• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2018 Fiscal Year Annual Research Report

Support activities to promote international collaboration to accomplish the research on noncoding RNA neo-taxonomy

International Activities Supporting Group

Project AreaNeo-taxonomy of noncoding RNAs
Project/Area Number 15K21720
Research InstitutionHokkaido University

Principal Investigator

廣瀬 哲郎  北海道大学, 遺伝子病制御研究所, 教授 (30273220)

Co-Investigator(Kenkyū-buntansha) 中川 真一  北海道大学, 薬学研究院, 教授 (50324679)
淺原 弘嗣  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (70294460)
泊 幸秀  東京大学, 定量生命科学研究所, 教授 (90447368)
鈴木 勉  東京大学, 大学院工学系研究科(工学部), 教授 (20292782)
塩見 美喜子  東京大学, 大学院理学系研究科(理学部), 教授 (20322745)
影山 裕二  神戸大学, バイオシグナル総合研究センター, 准教授 (90335480)
Project Period (FY) 2015-11-06 – 2019-03-31
KeywordsノンコーディングRNA / 国際シンポジウム / 若手支援
Outline of Annual Research Achievements

本年度も各国際活動支援班員が、それぞれの国際活動(国際共同研究、海外研究者の訪問、海外著名研究者の招聘など)を精力的に展開し、その結果数多くの国際共著論文の発表などの実質的な活動成果をあげることができた。代表的な活動内容は、以下の通りである。まず領域代表の廣瀬は、昨年に引き続き核内構造体の微細構造の電子顕微鏡観察、RNP相互作用解析をフランスCNRSと西オーストラリア大、イギリスのクリック研究所との共同研究を継続し、Mol Cellをはじめ5報の国際共著論文を発表した。中川は、lncRNA KOマウスを用いた機能解析研究を米国マウントサイナイ、オーガスタ大などとの共同研究で実施し、PNAS誌を含む6本の国際共著論文発表に至った。また浅原は米国スクリプス研究所との国際共同研究を継続し2報の国際共著論文を発表した。この他の班員も継続して欧米、中国との国際共同研究を継続し研究発展に努めた。
一方で、領域班員及び関連若手研究者の海外研究機関への短期滞在の支援も実施し計5名を米国テキサス大学、イスラエルワイズマン研究所などの海外研究機関に派遣し、国際共同研究のより一層の推進をサポートした。この他に、本領域主催の国際ミーティング(JAJ2018)に合わせてオーストラリアのRNA研究者20名を招聘し、共同研究に関する直接的なディスカッションの場を設けることによって国際共同研究の推進を後押しした。さらに当該研究分野の海外著名研究者をコロラド大学、マックスプランク研究所、カリフォルニア大学などから招聘した。

  • Research Products

    (19 results)

All 2019 2018 Other

All Int'l Joint Research (6 results) Journal Article (6 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 6 results) Presentation (6 results) (of which Int'l Joint Research: 6 results,  Invited: 6 results) Funded Workshop (1 results)

  • [Int'l Joint Research] University of Western Australia(オーストラリア)

    • Country Name
      AUSTRALIA
    • Counterpart Institution
      University of Western Australia
  • [Int'l Joint Research] Stanford University/University of Texas/Northwestern University(米国)

    • Country Name
      U.S.A.
    • Counterpart Institution
      Stanford University/University of Texas/Northwestern University
    • # of Other Institutions
      1
  • [Int'l Joint Research] DZHK/IMB-Mainz/Helmholtz Zentrum(ドイツ)

    • Country Name
      GERMANY
    • Counterpart Institution
      DZHK/IMB-Mainz/Helmholtz Zentrum
  • [Int'l Joint Research] CNRS/University of Toulouse(フランス)

    • Country Name
      FRANCE
    • Counterpart Institution
      CNRS/University of Toulouse
  • [Int'l Joint Research] Francis Crick Institute(英国)

    • Country Name
      UNITED KINGDOM
    • Counterpart Institution
      Francis Crick Institute
  • [Int'l Joint Research]

    • # of Other Countries
      3
  • [Journal Article] The expression of long noncoding RNA NEAT1 is reduced in schizophrenia and modulates oligodendrocytes transcription.2019

    • Author(s)
      Katsel P, Roussos P, Fam P, Khan S, Tan W, Hirose T, Nakagawa S, Pletnikov MV, Haroutunian V.
    • Journal Title

      NPJ Schizophr.

