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2021 Fiscal Year Annual Research Report

Personalized values in adolescence support team for international activities

International Activities Supporting Group

Project AreaScience of personalized value development through adolescence: integration of brain, real-world, and life-course approaches
Project/Area Number 16K21720
Research InstitutionThe University of Tokyo

Principal Investigator

笠井 清登  東京大学, 医学部附属病院, 教授 (80322056)

Project Period (FY) 2016-06-30 – 2022-03-31
Keywords思春期 / 主体価値 / コホート研究 / リカバリー / Well-being / 国際共同研究 / 国際比較研究 / 若手育成
Outline of Annual Research Achievements

令和3年度は、主に英米の研究者との連携(下記1~4)と海外派遣後の研究(5)を継続し、思春期科学国際連携ネットワークを強化した。
(1)King's College Londonが所管するREACHコホート責任者のCraig Morgan教授及びGemma Knowles研究員と複数回のオンラインミーティングを行い、東京ティーンコホート(TTC)とREACHコホートとの間での日英クロスコホート研究に向けた打合せを進めた。REACHコホートにリサーチアシスタントとして関与した経験を持つDaniel Stanyon研究員を都医学研において雇用し、両者の共同研究を推進した。(2)Fordham大学のJordan DeVylder教授との共同研究を進め、親世代の海外からの移住が子供の思春期メンタルヘルスに及ぼす影響について、論文が国際誌に受理された。同教授と共に、国際統合失調症学会国際シンポジウムにてTTCの成果を報告した。(3)ALSPACコホートの共同研究者であるSarah Sullivan研究員とのTTCを用いた共同研究について、日本統合失調症学会にて報告した。
(4)リカバリー研究において、笠井は主体価値の不調からの回復に関する研究について、英語論文を執筆・投稿し、国際誌に掲載された。回復の促進因子として抽出されたピアサポートについて、その要素をまとめた冊子を作成しWeb掲載した。また、若者の困難からの回復過程について質問紙作成を行った。
(5)海外派遣は、平成31年度までに派遣を終えた研究員4名(豪国1、英国2、オーストリア1)が、研究を継続した。豪国派遣研究員は、TTCデータを用いた共同研究を継続、英国派遣研究員1名は共同研究を継続し、もう1名は大規模脳画像データと機械学習技術を用いた研究の継続を、オーストリア派遣研究員は、既存のMRIデータの整理と取得のサポートを行なった。

  • Research Products

    (46 results)

All 2022 2021 Other

All Int'l Joint Research (6 results) Journal Article (25 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 25 results,  Open Access: 21 results) Presentation (13 results) (of which Int'l Joint Research: 10 results,  Invited: 1 results) Remarks (2 results)

  • [Int'l Joint Research] ロンドン大学/ブリストル大学/ケンブリッジ大学(英国)

    • Country Name
      UNITED KINGDOM
    • Counterpart Institution
      ロンドン大学/ブリストル大学/ケンブリッジ大学
    • # of Other Institutions
      2
  • [Int'l Joint Research] カリフォルニア大学/フォーダム大学/ハーバード大学(米国)

    • Country Name
      U.S.A.
    • Counterpart Institution
      カリフォルニア大学/フォーダム大学/ハーバード大学
  • [Int'l Joint Research] メルボルン大学/マードック小児研究所(オーストラリア)

    • Country Name
      AUSTRALIA
    • Counterpart Institution
      メルボルン大学/マードック小児研究所
  • [Int'l Joint Research] 北京大学(中国)

    • Country Name
      CHINA
    • Counterpart Institution
      北京大学
  • [Int'l Joint Research] ソウル大学(韓国)

    • Country Name
      KOREA (REP. OF KOREA)
    • Counterpart Institution
      ソウル大学
  • [Int'l Joint Research]

    • # of Other Countries
      2
  • [Journal Article] Psychotic experiences predict subsequent loneliness among adolescents: A population-based birth cohort study2022

