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2017 Fiscal Year Research-status Report

生命分子システムにおける動的秩序形成と高次機能発現の研究推進のための国際活動支援

International Activities Supporting Group

Project AreaDynamical ordering of biomolecular systems for creation of integrated functions
Project/Area Number 15K21708
Research InstitutionOkazaki Research Facilities, National Institutes of Natural Sciences

Principal Investigator

加藤 晃一  大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 教授 (20211849)

Co-Investigator(Kenkyū-buntansha) 佐藤 啓文  京都大学, 工学研究科, 教授 (70290905)
平岡 秀一  東京大学, 大学院総合文化研究科, 教授 (10322538)
上久保 裕生  奈良先端科学技術大学院大学, 物質創成科学研究科, 准教授 (20311128)
寺嶋 正秀  京都大学, 理学研究科, 教授 (00188674)
芳坂 貴弘  北陸先端科学技術大学院大学, マテリアルサイエンス研究科, 教授 (30263619)
佐藤 宗太  東京大学, 大学院理学系研究科(理学部), 准教授 (40401129)
岡本 祐幸  名古屋大学, 理学研究科, 特任准教授 (70185487)
稲垣 直之  奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (20223216)
Project Period (FY) 2015-11-06 – 2019-03-31
Keywords生命分子 / 超分子 / 動的秩序 / 高次機能 / 集合離散
Outline of Annual Research Achievements

本領域は領域発足当初より、分野間の垣根を超えた共同研究を推進するとともに、国内外への情報発信を広く実施してきた。本年度は、引き続き海外の卓越した研究者との活発な意見交換を通じて、本領域の活動を国際的により一層進展させた。また、国際的に活躍できる若手人材の育成のために長期間に渡って若手研究者を海外に派遣し、国際的な共同研究の推進に努めた。
1. 若手研究者の海外派遣
本領域研究に関わる最新技術の習得、及び普及を行うために、計画研究班、加藤グループに所属する福田真吾研究員を海外のグループに1年間派遣し、本領域活動の啓発を推進した。
2.国際共同研究の推進
共同研究のための消耗品等の購入や旅費など、国際共同研究にかかる経費の一部を国際活動支援班の経費から援助することで効果的に研究を推進し、国際的ネットワークの発展に務めた。さらに、国際共同研究を加速するための国際ワークショップを開催し、本領域の研究を海外にも波及させた。異分野融合の促進と、海外の研究者を交えた研究者間の強固な協力体制を築くため、グループ討論を行う機会を積極的に設けることで、分野を異にする研究者が相互に理解を深めるための場を提供した。平成29年度は特にアカデミアシニカ(台湾)にてFrontier Bioorganization Forum 2017を開催し、アジアにおける研究者ネットワークの拡大と、本領域の認知を高めることが出来た。また、若手による異分野融合型の国際共同研究企画Germany-Japan Young Scientist Meeting on "Dynamic ordring of biomolecular systems for creation of integrated function" をドイツのマックスプランク研究所にて開催し、若手研究者間における国際連携の強化に取り組んだ。

Current Status of Research Progress
Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

平成29年度は当初の計画以上に活発な国際的な活動を行うことが出来た。アカデミアシニカ(台湾)にてFrontier Bioorganization Forum 2017を開催し、アジアにおける研究者ネットワークの拡大と、本領域の認知を高めることが出来た。また、ドイツのマックスプランク研究所にて開催した、若手による異分野融合型の国際共同研究企画Germany-Japan Young Scientist Meeting on "Dynamic ordring of biomolecular systems for creation of integrated function" も新しい試みであったが、若手研究者の活発な意見交換を通し、本領域活動の啓発および国際連携の強化に繋がった。

Strategy for Future Research Activity

Frontier Bioorganization Forum 2017の成功を受け、今年度も同様にアジアにおける研究者ネットワークの拡大と、本領域の認知を高めるための活動を行う。

