inoue H, Guo Y, Mokuda S, Nobukiyo A, Nakatani N, Yamaide F, Nakano T, Kohno Y, Ikeda K, Nakanishi Y, Ohno H, Arita M, Shimojo N, Kanno M.
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 13109-13109
  • DOI: 10.1038/s41598-021-92282-0
  • Peer Reviewed / Open Access
• [Journal Article] 12/15-Lipoxygenase Regulates IL-33-Induced Eosinophilic Airway Inflammation in Mice (2021)
  • Author(s): Miyata Jun、Yokokura Yoshiyuki、Moro Kazuyo、Arai Hiroyuki、Fukunaga Koichi、Arita Makoto
  • Journal Title: Frontiers in Immunology Volume: 12 Pages: 687192-687192
  • DOI: 10.3389/fimmu.2021.687192
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Global profiling of gut microbiota-associated lipid metabolites in antibiotic-treated mice by LC-MS/MS-based analyses (2021)
  • Author(s): Okahashi Nobuyuki、Ueda Masahiro、Yasuda Shu、Tsugawa Hiroshi、Arita Makoto
  • Journal Title: STAR Protocols Volume: 2 Issue: 2 Pages: 100492-100492
  • DOI: 10.1016/j.xpro.2021.100492
  • Peer Reviewed / Open Access
• [Journal Article] ADIPOR1 deficiency-induced suppression of retinal ELOVL2 and docosahexaenoic acid levels during photoreceptor degeneration and visual loss (2021)
  • Author(s): Osada Hideto、Toda Eriko、Homma Kohei、Guzman Naymel A.、Nagai Norihiro、Ogawa Mamoru、Negishi Kazuno、Arita Makoto、Tsubota Kazuo、Ozawa Yoko
  • Journal Title: Cell Death & Disease Volume: 12 Issue: 5 Pages: 458-458
  • DOI: 10.1038/s41419-021-03741-5
  • Peer Reviewed / Open Access
• [Journal Article] ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α (2021)
  • Author(s): Saika, A., Nagatake, T., Hirata, S.I., Sawane, K., Adachi, J., Abe, Y., Isoyama, J., Morimoto, S., Node, E., Tiwari, P., Hosomi, K., Matsunaga, A., Honda, T., Tomonaga, T., Arita, M., Kabashima, K., and Kunisawa, J.
  • Journal Title: FASEB J Volume: 35 Issue: 4
  • DOI: 10.1096/fj.202001687r
  • Peer Reviewed / Open Access
• [Presentation] Advanced non-targeted lipidomics and its application to vascular biology (2022)
  • Author(s): Makoto Arita
  • Organizer: 10th International Singapore Lipid Symposium (iSLS10)
  • Int'l Joint Research / Invited
• [Presentation] 脂質多様性（リポクオリティ）の生物学 (2021)
  • Author(s): 有田誠
  • Organizer: 日本生化学会東北支部第87回例会・シンポジウム
  • Invited
• [Presentation] 脂質多様性（リポクオリティ）の生物学 (2021)
  • Author(s): 有田誠
  • Organizer: 第11回「機能性バイオ」ミニシンポジウム
  • Invited
• [Presentation] 生命の脂質多様性から解き明かす病態・バイオロジー研究 (2021)
  • Author(s): 有田誠
  • Organizer: 第65回日本薬学会関東支部大会
  • Invited
• [Presentation] 最先端リピドミクスで解き明かす生命の脂質多様性と疾患制御 (2021)
  • Author(s): 有田誠
  • Organizer: 第46回日本医用マススペクトル学会年会
  • Invited
• [Presentation] Advanced non-targeted lipidomics and its application to vascular biology (2021)
  • Author(s): Makoto Arita
  • Organizer: 19th International Symposium on Atherosclerosis (ISA2021)
  • Int'l Joint Research / Invited
• [Presentation] Omega-3 fatty acid metabolism that controls inflammation and tissue homeostasis (2021)
  • Author(s): 有田誠
  • Organizer: World Congress of OMEGA3 Science and Technology (WCOST)
  • Int'l Joint Research / Invited
• [Presentation] リピドミクス新技術と脂質多様性（リポクオリティ）の生物学 (2021)
  • Author(s): 有田誠
  • Organizer: 日本学術会議食料科学委員会・農学委員会合同公開シンポジウム「SDGs達成に向けた農芸化学の挑戦：第２回 地球と生命をつなぐ高度な化学物質ネットワーク」
  • Invited
• [Remarks] リポクオリティ領域HP
  • URL: https://sites.google.com/site/lipoqualityjpn/