    • Author(s)
      Endo Kaori、Yamasaki Syudo、Nakanishi Miharu、DeVylder Jordan、Usami Satoshi、Morimoto Yuko、Stanyon Daniel、Suzuki Kazuhiro、Miyashita Mitsuhiro、Arai Makoto、Fujikawa Shinya、Kanata Sho、Ando Shuntaro、Hiraiwa-Hasegawa Mariko、Kasai Kiyoto、Nishida Atsushi
    • Journal Title

      Schizophrenia Research

      Volume: 239 Pages: 123~127

    • DOI

      10.1016/j.schres.2021.11.031

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The association between clinical symptoms and later subjective quality of life in individuals with ultra‐high risk for psychosis and recent‐onset psychotic disorder: A longitudinal investigation2022

    • Author(s)
      Usui Kaori、Kirihara Kenji、Tada Mariko、Fujioka Mao、Koshiyama Daisuke、Tani Motoko、Tsuchiya Maiko、Morita Susumu、Kawakami Shintaro、Kanehara Akiko、Morita Kentaro、Satomura Yoshihiro、Koike Shinsuke、Suga Motomu、Araki Tsuyoshi、Kasai Kiyoto
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: - Pages: -

    • DOI

      10.1111/pcn.13359

    • Peer Reviewed
  • [Journal Article] Migration and psychotic experiences in the Tokyo Teen Cohort2022

    • Author(s)
      DeVylder Jordan、Endo Kaori、Yamasaki Syudo、Ando Shuntaro、Hiraiwa-Hasegawa Mariko、Kasai Kiyoto、Nishida Atsushi
    • Journal Title

      Journal of Migration and Health

      Volume: 5 Pages: 100078~100078

    • DOI

      10.1016/j.jmh.2022.100078

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A behavioural correlate of the synaptic eligibility trace in the nucleus accumbens2022

    • Author(s)
      Yamaguchi Kenji、Maeda Yoshitomo、Sawada Takeshi、Iino Yusuke、Tajiri Mio、Nakazato Ryosuke、Ishii Shin、Kasai Haruo、Yagishita Sho
    • Journal Title

      Scientific Reports

      Volume: 12 Pages: -

    • DOI

      10.1038/s41598-022-05637-6

    • Peer Reviewed / Open Access
  • [Journal Article] Culture-dependent and universal constructs and promoting factors for the process of personal recovery in users of mental health services: qualitative findings from Japan2022

    • Author(s)
      Kanehara Akiko、Koike Haruna、Fujieda Yumiko、Yajima Sayaka、Kabumoto Asami、Kumakura Yousuke、Morita Kentaro、Miyamoto Yuki、Nochi Masahiro、Kasai Kiyoto
    • Journal Title

      BMC Psychiatry

      Volume: 22 Pages: -

    • DOI

      10.1186/s12888-022-03750-4

    • Peer Reviewed / Open Access
  • [Journal Article] Trajectory and course of problematic alcohol use after the Great East Japan Earthquake: Eight‐year follow‐up of the Higashi‐Matsushima cohort study2022

    • Author(s)
      Morishima Ryo、Usami Satoshi、Ando Shuntaro、Kiyono Tomoki、Morita Masaya、Fujikawa Shinya、Araki Tsuyoshi、Kasai Kiyoto
    • Journal Title

      Alcoholism: Clinical and Experimental Research

      Volume: 46 Pages: 570~580

    • DOI

      10.1111/acer.14787

    • Peer Reviewed
  • [Journal Article] The role of bullying victimization in the pathway between autistic traits and psychotic experiences in adolescence: Data from the Tokyo Teen Cohort study2022

    • Author(s)
      Stanyon Daniel、Yamasaki Syudo、Ando Shuntaro、Endo Kaori、Nakanishi Miharu、Kiyono Tomoki、Hosozawa Mariko、Kanata Sho、Fujikawa Shinya、Morimoto Yuko、Hiraiwa-Hasegawa Mariko、Kasai Kiyoto、Nishida Atsushi
    • Journal Title

