「ネオウイルス学」の国際活動支援

2018 Fiscal Year Research-status Report

• Project Area: Neo-virology: the raison d'etre of viruses
• Project/Area Number: 16K21723
• Research Institution: The University of Tokyo
• Principal Investigator: 河岡 義裕 東京大学, 医科学研究所, 教授 (70135838)
• Co-Investigator(Kenkyū-buntansha): 朝長 啓造 京都大学, ウイルス・再生医科学研究所, 教授 (10301920) ; 澤 洋文 北海道大学, 人獣共通感染症リサーチセンター, 教授 (30292006) ; 高橋 英樹 東北大学, 農学研究科, 教授 (20197164) ; 川口 寧 東京大学, 医科学研究所, 教授 (60292984) ; 渡辺 登喜子 東京大学, 医科学研究所, 特任准教授 (60557479) ; 松浦 善治 大阪大学, 微生物病研究所, 教授 (50157252) ; 鈴木 信弘 岡山大学, 資源植物科学研究所, 教授 (70206514) ; 長崎 慶三 高知大学, 教育研究部自然科学系理工学部門, 教授 (00222175)
• Project Period (FY): 2016-06-30 – 2021-03-31
• Keywords: ウイルス / 国際共同研究 / ネットワーク構築

Outline of Annual Research Achievements

国際活動支援班では、各計画研究班の海外における研究活動を促進し、本領域を日本が牽引する国際的に重要な学術分野に発展させることを目指す。そのため、(1) 国際研究ネットワークの整備および強化、(2) 円滑な海外での研究試料の採取支援・提供、(3) 国際シンポジウムの開催および海外研究者の招聘による人的連携の促進、(4) サンプル収集のための海外への研究者の派遣の支援、(5) 最先端研究を行う先進諸国への若手研究者の中長期的派遣の支援、(6) 国際研究者ネットワークへの積極的な情報発信を行なっている。
平成30年度においては、国内で国際学会2回、ワークショップ1回、研究会を1回共催し、海外から総計12名の研究者を招聘した。本活動により、人的連携を促進すると共に国際研究ネットワークを強化した。また、最先端研究を行うオランダ王国・ワーゲニンゲン大学の研究室へ修士課程学生1名を派遣し、さらにフランスで開催された国際学会での発表を支援した。中国から3名の若手研究者を海外から日本へ招聘し、共同研究の打ち合わせを実施することで国際研究ネットワークを強化した。さらに、アフリカのシエラレオネに、計画研究班の若手研究者を2名派遣し、サンプルの収集を実施させた。上記の活動により採集した検体、検体から抽出した核酸を用いて、ウイルスゲノムの検出・ウイルスの単離を試みている。
平成29年度に引き続き、本領域のホームページの英語版を通して国際社会に本領域の活動を発信している。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

国際活動支援班において計画している6つの計画について、それぞれの平成30年度の進捗状況を下記に記載する。
(1) 国際研究ネットワークの整備および強化、(3) 国際シンポジウムの開催および海外研究者の招聘による人的連携の促進については、9月に第17回あわじしま感染症・免疫フォーラム、10月に第66回ウイルス学会、IMSUT-CAS Workshop on Infectious Diseases 2018、Environmental Virology Workshopを共催して海外から著名な研究者である、Jean Michel Claverie博士、Ricardo Flores博士、Benjamin tenOever博士、David Dunigan博士、Yong-Zhen Zhang博士、Valerian V. Dolja博士らを招聘した。(5) 最先端研究を行う先進諸国への若手研究者の中長期的派遣の支援では、東京農工大学の修士課程1年目の学生をオランダ王国のワーゲニンゲン大学Bart Thomma教授の研究室に派遣して、高橋班が国際共同研究として進めている、植物病原菌に潜伏感染する新規ウイルスの探索プロジェクトについて東京農工大学の宮下助教を交えて研究情報を交換した。(2) 円滑な海外での研究試料の採取支援・提供、(4) サンプル収集のための海外への研究者の派遣の支援に関しては、澤班から松野講師、大場講師を5月にシエラレオネに派遣して、渡辺班の前村研究員（米国ウイスコンシン大）、渡辺准教授および澤班の澤教授と連携して、シエラレオネ大学Alhaji U.N’jai博士、Ishamil Barrie氏の協力を得て、現地のマダニ及び蚊を採集した。上記の活動により採集した検体、検体から抽出した核酸は日本に輸送後、保有ウイルスの解析に供された。(6) 国際研究者ネットワークへの積極的な情報発信は、平成29年度に引き続きホームページを通しての発信に務めている。以上より、本研究課題は概ね順調に進展していると判断される。

Strategy for Future Research Activity

2019年度においては、(1) 国際研究ネットワークの整備および強化、(3) 国際シンポジウムの開催および海外研究者の招聘による人的連携の促進については、9月に開催される第18回あわじしま感染症・免疫フォーラム、10月に東京で開催される第67回日本ウイルス学会学術集会を共催し、両学会のネオウイルスセッションでそれぞれ、2名、および3名の海外から招聘する研究者の講演が決定している。さらに、9月に福岡で開催される国際学会Thermophiles 2019のネオウイルス学協賛セッションにおいて2名の海外からの研究者を、10月に三重県津市で開催されるAsian Mycological Congress (AMC)のネオウイルスセッションで3名の海外からの研究者を招聘して講演を実施する予定である。
また、(2) 円滑な海外での研究試料の採取支援・提供、(4) サンプル収集のための海外への研究者の派遣の支援に関しては、計画研究班の澤班の研究者3名が2019年度内にボリビアを訪問して、動物に寄生するダニ、また蚊の採集を実施する予定である。また計画研究班の渡辺班は南米およびシエラレオネを訪問し、コウモリなどの野生動物からのサンプリングを予定している。