Causes of Carryover

Frontier Bioorganization Forum 2017の後続イベントを平成29年度内に行う予定であったが、参加国のメンバーの予定の調整がつかず、平成30年度に開催する運びとなった。本領域を基点として発展した重要なイベントであるため、次年度に使用予定額を持ち越し、アジアに本領域の認知度を広める活動を継続する。

  • Research Products

    (43 results)

All 2018 2017 Other

All Int'l Joint Research (6 results) Journal Article (13 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 13 results,  Open Access: 6 results) Presentation (20 results) (of which Int'l Joint Research: 20 results,  Invited: 20 results) Remarks (1 results) Funded Workshop (3 results)

  • [Int'l Joint Research] National Institutes of Health/The Scripps Research/University of California(米国)

    • Country Name
      U.S.A.
    • Counterpart Institution
      National Institutes of Health/The Scripps Research/University of California
  • [Int'l Joint Research] Max Planck Institute/Free University of Berlin(ドイツ)

    • Country Name
      GERMANY
    • Counterpart Institution
      Max Planck Institute/Free University of Berlin
  • [Int'l Joint Research] National Chiao Tung University/Academia Sinica(台湾)

    • Country Name
      その他の国・地域
    • Counterpart Institution
      National Chiao Tung University/Academia Sinica
  • [Int'l Joint Research] Chimie Paris Teck(フランス)

    • Country Name
      FRANCE
    • Counterpart Institution
      Chimie Paris Teck
  • [Int'l Joint Research] University of Cambridge/University of Edinburgh(英国)

    • Country Name
      UNITED KINGDOM
    • Counterpart Institution
      University of Cambridge/University of Edinburgh
  • [Int'l Joint Research]

    • # of Other Countries
      4
  • [Journal Article] Theoretical and Experimental Studies on Inclusion Complexes of Pinostrobin and β-Cyclodextrins2018

    • Author(s)
      Kicuntod Jintawee、Sangpheak Kanyani、Mueller Monika、Wolschann Peter、Viernstein Helmut、Yanaka Saeko、Kato Koichi、Chavasiri Warinthorn、Pongsawasdi Piamsook、Kungwan Nawee、Rungrotmongkol Thanyada
    • Journal Title

      Sci. Pharm.

      Volume: 86 Pages: 5

    • DOI

      10.3390/scipharm86010005

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Site-specific N-glycosylation analysis of soluble Fcγ receptor IIIb in human serum2018

    • Author(s)
      Yagi Hirokazu、Takakura Daisuke、Roumenina Lubka T.、Fridman Wolf Herman、Sautes-Fridman Catherine、Kawasaki Nana、Kato Koichi
    • Journal Title

      Sci. Rep.

      Volume: 8 Pages: 2719

    • DOI

      10.1038/s41598-018-21145-y

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Solution NMR views of dynamical ordering of biomacromolecules2018

    • Author(s)
      Ikeya Teppei、Ban David、Lee Donghan、Ito Yutaka、Kato Koichi、Griesinger Christian
    • Journal Title

      Biochim. Biophys. Acta-General Subjects

      Volume: 1862 Pages: 287~306

    • DOI

      10.1016/j.bbagen.2017.08.020

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Photoreaction Dynamics of LOV1 and LOV2 of Phototropin from Chlamydomonas reinhardtii2018

    • Author(s)
      Nakasone Yusuke、Ohshima Masumi、Okajima Koji、Tokutomi Satoru、Terazima Masahide
    • Journal Title

      J.Phys.Chem.B

      Volume: 122 Pages: 1801~1815

    • DOI

      10.1021/acs.jpcb.7b10266

    • Peer Reviewed
  • [Journal Article] Sequential DNA Binding and Dimerization Processes of the Photosensory Protein EL2222018

    • Author(s)
      Takakado Akira、Nakasone Yusuke、Terazima Masahide
    • Journal Title

      Biochemistry

      Volume: 57 Pages: 1603~1610

    • DOI

      10.1021/acs.biochem.7b01206

    • Peer Reviewed
  • [Journal Article] Photoreaction of BlrP1: the role of a nonlinear photo-intensity sensor2018

    • Author(s)
      Shibata Kosei、Nakasone Yusuke、Terazima Masahide
    • Journal Title

      Phys.Chem.Chem.Phys.