      Schizophrenia Research

      Volume: 239 Pages: 111~115

    • DOI

      10.1016/j.schres.2021.11.015

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between maternal perceived capacity in life and physical punishment of teenage children: a longitudinal analysis of a population-based cohort in Tokyo, Japan2022

    • Author(s)
      Nakanishi Miharu、Yamasaki Syudo、Niimura Junko、Endo Kaori、Nakajima Naomi、Stanyon Daniel、Baba Kaori、Oikawa Nao、Hosozawa Mariko、Ando Shuntaro、Hiraiwa-Hasegawa Mariko、Kasai Kiyoto、Nishida Atsushi
    • Journal Title

      BMJ Open

      Volume: 12 Pages: e058862

    • DOI

      10.1136/bmjopen-2021-058862

    • Peer Reviewed / Open Access
  • [Journal Article] Trends in big data analyses by multicenter collaborative translational research in psychiatry2022

    • Author(s)
      Onitsuka Toshiaki、Hirano Yoji、Nemoto Kiyotaka、Hashimoto Naoki、Kushima Itaru、Koshiyama Daisuke、Koeda Michihiko、Takahashi Tsutomu、Noda Yoshihiro、Matsumoto Junya、Miura Kenichiro、Nakazawa Takanobu、Hikida Takatoshi、Kasai Kiyoto、Ozaki Norio、Hashimoto Ryota
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 76 Pages: 1~14

    • DOI

      10.1111/pcn.13311

    • Peer Reviewed / Open Access
  • [Journal Article] Criticality in the Healthy Brain2022

    • Author(s)
      Shi Jifan、Kirihara Kenji、Tada Mariko、Fujioka Mao、Usui Kaori、Koshiyama Daisuke、Araki Tsuyoshi、Chen Luonan、Kasai Kiyoto、Aihara Kazuyuki
    • Journal Title

      Frontiers in Network Physiology

      Volume: 1 Pages: -

    • DOI

      10.3389/fnetp.2021.755685

    • Peer Reviewed / Open Access
  • [Journal Article] Associations Between Personal Values and Work Engagement2021

    • Author(s)
      Sato Nana、Watanabe Kazuhiro、Nishi Daisuke、Kawakami Norito
    • Journal Title

      Journal of Occupational and Environmental Medicine

      Volume: 63 Pages: e335~e340

    • DOI

      10.1097/JOM.0000000000002209

    • Peer Reviewed / Open Access
  • [Journal Article] Cell type‐specific DNA methylation analysis of the prefrontal cortex of patients with schizophrenia2021

    • Author(s)
      Ueda Junko、Bundo Miki、Nakachi Yutaka、Kasai Kiyoto、Kato Tadafumi、Iwamoto Kazuya
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 75 Pages: 297~299

    • DOI

      10.1111/pcn.13282

    • Peer Reviewed / Open Access
  • [Journal Article] Set-shifting-related basal ganglia deformation as a novel familial marker of obsessive-compulsive disorder2021

    • Author(s)
      Isobe Masanori、Vaghi Matilde、Fineberg Naomi A.、Apergis-Schoute Annemieke M.、Bullmore Edward T.、Sahakian Barbara J.、Robbins Trevor W.、Chamberlain Samuel R.
    • Journal Title

      The British Journal of Psychiatry

      Volume: - Pages: 1~4

    • DOI

      10.1192/bjp.2021.45

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Children with special health care needs and mothers' anxiety/depression: Findings from the Tokyo Teen Cohort study2021

    • Author(s)
      Kaji Namiko、Ando Shuntaro、Nishida Atsushi、Yamasaki Syudo、Kuwabara Hitoshi、Kanehara Akiko、Satomura Yoshihiro、Jinde Seiichiro、Kano Yukiko、Hiraiwa‐Hasegawa Mariko、Igarashi Takashi、Kasai Kiyoto
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 75 Pages: 394~400