2019年度も、海外活動支援班への活動申請を随時受け付けることにより、各計画研究班の海外における研究活動を促進し、本領域を日本が牽引する国際的に重要な学術分野に発展させることに貢献する。
以上の支援活動により、本領域への上質の国際共同研究成果のフィードバックを目指して、若手を主体とした研究者の人脈形成の機会を提供する。また、実施した活動内容を、英語版ホームページ、SNS、プレスリリースなどを用いて、国際研究者ネットワークへ積極的に情報発信を試みる。

Causes of Carryover

平成30年度内の実施を計画していた一部の研究者の派遣・招聘について、派遣予定の研究者あるいは招聘研究者および受入先の都合等の理由により実施できなかった場合が有った。研究者派遣については所属機関などの支援により、異なる財源によって実施した場合もあったため、予定数を下回る支援となった。サンプル輸入費用や現地での必要経費が予定よりも少額に抑えられたために次年度使用額が生じた。
研究者派遣および招聘については、既に領域班会議などを通して構成員に周知しており、若手研究者の派遣および国際シンポジウムなどへの研究者招聘を活発に実施して使用する計画を立てている。具体的な招聘計画としては、次年度は、9月に開催される第18回あわじしま感染症・免疫フォーラム、10月に東京で開催される第67回日本ウイルス学会学術集会の共催において海外からの研究者を招聘して講演を実施する、また、9月に福岡で開催される国際学会Thermophiles 2019のネオウイルス学協賛セッション、および10月に三重県津市で開催されるAsian Mycological Congress (AMC)のネオウイルスセッションにおいても、海外から研究者を招聘して講演を実施する予定である。
また海外でのサンプリング機会を広く領域内に提供し、多種多様なサンプルを輸入する費用を国際活動支援班より支援するために、次年度使用額の一部を用いる計画である。

Research Products

• [Int'l Joint Research] ワーゲニンゲン大学(オランダ)
  • Country Name: NETHERLANDS
  • Counterpart Institution: ワーゲニンゲン大学
• [Int'l Joint Research] シエラレオネ大学(シエラレオネ)
  • Country Name: SIERRA LEONE
  • Counterpart Institution: シエラレオネ大学
• [Journal Article] Endornaviruses: persistent dsRNA viruses with symbiotic properties in diverse eukaryotes. (2019)
  • Author(s): Fukuhara T
  • Journal Title: Virus Genes Volume: 55 Pages: 165-173
  • DOI: 10.1007/s11262-019-01635-5
  • Peer Reviewed
• [Journal Article] Hijacking a host scaffold protein, RACK1, for replication of a plant RNA virus. (2019)
  • Author(s): Hyodo K, Suzuki N, Okuno T.
  • Journal Title: New Phytol. Volume: 221 Pages: 935-945
  • DOI: 10.1111/nph.15412
  • Peer Reviewed
• [Journal Article] Network-Guided Discovery of Influenza Virus Replication Host Factors. (2019)
  • Author(s): Ackerman EE, Kawakami E, Katoh M, Watanabe T, Watanabe S, Tomita Y, Lopes TJ, Matsuoka Y, Kitano H, Shoemaker JE, Kawaoka Y
  • Journal Title: MBio Volume: 9 Pages: e02002-18
  • DOI: 10.1128/mBio.02002-18
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Injectable Excipients as Novel Influenza Vaccine Adjuvants (2019)
  • Author(s): Feng H, Yamashita M, da Silva Lopes TJ, Watanabe T, Kawaoka Y.
  • Journal Title: Front. Microbiol Volume: 10 Pages: 1-9
  • DOI: 10.3389/fmicb.2019.00019
  • Peer Reviewed
• [Journal Article] Characterization of Mouse Monoclonal Antibodies Against the HA of A(H7N9) Influenza Virus. (2019)
  • Author(s): Ito M, Yamayoshi S, Murakami K, Saito K, Motojima A, Nakaishi K, Kawaoka Y.
  • Journal Title: Viruses Volume: 11 Pages: pii: E149
  • DOI: 10.3390/v11020149
  • Peer Reviewed
• [Journal Article] 高病原性H7N9鳥インフルエンザウイルスはヒトの間で大流行を起こすのか (2019)
  • Author(s): 今井正樹、河岡義裕
  • Journal Title: 臨牀と研究 Volume: 95 Pages: 1245-1248
• [Journal Article] スペイン・インフルエンザ その2 スペイン・インフルエンザの病原性の謎 (2019)
  • Author(s): 渡辺登喜子.