      Volume: 5 Pages: 3

    • DOI

      10.1038/s41537-019-0071-2.

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Immune system-mediated atherosclerosis caused by deficiency of long non-coding RNA MALAT1 in ApoE-/-mice.2019

    • Author(s)
      Gast M, Rauch BH, Nakagawa S, Haghikia A, Jasina A, Haas J, Nath N, Jensen L, Stroux A, Bohm A, Friebel J, Rauch U, Skurk C, Blankenberg S, Zeller T, Prasanth KV, Meder B, Kuss A, Landmesser U, Poller W.
    • Journal Title

      Cardiovasc Res.

      Volume: 115 Pages: 302-314.

    • DOI

      10.1093/cvr/cvy202.

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Wwp2 maintains cartilage homeostasis through regulation of Adamts52019

    • Author(s)
      Mokuda S, Nakamichi R, Matsuzaki T, Ito Y, Sato T, Miyata K, Inui M, Olmer M, Sugiyama E, Lotz M, Asahara H
    • Journal Title

      Nat Commun.

      Volume: - Pages: -

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation.2018

    • Author(s)
      Yamazaki T, Souquere S, Chujo T, Kobelke S, Chong YS, Fox AH, Bond CS, Nakagawa S, Pierron G, Hirose T.
    • Journal Title

      Mol Cell.

      Volume: 70 Pages: 1038-1053

    • DOI

      10.1016/j.molcel.2018.05.019.

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Long noncoding RNA MALAT1 suppresses breast cancer metastasis.2018

    • Author(s)
      Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z, Gan B, Nakagawa S, Ellis MJ, Liang H, Hung MC, You MJ, Sun Y, Ma L.
    • Journal Title

      Nat Genet

      Volume: 50 Pages: 1705-1715

    • DOI

      10.1038/s41588-018-0252-3.

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Long noncoding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) is critical for phenotypic switching of vascular smooth muscle cells.2018

    • Author(s)
      Ahmed ASI, Dong K, Liu J, Wen T, Yu L, Xu F, Kang X, Osman I, Hu G, Bunting KM, Crethers D, Gao H, Zhang W, Liu Y, Wen K, Agarwal G, Hirose T, Nakagawa S, Vazdarjanova A, Zhou J.
    • Journal Title

      PNAS

      Volume: 115 Pages: E8660-E8667

    • DOI

      10.1073/pnas.1803725115.

    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Metabolic and Chemical Regulation of RNA Modifications Associated with Various Biological Processes2019

    • Author(s)
      鈴木勉
    • Organizer
      RNA Editing Gordon Research Conference,Next-Generation Epitranscriptomics in Health and Disease
    • Int'l Joint Research / Invited
  • [Presentation] Requirements for multivalent Yb body assembly in piRNA-mediated transposon silencing in Drosophila2019

    • Author(s)
      塩見美喜子
    • Organizer
      40th LORNE GENOME CONFERENCE 2019
    • Int'l Joint Research / Invited
  • [Presentation] Cartilage Development and Homeostasis via Pre- and Post-Transcriptional Regulation2019

    • Author(s)
      浅原弘嗣
    • Organizer
      Gordon Conference: Cartilage Development and Regeneration and Their Implications in Disease Therapies
    • Int'l Joint Research / Invited
  • [Presentation] Nuclear architecture by long noncoding RNAs through phase separation.2018

    • Author(s)
      廣瀬哲郎
    • Organizer
      China Nucleic Acid Forum 2018
    • Int'l Joint Research / Invited
  • [Presentation] Attempts towards identification of novel functional lncRNAs2018

    • Author(s)
      中川真一
    • Organizer
      Noncoding RNAs in embryonic development and cell differentiation
    • Int'l Joint Research / Invited
  • [Presentation] 3´-end maturation of silkworm piRNAs―a conserved mechanism of piRNA biogenesis2018

    • Author(s)
      泊幸秀
    • Organizer
      EMBO Workshop "piRNAs and PIWI proteins"
    • Int'l Joint Research / Invited
  • [Funded Workshop] The 2nd Japan Australia joint RNA meeting2018

URL: 

Published: 2019-12-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi