Middle molecular strategy: Creation of higher bio-functional molecules by integrated synthesis

2022 Fiscal Year Final Research Report

• Project Area: Middle molecular strategy: Creation of higher bio-functional molecules by integrated synthesis.
• Project/Area Number: 15K21713
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Multi-year Fund
• Review Section: Science and Engineering
• Research Institution: Osaka University
• Principal Investigator: Koichi Fukase 大阪大学, 大学院理学研究科, 教授 (80192722)
• Project Period (FY): 2015-11-06 – 2023-03-31
• Keywords: 中分子 / 反応集積 / 生体機能制御 / 糖鎖 / 免疫

Outline of Final Research Achievements

Reaction integration, which sustains the synthesis of middle-molecules, is rapidly developing in both academia and industry as a key technology supporting a new era of synthetic processes in the industrial manufacture of pharmaceuticals and fine chemicals. In this research field, we aim to advance "reaction integration" to a higher level to dramatically improve the efficiency of functional molecule synthesis, and furthermore, to expand it to the practical material production. This International Support Group aims to promote international collaboration and the formation of research networks, to help our research area become an international hub for the creation of middle-molecular functions, and to demonstrate the significant presence of our research area and Japan, in the international community.

Free Research Field

生物分子化学

Academic Significance and Societal Importance of the Research Achievements

現代社会では、環境に負荷をかけず物質変換効率を向上させるとともに、諸問題を解決する高効率機能性物質を創製する合成化学が強く求められている。本領域研究は、様々な機能性物質の合成効率を飛躍的に向上させ、将来的には医農薬などの生物機能分子製造にも大きく貢献する。このように極めて重要な研究領域において、国際共同研究を主導し、日本のプレゼンスを示すことができた。これにより、日本において、本分野がますます発展し、大きな社会貢献が期待できる。例えば、生物機能分子研究を飛躍的に進展させ、新たな医農薬開発への貢献が期待できる。