  • Journal Title: インフルエンザ その他の呼吸器感染症 Volume: 20 Pages: 37-40
• [Journal Article] エボラ出血熱の重症かメカニズムならびに予後を予測するためのバイオマーカーの同定 (2019)
  • Author(s): 渡辺登喜子、河岡義裕
  • Journal Title: 感染・炎症・免疫 Volume: 49 Pages: 65-67
• [Journal Article] エボラ出血熱について－エボラウイルス感染者の宿主応答解析から得られた知見－ (2019)
  • Author(s): 渡辺登喜子、河岡義裕
  • Journal Title: 最新医学 Volume: 74 Pages: 51-57
• [Journal Article] Systematic survey of non-retroviral virus-like elements in eukaryotic genomes. (2019)
  • Author(s): Kryukov K, Ueda MT, Imanishi T, Nakagawa S.
  • Journal Title: Virus Research Volume: 262 Pages: 30-36
  • DOI: 10.1016/j.virusres.2018.02.002
  • Peer Reviewed
• [Journal Article] Comparative description of the expression profile of interferon-stimulated genes in multiple cell lineages targeted by HIV-1 infection (2019)
  • Author(s): Hirofumi Aso, Jumpei Ito, Yoshio Koyanagi & Kei Sato
  • Journal Title: Front Microbiol Volume: 10 Pages: 429
  • DOI: 10.3389/fmicb.2019.00429
  • Peer Reviewed / Open Access
• [Journal Article] "Integration of viral sequences into eukaryotic host genomes: legacy of ancient infections". (2019)
  • Author(s): Tomonaga K, Suzuki N, Berkhout B.
  • Journal Title: Virus Res. Volume: 262 Pages: 1
  • DOI: doi: 10.1016/j.virusres.2018.12.012.
  • Int'l Joint Research
• [Journal Article] Paleovirology of bornaviruses: What can be learned from molecular fossils of bornaviruses. (2019)
  • Author(s): Horie M, Tomonaga K.
  • Journal Title: Virus Res. Volume: 262 Pages: 002-009
  • DOI: doi: 10.1016/j.virusres.2018.04.006.
  • Peer Reviewed
• [Journal Article] Interactions among eukaryotes, retrotransposons, and riboviruses: Endogenous riboviral elements in eukaryotic genomes (2019)
  • Author(s): Horie M
  • Journal Title: Genes Genet Syst Volume: 印刷中 Pages: 印刷中
  • Peer Reviewed / Open Access
• [Journal Article] Direct RNA sequencing on nanopore arrays redefines the transcriptional complexity of a viral pathogen. (2019)
  • Author(s): Daniel P. Depledge, Kalanghad Puthankalam Srinivas, Tomohiko Sadaoka, Devin Bready, Yasuko Mori, Dimitris G. Placantonakis, Ian Mohr, Angus C. Wilson
  • Journal Title: Nature Communications Volume: 10 Pages: 754-767
  • DOI: 10.1038/s41467-019-08734-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] In-Solution Microscopic Imaging of Fractal Aggregates of a Stressed Therapeutic Antibody (2019)
  • Author(s): Senga Y, Imamura H, Ogura T, Honda S
  • Journal Title: Analytical Chemistry Volume: 91 Pages: 4640-4648
  • DOI: 10.1021/acs.analchem.8b05979
  • Peer Reviewed / Open Access
• [Journal Article] Medusavirus, a novel large DNA virus discovered from hot spring water (2019)
  • Author(s): Yoshikawa G, Blanc-Mathieu R, Song C, Kayama Y, Mochizuki T, Murata K, Ogata H, Takemura M
  • Journal Title: J Virol Volume: 93 Pages: e02130-18
  • DOI: 10.1128/JVI.02130-18
  • Peer Reviewed / Open Access
• [Journal Article] Long DCL4-substrate dsRNAs efficiently induce RNA interference in plant cells. (2019)
  • Author(s): Kakiyama S, Tabara M, Nishibori Y, Moriyama H, Fukuhara T.
  • Journal Title: Sci Rep Volume: 印刷中 Pages: -
  • Peer Reviewed / Open Access
• [Journal Article] Predicting congenital rubella syndrome in Japan, 2018-2019. (2019)
  • Author(s): Lee H, Kayano T, Nishiura H.
  • Journal Title: International Journal of Infectious Diseases Volume: 82 Pages: 1-5.
  • DOI: 10.1016/j.ijid.2019.02.021
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sexual transmission and the probability of an end of the Ebola virus disease epidemic. (2019)
  • Author(s): Lee H, Nishiura H.
  • Journal Title: Journal of Theoretical Biology Volume: 471 Pages: 1-12.
  • DOI: 10.1016/j.jtbi.2019.03.022.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Quantifying heterogeneous contact patterns in Japan: A social contact survey. (2019)
  • Author(s): Munasinghe L, Asai Y, Nishiura H.
  • Journal Title: Theoretical Biology and Medical Modelling Volume: 16 Pages: 6-14.
  • DOI: 10.1186/s12976-019-0102-8.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Estimating the force of infection with Helicobacter pylori in Japan. (2019)
  • Author(s): Kayano T, Lee KD, Nishiura H.
  • Journal Title: Canadian Journal of Infectious Diseases and Medical Microbiology Volume: 2019 Pages: 1451490 (1-7).
  • DOI: 10.1155/2019/1451490
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] An endogenous adeno-associated virus element in elephants (2019)
  • Author(s): Kobayashi Y, Shimazu T, Murata K, Itou T, Suzuki Y.