      Volume: 20 Pages: 8133~8142

    • DOI

      10.1039/c7cp08436f

    • Peer Reviewed
  • [Journal Article] Novel physical chemistry approaches in biophysical researches with advanced application of lasers: Detection and manipulation2018

    • Author(s)
      Iwata Koichi、Terazima Masahide、Masuhara Hiroshi
    • Journal Title

      BBA

      Volume: 1862 Pages: 335~357

    • DOI

      10.1016/j.bbagen.2017.11.003

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Applications of high-speed atomic force microscopy to real-time visualization of dynamic biomolecular processes2018

    • Author(s)
      Takayuki Uchihashi, Simon Scheuring
    • Journal Title

      Biochimica et Biophysica Acta(BBA)

      Volume: 1862 Pages: 229-240

    • Peer Reviewed
  • [Journal Article] Solution NMR views of dynamical ordering of biomacromolecules2018

    • Author(s)
      Teppei Ikeya, David Ban, Donghan Lee, Yutaka Ito, Christian Griesinger
    • Journal Title

      Biochimica et Biophysica Acta(BBA)

      Volume: 1862 Pages: 287-306

    • Peer Reviewed
  • [Journal Article] Dynamic membrane interactions of antibacterial and antifungal biomolecules, and amyloid peptides, revealed by solid-state NMR spectroscopy2018

    • Author(s)
      Akira Naito, Nobuaki Matsumori, Ayyalusamy Ramamoorthy
    • Journal Title

      Biochimica et Biophysica Acta(BBA)

      Volume: 1862 Pages: 307-323

    • Peer Reviewed
  • [Journal Article] Cryo-electron microscopy for structural analysis of dynamic biological macromolecules2018

    • Author(s)
      Kazuyoshi Murata, Matthias Wolf
    • Journal Title

      Biochimica et Biophysica Acta(BBA)

      Volume: 1862 Pages: 324-334

    • Peer Reviewed / Open Access
  • [Journal Article] O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals2017

    • Author(s)
      Shogo Sawaguchi, Shweta Varshney, Mitsutaka Ogawa, Yuta Sakaidani, Hirokazu Yagi, Kyosuke Takeshita, Toyoaki Murohara, Koichi Kato, Subha Sundaram, Pamela Stanley, and Tetsuya Okajima
    • Journal Title

      eLife

      Volume: 6 Pages: e24419

    • DOI

      10.7554/eLife.24419

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Formation of the chaperonin complex studied by 2D NMR spectroscopy2017

    • Author(s)
      Takenaka Toshio、Nakamura Takashi、Yanaka Saeko、Yagi-Utsumi Maho、Chandak Mahesh S.、Takahashi Kazunobu、Paul Subhankar、Makabe Koki、Arai Munehito、Kato Koichi、Kuwajima Kunihiro
    • Journal Title

      PLOS ONE

      Volume: 12 Pages: e0187022

    • DOI

      10.1371/journal.pone.0187022

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Reaction Dynamics of Photo-induced Protein-DNA Interaction2018

    • Author(s)
      M.Terazima
    • Organizer
      Trombay Symposium on Radiation & Photochemistry
    • Int'l Joint Research / Invited
  • [Presentation] Structural insights into dynamic orchestration of biomolecular systems2017

    • Author(s)
      Koichi Kato
    • Organizer
      Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems
    • Int'l Joint Research / Invited
  • [Presentation] Versatile structural architectures of archaeal homolog of proteasome assembly chaperone2017

    • Author(s)
      Maho Yagi-Utsumi, Arunima Sikdar, Tadashi Satoh and Koichi Kato
    • Organizer
      Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems
    • Int'l Joint Research / Invited
  • [Presentation] Native mass spectrometry: complementary to other biophysical methods2017

    • Author(s)
      Susumu Uchiyama
    • Organizer
      Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems
    • Int'l Joint Research / Invited
  • [Presentation] Biomolecular simulations in generalized ensemble2017