    • DOI

      10.1111/pcn.13301

    • Peer Reviewed
  • [Journal Article] Bidirectional relationship of problematic Internet use with hyperactivity/inattention and depressive symptoms in adolescents: a population-based cohort study2021

    • Author(s)
      Morita Masaya、Ando Shuntaro、Kiyono Tomoki、Morishima Ryo、Yagi Tomoko、Kanata Sho、Fujikawa Shinya、Yamasaki Syudo、Nishida Atsushi、Kasai Kiyoto
    • Journal Title

      European Child and Adolescent Psychiatry

      Volume: - Pages: -

    • DOI

      10.1007/s00787-021-01808-4

    • Peer Reviewed / Open Access
  • [Journal Article] Fingertip advanced glycation end products and psychotic symptoms among adolescents2021

    • Author(s)
      Miyashita M、Yamasaki S、Ando S、Suzuki K、Toriumi K、Horiuchi Y、Yoshikawa A、Imai A、Nagase Y、Miyano Y、Inoue T、Endo K、Morimoto Y、Morita M、Kiyono T、Usami S、Okazaki Y、Furukawa T A.、Hiraiwa-Hasegawa M、Itokawa M、Kasai K、Nishida A、Arai M
    • Journal Title

      npj Schizophrenia

      Volume: 7 Pages: -

    • DOI

      10.1038/s41537-021-00167-y

    • Peer Reviewed / Open Access
  • [Journal Article] Decreased DNA methylation at promoters and gene-specific neuronal hypermethylation in the prefrontal cortex of patients with bipolar disorder2021

    • Author(s)
      Bundo Miki、Ueda Junko、Nakachi Yutaka、Kasai Kiyoto、Kato Tadafumi、Iwamoto Kazuya
    • Journal Title

      Molecular Psychiatry

      Volume: 26 Pages: 3407~3418

    • DOI

      10.1038/s41380-021-01079-0

    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive DNA Methylation Analysis of Human Neuroblastoma Cells Treated With Haloperidol and Risperidone2021

    • Author(s)
      Du Jianbin、Nakachi Yutaka、Kiyono Tomoki、Fujii Shinya、Kasai Kiyoto、Bundo Miki、Iwamoto Kazuya
    • Journal Title

      Frontiers in Molecular Neuroscience

      Volume: 14 Pages: -

    • DOI

      10.3389/fnmol.2021.792874

    • Peer Reviewed / Open Access
  • [Journal Article] Intergenerational transmission of the patterns of functional and structural brain networks2021

    • Author(s)
      Takagi Yu、Okada Naohiro、Ando Shuntaro、Yahata Noriaki、Morita Kentaro、Koshiyama Daisuke、Kawakami Shintaro、Sawada Kingo、Koike Shinsuke、Endo Kaori、Yamasaki Syudo、Nishida Atsushi、Kasai Kiyoto、Tanaka Saori C
    • Journal Title

      iScience

      Volume: 24 Pages: 102708~102708

    • DOI

      10.1016/j.isci.2021.102708

    • Peer Reviewed / Open Access
  • [Journal Article] Oral corticosteroid dosage and clinical presentation of psychiatric conditions after steroid use: A consultation‐liaison psychiatry service’s experience2021

    • Author(s)
      Yagi Yuko、Takahashi Yusuke、Ogata Yu、Yamana Hayato、Kumakura Yousuke、Ichihashi Kayo、Kasai Kiyoto、Kondo Shinsuke
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 41 Pages: 471~475

    • DOI

      10.1002/npr2.12204

    • Peer Reviewed / Open Access
  • [Journal Article] Lower help-seeking intentions mediate subsequent depressive symptoms among adolescents with high autistic traits: a population-based cohort study2021