  • Journal Title: Virus Res Volume: 262 Pages: 10-14
  • DOI: 10.1016/j.virusres.2018.04.015.
  • Peer Reviewed
• [Journal Article] Investigation of host range of and host defense against a mitochondrially replicating mitovirus. (2019)
  • Author(s): Shahi, S., Eusebio-Cope, A., I. B., Hillman, B. I., and Suzuki, N.
  • Journal Title: J. Virol Volume: 93 Pages: e01503-18
  • DOI: 10.1128/JVI.01503-18.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dicer functions transcriptionally and post-transcriptionally in a multilayer antiviral defense. (2019)
  • Author(s): Andika, I. B., Kondo, H., and Suzuki, N.
  • Journal Title: PNAS Volume: 116 Pages: 2274-2281
  • DOI: 10.1073/pnas.1812407116
  • Peer Reviewed
• [Journal Article] A novel insect-infecting virga/nege-like virus group and its pervasive endogenization into insect genomes. (2019)
  • Author(s): Kondo, H., Hirota, K., Maruyama, K., Andika, I. B., and Suzuki, N.
  • Journal Title: Virus Research Volume: 262 Pages: 37-47
  • DOI: 10.1016/j.virusres.2017.11.020
  • Peer Reviewed
• [Journal Article] Capsid structure of dsRNA fungal viruses. (2019)
  • Author(s): Luque, D., Mata, C. P., Ghabrial, S. A., Suzuki, N., and Caston, J. R.
  • Journal Title: Viruses Volume: 10 Pages: E481
  • DOI: 10.3390/v10090481
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The biological attributes, genome architecture and packaging of diverse multi-component fungal viruses. (2019)
  • Author(s): Sato, Y., Caston, J., and Suzuki, N.
  • Journal Title: Current Opinion in Virology Volume: 33 Pages: 55-65
  • DOI: 10.1016/j.coviro.2018.07.009
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Development of stable rotavirus reporter expression (2019)
  • Author(s): Kanai Y, Kawagishi T, Nouda R, Onishi M, Pannacha P, Nurdin J, Nomura K, Matsuura Y, Kobayashi T.
  • Journal Title: J Virol Volume: 93 Pages: e01774-18
  • DOI: 10.1128/JVI.01774-18
  • Peer Reviewed
• [Journal Article] Cell-cell fusion induced by reovirus FAST proteins enhances replication and pathogenicity of non-enveloped dsRNA viruses (2019)
  • Author(s): Kanai Y, Kawagishi T, Sakai Y, Nouda R, Shimojima M, Saijo M, Matsuura Y, Kobayashi T.
  • Journal Title: Plos Pathogens Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1371/journal.ppat.1007675
  • Peer Reviewed / Open Access
• [Journal Article] USP15 participates in HCV propagation through the regulation of viral RNA translation and lipid droplet formation. (2019)
  • Author(s): Kusakabe S, Suzuki T, Sugiyama Y, Haga S, Horike K, Tokunaga M, Hirano J, He Z, Chen D, Ishiga H, Komoda Y, Ono C, Fukuhara T, Yamamoto M, Ikawa M, Satoh T, Akira S, Tanaka T, Moriishi K, Fukai M, Taketomi A, Yoshio S, Kanto T, Suzuki T, Okamoto T and Matsuura Y
  • Journal Title: J Virol Volume: 93 Pages: e01708-18
  • DOI: 10.1128/JVI.01708-18
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Infection of newly identified phleboviruses in ticks and wild animals in Hokkaido, Japan indicating tick-borne life cycles. (2019)
  • Author(s): Torii S, Matsuno K, Qiu Y, Mori-Kajihara A, Kajihara M, Nakao R, Nao N, Okazaki K, Sashika M, Hiono T, Okamatsu M, Sakoda Y, Ebihara H, Takada A, Sawa H
  • Journal Title: Ticks and Tick-borne Diseases Volume: 10(2) Pages: 328-335
  • DOI: 10.1016/j.ttbdis.2018.11.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Recombination and purifying and balancing selection determine the evolution of major antigenic protein 1 (map 1) family genes in Ehrlichia ruminantium. (2019)
  • Author(s): Salim B, Amin M, Igarashi M, Ito K, Jongejan F, Katakura K, Sugimoto C, Nakao R.