    • Author(s)
      Yuko Okamoto
    • Organizer
      Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems
    • Int'l Joint Research / Invited
  • [Presentation] Theoretical study on substituent and solvent effects for nanocube formed with gear-shaped amphiphile molecules2017

    • Author(s)
      Masanori Tachikawa
    • Organizer
      Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems
    • Int'l Joint Research / Invited
  • [Presentation] Molecular Mechanism for Axon Navigation in the Brain2017

    • Author(s)
      Naoyuki Inagaki
    • Organizer
      Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems
    • Int'l Joint Research / Invited
  • [Presentation] Strain-sensitive regulation of mechanical activities of dyneins underlying oscillatory movement of sperm flagella2017

    • Author(s)
      Chikako Shingyoji
    • Organizer
      Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems
    • Int'l Joint Research / Invited
  • [Presentation] Multi-component equilibrium in biological systems explored by using continuous titration SAXS2017

    • Author(s)
      Hironari Kamikubo
    • Organizer
      Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems
    • Int'l Joint Research / Invited
  • [Presentation] Design of Protein Assemblies as Supramolecular Platforms2017

    • Author(s)
      Takafumi Ueno
    • Organizer
      Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems
    • Int'l Joint Research / Invited
  • [Presentation] Investigation on domain motion of protein by neutron scattering2017

    • Author(s)
      Masaaki Sugiyama
    • Organizer
      Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems
    • Int'l Joint Research / Invited
  • [Presentation] Nanocube: Ultra-Thermostble Self-Assemblies in Water2017

    • Author(s)
      Shuichi Hiraoka
    • Organizer
      Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems
    • Int'l Joint Research / Invited
  • [Presentation] Control over differentiation of a metastable supramolecular assembly2017

    • Author(s)
      Kazunori Sugiyasu
    • Organizer
      Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems
    • Int'l Joint Research / Invited
  • [Presentation] Chemo-mechanical coupling mechanisms of linear and rotary molecular motors revealed by high-speed single-molecule imaging analysis2017

    • Author(s)
      Ryota Iino
    • Organizer
      Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems
    • Int'l Joint Research / Invited
  • [Presentation] Direct visualization of dynamic molecular interactions using HS-AFM2017

    • Author(s)
      Takayuki Uchihashi
    • Organizer
      Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems
    • Int'l Joint Research / Invited
  • [Presentation] Viscosity, thermal diffusivity, and polarity of lipid bilayer membranes estimated from fast time-resolved spectroscopic measurements2017

    • Author(s)
      Koichi Iwata
    • Organizer
      Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems
    • Int'l Joint Research / Invited
  • [Presentation] Understanding of Self-Assembly Process at Molecular Level2017

    • Author(s)
      Hirofumi Sato
    • Organizer
      Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems
    • Int'l Joint Research / Invited
  • [Presentation] Structural views of fate determination of glycoproteins in cells2017

    • Author(s)
      Koichi Kato
    • Organizer
      Seminar at Max Planck Institute for Biophysical Chemistry
    • Int'l Joint Research / Invited
  • [Presentation] Light induced heating and volume changes to reveal protein reactions2017

    • Author(s)
      M.Terazima
    • Organizer
      9th International Conference on Photoacoustic and Photothermal Phenomena
    • Int'l Joint Research / Invited
  • [Presentation] Time-resolved diffusion technique can detect conformation dynamics of photosensor proteins2017

    • Author(s)
      M.Terazima
    • Organizer
      Asia Oceania Conference on Photobiology
    • Int'l Joint Research / Invited
  • [Remarks] Dynamical ordering of biomolecular systems~

    • URL

      http://seimei.ims.ac.jp/index_e.html

  • [Funded Workshop] The 6th International Symposium of Dynamical Ordering of Biomolecular Systems2018

  • [Funded Workshop] Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems2017

  • [Funded Workshop] Germany-Japan Young Scientist meeting on “Dynamic ordering of biomolecular systems for creation of integrated function”2017

URL: 

Published: 2018-12-17   Modified: 2022-10-18  

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