    • Author(s)
      Hosozawa Mariko、Yamasaki Syudo、Ando Shuntaro、Endo Kaori、Morimoto Yuko、Kanata Sho、Fujikawa Shinya、Cable Noriko、Iso Hiroyasu、Hiraiwa-Hasegawa Mariko、Kasai Kiyoto、Nishida Atsushi
    • Journal Title

      European Child and Adolescent Psychiatry

      Volume: - Pages: 1~10

    • DOI

      10.1007/s00787-021-01895-3

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reduced cortical thickness of the paracentral lobule in at-risk mental state individuals with poor 1-year functional outcomes2021

    • Author(s)
      Sasabayashi D, Takayanagi Y、Takahashi T、Nishiyama S、Mizukami Y、Katagiri N、Tsujino N、Nemoto T、Sakuma A、Katsura M、Ohmuro N、Okada N、Tada M、Suga M、Maikusa N、Koike S、Furuichi A、Kido M、Noguchi K、Yamasue H、Matsumoto K、Mizuno M、Kasai K、Suzuki M
    • Journal Title

      Translational Psychiatry

      Volume: 11 Pages: 396

    • DOI

      10.1038/s41398-021-01516-2

    • Peer Reviewed / Open Access
  • [Journal Article] Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis2021

    • Author(s)
      ENIGMA Clinical High Risk for Psychosis Working Group、Jalbrzikowski M、et al
    • Journal Title

      JAMA Psychiatry

      Volume: 78 Pages: 753~753

    • DOI

      10.1001/jamapsychiatry.2021.0638

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Longitudinal Bidirectional Relationships Between Maternal Depressive/Anxious Symptoms and Children's Tic Frequency in Early Adolescence2021

    • Author(s)
      Yagi Tomoko、Ando Shuntaro、Usami Satoshi、Yamasaki Syudo、Morita Masaya、Kiyono Tomoki、Hayashi Noriyuki、Endo Kaori、Iijima Yudai、Morimoto Yuko、Kanata Sho、Fujikawa Shinya、Koike Shinsuke、Kano Yukiko、Hiraiwa-Hasegawa Mariko、Nishida Atsushi、Kasai Kiyoto
    • Journal Title

      Frontiers in Psychiatry

      Volume: 12 Pages: -

    • DOI

      10.3389/fpsyt.2021.767571

    • Peer Reviewed / Open Access
  • [Journal Article] Birth order and prosociality in the early adolescent brain2021

    • Author(s)
      Okada N、Yamamoto Y、Yahata N、Morita S、Koshiyama D、Morita K、Sawada K、Kanata S、Fujikawa S、Sugimoto N、Toriyama R、Masaoka M、Koike S、Araki T、Kano Y、Endo K、Yamasaki S、Ando S、Nishida A、Hiraiwa-Hasegawa M、Yokoyama C、Kasai K
    • Journal Title

      Scientific Reports

      Volume: 11 Pages: 1~14

    • DOI

      10.1038/s41598-021-01146-0

    • Peer Reviewed
  • [Presentation] 神経性やせ症と脳内報酬系2021

    • Author(s)
      磯部昌憲
    • Organizer
      第24回日本摂食障害学会学術集会・シンポジウム
  • [Presentation] うつ病における安静時脳内報酬系ネットワークの変化2021

    • Author(s)
      森麻子、岡田剛、横山仁史、高村真広、高垣耕企、市川奈穂、吉野敦雄、岡本泰昌
    • Organizer
      第43回日本生物学的精神医学会
  • [Presentation] Optimal dose of brexpiprazole for augmentation therapy of antidepressant-refractory depression: Protocol for a systematic review and dose-effect meta-analysis2021

    • Author(s)
      Furukawa Y, Oguro S, Obata S, Hamza T, Edoardo G Ostinelli, Kasai K
    • Organizer
      8th BESETO International Psychiatry Conference
    • Int'l Joint Research
  • [Presentation] Young carers in Japan: Reliability and validity testing of the BBC/University of Nottingham young carers survey questionnaire and prevalence estimation in 5,000 adolescents2021