  • Journal Title: Gene Volume: 683 Pages: 216-224
  • DOI: 10.1016/j.gene.2018.10.028
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Diversity of spotted fever group rickettsiae and their association with host ticks in Japan (2019)
  • Author(s): Thu MJ, Qiu Y, Matsuno K, Kajihara M, Mori-Kajihara A, Omori R, Monma N, Chiba K, Seto J, Gokuden M, Andoh M, Oosako H, Katakura K, Takada A, Sugimoto C, Isoda N, Nakao R
  • Journal Title: Scientific Reports Volume: 9(1) Pages: 1500
  • DOI: 10.1038/s41598-018-37836-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Epidermal growth factor receptor is a host entry cofactor triggering hepatitis B virus internalization (2019)
  • Author(s): M. Iwamoto, W. Saso, R. Sugiyama, K. Ishii, M. Ohki, S. Nagamori, R. Suzuki, H. Aizaki, A. Ryo, J-H Yun, S-Y Park, N. Ohtani, M. Muramatsu, S. Iwami, Y. Tanaka, C. Sureau, T. Wakita and K. Watashi
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 116 Pages: 8487-8492
  • DOI: 10.1073/pnas.1811064116
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mathematical analysis of a transformed ODE from a PDE multiscale model of hepatitis C virus infection (2019)
  • Author(s): K. Kitagawa, T. Kuniya, S. Nakaoka, Y. Asai, K. Watashi and S. Iwami
  • Journal Title: Bulletin of Mathematical Biology Volume: 81 Pages: 1427-1441
  • DOI: 10.1007/s11538-018-00564-y
  • Peer Reviewed
• [Journal Article] Quantitative immunology by data analysis using mathematical models (2019)
  • Author(s): S. Iwanami and S. Iwami
  • Journal Title: Encyclopedia of Bioinformatics and Computational Biology Volume: 2 Pages: 984-992
  • DOI: 10.1016/B978-0-12-809633-8.20250-1
  • Peer Reviewed
• [Journal Article] Minimum Information about Uncultivated Virus Genomes (MIUViG): a community consensus on standards and best practices for describing genome sequences from uncultivated viruses. (2019)
  • Author(s): Roux S, Adriaenssens EM, Dutilh BE, Koonin EV, et al
  • Journal Title: Nat Biotechnol Volume: 37 Pages: 29-37
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• [Journal Article] Medusavirus, a novel large DNA virus discovered from hot spring water. (2019)
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• [Journal Article] Plasma lipidome reveals critical illness and recovery from human Ebola virus disease. (2018)
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• [Journal Article] Characterization of a Feline Influenza A(H7N2) Virus. (2018)
  • Author(s): Hatta M, Zhong G, Gao Y, Nakajima N, Fan S, Chiba S, Deering KM, Ito M, Imai M, Kiso M, Nakatsu S, Lopes TJ, Thompson AJ, McBride R, Suarez DL, Macken CA, Sugita S, Neumann G, Hasegawa H, Paulson JC, Toohey-Kurth KL, Kawaoka Y.
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• [Journal Article] Syrian hamster as an animal model for the study of human influenza virus infection. (2018)
  • Author(s): Iwatsuki-Horimoto K, Nakajima N, Ichiko Y, Sakai-Tagawa Y, Noda T, Hasegawa H, Kawaoka Y
  • Journal Title: J Virol Volume: 92 Pages: e01693-17
  • DOI: 10.1128/JVI.01693-17
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• [Journal Article] Identification of novel amino acid residues of influenza virus PA-X that are important for PA-X shutoff activity by using yeast. (2018)
  • Author(s): Oishi K, Yamayoshi S, Kawaoka Y.
  • Journal Title: Virology Volume: 516 Pages: 71-75
  • DOI: 10.1016/j.virol.2018.01.004
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• [Journal Article] Influenza C and D viruses package eight organized ribonucleoprotein complexes. (2018)
  • Author(s): Nakatsu S, Murakami S, Shindo K, Horimoto T, Sagara H, Noda T, Kawaoka Y.
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  • DOI: 10.1128/JVI.02084-17
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• [Journal Article] Importance of the 1+7 configuration of ribonucleoprotein complexes for influenza A virus genome packaging. (2018)
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• [Journal Article] Human protective monoclonal antibodies against the HA stem of group 2 HAs derived from H3N2 virus-infected humans. (2018)
  • Author(s): Yamayoshi S, Ito M, Uraki R, Sasaki T, Ikuta K, Kawaoka Y.
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  • DOI: 10.1016/j.jinf.2017.12.004
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• [Journal Article] Ebola virus requires a host scramblase for externalization of phosphatidylserine on the surface of viral particles (2018)
  • Author(s): Nanbo A, Maruyama J, Imai M, Ujie M, Fujioka Y, Nishide S, Takada A, Ohba Y, Kawaoka Y.
  • Journal Title: PLoS Pathog Volume: 14 Pages: e1006848
  • DOI: 10.1371/journal.ppat.1006848
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• [Journal Article] Lung-derived exosomal miR-483-3p regulates the innate immune response to influenza virus infection. (2018)
  • Author(s): Maemura T, Fukuyama S, Sugita Y, Lopes TJS, Nakao T, Noda T, Kawaoka Y.
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  • DOI: 10.1093/infdis/jiy035
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• [Journal Article] Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans. (2018)
  • Author(s): Yamayoshi S, Kiso M, Yasuhara A, Ito M, Shu Y, Kawaoka Y.
  • Journal Title: Emerg Infect Dis Volume: 24 Pages: 746-750
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• [Journal Article] Stimulation of alpha2-adrenergic receptors impairs influenza virus infection. (2018)
  • Author(s): Matsui K, Ozawa M, Kiso M, Yamashita M, Maekawa T, Kubota M, Sugano S, Kawaoka Y.
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• [Journal Article] Evaluation of the fusion partner cell line SPYMEG for obtaining human monoclonal antibodies against influenza B virus. (2018)
  • Author(s): Soni P, Yasuhara A, Takenaga T, Iwatsuki-Horimoto K, Uraki R, Ito M, Sasaki T, Ikuta K, Yamayoshi S, Kawaoka Y.
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  • DOI: 10.1292/jvms.18-0146
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• [Journal Article] The marmoset as an animal model of influenza: infection with A(H1N1)pdm09 and highly pathogenic A(H5N1) viruses via the conventional or tracheal spray route. (2018)
  • Author(s): Iwatsuki-Horimoto K, Nakajima N, Kiso M, Takahashi K, Ito M, Inoue T, Horiuchi M, Okahara N, Sasaki E, Hasegawa H, Kawaoka Y.
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  • DOI: 10.3389/fmicb.2018.00844
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• [Journal Article] Diversity of influenza A(H5N1) Viruses in infected humans, Northern Vietnam, 2004-2010. (2018)
  • Author(s): Imai H, Dinis JM, Zhong G, Moncla LH, Lopes TJS, McBride R, Thompson AJ, Peng W, Le MTQ, Hanson A, Lauck M, Sakai-Tagawa Y, Yamada S, Eggenberger J, O'Connor DH, Suzuki Y, Hatta M, Paulson JC, Neumann G, Friedrich TC, Kawaoka Y.
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• [Journal Article] Development of an influenza rapid diagnostic kit specific for the H7 subtype. (2018)
  • Author(s): Iwatsuki-Horimoto K, Shi J, Wang X, Sakai-Tagawa Y, Ito M, Murakami K, da Silva Lopes TJ, Nakaishi K, Yamayoshi S, Watanabe S, Chen H, Kawaoka Y.
  • Journal Title: Front Microbiol Volume: 9 Pages: 1346
  • DOI: 10.3389/fmicb.2018.01346
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• [Journal Article] Strain-specific contribution of eukaryotic elongation factor 1 gamma to the translation of influenza A virus proteins. (2018)
  • Author(s): Sammaibashi S, Yamayoshi S, Kawaoka Y.
  • Journal Title: Front Microbiol Volume: 9 Pages: 1446
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• [Journal Article] N-terminal acetylation by NatB is required for the shutoff activity of influenza A virus PA-X. (2018)
  • Author(s): Oishi K, Yamayoshi S, Kozuka-Hata H, Oyama M, Kawaoka Y.
  • Journal Title: Cell Rep Volume: 24 Pages: 851-860
  • DOI: 10.1016/j.celrep.2018.06.078
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• [Journal Article] Host Factor Nucleoporin 93 Is Involved in the Nuclear Export of Influenza Virus RNA. (2018)
  • Author(s): Furusawa Y, Yamada S, Kawaoka Y.
  • Journal Title: Front Microbiol Volume: 9 Pages: 1675
  • DOI: 10.3389/fmicb.2018.01675
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• [Journal Article] Differences in the ease with which mutant viruses escape from human monoclonal antibodies against the HA stem of influenza A virus. (2018)
  • Author(s): Yamayoshi S, Yasuhara A, Ito M, Uraki R, Kawaoka Y.
  • Journal Title: J Clin Virol Volume: 108 Pages: 105-111
  • DOI: 10.1016/j.jcv.2018.09.016
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• [Journal Article] Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex at 3.6 A resolution. (2018)
  • Author(s): Sugita Y, Matsunami H, Kawaoka Y, Noda T, Wolf M.
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• [Journal Article] Isolation and Characterization of Human Monoclonal Antibodies That Recognize the Influenza A(H1N1)pdm09 Virus Hemagglutinin Receptor-Binding Site and Rarely Yield Escape Mutant Viruses. (2018)
  • Author(s): Yasuhara A, Yamayoshi S, Ito M, Kiso M, Yamada S, Kawaoka Y.
  • Journal Title: Front Microbiol Volume: 9 Pages: 2660
  • DOI: 10.3389/fmicb.2018.02660
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• [Journal Article] スペインかぜ その１ 100年前に起こった疫学史上最悪の出来事 (2018)
  • Author(s): 渡辺登喜子
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• [Journal Article] 新興再興感染症に対するワクチン開発～エボラワクチン開発における最近の進展～. (2018)
  • Author(s): 渡辺登喜子、河岡義裕
  • Journal Title: BIO Clinica Volume: 32 Pages: 25-29
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  • DOI: 10.1099/jgv.0.001046
  • Peer Reviewed
• [Journal Article] New World feline APOBEC3 potently controls inter-genus lentiviral transmission (2018)
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  • Journal Title: Rerovirology Volume: 15 Pages: 31
  • DOI: 10.1186/s12977-018-0414-5
  • Peer Reviewed / Open Access
• [Journal Article] Integration of danger peptide signals with herbivore-associated molecular pattern signaling amplifies anti-herbivore defense responses in rice. (2018)
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• [Journal Article] Degradation of amyloid _ peptide by neprilysin expressed from Borna disease virus vector. (2018)
  • Author(s): Sakai M, Ueda S, Daito T, Asada-Utsugi M, Komatsu Y, Kinoshita A, Maki T, Kuzuya A, Takahashi R, Makino A, Tomonaga K.