    • Author(s)
      Kanehara A, Morishima R, Takahashi Y, Usui K, Sato S, Uno A, Sawai Y, Kumakura Y, Yagishita S, Morita K, Okada N, Ando S, Koike S, Shibuya T, Joseph S, Kasai K
    • Organizer
      8th BESETO International Psychiatry Conference
    • Int'l Joint Research
  • [Presentation] School Closures due to COVID-19 and Mental Health Symptoms after School Reopening in Japan2021

    • Author(s)
      Morishima R, Koike H, Kanehara S, Usui K, Okada N, Ando S, Kasai K
    • Organizer
      8th BESETO International Psychiatry Conference
    • Int'l Joint Research
  • [Presentation] Developmental changes in educational challenges at schools for children and adolescents with 22q11.2 deletion syndrom2021

    • Author(s)
      Tanaka M, Kanehara A, Morishima R, Kumakura Y, Okouchi N, Nakajima N, Hamada J, Ogawa T, Tamune H, Nakahara M, Jinde S, Kano Y, Kasai K
    • Organizer
      8th BESETO International Psychiatry Conference
    • Int'l Joint Research
  • [Presentation] Culture-dependent and universal constructs and promoting factors for the process of personal recovery2021

    • Author(s)
      Kanehara A, Koike H, Fujieda Y, Yajima S, Kabumoto A, Kumakura Y, Morita K, Miyamoto Y, Nochi M, Kasai K
    • Organizer
      8th BESETO International Psychiatry Conference
    • Int'l Joint Research
  • [Presentation] The progress of the Asian Consortium on MRI studies in Psychosis (ACMP)2021

    • Author(s)
      Koike S, Morita K, Okada N, Xin Yu, Jun Soo Kwon, Kasai K
    • Organizer
      8th BESETO International Psychiatry Conference
    • Int'l Joint Research
  • [Presentation] Gene expression analysis of the globus pallidus in a mouse model of 22q11.2 deletion syndrome2021

    • Author(s)
      Zhao Z, Jinde S, Kasai K
    • Organizer
      8th BESETO International Psychiatry Conference
    • Int'l Joint Research
  • [Presentation] Development of mismatch negativity is associated with psychological difficulties in adolescence2021

    • Author(s)
      Usui K, Kirihara K, Araki T, Tada M, Koshiyama D, Fujioka M, Nishimura R, Ando S, Koike S, Kasai K
    • Organizer
      8th BESETO International Psychiatry Conference
    • Int'l Joint Research
  • [Presentation] Betaine and Structural Changes in Schizophrenia2021

    • Author(s)
      Omileke F, Okada N, Kasai K
    • Organizer
      8th BESETO International Psychiatry Conference
    • Int'l Joint Research
  • [Presentation] Reciprocal relationships among psychotic symptoms, suicidal behaviour and help-seeking in adolescence: Evidence from Tokyo Teen Cohort Study. Longitudinal associations between psychotic experiences and psychosis with suicidality in children and youth.2021

    • Author(s)
      Yamasaki S, Nishida A, Ando S
    • Organizer
      Congress of the Schizophrenia International Society
    • Int'l Joint Research / Invited
  • [Presentation] 言語・運動発達からみた思春期精神病症状体験と自閉スペクトラム傾向:大規模出生コホートと母子手帳情報を用いた解析2021

    • Author(s)
      山崎修道・Sarah Sullivan・清野知樹・遠藤香織・星野彩・安藤俊太郎・笠井清登・長谷川眞理子・西田淳志
    • Organizer
      第15回日本統合失調症学会
  • [Remarks] 思春期主体価値ホームページ

    • URL

      value.umin.jp

  • [Remarks] 東京ティーンコホート

    • URL

      ttcp.umin.jp

URL: 

Published: 2022-12-28  

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