  • Journal Title: Microbiol Immunol. Volume: 62 Pages: 467-472
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• [Journal Article] Systematic estimation of insertion dates of endogenous bornavirus-like elements in vesper bats. (2018)
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• [Journal Article] Splicing-Dependent Subcellular Targeting of Borna Disease Virus Nucleoprotein Isoforms. (2018)
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• [Journal Article] Molecular Aspects of Varicella-Zoster Virus Latency. (2018)
  • Author(s): Daniel P. Depledge, Tomohiko Sadaoka, Werner J. D. Ouwendijk
  • Journal Title: Viruses Volume: 10 Pages: 349-360
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  • Peer Reviewed / Open Access / Int'l Joint Research
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• [Journal Article] Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis. (2018)
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  • DOI: 10.1038/s41590-018-0203-2
  • Peer Reviewed / Open Access
• [Journal Article] Roles of the Phosphorylation of Herpes Simplex Virus 1 UL51 at a Specific Site in Viral Replication and Pathogenicity (2018)
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  • Journal Title: Journal of Virology Volume: 92 Pages: -
  • DOI: 10.1128/JVI.01035-18
  • Peer Reviewed / Open Access
• [Journal Article] Regulation of Herpes Simplex Virus 2 Protein Kinase UL13 by Phosphorylation and Its Role in Viral Pathogenesis (2018)
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  • Journal Title: Journal of Virology Volume: 92 Pages: -
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• [Journal Article] ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity (2018)
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• [Journal Article] Cryo-EM structure of a Marseilleviridae virus particle reveals a large internal microassembly (2018)
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  • Journal Title: Virology Volume: 516 Pages: 239-245
  • DOI: 10.1016/j.virol.2018.01.021
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Investigation of recombination-intense viral groups and their genes in the Earth's virome (2018)
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• [Journal Article] Expression of human mutant cyclin dependent kinase 4, Cyclin D and telomerase extends the life span but does not immortalize fibroblasts derived from loggerhead sea turtle (Caretta caretta). (2018)
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• [Journal Article] A Single Amino Acid Substitution within the Paramyxovirus Sendai Virus Nucleoprotein Is a Critical Determinant for Production of Interferon-Beta-Inducing Copyback-Type Defective Interfering Genomes. (2018)
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• [Journal Article] Size distribution of small interfering RNAs in various organs at different developmental stages is primarily determined by the dicing activity of Dicer-like proteins in plants (2018)
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  • Journal Title: Plant Cell Physiol Volume: 59 Pages: 2228-2238
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• [Journal Article] The role of migration in maintaining the transmission of avian influenza in waterfowl: a multi-site multi-species transmission model along East Asian-Australian Flyway. (2018)
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• [Journal Article] An investigation of a measles outbreak in Japan and Taiwan, China, March-May 2018. (2018)
  • Author(s): Shimizu K, Kinoshita R, Yoshii K, Akhmetzhanov AR, Jung SM, Lee H, Nishiura H.
  • Journal Title: Western Pacific Surveillance and Response Journal Volume: 9 Pages: 1-8.
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  • Journal Title: Environ Microbiol Volume: 20 Pages: 1464-1483
  • DOI: 10.1111/1462-2920.14065
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• [Journal Article] Novel mitoviruses and a unique tymo-like virus in hypovirulent and virulent strains of the Fusarium Head Blight fungus, Fusarium boothii (2018)
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  • Journal Title: Viruses Volume: 10 Pages: E584
  • DOI: 10.3390/v10110584
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• [Journal Article] Dichorhaviruses in their host plants and mite vectors. (2018)
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  • Journal Title: Advances in Virus Research Volume: 102 Pages: 119-148
  • DOI: 10.1016/bs.aivir.2018.06.001
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• [Journal Article] Induction of selective autophagy in cells replicating hepatitis C virus genome. (2018)
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  • Journal Title: J Gen Virol Volume: 99 Pages: 1643-57
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• [Journal Article] Infection with flaviviruses requires BCLXL for cell survival. (2018)
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  • Journal Title: PLoS Pathog Volume: 14 Pages: e1007299
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characterization of recombinant Flaviviridae viruses possessing a small reporter tag. (2018)
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• [Journal Article] Discovery of Mwinilunga alphavirus: A novel alphavirus in Culex mosquitoes in Zambia. (2018)
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  • Journal Title: Virus Res Volume: 250 Pages: 31-36
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Tick-borne haemoparasites and Anaplasmataceae in domestic dogs in Zambia. (2018)
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  • Journal Title: Ticks and Tick-borne Diseases Volume: 9(4) Pages: 988-995
  • DOI: 10.1016/j.ttbdis.2018.03.025
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ribavirin-related compounds exert in vitro inhibitory effects toward rabies virus. (2018)
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  • Journal Title: mSphere Volume: 3(3) Pages: pii: e00239-18
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• [Journal Article] First isolation of West Nile virus in Zambia from mosquitoes. (2018)
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  • Journal Title: Transboundry Emerging Disease Volume: 65(4) Pages: 933-938
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• [Journal Article] Identification of group A rotaviruses from Zambian fruit bats provides evidence for long-distance dispersal events in Africa. (2018)
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• [Journal Article] Fatal tickborne phlebovirus infection in captive cheetahs, Japan. (2018)
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• [Journal Article] Malaria incidences in South Africa linked to a climate mode in southwestern Indian Ocean (2018)
  • Author(s): SK. Behera, Y. Morioka, T. Ikeda, T. Doi, JV. Ratnam, M. Nonaka, A. Tsuzuki, C. Imai, Y. Kim, M. Hashizume, S. Iwami, P. Kruger, R. Maharaj, N. Sweijd and N. Minakawa
  • Journal Title: Environmental Development Volume: 27 Pages: 47-57
  • DOI: 10.1016/j.envdev.2018.07.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dynamics of HIV-1 coinfection in different susceptible target cell populations during cell-free infection (2018)
  • Author(s): Y. Ito, A. Tauzin, A. Remion, K. Ejima, F. Mammano and S. Iwami
  • Journal Title: Journal of Theoretical Biology Volume: 455 Pages: 39-46
  • DOI: 10.1016/j.jtbi.2018.06.025
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A PDE multiscale model of hepatitis C virus infection can be transformed to a system of ODEs (2018)
  • Author(s): K. Kitagawa, S. Nakaoka, Y. Asai, K. Watashi, and S. Iwami
  • Journal Title: Journal of Theoretical Biology Volume: 448 Pages: 80-85
  • DOI: 10.1016/j.jtbi.2018.04.006
  • Peer Reviewed
• [Journal Article] Complete genome sequence of a novel RNA virus identified from a deep-sea animal, Osedax japonicus (2018)
  • Author(s): Urayama S, Takaki Y, Nunoura T, Miyamoto N
  • Journal Title: Microbes and Environments Volume: 33 Pages: 446-449
  • DOI: 10.1264/jsme2.ME18089
  • Peer Reviewed / Open Access
• [Journal Article] Unveiling the RNA virosphere associated with marine microorganisms (2018)
  • Author(s): Urayama S, Takaki Y, Nishi S, Yoshida-Takashima Y, Deguchi S, Takai K, Nunoura T.
  • Journal Title: Molecular Ecology Resources Volume: 18 Pages: 1444-1455
  • DOI: 10.1111/1755-0998.12936
  • Peer Reviewed / Open Access
• [Journal Article] 藻類ウイルスの多様性と珪藻ウイルス研究の現状． (2018)
  • Author(s): 木村圭, 外丸裕司.
  • Journal Title: 藻類 Volume: 66 Pages: 118-124
  • Peer Reviewed
• [Journal Article] Aggregate formation during the viral lysis of a marine diatom. (2018)
  • Author(s): Yamada Y, Tomaru Y, Fukuda H, Nagata T.
  • Journal Title: Front Mar Sci Volume: 5 Pages: 167-173
  • DOI: 10.3389/fmars.2018.00167
  • Peer Reviewed / Open Access
• [Journal Article] Visualization of a dinoflagellate-infecting virus HcDNAV and its infection process. (2018)
  • Author(s): Takano Y, Tomaru Y, Nagasaki K.
  • Journal Title: Viruses Volume: 10 Pages: 554-560
  • DOI: 10.3390/v10100554
  • Peer Reviewed / Open Access
• [Journal Article] Locality and diel cycling of viral production revealed by a 24 h time course cross-omics analysis in a coastal region of Japan. (2018)
  • Author(s): Yoshida T, Nishimura Y, Watai H, Haruki N, Morimoto D, Kaneko H, Honda T, Yamamoto K, Hingamp P, Sako Y, Goto S, Ogata H.
  • Journal Title: ISME J Volume: 12 Pages: 1287-1295
  • DOI: 10.1038/s41396-018-0052-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Xanthomonas citri jumbo phage XacN1 exhibits a wide host range and high complement of tRNA genes. (2018)
  • Author(s): Yoshikawa G., Askora A., Blanc-Mathieu R, Kawasaki T, Li Y, Nakano M, Ogata H, Yamada T.
  • Journal Title: Sci Rep Volume: 8 Pages: 4486-4495
  • DOI: 10.1038/s41598-018-22239-3
  • Peer Reviewed / Open Access
• [Journal Article] Taxon richness of Megaviridae exceeds those of Bacteria and Archaea in the ocean. (2018)
  • Author(s): Mihara T, Koyano H, Hingamp P, Grimsley N, Goto S , Ogata H.
  • Journal Title: Microbes Environ Volume: 33 Pages: 162-171
  • DOI: 10.1038/s41598-018-22239-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Habitat Alterations by Viruses: Strategies by Tupanviruses and Others. (2018)
  • Author(s): Ogata H.
  • Journal Title: Microbes Environ Volume: 33 Pages: 117-119
  • DOI: 10.1264/jsme2.ME3302rh
  • Peer Reviewed
• [Journal Article] Degenerate PCR primers to reveal the diversity of giant viruses in coastal waters. (2018)
  • Author(s): Li Y, Hingamp P, Watai H, Endo H, Yoshida T, Ogata H.
  • Journal Title: Viruses Volume: 10 Pages: 496-511
  • DOI: 10.3390/v10090496
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Remarks] Neo Virology
  • URL: http://neo-virology.org/en/
• [Remarks] Hokkaido University
  • URL: http://www.czc.hokudai.ac.jp/pathobiol/en/
• [Funded Workshop] The 17th Awaji International Forum on Infection and Immunity (2018)
• [Funded Workshop] The 66th Annual Meeting of the Japanese Society for Virology (2018)
• [Funded Workshop] IMSUT-CAS Workshop on Infectious Diseases 2018 (2018)
• [Funded Workshop] Environmental Virology Workshop (2018)